The P2X7 Receptor in the Maintenance of Cancer Stem Cells, Chemoresistance and Metastasis.

Abstract:

:Metastasis is the worst prognosis predictor in the clinical course of cancer development. Features of metastatic cancer cells include migratory ability, low degree of differentiation, self-renewal and proliferation potentials, as well as resistance to therapies. Metastatic cells do not present all of the necessary characteristics at once. Indeed, they have a unique phenotypic plasticity, allowing the acquisition of features that make them successful in all steps of metastasis. Cancer stem cells (CSC), the most undifferentiated cells in the tumor mass, display highest metastatic potential and resistance to radio- and chemotherapy. Growing tumors exhibit marked upregulation of P2X7 receptor expression and secrete ATP. Since the P2X7 receptor plays an important role in the maintenance of undifferentiated state of pluripotent cells, its importance on cell fate regulation in the tumor mass is suggested. Considering the extensive crosstalk between CSCs, epithelial-mesenchymal transition, drug resistance and metastasis, current knowledge implicating P2X7 receptor function in these phenomena and new avenues for therapeutic strategies to control metastasis are reviewed.

journal_name

Stem Cell Rev Rep

authors

Arnaud-Sampaio VF,Rabelo ILA,Ulrich H,Lameu C

doi

10.1007/s12015-019-09936-w

subject

Has Abstract

pub_date

2020-04-01 00:00:00

pages

288-300

issue

2

eissn

2629-3269

issn

2629-3277

pii

10.1007/s12015-019-09936-w

journal_volume

16

pub_type

杂志文章,评审
  • Therapeutic application of adipose derived stem cells in acute myocardial infarction: lessons from animal models.

    abstract::The majority of patients survive an acute myocardial infarction (AMI). Their outcome is negatively influenced by post-AMI events, such as loss of viable cardiomyocytes due to a post-AMI inflammatory response, eventually resulting in heart failure and/or death. Recent pre-clinical animal studies indicate that mesenchym...

    journal_title:Stem cell reviews and reports

    pub_type: 杂志文章,评审

    doi:10.1007/s12015-014-9502-7

    authors: Naaijkens BA,van Dijk A,Kamp O,Krijnen PA,Niessen HW,Juffermans LJ

    更新日期:2014-06-01 00:00:00

  • Use of UTF1 genetic control elements as iPSC reporter.

    abstract::The reprogramming of adult somatic cells into an embryonic stem cell (ESC) state by various means has opened a new chapter in basic and applied life science. While this technology will create great opportunities for regenerative medicine, the more immediate impact is likely to be found in human disease modeling and dr...

    journal_title:Stem cell reviews and reports

    pub_type: 杂志文章

    doi:10.1007/s12015-011-9342-7

    authors: Morshedi A,Soroush Noghabi M,Dröge P

    更新日期:2013-08-01 00:00:00

  • Functional and transcriptomic recovery of infarcted mouse myocardium treated with bone marrow mononuclear cells.

    abstract::Although bone marrow-derived mononuclear cells (BMNC) have been extensively used in cell therapy for cardiac diseases, little mechanistic information is available to support reports of their efficacy. To address this shortcoming, we compared structural and functional recovery and associated global gene expression prof...

    journal_title:Stem cell reviews and reports

    pub_type: 杂志文章

    doi:10.1007/s12015-011-9282-2

    authors: Lachtermacher S,Esporcatte BL,Fortes Fda S,Rocha NN,Montalvão F,Costa PC,Belem L,Rabischoffisky A,Faria Neto HC,Vasconcellos R,Iacobas DA,Iacobas S,Spray DC,Thomas NM,Goldenberg RC,de Carvalho AC

    更新日期:2012-03-01 00:00:00

  • MicroRNA-221 is required for proliferation of mouse embryonic stem cells via P57 targeting.

    abstract::Factors responsible for the rapid proliferative properties of embryonic stem (ES) cells are largely unknown. MicroRNA-221/222 (miR-221/222) regulate proliferation in many somatic cells, however, their roles in proliferation of ES cells are unclear. In this study, E14 mouse ES cells proliferation was determined by tota...

    journal_title:Stem cell reviews and reports

    pub_type: 杂志文章

    doi:10.1007/s12015-014-9543-y

    authors: Li J,Bei Y,Liu Q,Lv D,Xu T,He Y,Chen P,Xiao J

    更新日期:2015-02-01 00:00:00

  • Elucidating the Preadipocyte and Its Role in Adipocyte Formation: a Comprehensive Review.

