(18)F-FPPRGD2 PET/CT: pilot phase evaluation of breast cancer patients.

Abstract:

PURPOSE:To present data from the first prospective pilot phase trial of breast cancer participants imaged with fluorine 18 ((18)F)-2-fluoropropionyl-labeled PEGylated dimeric arginine-glycine-aspartic acid ( RGD arginine-glycine-aspartic acid ) peptide (PEG3-E[c{ RGD arginine-glycine-aspartic acid yk}]2) ( FPPRGD2 2-fluoropropionyl labeled PEGylated dimeric RGD peptide (PEG3-E[c{RGDyk}]2) ), a radiopharmaceutical agent used in positron emission tomographic (PET) imaging. MATERIALS AND METHODS:The local institutional review board approved the HIPAA-compliant protocol. Written informed consent was obtained from each patient. Eight women (age range, 44-67 years; mean age, 54.3 years ± 8.8 [standard deviation]) with newly diagnosed or recurrent breast cancer were recruited between November 2010 and February 2011. (18)F- FPPRGD2 2-fluoropropionyl labeled PEGylated dimeric RGD peptide (PEG3-E[c{RGDyk}]2) PET/computed tomographic (CT) and (18)F-fluorodeoxyglucose ( FDG fluorine 18 fluorodeoxyglucose ) PET/CT examinations were performed within 3 weeks of each other. Dynamic (18)F- FPPRGD2 2-fluoropropionyl labeled PEGylated dimeric RGD peptide (PEG3-E[c{RGDyk}]2) PET and two whole-body static (18)F- FPPRGD2 2-fluoropropionyl labeled PEGylated dimeric RGD peptide (PEG3-E[c{RGDyk}]2) PET/CT scans were obtained. During this time, vital signs and electrocardiograms were recorded at regular intervals. Blood samples were obtained before the injection of (18)F- FPPRGD2 2-fluoropropionyl labeled PEGylated dimeric RGD peptide (PEG3-E[c{RGDyk}]2) and at 24 hours and 1 week after injection to evaluate for toxicity. A nonparametric version of multivariate analysis of variance was used to assess the safety outcome measures simultaneously across time points. A paired two-sample t test was performed to compare the maximum standardized uptake values ( SUVmax maximum standardized uptake value ). RESULTS:(18)F- FPPRGD2 2-fluoropropionyl labeled PEGylated dimeric RGD peptide (PEG3-E[c{RGDyk}]2) was well tolerated, without noticeable changes in vital signs, on electrocardiograms, or in laboratory values. A total of 30 lesions were evaluated at (18)F- FDG fluorine 18 fluorodeoxyglucose PET/CT and (18)F- FPPRGD2 2-fluoropropionyl labeled PEGylated dimeric RGD peptide (PEG3-E[c{RGDyk}]2) PET/CT. The primary breast lesions had (18)F- FPPRGD2 2-fluoropropionyl labeled PEGylated dimeric RGD peptide (PEG3-E[c{RGDyk}]2) uptake with SUVmax maximum standardized uptake value of 2.4-9.4 (mean, 5.6 ± 2.8) 60 minutes after injection, compared with (18)F- FDG fluorine 18 fluorodeoxyglucose uptake with SUVmax maximum standardized uptake value of 2.8-18.6 (mean, 10.4 ± 7.2). Metastatic lesions also showed (18)F- FPPRGD2 2-fluoropropionyl labeled PEGylated dimeric RGD peptide (PEG3-E[c{RGDyk}]2) uptake, with SUVmax maximum standardized uptake value of 2.4-9.7 (mean, 5.0 ± 2.3) at 60 minutes, compared with (18)F- FDG fluorine 18 fluorodeoxyglucose uptake with SUVmax maximum standardized uptake value of 2.2-14.6 (mean, 6.6 ± 4.2). CONCLUSION:Data from this pilot phase study suggest that (18)F- FPPRGD2 2-fluoropropionyl labeled PEGylated dimeric RGD peptide (PEG3-E[c{RGDyk}]2) is a safe PET radiopharmaceutical agent. Evaluation of (18)F- FPPRGD2 2-fluoropropionyl labeled PEGylated dimeric RGD peptide (PEG3-E[c{RGDyk}]2) in participants with breast cancer demonstrated significant uptake in the primary lesion and in the metastases. Larger cohorts are required to confirm these preliminary findings.

