Abstract：
:Orthotopic liver transplant (OLT) remains the standard of care for end stage liver disease. To circumvent allo-rejection, OLT subjects receive gluococorticoids (GC). We investigated the effects of GC on endogenous mesenchymal stem (stromal) cells (MSCs) in OLT. This question is relevant because MSCs have regenerative potential and immune suppressor function. Phenotypic analyses of blood samples from 12 OLT recipients, at pre-anhepatic, anhepatic and post-transplant (2 h, Days 1 and 5) indicated a significant decrease in MSCs after GC injection. The MSCs showed better recovery in the blood from subjects who started with relatively low MSCs as compared to those with high levels at the prehepatic phase. This drop in MSCs appeared to be linked to GC since similar change was not observed in liver resection subjects. In order to understand the effects of GC on decrease MSC migration, in vitro studies were performed in transwell cultures. Untreated MSCs could not migrate towards the GC-exposed liver tissue, despite CXCR4 expression and the production of inflammatory cytokines from the liver cells. GC-treated MSCs were inefficient with respect to migration towards CXCL12, and this correlated with retracted cytoskeleton and motility. These dysfunctions were partly explained by decreases in the CXCL12/receptor axis. GC-associated decrease in MSCs in OLT recipients recovered post-transplant, despite poor migratory ability towards GC-exposed liver. In total, the study indicated that GC usage in transplant needs to be examined to determine if this could be reduced or avoided with adjuvant cell therapy.
journal_name
Stem Cell Rev Repjournal_title
Stem cell reviews and reportsauthors
Walker ND,Mourad Y,Liu K,Buxhoeveden M,Schoenberg C,Eloy JD,Wilson DJ,Brown LG,Botea A,Chaudhry F,Greco SJ,Ponzio NM,Pyrsopoulos N,Koneru B,Gubenko Y,Rameshwar Pdoi
10.1007/s12015-017-9751-3subject
Has Abstractpub_date
2017-10-01 00:00:00pages
644-658issue
5eissn
2629-3269issn
2629-3277pii
10.1007/s12015-017-9751-3journal_volume
13pub_type
杂志文章abstract：:Adipogenesis is a complex process whereby the multipotent adipose-derived stem cell is converted to a preadipocyte before terminal differentiation into the mature adipocyte. Preadipocytes are present throughout adult life, exhibit adipose fat depot specificity, and differentiate and proliferate from distinct progenito...
journal_title：Stem cell reviews and reports
pub_type： 杂志文章,评审
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journal_title：Stem cell reviews and reports
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更新日期：2016-06-01 00:00:00
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journal_title：Stem cell reviews and reports
pub_type： 杂志文章,已发布勘误
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更新日期：2020-06-01 00:00:00
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journal_title：Stem cell reviews and reports
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journal_title：Stem cell reviews and reports
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journal_title：Stem cell reviews and reports
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journal_title：Stem cell reviews and reports
pub_type： 杂志文章,评审
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更新日期：2012-12-01 00:00:00
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journal_title：Stem cell reviews and reports
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journal_title：Stem cell reviews and reports
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journal_title：Stem cell reviews and reports
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journal_title：Stem cell reviews and reports
pub_type： 杂志文章,评审
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journal_title：Stem cell reviews and reports
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更新日期：2009-03-01 00:00:00
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journal_title：Stem cell reviews and reports
pub_type： 杂志文章,评审
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更新日期：2020-08-01 00:00:00
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journal_title：Stem cell reviews and reports
pub_type： 杂志文章
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更新日期：2017-08-01 00:00:00
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journal_title：Stem cell reviews and reports
pub_type： 杂志文章
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journal_title：Stem cell reviews and reports
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更新日期：2010-09-01 00:00:00
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journal_title：Stem cell reviews and reports
pub_type： 杂志文章
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更新日期：2009-12-01 00:00:00
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journal_title：Stem cell reviews and reports
pub_type： 杂志文章
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journal_title：Stem cell reviews and reports
pub_type： 杂志文章,评审
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journal_title：Stem cell reviews and reports
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journal_title：Stem cell reviews and reports
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journal_title：Stem cell reviews and reports
pub_type： 杂志文章
doi：10.1007/s12015-014-9543-y
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journal_title：Stem cell reviews and reports
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journal_title：Stem cell reviews and reports
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journal_title：Stem cell reviews and reports
pub_type： 杂志文章,评审
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更新日期：2021-01-05 00:00:00
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journal_title：Stem cell reviews and reports
pub_type： 杂志文章
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更新日期：2014-10-01 00:00:00
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journal_title：Stem cell reviews and reports
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更新日期：2021-01-03 00:00:00
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journal_title：Stem cell reviews and reports
pub_type： 杂志文章
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更新日期：2014-04-01 00:00:00
abstract：:The discovery of induced pluripotent stem (iPS) cells in 2006 marked a major breakthrough in regenerative medicine, enabling reversal of terminally differentiated somatic cells into pluripotent stem cells. The embryonic stem (ES) cells-like pluripotency and unlimited self-renewal capability of iPS cells have granted t...
journal_title：Stem cell reviews and reports
pub_type： 杂志文章,评审
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更新日期：2020-04-01 00:00:00
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journal_title：Stem cell reviews and reports
pub_type： 杂志文章,评审
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