abstract：:Traumatic injuries are a leading cause of death and disability in both military and civilian populations. Given the complexity and diversity of traumatic injuries, novel and individualized treatment strategies are required to optimize outcomes. Cellular therapies have potential benefit for the treatment of acute or ch...

journal_title：Stem cell reviews and reports

authors： Lowry LE,Herzig MC,Christy BA,Schäfer R,Pati S,Cap AP,Bynum JA

更新日期：2021-01-08 00:00:00

abstract：:The COVID-19 pandemic has profoundly influenced public health and contributed to global economic divergences of unprecedented dimensions. Due to the high prevalence and mortality rates, it is then expected that the consequence and public health challenges will last for long periods. The rapid global spread of COVID-19...

journal_title：Stem cell reviews and reports

authors： Bagheri HS,Karimipour M,Heidarzadeh M,Rajabi H,Sokullu E,Rahbarghazi R

更新日期：2021-01-05 00:00:00

abstract：:Cirrhosis is associated with dysregulated immune cell activation and immune dysfunction. These conditions modify gut flora, facilitate bacterial translocation, and increase susceptibility to bacterial peritonitis and consequent systemic infections by dramatically affecting long-term patient survival. Human amnion-deri...

journal_title：Stem cell reviews and reports

authors： Pampalone M,Corrao S,Amico G,Vitale G,Alduino R,Conaldi PG,Pietrosi G

更新日期：2021-01-03 00:00:00

abstract：:Metabolomic profiles of somatic cells, embryonic stem cells (ESCs), and induced pluripotent stem cells (iPSCs) reflect their metabolic phenotypes. The comparative study of metabolomes of these cells is important for understanding the differences in metabolism between somatic and pluripotent cells, and also the possibl...

journal_title：Stem cell reviews and reports

authors： Sherstyuk VV,Yanshole LV,Zelentsova EA,Melnikov AD,Medvedev SP,Tsentalovich YP,Zakian SM

更新日期：2020-12-01 00:00:00

abstract：:The intestine integrates the function of digestion, absorption, and barrier, which is easily damaged by the external factors upon ageing. The intestinal stem cells (ISCs) exist at the intestinal crypt base and play an indispensable role in intestinal homeostasis and regeneration. The intestine ageing contributes to ma...

journal_title：Stem cell reviews and reports

authors： Liang SJ,Zhou JY,Wang XQ

更新日期：2020-11-17 00:00:00

abstract：:Stem cells in the endometrium and myometrium possess an immense regenerative potential which is necessary to maintain the menstrual cycle and support pregnancy. These cells, as well as bone marrow stem cells, have also been implicated in the development of common benign gynecological disorders including leiomyomas, en...

journal_title：Stem cell reviews and reports

authors： El Sabeh M,Afrin S,Singh B,Miyashita-Ishiwata M,Borahay M

更新日期：2020-11-05 00:00:00

abstract：:Mesenchymal stromal cells (MSCs) constitute a heterogeneous population of stromal cells with immunomodulatory and regenerative properties that support their therapeutic use. MSCs isolated from many tissue sources replicate vigorously in vitro and maintain their main biological properties allowing their widespread clin...

journal_title：Stem cell reviews and reports

authors： Rocha JLM,de Oliveira WCF,Noronha NC,Dos Santos NCD,Covas DT,Picanço-Castro V,Swiech K,Malmegrim KCR

更新日期：2020-09-07 00:00:00

abstract：:An unfortunate emergence of a new virus SARS-CoV-2, causing a disease known as COVID-19, has spread all around the globe and has caused a pandemic. It primarily affects the respiratory tract and lungs in some cases causing severe organ damage and pneumonia due to overwhelming immune responses. Clinical reports show th...

