A Singular Role of IK1 Promoting the Development of Cardiac Automaticity during Cardiomyocyte Differentiation by IK1 -Induced Activation of Pacemaker Current.

abstract：:The absence of effective and satisfactory treatments that contribute to repairing the dopaminergic damage caused by Parkinson's Disease (PD) and the limited recovery capacity of the nervous system are troubling issues and the focus of many research and clinical domains. Recent advances in the treatment of PD through s...

journal_title：Stem cell reviews and reports

authors： Hurtado JDC,Sánchez JPB,Nunes RB,de Oliveira AA

更新日期：2018-04-01 00:00:00

abstract：:Cerebral ischemia induces death of all neural cell types within the region affected by the loss of blood flow. We have shown that administering human umbilical cord blood cells after a middle cerebral artery occlusion in rats significantly reduces infarct size, presumably by rescuing cells within the penumbra. In this...

journal_title：Stem cell reviews and reports

authors： Jiang L,Saporta S,Chen N,Sanberg CD,Sanberg P,Willing A

更新日期：2010-12-01 00:00:00

abstract：:The propensity of induced pluripotent stem (iPS) cells to differentiate into specific lineages may be influenced by a number of factors, including the selection of the somatic cell type used for reprogramming. Herein we report the generation of new iPS cells, which we derived from human articular chondrocytes and from...

journal_title：Stem cell reviews and reports

authors： Guzzo RM,Scanlon V,Sanjay A,Xu RH,Drissi H

更新日期：2014-12-01 00:00:00

abstract：:Angiotensin-converting enzyme 2 (ACE2) plays an important role as a member of the renin-angiotensin-aldosterone system (RAAS) in regulating the conversion of angiotensin II (Ang II) into angiotensin (1-7) (Ang [1-7]). But at the same time, while expressed on the surface of human cells, ACE2 is the entry receptor for S...

journal_title：Stem cell reviews and reports

authors： Ratajczak MZ,Bujko K,Ciechanowicz A,Sielatycka K,Cymer M,Marlicz W,Kucia M

更新日期：2020-07-20 00:00:00

abstract：:Pre-clinical studies have supported the use of mesenchymal stem cells (MSC) to treat highly prevalent neurodegenerative diseases such as Parkinson's disease (PD) but preliminary trials have reported controversial results. In a rat model of PD induced by MPTP neurotoxin, we first observed a significant bilateral preser...

journal_title：Stem cell reviews and reports

authors： Pereira MC,Secco M,Suzuki DE,Janjoppi L,Rodini CO,Torres LB,Araújo BH,Cavalheiro EA,Zatz M,Okamoto OK

更新日期：2011-11-01 00:00:00

abstract：:The practice of travelling abroad to receive unproven and unregulated stem cell treatments has become an increasingly problematic global phenomenon known as 'stem cell tourism'. In this paper, we examine representations of nine major clinics and providers of such treatments on the microblogging network Twitter. We col...

journal_title：Stem cell reviews and reports

authors： Kamenova K,Reshef A,Caulfield T

更新日期：2014-12-01 00:00:00

abstract：:The majority of patients survive an acute myocardial infarction (AMI). Their outcome is negatively influenced by post-AMI events, such as loss of viable cardiomyocytes due to a post-AMI inflammatory response, eventually resulting in heart failure and/or death. Recent pre-clinical animal studies indicate that mesenchym...

journal_title：Stem cell reviews and reports

authors： Naaijkens BA,van Dijk A,Kamp O,Krijnen PA,Niessen HW,Juffermans LJ

更新日期：2014-06-01 00:00:00

abstract：:Since its early days, stem cell research, particularly human embryonic stem cell research, has been the focus of intense social debate, and the question of the moral status of the embryo has been a central issue in the controversy. Despite this friction, and while it has yet to obtain widespread success in clinical ap...

journal_title：Stem cell reviews and reports

authors： Zarzeczny A,Caulfield T

更新日期：2009-06-01 00:00:00

abstract：:Here we present the principles and steps of a protocol that we have recently developed for the differentiation of hES/iPS cells into the authentic human striatal projection medium spiny neurons (MSNs) that die in Huntington's Disease (HD). Authenticity is judged by the convergence of multiple features within individua...

journal_title：Stem cell reviews and reports

authors： Delli Carri A,Onorati M,Castiglioni V,Faedo A,Camnasio S,Toselli M,Biella G,Cattaneo E

更新日期：2013-08-01 00:00:00

abstract：:The discovery of induced pluripotent stem (iPS) cells in 2006 marked a major breakthrough in regenerative medicine, enabling reversal of terminally differentiated somatic cells into pluripotent stem cells. The embryonic stem (ES) cells-like pluripotency and unlimited self-renewal capability of iPS cells have granted t...