journal_name

Radiology

journal_title

Radiology

authors

Iagaru A,Mosci C,Shen B,Chin FT,Mittra E,Telli ML,Gambhir SS

doi

10.1148/radiol.14140028

subject

Has Abstract

pub_date

2014-11-01 00:00:00

pages

549-59

issue

2

eissn

0033-8419

issn

1527-1315

journal_volume

273

pub_type

杂志文章
  • Contrast-enhanced MR imaging of hepatic lesions treated with percutaneous ethanol ablation therapy.

    abstract:PURPOSE:Magnetic resonance (MR) images were correlated with results of fine-needle aspiration (FNA) to determine the role of MR imaging in evaluating hepatic neoplasms treated with percutaneous ethanol ablation therapy (PEAT). MATERIALS AND METHODS:Contrast material-enhanced and unenhanced MR images were obtained in 1...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.189.1.7690490

    authors: Nagel HS,Bernardino ME

    更新日期:1993-10-01 00:00:00

  • Apparent diffusion coefficient in estrogen receptor-positive invasive ductal breast carcinoma: correlations with tumor-stroma ratio.

    abstract:PURPOSE:To determine whether apparent diffusion coefficient (ADC) values vary according to tumor-stroma ratio, dominant stroma type, or presence of central fibrosis in estrogen receptor-positive breast cancer. MATERIALS AND METHODS:Institutional review board approval was obtained, and patient consent was waived. Sixty...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.13131073

    authors: Ko ES,Han BK,Kim RB,Cho EY,Ahn S,Nam SJ,Ko EY,Shin JH,Hahn SY

    更新日期:2014-04-01 00:00:00

  • Emergency room radiography of asthma: an efficacy study.

    abstract::The chest radiographs of asthmatic patients in an emergency room setting over a four-year period were reviewed. A total of 997 radiographs was reviewed; radiographic findings were compared with history and clinical data. In adults 2.2% of the radiographs were abnormal; in children 13%. It is concluded that a chest rad...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.145.1.7122890

    authors: Zieverink SE,Harper AP,Holden RW,Klatte EC,Brittain H

    更新日期:1982-10-01 00:00:00

  • Shear-wave elastography of the breast: value of a quality measure and comparison with strain elastography.

    abstract:PURPOSE:To determine whether addition of quality measure (QM) of shear-wave (SW) velocity (Vs) estimation can increase SW elastography sensitivity for breast cancer. MATERIALS AND METHODS:With written informed consent, this institutional review board-approved, HIPAA-compliant study included 143 women (mean age, 48.5 y...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.14132404

    authors: Barr RG,Zhang Z

    更新日期:2015-04-01 00:00:00

  • Comprehensive assessment of myocardial perfusion defects, regional wall motion, and left ventricular function by using 64-section multidetector CT.

    abstract:PURPOSE:To evaluate the accuracy of 64-section multidetector computed tomography (CT) for the assessment of perfusion defects (PDs), regional wall motion (RWM), and global left ventricular (LV) function. MATERIALS AND METHODS:All myocardial infarction (MI) patients signed informed consent. The IRB approved the study a...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.2482071478

    authors: Cury RC,Nieman K,Shapiro MD,Butler J,Nomura CH,Ferencik M,Hoffmann U,Abbara S,Jassal DS,Yasuda T,Gold HK,Jang IK,Brady TJ

    更新日期:2008-08-01 00:00:00

  • Pheochromocytomas: detection with 18F DOPA whole body PET--initial results..

    abstract:PURPOSE:To evaluate fluorine 18 ((18)F) dihydroxyphenylalanine (DOPA) whole-body positron emission tomography (PET) as a biochemical imaging approach for detection of pheochromocytomas. MATERIALS AND METHODS:(18)F DOPA PET and magnetic resonance (MR) imaging were performed in 14 consecutive patients suspected of havin...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.2222010622

    authors: Hoegerle S,Nitzsche E,Altehoefer C,Ghanem N,Manz T,Brink I,Reincke M,Moser E,Neumann HP

    更新日期:2002-02-01 00:00:00

  • High Signal Intensity in Globus Pallidus and Dentate Nucleus on Unenhanced T1-weighted MR Images: Evaluation of Two Linear Gadolinium-based Contrast Agents.