journal_title：Stem cell reviews and reports

authors： Esquivel D,Mishra R,Soni P,Seetharaman R,Mahmood A,Srivastava A

更新日期：2020-08-01 00:00:00

abstract：:Angiotensin-converting enzyme 2 (ACE2) plays an important role as a member of the renin-angiotensin-aldosterone system (RAAS) in regulating the conversion of angiotensin II (Ang II) into angiotensin (1-7) (Ang [1-7]). But at the same time, while expressed on the surface of human cells, ACE2 is the entry receptor for S...

journal_title：Stem cell reviews and reports

authors： Ratajczak MZ,Bujko K,Ciechanowicz A,Sielatycka K,Cymer M,Marlicz W,Kucia M

更新日期：2020-07-20 00:00:00

abstract：:Motor neuron loss or degeneration is the typical characteristic of amyotrophic lateral sclerosis (ALS), which often leads to weakness, paralysis, or even death. The underlying mechanisms of motor neuron degeneration and ALS progression remain elusive, and there is no effective treatment for ALS. The advances of stem c...

journal_title：Stem cell reviews and reports

authors： Zhao A,Pan Y,Cai S

更新日期：2020-06-01 00:00:00

abstract：:The original version of this article unfortunately contained a mistake. In the author group, the correct family name of Dr. Rebeca is "Blázquez" and the correct family name of Dr. Francisco Miguel is "Sánchez-Margallo." ...

journal_title：Stem cell reviews and reports

authors： López E,Blázquez R,Marinaro F,Álvarez V,Blanco V,Báez C,González I,Abad A,Moreno B,Sánchez-Margallo FM,Crisóstomo V,Casado JG

更新日期：2020-06-01 00:00:00

abstract：:Metastasis is the worst prognosis predictor in the clinical course of cancer development. Features of metastatic cancer cells include migratory ability, low degree of differentiation, self-renewal and proliferation potentials, as well as resistance to therapies. Metastatic cells do not present all of the necessary cha...

journal_title：Stem cell reviews and reports

authors： Arnaud-Sampaio VF,Rabelo ILA,Ulrich H,Lameu C

更新日期：2020-04-01 00:00:00

abstract：:The discovery of induced pluripotent stem (iPS) cells in 2006 marked a major breakthrough in regenerative medicine, enabling reversal of terminally differentiated somatic cells into pluripotent stem cells. The embryonic stem (ES) cells-like pluripotency and unlimited self-renewal capability of iPS cells have granted t...

journal_title：Stem cell reviews and reports

authors： Khoo TS,Jamal R,Abdul Ghani NA,Alauddin H,Hussin NH,Abdul Murad NA

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND:Bone marrow-derived mononuclear cells (BM-MNC) consist of a heterogeneous mix of mesenchymal stem cells (MSC), hematopoietic progenitor cells (HPC), endothelial progenitor cells (EPC), monocytes, lymphocytes and pluripotent stem cells. Whereas the importance of MSC and EPC has been well documented in bone he...

journal_title：Stem cell reviews and reports

authors： Leppik L,Sielatycka K,Henrich D,Han Z,Wang H,Eischen-Loges MJ,Oliveira KMC,Bhavsar MB,Ratajczak MZ,Barker JH

更新日期：2020-02-01 00:00:00

abstract：:Osteoarthritis (OA) remains incurable in humans or horses and mesenchymal stromal/stem cells (MSCs) represent an attractive solution for producing a neocartilage substitute. However, the best MSC source still needs to be identified. This study compared the chondrogenic potential of equine MSCs derived from bone marrow...

journal_title：Stem cell reviews and reports

authors： Contentin R,Demoor M,Concari M,Desancé M,Audigié F,Branly T,Galéra P

更新日期：2020-02-01 00:00:00

abstract：:Neural progenitor cells (NPCs) are multipotent cells that have the potential to produce neurons and glial cells in the neural system. NPCs undergo identity maintenance or differentiation regulated by different kinds of transcription factors. Here we present evidence that ETV5, which is an ETS transcription factor, pro...