journal_title：Stem cell reviews and reports

authors： Khoo TS,Jamal R,Abdul Ghani NA,Alauddin H,Hussin NH,Abdul Murad NA

更新日期：2020-04-01 00:00:00

abstract：:Although bone marrow-derived mononuclear cells (BMNC) have been extensively used in cell therapy for cardiac diseases, little mechanistic information is available to support reports of their efficacy. To address this shortcoming, we compared structural and functional recovery and associated global gene expression prof...

journal_title：Stem cell reviews and reports

authors： Lachtermacher S,Esporcatte BL,Fortes Fda S,Rocha NN,Montalvão F,Costa PC,Belem L,Rabischoffisky A,Faria Neto HC,Vasconcellos R,Iacobas DA,Iacobas S,Spray DC,Thomas NM,Goldenberg RC,de Carvalho AC

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND:Mesenchymal stem cells derived from the chorionic villi of human term placenta (pMSCs) have drawn considerable interest because of their multipotent differentiation potential and their immunomodulatory capacity. These properties are the foundation for their clinical application in the fields of stem cell tra...

journal_title：Stem cell reviews and reports

authors： Abomaray FM,Al Jumah MA,Kalionis B,AlAskar AS,Al Harthy S,Jawdat D,Al Khaldi A,Alkushi A,Knawy BA,Abumaree MH

更新日期：2015-06-01 00:00:00

abstract：PURPOSE:Evaluation of potential tropic effects of vascular endothelial growth factor (VEGF) on the incorporation and differentiation of bone-marrow-derived stem cells (BMSCs) in a murine model of anterior ischemic optic neuropathy (AION). METHODS:In the first approach, small-sized subset of BMCs were isolated from GFP...

journal_title：Stem cell reviews and reports

authors： Avraham-Lubin BC,Goldenberg-Cohen N,Sadikov T,Askenasy N

更新日期：2012-12-01 00:00:00

abstract：:The Networks of Centres of Excellence (NCE) is an innovative model of large-scale research networks that began in Canada in 1989, and has since been adopted by numerous countries around the globe. The Canadian Stem Cell Network (SCN), an NCE that has fostered stem cell research and innovation in Canada, has supported ...

journal_title：Stem cell reviews and reports

authors： Jacob KJ,Roskams-Edris D,Illes J

更新日期：2015-12-01 00:00:00

abstract：:Osteoarthritis (OA) remains incurable in humans or horses and mesenchymal stromal/stem cells (MSCs) represent an attractive solution for producing a neocartilage substitute. However, the best MSC source still needs to be identified. This study compared the chondrogenic potential of equine MSCs derived from bone marrow...

journal_title：Stem cell reviews and reports

authors： Contentin R,Demoor M,Concari M,Desancé M,Audigié F,Branly T,Galéra P

更新日期：2020-02-01 00:00:00

abstract：:Motor neuron loss or degeneration is the typical characteristic of amyotrophic lateral sclerosis (ALS), which often leads to weakness, paralysis, or even death. The underlying mechanisms of motor neuron degeneration and ALS progression remain elusive, and there is no effective treatment for ALS. The advances of stem c...

journal_title：Stem cell reviews and reports

authors： Zhao A,Pan Y,Cai S

更新日期：2020-06-01 00:00:00

abstract：:The facile regeneration of undifferentiated human mesenchymal stem cells (hMSCs) from thermoresponsive surfaces facilitates the collection of stem cells avoiding the use of animal derived cell detachment agents commonly used in cell culture. This communication proposes a procedure to fabricate coatings from commercial...

journal_title：Stem cell reviews and reports

authors： Nash ME,Fan X,Carroll WM,Gorelov AV,Barry FP,Shaw G,Rochev YA

更新日期：2013-04-01 00:00:00

abstract：:Reliable and efficient DNA and RNA transfection methods are required when studying the role of individual genes in mouse pluripotent stem cells. However, these cells usually grow in tight clusters and are therefore more difficult to transfect than many other cell lines. We have found that transfection is especially ch...

journal_title：Stem cell reviews and reports

authors： Tamm C,Kadekar S,Pijuan-Galitó S,Annerén C

更新日期：2016-10-01 00:00:00

abstract：:Understanding the healthy and diseased state of skin is important in many areas of basic and applied research. Although the field of skin tissue engineering has advanced greatly over the last years, current in vitro skin models still do not mimic the complexity of the human skin. Skin-on-chip and induced pluripotent s...

journal_title：Stem cell reviews and reports

authors： van den Broek LJ,Bergers LIJC,Reijnders CMA,Gibbs S

更新日期：2017-06-01 00:00:00

abstract：:An unfortunate emergence of a new virus SARS-CoV-2, causing a disease known as COVID-19, has spread all around the globe and has caused a pandemic. It primarily affects the respiratory tract and lungs in some cases causing severe organ damage and pneumonia due to overwhelming immune responses. Clinical reports show th...