    abstract:PURPOSE:To determine if a correlation exists between the number of previous enhanced magnetic resonance (MR) imaging examinations and high signal intensity in the globus pallidus (GP) and dentate nucleus (DN) in patients who received gadodiamide (Omniscan), a linear nonionic gadolinium-based contrast agent, and in thos...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.2015150872

    authors: Ramalho J,Castillo M,AlObaidy M,Nunes RH,Ramalho M,Dale BM,Semelka RC

    更新日期:2015-09-01 00:00:00

  • Colorectal carcinoma metastases in liver: laser-induced interstitial thermotherapy--local tumor control rate and survival data.

    abstract:PURPOSE:To evaluate the local tumor control and survival data for magnetic resonance (MR) imaging-guided laser-induced interstitial thermotherapy (LITT) of colorectal liver metastases. MATERIALS AND METHODS:MR imaging-guided LITT was performed in 603 patients (mean age, 61.2 years) with 1,801 liver metastases of color...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.2302020646

    authors: Vogl TJ,Straub R,Eichler K,Söllner O,Mack MG

    更新日期:2004-02-01 00:00:00

  • Lung transplantation for lymphangioleiomyomatosis: role of imaging in the assessment of complications related to the underlying disease.

    abstract:PURPOSE:To identify the complications and imaging findings related to lymphangioleiomyomatosis (LAM) after lung transplantation. MATERIALS AND METHODS:The authors retrospectively reviewed the clinical histories and imaging studies of 13 patients from five major medical centers who underwent unilateral (n = 8) or bilat...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.210.2.r99fe11325

    authors: Collins J,Müller NL,Kazerooni EA,McAdams HP,Leung AN,Love RB

    更新日期:1999-02-01 00:00:00

  • Integrated stereotaxic imaging with CT, MR imaging, and digital subtraction angiography.

    abstract::A stereotaxic frame, compatible with digital subtraction angiography, computed tomography, and magnetic resonance imaging, is described along with a set of software programs that run in an independent imaging computer system, as well as in the computers associated with each modality. Plexiglas plates fastened to the s...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.161.3.3538140

    authors: Peters TM,Clark JA,Olivier A,Marchand EP,Mawko G,Dieumegarde M,Muresan LV,Ethier R

    更新日期:1986-12-01 00:00:00

  • Workers with Libby amphibole exposure: retrospective identification and progression of radiographic changes.

    abstract:PURPOSE:To assess how early pleural and/or parenchymal abnormalities consistent with asbestos exposure could be ascertained and to identify factors associated with progression. MATERIALS AND METHODS:Informed consent was obtained under an institutional review board-approved protocol. Multiple sequential chest radiograp...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.10091447

    authors: Larson TC,Meyer CA,Kapil V,Gurney JW,Tarver RD,Black CB,Lockey JE

    更新日期:2010-06-01 00:00:00

  • Internal contamination of laboratory personnel by 131I1.

    abstract::Internal contamination by 131I among the personnel in a nuclear medicine laboratory was surveyed from January to July, 1979. Because of the formulation change made by the manufacturer in April to reduce volatility, it was possible to study two different therapeutic solutions of 131I. Internal contamination of personne...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.137.3.7444060

    authors: Nishiyama H,Lukes SJ,Mayfield G,Grossman LW

    更新日期:1980-12-01 00:00:00

  • Biliary atresia and noncardiac polysplenic syndrome: US and surgical considerations.

    abstract::Ten percent of children with biliary atresia have an associated complex of anomalies, including polysplenia, azygous continuation of the inferior vena cava, preduodenal portal vein, hepatic arterial anomalies, and bilaterally bilobed lungs. These abnormalities will not be detected if the preoperative workup is limited...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.163.2.3550880

    authors: Abramson SJ,Berdon WE,Altman RP,Amodio JB,Levy J

    更新日期:1987-05-01 00:00:00

  • Lung morphology in the elderly: comparative CT study of subjects over 75 years old versus those under 55 years old.

    abstract:PURPOSE:To describe thin-section pulmonary computed tomographic (CT) features in asymptomatic elderly individuals. MATERIALS AND METHODS:Institutional review board approval was given, and informed consent was obtained. Two study groups (older group, over 75 years of age; younger group, under 55 years) were prospective...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.2512081242

    authors: Copley SJ,Wells AU,Hawtin KE,Gibson DJ,Hodson JM,Jacques AE,Hansell DM

    更新日期:2009-05-01 00:00:00

  • Soft-tissue sarcoma involving bone or neurovascular structures: MR imaging prognostic factors.

