Abstract:
:Cirrhosis is associated with dysregulated immune cell activation and immune dysfunction. These conditions modify gut flora, facilitate bacterial translocation, and increase susceptibility to bacterial peritonitis and consequent systemic infections by dramatically affecting long-term patient survival. Human amnion-derived mesenchymal stromal cells (hA-MSCs) exert immunomodulatory potential benefit, and have the ability to modulate their actions, especially in situations requiring immune activation through mechanisms not fully understood. In this study, we aimed to investigate, in vitro, the immunostimulant or immunosuppressive effects of hA-MSCs on cellular components of ascitic fluid obtained from cirrhotic patients with refractory ascites. We found that hA-MSCs viability is not affected by ascitic fluid and, interestingly, hA-MSCs diminished the pro-inflammatory cytokine production, and promoted anti-inflammatory M2 macrophage polarization. Moreover, we found that there was no simultaneous significant decrease in the M1-like component, allowing a continual phagocytosis activity of macrophages and NK cells to restore a physiological condition. These data highlight the plasticity of hA-MSCs' immunomodulatory capacity, and pave the way to further understanding their role in conditions such as spontaneous bacterial peritonitis.
journal_name
Stem Cell Rev Repjournal_title
Stem cell reviews and reportsauthors
Pampalone M,Corrao S,Amico G,Vitale G,Alduino R,Conaldi PG,Pietrosi Gdoi
10.1007/s12015-020-10104-8subject
Has Abstractpub_date
2021-01-03 00:00:00eissn
2629-3269issn
2629-3277pii
10.1007/s12015-020-10104-8pub_type
杂志文章abstract::Trithorax group (TrxG) proteins play critical roles in transcriptional activation by promoting methylation of histone H3 Lysine 4 (H3K4), but the precise functions of the individual TrxG members during embryonic differentiation are not fully understood. Here we show that Mll2, a TrxG member, is required for proliferat...
journal_title:Stem cell reviews and reports
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journal_title:Stem cell reviews and reports
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journal_title:Stem cell reviews and reports
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journal_title:Stem cell reviews and reports
pub_type: 杂志文章,评审
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abstract::Zinc-finger nucleases (ZFNs) are sequence-specific genome engineering tools with great potential for the development of gene therapies. The achievement of permanent cures through gene therapy requires targeting of stem cells but the effects and/or side effects of ZFN treatment on adult stem cell potency are largely un...
journal_title:Stem cell reviews and reports
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journal_title:Stem cell reviews and reports
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journal_title:Stem cell reviews and reports
pub_type: 杂志文章,评审
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journal_title:Stem cell reviews and reports
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journal_title:Stem cell reviews and reports
pub_type: 杂志文章
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更新日期:2017-08-01 00:00:00
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journal_title:Stem cell reviews and reports
pub_type: 杂志文章
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更新日期:2010-12-01 00:00:00
abstract::The propensity of induced pluripotent stem (iPS) cells to differentiate into specific lineages may be influenced by a number of factors, including the selection of the somatic cell type used for reprogramming. Herein we report the generation of new iPS cells, which we derived from human articular chondrocytes and from...
journal_title:Stem cell reviews and reports
pub_type: 杂志文章
doi:10.1007/s12015-014-9538-8
更新日期:2014-12-01 00:00:00
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journal_title:Stem cell reviews and reports
pub_type: 杂志文章,评审
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abstract::The discovery of induced pluripotent stem (iPS) cells in 2006 marked a major breakthrough in regenerative medicine, enabling reversal of terminally differentiated somatic cells into pluripotent stem cells. The embryonic stem (ES) cells-like pluripotency and unlimited self-renewal capability of iPS cells have granted t...
journal_title:Stem cell reviews and reports
pub_type: 杂志文章,评审
doi:10.1007/s12015-020-09956-x
更新日期:2020-04-01 00:00:00
abstract:INTRODUCTION:Whether transplanted cardiac stem cells (CSCs) and mesenchymal stem cells (MSCs) improved ventricular fibrillation threshold (VFT) similarly is still unclear. We sought to compare the effects of the CSC and MSC transplantation on the electrophysiological characteristics and VFT in rats with myocardial infa...