journal_title：Stem cell reviews and reports

authors： Esquivel D,Mishra R,Soni P,Seetharaman R,Mahmood A,Srivastava A

更新日期：2020-08-01 00:00:00

abstract：:Retinal degenerative diseases that target photoreceptors or the adjacent retinal pigment epithelium (RPE) affect millions of people worldwide. Retinal degeneration (RD) is found in many different forms of retinal diseases including retinitis pigmentosa (RP), age-related macular degeneration (AMD), diabetic retinopathy...

journal_title：Stem cell reviews and reports

authors： Huang Y,Enzmann V,Ildstad ST

更新日期：2011-06-01 00:00:00

abstract：:Understanding the genetic and molecular mechanisms of ovarian cancer has been the focus of research efforts working toward the greater goal of improving cancer therapy for patients with residual disease after initial treatment with conventional surgery and neoadjuvant chemotherapy. The focus of this review will be cen...

journal_title：Stem cell reviews and reports

authors： Aguilar-Gallardo C,Rutledge EC,Martínez-Arroyo AM,Hidalgo JJ,Domingo S,Simón C

更新日期：2012-09-01 00:00:00

abstract：:Human embryonic stem cells (hESCs) are especially resistant to several cellular stresses, but the existence and induction of Endoplasmic Reticulum (ER) stress by culture conditions are unknown. Using qPCR, here, we investigated the behavior of the principal sensors of ER stress and their relation with the feeder layer...

journal_title：Stem cell reviews and reports

authors： Blanco-Gelaz MA,Suarez-Alvarez B,Ligero G,Sanchez L,Vidal-Castiñeira JR,Coto E,Moore H,Menendez P,Lopez-Larrea C

更新日期：2010-09-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) are adult, self-renewable, multipotent cells that can be found in almost all postnatal tissues. Because of their capacity for self-renewal and differentiation into tissues of mesodermal origin and due to their immunomodulatory ability, MSCs are used in many preclinical and clinical studie...

journal_title：Stem cell reviews and reports

authors： Gazdic M,Volarevic V,Arsenijevic N,Stojkovic M

更新日期：2015-04-01 00:00:00

abstract：:Zinc-finger nucleases (ZFNs) are sequence-specific genome engineering tools with great potential for the development of gene therapies. The achievement of permanent cures through gene therapy requires targeting of stem cells but the effects and/or side effects of ZFN treatment on adult stem cell potency are largely un...

journal_title：Stem cell reviews and reports

authors： Höher T,Wallace L,Khan K,Cathomen T,Reichelt J

更新日期：2012-06-01 00:00:00

abstract：:During the process of development, neural crest cells migrate out from their niche between the newly formed ectoderm and the neural tube. Thereafter, they give rise not only to ectodermal cell types, but also to mesodermal cell types. Cell types with neural crest ancestry consequently comprise a number of specialized ...

journal_title：Stem cell reviews and reports

authors： Kaltschmidt B,Kaltschmidt C,Widera D

更新日期：2012-09-01 00:00:00

abstract：:The ROCK inhibitor Y-27632 inhibits apoptosis and increases proliferation of frozen-thawed cells. We examined the role of Y-27632 on human umbilical cord Wharton's jelly stem cells (hWJSCs) for (1) thaw-survival (2) proliferation and (3) preservation of stemness and differentiation potential after cryopreservation. hW...

journal_title：Stem cell reviews and reports

authors： Gauthaman K,Fong CY,Subramanian A,Biswas A,Bongso A

更新日期：2010-12-01 00:00:00

abstract：:Mesenchymal stem cells (MSC) have been extensively studied over the past years for the treatment of different diseases. Most of the ongoing clinical trials currently involve the use of MSC derived from adult tissues. This source may have some limitations, particularly with therapies that may require extensive and repe...

journal_title：Stem cell reviews and reports

authors： Luzzani CD,Miriuka SG

更新日期：2017-02-01 00:00:00

abstract：:The molecular profile of human mesenchymal stem cells (MSCs) have emerged as a key factor in defining their identity. Nevertheless, the effect of fetal bovine serum (FBS) batches or origin on MSC molecular signature has been neglected. In this frame, chemical fingerprint of FBS batches from unrelated countries showed ...

journal_title：Stem cell reviews and reports

authors： Banfi F,Colombini A,Perucca Orfei C,Parazzi V,Ragni E

更新日期：2018-12-01 00:00:00

abstract：:Metastasis is the worst prognosis predictor in the clinical course of cancer development. Features of metastatic cancer cells include migratory ability, low degree of differentiation, self-renewal and proliferation potentials, as well as resistance to therapies. Metastatic cells do not present all of the necessary cha...

journal_title：Stem cell reviews and reports

authors： Arnaud-Sampaio VF,Rabelo ILA,Ulrich H,Lameu C

更新日期：2020-04-01 00:00:00