Abstract：
:Understanding the healthy and diseased state of skin is important in many areas of basic and applied research. Although the field of skin tissue engineering has advanced greatly over the last years, current in vitro skin models still do not mimic the complexity of the human skin. Skin-on-chip and induced pluripotent stem cells (iPSC) might be key technologies to improve in vitro skin models. This review summarizes the state of the art of in vitro skin models with regard to cell sources (primary, cell line, iPSC) and microfluidic devices. It can be concluded that iPSC have the potential to be differentiated into many kinds of immunologically matched cells and skin-on-chip technology might lead to more physiologically relevant skin models due to the controlled environment, possible exchange of immune cells, and an increased barrier function. Therefore the combination of iPSC and skin-on-chip is expected to lead to superior healthy and diseased in vitro skin models.
journal_name
Stem Cell Rev Repjournal_title
Stem cell reviews and reportsauthors
van den Broek LJ,Bergers LIJC,Reijnders CMA,Gibbs Sdoi
10.1007/s12015-017-9737-1subject
Has Abstractpub_date
2017-06-01 00:00:00pages
418-429issue
3eissn
2629-3269issn
2629-3277pii
10.1007/s12015-017-9737-1journal_volume
13pub_type
杂志文章,评审abstract：:Please note the following errors in the original version. ...
journal_title：Stem cell reviews and reports
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journal_title：Stem cell reviews and reports
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