Abstract：
:The ketogenic diet (KD) controls seizure and improves cognition in patients with drug refractory epilepsy. However, few experimental models have shown this neuroprotective effect on cognition. In this study, we investigated the cognitive protective effects of KD in pentylenetetrazol (PTZ)-kindled rats. We used two relatively low-stress behavioral assessment methods, the novel object recognition (NOR) task and the novel placement recognition (NPR) task, to reveal impairment in item and spatial memory, respectively. We used the Morris water maze (MWM) test for comparisons amongst memory assessment methods. The KD group had a slower body weight gain and shorter bregma-lambda length than the control normal diet (ND) group. KD did not increase anxiety or decrease motor activities in an open-field test. KD attenuated the decrease in exploration ratio both in NOR and NPR tasks in kindled rats. Compared to the kindled ND rats, kindled KD rats stayed longer in target quarter during the probe trial testing of MWM. However, there were no differences in memory acquisition based on the MWM test results. In conclusion, KD attenuated the spatial and item memory impairment in PTZ-induced seizures.
journal_name
Brain Resjournal_title
Brain researchauthors
Jiang Y,Lu Y,Jia M,Wang X,Zhang Z,Hou Q,Wang Bdoi
10.1016/j.brainres.2016.06.029subject
Has Abstractpub_date
2016-09-01 00:00:00pages
451-458eissn
0006-8993issn
1872-6240pii
S0006-8993(16)30453-Xjournal_volume
1646pub_type
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