journal_title:Stem cell reviews and reports
pub_type: 杂志文章
doi:10.1007/s12015-012-9367-6
更新日期:2013-06-01 00:00:00
abstract::The original version of this article unfortunately contained a mistake. In the author group, the correct family name of Dr. Rebeca is "Blázquez" and the correct family name of Dr. Francisco Miguel is "Sánchez-Margallo." ...
journal_title:Stem cell reviews and reports
pub_type: 杂志文章,已发布勘误
doi:10.1007/s12015-020-09962-z
更新日期:2020-06-01 00:00:00
abstract::Motor neuron loss or degeneration is the typical characteristic of amyotrophic lateral sclerosis (ALS), which often leads to weakness, paralysis, or even death. The underlying mechanisms of motor neuron degeneration and ALS progression remain elusive, and there is no effective treatment for ALS. The advances of stem c...
journal_title:Stem cell reviews and reports
pub_type: 杂志文章,评审
doi:10.1007/s12015-019-09946-8
更新日期:2020-06-01 00:00:00
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journal_title:Stem cell reviews and reports
pub_type: 杂志文章,评审
doi:10.1007/s12015-014-9502-7
更新日期:2014-06-01 00:00:00
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journal_title:Stem cell reviews and reports
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journal_title:Stem cell reviews and reports
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journal_title:Stem cell reviews and reports
pub_type: 杂志文章
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更新日期:2019-06-01 00:00:00
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journal_title:Stem cell reviews and reports
pub_type: 杂志文章
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更新日期:2020-07-20 00:00:00
abstract:BACKGROUND:Mesenchymal stem cells derived from the chorionic villi of human term placenta (pMSCs) have drawn considerable interest because of their multipotent differentiation potential and their immunomodulatory capacity. These properties are the foundation for their clinical application in the fields of stem cell tra...
journal_title:Stem cell reviews and reports
pub_type: 杂志文章
doi:10.1007/s12015-014-9562-8
更新日期:2015-06-01 00:00:00
abstract::Stem cell research has generated considerable attention for its potential to remediate many disorders of the central nervous system including neurodevelopmental disorders such as autism spectrum disorder (ASD) and cerebral palsy (CP) that place a high burden on individual children, families and society. Here we charac...
journal_title:Stem cell reviews and reports
pub_type: 杂志文章
doi:10.1007/s12015-015-9627-3
更新日期:2016-02-01 00:00:00
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journal_title:Stem cell reviews and reports
pub_type: 杂志文章,评审
doi:10.1007/s12015-011-9340-9
更新日期:2012-09-01 00:00:00
abstract::Here we present the principles and steps of a protocol that we have recently developed for the differentiation of hES/iPS cells into the authentic human striatal projection medium spiny neurons (MSNs) that die in Huntington's Disease (HD). Authenticity is judged by the convergence of multiple features within individua...
journal_title:Stem cell reviews and reports
pub_type: 杂志文章
doi:10.1007/s12015-013-9441-8
更新日期:2013-08-01 00:00:00
abstract::Please note the following errors in the original version. ...
journal_title:Stem cell reviews and reports
pub_type: 已发布勘误
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更新日期:2019-02-01 00:00:00
abstract::Surface topography of Titanium (Ti) dental implants strongly influences osseointegration. In the present work, we have analyzed the influence of two Ti implant surfaces characterized by similar microtopography but different nanotopography and chemistry on the osteoblastic phenotype of Dental Pulp Stem Cells (DPSCs). T...
journal_title:Stem cell reviews and reports
pub_type: 杂志文章
doi:10.1007/s12015-016-9669-1
更新日期:2016-10-01 00:00:00
abstract::Pre-clinical studies have supported the use of mesenchymal stem cells (MSC) to treat highly prevalent neurodegenerative diseases such as Parkinson's disease (PD) but preliminary trials have reported controversial results. In a rat model of PD induced by MPTP neurotoxin, we first observed a significant bilateral preser...
journal_title:Stem cell reviews and reports
pub_type: 杂志文章
doi:10.1007/s12015-011-9256-4
更新日期:2011-11-01 00:00:00