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Hepatitis C virus core antigen in the management of patients treated with new direct-acting antivirals.

Abstract：

:We evaluated the utility of Architect core antigen assay® Abbott Diagnostics (HCVAg) for monitoring patients with HCV infection and compared to HCV-RNA quantification (Cobas Ampliprep TaqMan-Roche Diagnostics). Samples from 262 patients were studied. Mean baseline HCV RNA and HCVAg levels were similar for responders (6.2 log IU/mL and 3.4 log fmol/L) and non-responders (6.1 log IU/mL and 3.2 log fmol/L), respectively. Only 10 patients failed to achieve SVR12 and all were detected by both assays. To evaluate HCVAg quantification as a tool for the detection of failure to DAAs, we performed a retrospective study of 132 non-responder patients. Mean HCV RNA and HCVAg levels at the time of detection of therapeutic failure were 5.88±0.97 log IU/mL and 3.19±0.79 log fmol/L, respectively. HCVAg (>3 fmol/L) was detected in 130/132 patients (98.5%). HCVAg assay was useful for patient selection and for evaluating virological response to DAAs in the real world.

journal_name

Diagn Microbiol Infect Dis

journal_title

Diagnostic microbiology and infectious disease

authors

Arboledas JCA,Guerrero IP,Rodríguez MJB,Martos ET,Pérez AB,León CC,Sierra Sánchez JF,Prieto MDL,Porcuna NC,Mochón MDO,Macías J,de la Iglesia Salgado A,Granger JR,Fernández MD,Lozano IG,Ramírez ER,Rivero A,Del Carmen Loz

doi

10.1016/j.diagmicrobio.2017.06.006

subject

Has Abstract

pub_date

2017-09-01 00:00:00

pages

29-34

issue

1

eissn

0732-8893

issn

1879-0070

pii

S0732-8893(17)30183-9

journal_volume

89

pub_type

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