Patient-Specific Cells for Modeling and Decoding Amyotrophic Lateral Sclerosis: Advances and Challenges.

Abstract:

:Motor neuron loss or degeneration is the typical characteristic of amyotrophic lateral sclerosis (ALS), which often leads to weakness, paralysis, or even death. The underlying mechanisms of motor neuron degeneration and ALS progression remain elusive, and there is no effective treatment for ALS. The advances of stem cells and reprogramming techniques has made it possible to generate patient-specific motor neurons as cell models for studying disease mechanisms and drug discovery. This review comprehensively discusses recent approaches to generate motor neurons from stem cells and somatic cells and highlights the application of induced motor neurons to modeling ALS diseases, dissecting the pathogenesis, and screening new drugs. New perspectives are also discussed on generating patient-specific motor neuron subtypes that are affected by ALS or creating 3D spinal cord organoid models for better recapitulating and understanding ALS.

journal_name

Stem Cell Rev Rep

authors

Zhao A,Pan Y,Cai S

doi

10.1007/s12015-019-09946-8

subject

Has Abstract

pub_date

2020-06-01 00:00:00

pages

482-502

issue

3

eissn

2629-3269

issn

2629-3277

pii

10.1007/s12015-019-09946-8

journal_volume

16

pub_type

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