    abstract::Adipogenesis is a complex process whereby the multipotent adipose-derived stem cell is converted to a preadipocyte before terminal differentiation into the mature adipocyte. Preadipocytes are present throughout adult life, exhibit adipose fat depot specificity, and differentiate and proliferate from distinct progenito...

    journal_title:Stem cell reviews and reports

    pub_type: 杂志文章,评审

    doi:10.1007/s12015-017-9774-9

    authors: Sarantopoulos CN,Banyard DA,Ziegler ME,Sun B,Shaterian A,Widgerow AD

    更新日期:2018-02-01 00:00:00

  • Mesenchymal Stem/Stromal Cells Derived From a Reproductive Tissue Niche Under Oxidative Stress Have High Aldehyde Dehydrogenase Activity.

    abstract::The use of mesenchymal stem/stromal cells (MSC) in regenerative medicine often requires MSC to function in environments of high oxidative stress. Human pregnancy is a condition where the mother's tissues, and in particular her circulatory system, are exposed to increased levels of oxidative stress. MSC in the maternal...

    journal_title:Stem cell reviews and reports

    pub_type: 杂志文章

    doi:10.1007/s12015-016-9649-5

    authors: Kusuma GD,Abumaree MH,Pertile MD,Perkins AV,Brennecke SP,Kalionis B

    更新日期:2016-06-01 00:00:00

  • Retention of Somatic Memory Associated with Cell Identity, Age and Metabolism in Induced Pluripotent Stem (iPS) Cells Reprogramming.

    abstract::The discovery of induced pluripotent stem (iPS) cells in 2006 marked a major breakthrough in regenerative medicine, enabling reversal of terminally differentiated somatic cells into pluripotent stem cells. The embryonic stem (ES) cells-like pluripotency and unlimited self-renewal capability of iPS cells have granted t...

    journal_title:Stem cell reviews and reports

    pub_type: 杂志文章,评审

    doi:10.1007/s12015-020-09956-x

    authors: Khoo TS,Jamal R,Abdul Ghani NA,Alauddin H,Hussin NH,Abdul Murad NA

    更新日期:2020-04-01 00:00:00

  • Efficient generation of schwann cells from human embryonic stem cell-derived neurospheres.

    abstract::Schwann cells (SC), the glial cells of peripheral nerves, are involved in many diseases including Charcot Marie Tooth and neurofibromatosis, and play a pivotal role in peripheral nerve regeneration. Although it is possible to obtain human SC from nerve biopsies, they are difficult to maintain and expand in culture. He...

    journal_title:Stem cell reviews and reports

    pub_type: 杂志文章

    doi:10.1007/s12015-010-9198-2

    authors: Ziegler L,Grigoryan S,Yang IH,Thakor NV,Goldstein RS

    更新日期:2011-06-01 00:00:00

  • Bioactive Phospholipids Enhance Migration and Adhesion of Human Leukemic Cells by Inhibiting Heme Oxygenase 1 (HO-1) and Inducible Nitric Oxygenase Synthase (iNOS) in a p38 MAPK-Dependent Manner.

    abstract::Bioactive phospholipids, including sphingosine-1-phosphate (S1P), ceramide-1-phosphate (C1P), lysophosphatidylcholine (LPC), and its derivative lysophosphatidic acid (LPA), have emerged as important mediators regulating the trafficking of normal and cancer cells. While the role of S1P in regulating migration of hemato...

    journal_title:Stem cell reviews and reports

    pub_type: 杂志文章

    doi:10.1007/s12015-018-9853-6

    authors: Abdelbaset-Ismail A,Cymer M,Borkowska-Rzeszotek S,Brzeźniakiewicz-Janus K,Rameshwar P,Kakar SS,Ratajczak J,Ratajczak MZ

    更新日期:2019-02-01 00:00:00

  • Human periosteum-derived stem cells for tissue engineering applications: the role of VEGF.

    abstract::Mesenchymal stem cells (MSCs) are promising tools for studying the mechanisms of development and for the regeneration of injured tissues. Correct selection of the MSCs source is crucial in order to obtain a more efficient treatment and, in this respect Periosteum-Derived Cells (PDPCs) may represent an interesting alte...

    journal_title:Stem cell reviews and reports

    pub_type: 杂志文章

    doi:10.1007/s12015-012-9374-7

    authors: Ferretti C,Borsari V,Falconi M,Gigante A,Lazzarini R,Fini M,Di Primio R,Mattioli-Belmonte M