journal_title：Stem cell reviews and reports

authors： Liu Y,Zhang Y

更新日期：2019-10-01 00:00:00

abstract：:Chemotherapy constitutes one of the key treatment modalities for solid and hematological malignancies. Albeit being an effective treatment, chemotherapy application is often limited by its damage to healthy tissues, and curative treatment options for chemotherapy-related side effects are largely missing. As mesenchyma...

journal_title：Stem cell reviews and reports

authors： Rühle A,Lopez Perez R,Zou B,Grosu AL,Huber PE,Nicolay NH

更新日期：2019-06-01 00:00:00

abstract：:Mobilization of stem cells from bone marrow (BM) into peripheral blood (PB) in response to tissue or organ injury, infections, strenuous exercise, or mobilization-inducing drugs is as we postulated result of a "sterile inflammation" in the BM microenvironment that triggers activation of the Complement Cascade (ComC). ...

journal_title：Stem cell reviews and reports

authors： Lenkiewicz AM,Adamiak M,Thapa A,Bujko K,Pedziwiatr D,Abdel-Latif AK,Kucia M,Ratajczak J,Ratajczak MZ

更新日期：2019-06-01 00:00:00

abstract：:Endothelial progenitors are a population of cells with the inherent capacity to differentiate into mature endothelial cells and proangiogenic paracrine action. These characteristics have led to extensive studies being performed and tested in the treatment of tissue ischemia. The natural course of diabetes mellitus (DM...

journal_title：Stem cell reviews and reports

authors： Pyšná A,Bém R,Němcová A,Fejfarová V,Jirkovská A,Hazdrová J,Jude EB,Dubský M

更新日期：2019-04-01 00:00:00

abstract：:Multipotent mesenchymal stem/stromal cells (MSCs) have regenerative and immunomodulatory properties to restore and repair injured tissues, making them attractive candidates for cell-based therapies. Experimental and clinical evidence has demonstrated the effectiveness of MSC transplantation in managing diabetes mellit...

journal_title：Stem cell reviews and reports

authors： Mahmoud M,Abu-Shahba N,Azmy O,El-Badri N

更新日期：2019-04-01 00:00:00

abstract：:Please note the following errors in the original version. ...

journal_title：Stem cell reviews and reports

authors： Cai X,Lin Y,Friedrich CC,Neville C,Pomerantseva I,Sundback CA,Zhang Z,Vacanti JP,Hauschka PV,Grottkau BE

更新日期：2019-02-01 00:00:00

abstract：:Bioactive phospholipids, including sphingosine-1-phosphate (S1P), ceramide-1-phosphate (C1P), lysophosphatidylcholine (LPC), and its derivative lysophosphatidic acid (LPA), have emerged as important mediators regulating the trafficking of normal and cancer cells. While the role of S1P in regulating migration of hemato...

journal_title：Stem cell reviews and reports

authors： Abdelbaset-Ismail A,Cymer M,Borkowska-Rzeszotek S,Brzeźniakiewicz-Janus K,Rameshwar P,Kakar SS,Ratajczak J,Ratajczak MZ

更新日期：2019-02-01 00:00:00

abstract：:The molecular profile of human mesenchymal stem cells (MSCs) have emerged as a key factor in defining their identity. Nevertheless, the effect of fetal bovine serum (FBS) batches or origin on MSC molecular signature has been neglected. In this frame, chemical fingerprint of FBS batches from unrelated countries showed ...

journal_title：Stem cell reviews and reports

authors： Banfi F,Colombini A,Perucca Orfei C,Parazzi V,Ragni E

更新日期：2018-12-01 00:00:00

abstract：:There is a need for physiologically relevant assay platforms to provide functionally relevant models of diabetes, to accelerate the discovery of new treatment options and boost developments in drug discovery. In this review, we compare several 3D-strategies that have been used to increase the functional relevance of e...

