Stem cell-based therapeutic applications in retinal degenerative diseases.

Abstract:

:Retinal degenerative diseases that target photoreceptors or the adjacent retinal pigment epithelium (RPE) affect millions of people worldwide. Retinal degeneration (RD) is found in many different forms of retinal diseases including retinitis pigmentosa (RP), age-related macular degeneration (AMD), diabetic retinopathy, cataracts, and glaucoma. Effective treatment for retinal degeneration has been widely investigated. Gene-replacement therapy has been shown to improve visual function in inherited retinal disease. However, this treatment was less effective with advanced disease. Stem cell-based therapy is being pursued as a potential alternative approach in the treatment of retinal degenerative diseases. In this review, we will focus on stem cell-based therapies in the pipeline and summarize progress in treatment of retinal degenerative disease.

journal_name

Stem Cell Rev Rep

authors

Huang Y,Enzmann V,Ildstad ST

doi

10.1007/s12015-010-9192-8

subject

Has Abstract

pub_date

2011-06-01 00:00:00

pages

434-45

issue

2

eissn

2629-3269

issn

2629-3277

journal_volume

7

pub_type

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