    更新日期:2012-09-01 00:00:00

  • Author Correction: The Intrapericardial Delivery of Extracellular Vesicles from Cardiosphere-Derived Cells Stimulates M2 Polarization during the Acute Phase of Porcine Myocardial Infarction.

    abstract::The original version of this article unfortunately contained a mistake. In the author group, the correct family name of Dr. Rebeca is "Blázquez" and the correct family name of Dr. Francisco Miguel is "Sánchez-Margallo." ...

    journal_title:Stem cell reviews and reports

    pub_type: 杂志文章,已发布勘误

    doi:10.1007/s12015-020-09962-z

    authors: López E,Blázquez R,Marinaro F,Álvarez V,Blanco V,Báez C,González I,Abad A,Moreno B,Sánchez-Margallo FM,Crisóstomo V,Casado JG

    更新日期:2020-06-01 00:00:00

  • Endothelial Progenitor Cells Biology in Diabetes Mellitus and Peripheral Arterial Disease and their Therapeutic Potential.

    abstract::Endothelial progenitors are a population of cells with the inherent capacity to differentiate into mature endothelial cells and proangiogenic paracrine action. These characteristics have led to extensive studies being performed and tested in the treatment of tissue ischemia. The natural course of diabetes mellitus (DM...

    journal_title:Stem cell reviews and reports

    pub_type: 杂志文章,评审

    doi:10.1007/s12015-018-9863-4

    authors: Pyšná A,Bém R,Němcová A,Fejfarová V,Jirkovská A,Hazdrová J,Jude EB,Dubský M

    更新日期:2019-04-01 00:00:00

  • Overcoming challenges of ovarian cancer stem cells: novel therapeutic approaches.

    abstract::Understanding the genetic and molecular mechanisms of ovarian cancer has been the focus of research efforts working toward the greater goal of improving cancer therapy for patients with residual disease after initial treatment with conventional surgery and neoadjuvant chemotherapy. The focus of this review will be cen...

    journal_title:Stem cell reviews and reports

    pub_type: 杂志文章,评审

    doi:10.1007/s12015-011-9344-5

    authors: Aguilar-Gallardo C,Rutledge EC,Martínez-Arroyo AM,Hidalgo JJ,Domingo S,Simón C

    更新日期:2012-09-01 00:00:00

  • Pluripotent Stem Cells as a Robust Source of Mesenchymal Stem Cells.

    abstract::Mesenchymal stem cells (MSC) have been extensively studied over the past years for the treatment of different diseases. Most of the ongoing clinical trials currently involve the use of MSC derived from adult tissues. This source may have some limitations, particularly with therapies that may require extensive and repe...

    journal_title:Stem cell reviews and reports

    pub_type: 杂志文章,评审

    doi:10.1007/s12015-016-9695-z

    authors: Luzzani CD,Miriuka SG

    更新日期:2017-02-01 00:00:00

  • Comparison of the Chondrogenic Potential of Mesenchymal Stem Cells Derived from Bone Marrow and Umbilical Cord Blood Intended for Cartilage Tissue Engineering.

    abstract::Osteoarthritis (OA) remains incurable in humans or horses and mesenchymal stromal/stem cells (MSCs) represent an attractive solution for producing a neocartilage substitute. However, the best MSC source still needs to be identified. This study compared the chondrogenic potential of equine MSCs derived from bone marrow...

    journal_title:Stem cell reviews and reports

    pub_type: 杂志文章

    doi:10.1007/s12015-019-09914-2

    authors: Contentin R,Demoor M,Concari M,Desancé M,Audigié F,Branly T,Galéra P

    更新日期:2020-02-01 00:00:00

  • Radiolabeling strategies for radionuclide imaging of stem cells.

    abstract::The interest in the use of stem cells as a source for therapy has increased dramatically over the last decades. Different stem cell types have been tested in both in vitro and in vivo models, because of their properties such as differentiation potential, trophic effects and immune modulatory properties. To further opt...

    journal_title:Stem cell reviews and reports

    pub_type: 杂志文章

    doi:10.1007/s12015-014-9575-3

    authors: Wolfs E,Verfaillie CM,Van Laere K,Deroose CM

    更新日期:2015-04-01 00:00:00

  • Neuroprotective effects of GDNF-expressing human amniotic fluid cells.

    abstract::Brain injury continues to be one of the leading causes of disability worldwide. Despite decades of research, there is currently no pharmacologically effective treatment for preventing neuronal loss and repairing the brain. As a result, novel therapeutic approaches, such as cell-based therapies, are being actively purs...