journal_title：Stem cell reviews and reports

authors： Ribeiro D,Kvist AJ,Wittung-Stafshede P,Hicks R,Forslöw A

更新日期：2018-04-01 00:00:00

abstract：:The absence of effective and satisfactory treatments that contribute to repairing the dopaminergic damage caused by Parkinson's Disease (PD) and the limited recovery capacity of the nervous system are troubling issues and the focus of many research and clinical domains. Recent advances in the treatment of PD through s...

journal_title：Stem cell reviews and reports

authors： Hurtado JDC,Sánchez JPB,Nunes RB,de Oliveira AA

更新日期：2018-04-01 00:00:00

abstract：:Idiopathic pulmonary fibrosis (IPF) is a devastating disease characterized by obliteration of alveolar architecture, resulting in declining lung function and ultimately death. Pathogenic mechanisms remain unclear but involve a concomitant accumulation of scar tissue together with myofibroblasts activation. Micropartic...

journal_title：Stem cell reviews and reports

authors： Bacha NC,Blandinieres A,Rossi E,Gendron N,Nevo N,Lecourt S,Guerin CL,Renard JM,Gaussem P,Angles-Cano E,Boulanger CM,Israel-Biet D,Smadja DM

更新日期：2018-04-01 00:00:00

abstract：:Adipogenesis is a complex process whereby the multipotent adipose-derived stem cell is converted to a preadipocyte before terminal differentiation into the mature adipocyte. Preadipocytes are present throughout adult life, exhibit adipose fat depot specificity, and differentiate and proliferate from distinct progenito...

journal_title：Stem cell reviews and reports

authors： Sarantopoulos CN,Banyard DA,Ziegler ME,Sun B,Shaterian A,Widgerow AD

更新日期：2018-02-01 00:00:00

abstract：:Derivation of human embryonic stem cell (hES) lines in 1998 was not only a major technological breakthrough in the field of regenerative medicine; it also triggered a passionate debate about the ethical issues associated with the utilization of human embryos for derivation of hESC lines. Successful derivation of induc...

journal_title：Stem cell reviews and reports

authors： Chhabra A

更新日期：2017-12-01 00:00:00

abstract：:Orthotopic liver transplant (OLT) remains the standard of care for end stage liver disease. To circumvent allo-rejection, OLT subjects receive gluococorticoids (GC). We investigated the effects of GC on endogenous mesenchymal stem (stromal) cells (MSCs) in OLT. This question is relevant because MSCs have regenerative ...

journal_title：Stem cell reviews and reports

authors： Walker ND,Mourad Y,Liu K,Buxhoeveden M,Schoenberg C,Eloy JD,Wilson DJ,Brown LG,Botea A,Chaudhry F,Greco SJ,Ponzio NM,Pyrsopoulos N,Koneru B,Gubenko Y,Rameshwar P

更新日期：2017-10-01 00:00:00

abstract：:The inward rectifier potassium current (IK1) is generally thought to suppress cardiac automaticity by hyperpolarizing membrane potential (MP). We recently observed that IK1 could promote the spontaneously-firing automaticity induced by upregulation of pacemaker funny current (If) in adult ventricular cardiomyocytes (C...

journal_title：Stem cell reviews and reports

authors： Sun Y,Timofeyev V,Dennis A,Bektik E,Wan X,Laurita KR,Deschênes I,Li RA,Fu JD

更新日期：2017-10-01 00:00:00

abstract：:Oligodendrocyte progenitor cells (OPCs) play a pivotal role in both health and disease within the central nervous system, with oligodendrocytes, arising from resident OPCs, being the main myelinating cell type. Disruption in OPC numbers can lead to various deleterious health defects. Numerous studies have described te...

journal_title：Stem cell reviews and reports

authors： Bianco J,Carradori D,Deumens R,des Rieux A

更新日期：2017-08-01 00:00:00

abstract：:Understanding the healthy and diseased state of skin is important in many areas of basic and applied research. Although the field of skin tissue engineering has advanced greatly over the last years, current in vitro skin models still do not mimic the complexity of the human skin. Skin-on-chip and induced pluripotent s...