    abstract:PURPOSE:To determine if magnetic resonance (MR) imaging findings of soft-tissue sarcoma involving bone or neurovascular structures allow prediction of local recurrence, distant metastasis, or disease-specific survival. MATERIALS AND METHODS:Preoperative MR images of 46 patients with soft-tissue sarcoma were reviewed f...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.205.3.9393550

    authors: Panicek DM,Go SD,Healey JH,Leung DH,Brennan MF,Lewis JJ

    更新日期:1997-12-01 00:00:00

  • Subjective vs. objective evaluation of gallbladder opacification during oral cholecystography in comparative clinical trials: implications for studies involving visual assessment.

    abstract::Radiographs and CT images taken during oral cholecystography in dogs were interpreted in an independent, blind fashion by three radiologists on two occasions and visual assessment of gallbladder density compared to the actual CT values. While there was significant intra- and inter-observer variation, the mean scores f...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.144.2.7089280

    authors: Fon GT,Hunter TB,Berk RN,Patton DD,Capp MP

    更新日期:1982-07-01 00:00:00

  • Transcatheter fiberoptic laser coagulation of blood vessels.

    abstract::In ten rabbit ears the central auricular artery was percutaneously catheterized and subjected to doses of laser energy transmitted through a flexible optical fiber within the artery. Arterial occlusion was not produced in the initial three ears using energy levels less than 600 mW. Higher levels of laser energy, in th...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.142.3.7199750

    authors: O'Reilly GV,Colucci VM,Astorian DG,Schoene WC,Clarke RH,Hammerschlag SB

    更新日期:1982-03-01 00:00:00

  • Staging non-small cell lung cancer with whole-body PET.

    abstract:PURPOSE:To compare the accuracies of whole-body 2-[fluorine 18]fluoro-2-deoxy-D-glucose (FDG) positron emission tomography (PET) and conventional imaging (thoracic computed tomography [CT], bone scintigraphy, and brain CT or magnetic resonance [MR] imaging) in staging bronchogenic carcinoma. MATERIALS AND METHODS:With...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.212.3.r99se21803

    authors: Marom EM,McAdams HP,Erasmus JJ,Goodman PC,Culhane DK,Coleman RE,Herndon JE,Patz EF Jr

    更新日期:1999-09-01 00:00:00

  • Renal mass biopsy to guide treatment decisions for small incidental renal tumors: a cost-effectiveness analysis.

    abstract:PURPOSE:To evaluate the effectiveness, cost, and cost-effectiveness of using renal mass biopsy to guide treatment decisions for small incidentally detected renal tumors. MATERIALS AND METHODS:A decision-analytic Markov model was developed to estimate life expectancy and lifetime costs for patients with small (< or = 4...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.10092013

    authors: Pandharipande PV,Gervais DA,Hartman RI,Harisinghani MG,Feldman AS,Mueller PR,Gazelle GS

    更新日期:2010-09-01 00:00:00

  • Direct chronotropic and dromotropic actions of contrast media: ineffectiveness of atropine in the prevention of bradyarrhythmias and conduction disturbances.

    abstract::Methyl glucamine sodium diatrizoate (Renografin 76) was directly infused into the isolated arteries to the sino-atrial and atrioventricular nodes of anesthetized dogs, causing a dose-related inhibition of sino-atrial nodal automaticity and atrioventricular nodal conductivity; these effects were not attenuated by auton...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/121.1.205

    authors: Higgins CB,Feld GK

    更新日期:1976-10-01 00:00:00

  • Pulmonary arteriography in the high-risk patient.

    abstract::Pulmonary arteriography is an invasive but relatively safe diagnostic procedure. It is generally believed that the presence of pulmonary hypertension is one risk factor that increases the likelihood of a major complication. To assess the magnitude of risk, the reports on 1,434 patients who underwent pulmonary arteriog...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.162.1.3786760

    authors: Perlmutt LM,Braun SD,Newman GE,Oke EJ,Dunnick NR

    更新日期:1987-01-01 00:00:00

  • Appraisal of the angiographic circulation time as an index of cerebral blood flow.

    abstract::The relationship of the brain angiographic mode circulation time (AVCT) to the mean transit time of the vascular indicator C15O-labeled hemoglobin (tc15o) and the regional cerebral blood flow (rCBF) as measured by the clearance of the diffusible tracer H2-15O was examined in 38 patients with selected cerebral diseases...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/115.1.107

    authors: Gado M,Eichling J,Grubb R,Phelps M,Raichie M,Ter-Pogossian MM

    更新日期:1975-04-01 00:00:00

  • Symmetrical extracranial fenestrations of the vertebral artery. Two cases revealed by angiography.