    journal_title:Stem cell reviews and reports

    pub_type: 杂志文章

    doi:10.1007/s12015-013-9484-x

    authors: Jezierski A,Rennie K,Zurakowski B,Ribecco-Lutkiewicz M,Haukenfrers J,Ajji A,Gruslin A,Sikorska M,Bani-Yaghoub M

    更新日期:2014-04-01 00:00:00

  • Specific gene signatures and pathways in mesodermal cells and their derivatives derived from embryonic stem cells.

    abstract::The vertebrate early stage embryo is consisting of the three primary germ layers ectoderm, mesoderm and endoderm, from which all organ tissues are developed. During early embryonic development, mesodermal cells become sequentially determined to more precisely defined cell types including muscle, heart, vasculature, bl...

    journal_title:Stem cell reviews and reports

    pub_type: 杂志文章,评审

    doi:10.1007/s12015-011-9263-5

    authors: Doss MX,Gaspar JA,Winkler J,Hescheler J,Schulz H,Sachinidis A

    更新日期:2012-03-01 00:00:00

  • Patient-Specific Cells for Modeling and Decoding Amyotrophic Lateral Sclerosis: Advances and Challenges.

    abstract::Motor neuron loss or degeneration is the typical characteristic of amyotrophic lateral sclerosis (ALS), which often leads to weakness, paralysis, or even death. The underlying mechanisms of motor neuron degeneration and ALS progression remain elusive, and there is no effective treatment for ALS. The advances of stem c...

    journal_title:Stem cell reviews and reports

    pub_type: 杂志文章,评审

    doi:10.1007/s12015-019-09946-8

    authors: Zhao A,Pan Y,Cai S

    更新日期:2020-06-01 00:00:00

  • ETV5 is Essential for Neuronal Differentiation of Human Neural Progenitor Cells by Repressing NEUROG2 Expression.

    abstract::Neural progenitor cells (NPCs) are multipotent cells that have the potential to produce neurons and glial cells in the neural system. NPCs undergo identity maintenance or differentiation regulated by different kinds of transcription factors. Here we present evidence that ETV5, which is an ETS transcription factor, pro...

    journal_title:Stem cell reviews and reports

    pub_type: 杂志文章

    doi:10.1007/s12015-019-09904-4

    authors: Liu Y,Zhang Y

    更新日期:2019-10-01 00:00:00

  • Stem Cell Transplantation and Physical Exercise in Parkinson's Disease, a Literature Review of Human and Animal Studies.

    abstract::The absence of effective and satisfactory treatments that contribute to repairing the dopaminergic damage caused by Parkinson's Disease (PD) and the limited recovery capacity of the nervous system are troubling issues and the focus of many research and clinical domains. Recent advances in the treatment of PD through s...

    journal_title:Stem cell reviews and reports

    pub_type: 杂志文章,评审

    doi:10.1007/s12015-017-9798-1

    authors: Hurtado JDC,Sánchez JPB,Nunes RB,de Oliveira AA

    更新日期:2018-04-01 00:00:00

  • Inducible Nitric Oxide Synthase (iNOS) Is a Novel Negative Regulator of Hematopoietic Stem/Progenitor Cell Trafficking.

    abstract::Nitric oxide (NO) is a gaseous free radical molecule involved in several biological processes related to inflammation, tissue damage, and infections. Based on reports that NO inhibits migration of granulocytes and monocytes, we became interested in the role of inducible NO synthetase (iNOS) in pharmacological mobiliza...

    journal_title:Stem cell reviews and reports

    pub_type: 杂志文章

    doi:10.1007/s12015-016-9693-1

    authors: Adamiak M,Abdelbaset-Ismail A,Moore JB 4th,Zhao J,Abdel-Latif A,Wysoczynski M,Ratajczak MZ

    更新日期:2017-02-01 00:00:00

  • Emerging ethical, legal and social issues associated with stem cell research & and the current role of the moral status of the embryo.

    abstract::Since its early days, stem cell research, particularly human embryonic stem cell research, has been the focus of intense social debate, and the question of the moral status of the embryo has been a central issue in the controversy. Despite this friction, and while it has yet to obtain widespread success in clinical ap...

    journal_title:Stem cell reviews and reports

    pub_type: 杂志文章,评审

    doi:10.1007/s12015-009-9062-4

    authors: Zarzeczny A,Caulfield T

    更新日期:2009-06-01 00:00:00

  • Thymosin β4 and cardiac regeneration: are we missing a beat?

    abstract::Epicardial resident stem cells are known to differentiate into cardiomyocytes during cardiac development, amongst other cell types. Whether epicardium-derived progenitor cells (EPDCs) retain this plasticity in the adult heart has been the topic of heated scientific debate. Priming with thymosin beta 4, a peptide which...