journal_title：Stem cell reviews and reports

authors： van den Broek LJ,Bergers LIJC,Reijnders CMA,Gibbs S

更新日期：2017-06-01 00:00:00

abstract：:Mesenchymal stem cells (MSC) have been extensively studied over the past years for the treatment of different diseases. Most of the ongoing clinical trials currently involve the use of MSC derived from adult tissues. This source may have some limitations, particularly with therapies that may require extensive and repe...

journal_title：Stem cell reviews and reports

authors： Luzzani CD,Miriuka SG

更新日期：2017-02-01 00:00:00

abstract：:Nitric oxide (NO) is a gaseous free radical molecule involved in several biological processes related to inflammation, tissue damage, and infections. Based on reports that NO inhibits migration of granulocytes and monocytes, we became interested in the role of inducible NO synthetase (iNOS) in pharmacological mobiliza...

journal_title：Stem cell reviews and reports

authors： Adamiak M,Abdelbaset-Ismail A,Moore JB 4th,Zhao J,Abdel-Latif A,Wysoczynski M,Ratajczak MZ

更新日期：2017-02-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) represent a population of cells which have the ability to regulate reactivity of T and B lymphocytes by multiple mechanisms. The immunoregulatory activities of MSCs are strictly influenced by the cytokine environment. Here we show that two functionally distinct cytokines, interleukin-4 (I...

journal_title：Stem cell reviews and reports

authors： Holan V,Hermankova B,Bohacova P,Kossl J,Chudickova M,Hajkova M,Krulova M,Zajicova A,Javorkova E

更新日期：2016-12-01 00:00:00

abstract：:Reliable and efficient DNA and RNA transfection methods are required when studying the role of individual genes in mouse pluripotent stem cells. However, these cells usually grow in tight clusters and are therefore more difficult to transfect than many other cell lines. We have found that transfection is especially ch...

journal_title：Stem cell reviews and reports

authors： Tamm C,Kadekar S,Pijuan-Galitó S,Annerén C

更新日期：2016-10-01 00:00:00

abstract：:Surface topography of Titanium (Ti) dental implants strongly influences osseointegration. In the present work, we have analyzed the influence of two Ti implant surfaces characterized by similar microtopography but different nanotopography and chemistry on the osteoblastic phenotype of Dental Pulp Stem Cells (DPSCs). T...

journal_title：Stem cell reviews and reports

authors： Gardin C,Ferroni L,Piattelli A,SIvolella S,Zavan B,Mijiritsky E

更新日期：2016-10-01 00:00:00

abstract：:The use of mesenchymal stem/stromal cells (MSC) in regenerative medicine often requires MSC to function in environments of high oxidative stress. Human pregnancy is a condition where the mother's tissues, and in particular her circulatory system, are exposed to increased levels of oxidative stress. MSC in the maternal...

journal_title：Stem cell reviews and reports

authors： Kusuma GD,Abumaree MH,Pertile MD,Perkins AV,Brennecke SP,Kalionis B

更新日期：2016-06-01 00:00:00

abstract：:Stem cell research has generated considerable attention for its potential to remediate many disorders of the central nervous system including neurodevelopmental disorders such as autism spectrum disorder (ASD) and cerebral palsy (CP) that place a high burden on individual children, families and society. Here we charac...

journal_title：Stem cell reviews and reports

authors： Sharpe K,Di Pietro N,Illes J

更新日期：2016-02-01 00:00:00

abstract：:The Networks of Centres of Excellence (NCE) is an innovative model of large-scale research networks that began in Canada in 1989, and has since been adopted by numerous countries around the globe. The Canadian Stem Cell Network (SCN), an NCE that has fostered stem cell research and innovation in Canada, has supported ...

journal_title：Stem cell reviews and reports

authors： Jacob KJ,Roskams-Edris D,Illes J

更新日期：2015-12-01 00:00:00