    abstract::Extracranial duplication of the vertebral artery was demonstrated angiographically on both sides in a patient with postmeningitis hydrocephalus and in another with hemangioblastoma. Forty-six cases of this anomaly are reviewed. ...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/131.2.408

    authors: Kowada M,Kikuchi K

    更新日期:1979-05-01 00:00:00

  • Fibroid-related menorrhagia: treatment with superselective embolization of the uterine arteries and midterm follow-up.

    abstract:PURPOSE:To prospectively evaluate the effectiveness and safety of selective embolization of the uterine arteries in the management of symptomatic uterine leiomyoma. MATERIALS AND METHODS:Eighty consecutive women (mean age, 44.7 years) with symptomatic uterine leiomyoma, none of whom desired future pregnancy, underwent...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.215.2.r00ma11428

    authors: Pelage JP,Le Dref O,Soyer P,Kardache M,Dahan H,Abitbol M,Merland JJ,Ravina JH,Rymer R

    更新日期:2000-05-01 00:00:00

  • Superior vena caval obstruction: detection using CT.

    abstract::A review of 210 chest computed tomographic (CT) examinations demonstrating upper chest masses revealed 16 cases of superior vena caval obstruction (SVCO); 11 of these were clinically occult. Two of the occult cases subsequently became clinically evident. Contrast-enhanced chest CT permits the diagnosis of clinically o...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.157.2.4048460

    authors: Bechtold RE,Wolfman NT,Karstaedt N,Choplin RH

    更新日期:1985-11-01 00:00:00

  • Bladder pseudomass following cystography-related bladder trauma.

    abstract::Transient sonographic abnormalities of the urinary bladder in children can be identified immediately after performance of voiding cystourethrography. Both cystic and solid masses may be mimicked by transient hematuria induced by minor, cystography-related trauma. After the bladder has been emptied and refilled, reexam...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.159.1.3513250

    authors: Markle BM,Catena L

    更新日期:1986-04-01 00:00:00

  • Computer network security for the radiology enterprise.

    abstract::As computer networks become an integral part of the radiology practice, it is appropriate to raise concerns regarding their security. The purpose of this article is to present an overview of computer network security risks and preventive strategies as they pertain to the radiology enterprise. A number of technologies ...

    journal_title:Radiology

    pub_type: 杂志文章,评审

    doi:10.1148/radiology.220.2.r01au32303

    authors: Eng J

    更新日期:2001-08-01 00:00:00

  • Contrast-induced renal failure: a radiological problem and radiological diagnosis.

    abstract::Renal failure induced by intravenous iodinated contrast media is a frequent medical problem. While such cases are generally reported first by the clinician, the phenomenon can be seen even earlier by the radiologist. An abnormally persistent nephrogram is a sign of abnormal clearance, which in turn should alert the ph...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/131.2.553

    authors: Older R

    更新日期:1979-05-01 00:00:00

  • Does the Clearance of Inhaled (99m)Tc-Sestamibi Correlate with Multidrug Resistance Protein 1 Expression in the Human Lung?

    abstract::Purpose To examine the relation between the lung elimination rate of inhaled technetium 99m ((99m)Tc)-sestamibi and immunohistochemical expression of bronchopulmonary multidrug resistance protein 1 (MRP1) and permeability glycoprotein (P-gp) and assess the repeatability of the inhaled (99m)Tc-sestamibi clearance techn...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.16151389

    authors: Mohan HK,Routledge T,Cane P,Livieratos L,Ballinger JR,Peters AM

    更新日期:2016-09-01 00:00:00

  • Dual-Energy CT for Suspected Radiographically Negative Wrist Fractures: A Prospective Diagnostic Test Accuracy Study.

    abstract::Background Patients with wrist trauma and negative findings on radiographs often undergo additional MRI examinations to assess for radiographically occult fractures. Dual-energy CT may be more readily available than MRI in some settings. Purpose To evaluate the diagnostic test accuracy of dual-energy CT in helping det...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.2020192701

    authors: Müller FC,Gosvig KK,Børgesen H,Gade JS,Brejnebøl M,Rodell A,Nèmery M,Boesen M

    更新日期:2020-09-01 00:00:00