    journal_title:Stem cell reviews and reports

    pub_type: 杂志文章,评审

    doi:10.1007/s12015-012-9378-3

    authors: Gajzer DC,Balbin J,Chaudhry HW

    更新日期:2013-06-01 00:00:00

  • Impact of Diabetes Mellitus on Human Mesenchymal Stromal Cell Biology and Functionality: Implications for Autologous Transplantation.

    abstract::Multipotent mesenchymal stem/stromal cells (MSCs) have regenerative and immunomodulatory properties to restore and repair injured tissues, making them attractive candidates for cell-based therapies. Experimental and clinical evidence has demonstrated the effectiveness of MSC transplantation in managing diabetes mellit...

    journal_title:Stem cell reviews and reports

    pub_type: 杂志文章,评审

    doi:10.1007/s12015-018-9869-y

    authors: Mahmoud M,Abu-Shahba N,Azmy O,El-Badri N

    更新日期:2019-04-01 00:00:00

  • 3D-Models of Insulin-Producing β-Cells: from Primary Islet Cells to Stem Cell-Derived Islets.

    abstract::There is a need for physiologically relevant assay platforms to provide functionally relevant models of diabetes, to accelerate the discovery of new treatment options and boost developments in drug discovery. In this review, we compare several 3D-strategies that have been used to increase the functional relevance of e...

    journal_title:Stem cell reviews and reports

    pub_type: 杂志文章,评审

    doi:10.1007/s12015-017-9783-8

    authors: Ribeiro D,Kvist AJ,Wittung-Stafshede P,Hicks R,Forslöw A

    更新日期:2018-04-01 00:00:00

  • Robust Generation of Cardiomyocytes from Human iPS Cells Requires Precise Modulation of BMP and WNT Signaling.

    abstract::Various strategies have been published enabling cardiomyocyte differentiation of human induced pluripotent stem (iPS) cells. However the complex nature of signaling pathways involved as well as line-to-line variability compromises the application of a particular protocol to robustly obtain cardiomyocytes from multiple...

    journal_title:Stem cell reviews and reports

    pub_type: 杂志文章

    doi:10.1007/s12015-014-9564-6

    authors: Kadari A,Mekala S,Wagner N,Malan D,Köth J,Doll K,Stappert L,Eckert D,Peitz M,Matthes J,Sasse P,Herzig S,Brüstle O,Ergün S,Edenhofer F

    更新日期:2015-08-01 00:00:00

  • Does the Global Outbreak of COVID-19 or Other Viral Diseases Threaten the Stem Cell Reservoir Inside the Body?

    abstract::The COVID-19 pandemic has profoundly influenced public health and contributed to global economic divergences of unprecedented dimensions. Due to the high prevalence and mortality rates, it is then expected that the consequence and public health challenges will last for long periods. The rapid global spread of COVID-19...

    journal_title:Stem cell reviews and reports

    pub_type: 杂志文章,评审

    doi:10.1007/s12015-020-10108-4

    authors: Bagheri HS,Karimipour M,Heidarzadeh M,Rajabi H,Sokullu E,Rahbarghazi R

    更新日期:2021-01-05 00:00:00

  • Redefining the concept of standardization for pluripotent stem cells.

    abstract::In this report we review the concept of standardization and propose an exhaustive framework for the proper management of technology on pluripotent stem cells based on studies of global and regional initiatives. We demonstrated detailed observational analysis on global initiatives for the standardization of related tec...

    journal_title:Stem cell reviews and reports

    pub_type: 杂志文章,评审

    doi:10.1007/s12015-010-9204-8

    authors: Sengoku S,Sumikura K,Oki T,Nakatsuji N

    更新日期:2011-06-01 00:00:00

  • Mesenchymal Stromal Cells in Viral Infections: Implications for COVID-19.

    abstract::Mesenchymal stromal cells (MSCs) constitute a heterogeneous population of stromal cells with immunomodulatory and regenerative properties that support their therapeutic use. MSCs isolated from many tissue sources replicate vigorously in vitro and maintain their main biological properties allowing their widespread clin...

    journal_title:Stem cell reviews and reports

    pub_type: 杂志文章,评审

    doi:10.1007/s12015-020-10032-7

    authors: Rocha JLM,de Oliveira WCF,Noronha NC,Dos Santos NCD,Covas DT,Picanço-Castro V,Swiech K,Malmegrim KCR

    更新日期:2020-09-07 00:00:00