Bioactive Phospholipids Enhance Migration and Adhesion of Human Leukemic Cells by Inhibiting Heme Oxygenase 1 (HO-1) and Inducible Nitric Oxygenase Synthase (iNOS) in a p38 MAPK-Dependent Manner.

abstract：:Adipogenesis is a complex process whereby the multipotent adipose-derived stem cell is converted to a preadipocyte before terminal differentiation into the mature adipocyte. Preadipocytes are present throughout adult life, exhibit adipose fat depot specificity, and differentiate and proliferate from distinct progenito...

journal_title：Stem cell reviews and reports

authors： Sarantopoulos CN,Banyard DA,Ziegler ME,Sun B,Shaterian A,Widgerow AD

更新日期：2018-02-01 00:00:00

abstract：:Undifferentiated mouse embryonic stem cells (ESCs) possess low numbers of mitochondrial DNA (mtDNA), which encodes key subunits associated with the generation of ATP through oxidative phosphorylation (OXPHOS). As ESCs differentiate, mtDNA copy number is regulated by the nuclear-encoded mtDNA replication factors, which...

journal_title：Stem cell reviews and reports

authors： Kelly RD,Sumer H,McKenzie M,Facucho-Oliveira J,Trounce IA,Verma PJ,St John JC

更新日期：2013-02-01 00:00:00

abstract：:Xenografting of normal and transformed mammalian tissues and cells to chick embryos has been performed for almost 100 years. Embryonic stem cells, derived more than 25 years ago from murine, and more than 10 years ago from human blastocysts, have transformed many fields of biological research. There is a growing body ...

journal_title：Stem cell reviews and reports

authors： Goldstein RS

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND:Bone marrow-derived mononuclear cells (BM-MNC) consist of a heterogeneous mix of mesenchymal stem cells (MSC), hematopoietic progenitor cells (HPC), endothelial progenitor cells (EPC), monocytes, lymphocytes and pluripotent stem cells. Whereas the importance of MSC and EPC has been well documented in bone he...

journal_title：Stem cell reviews and reports

authors： Leppik L,Sielatycka K,Henrich D,Han Z,Wang H,Eischen-Loges MJ,Oliveira KMC,Bhavsar MB,Ratajczak MZ,Barker JH

更新日期：2020-02-01 00:00:00

abstract：:Derivation of human embryonic stem cell (hES) lines in 1998 was not only a major technological breakthrough in the field of regenerative medicine; it also triggered a passionate debate about the ethical issues associated with the utilization of human embryos for derivation of hESC lines. Successful derivation of induc...

journal_title：Stem cell reviews and reports

authors： Chhabra A

更新日期：2017-12-01 00:00:00

abstract：:Reliable and efficient DNA and RNA transfection methods are required when studying the role of individual genes in mouse pluripotent stem cells. However, these cells usually grow in tight clusters and are therefore more difficult to transfect than many other cell lines. We have found that transfection is especially ch...

journal_title：Stem cell reviews and reports

authors： Tamm C,Kadekar S,Pijuan-Galitó S,Annerén C

更新日期：2016-10-01 00:00:00

abstract：:Nitric oxide (NO) is a gaseous free radical molecule involved in several biological processes related to inflammation, tissue damage, and infections. Based on reports that NO inhibits migration of granulocytes and monocytes, we became interested in the role of inducible NO synthetase (iNOS) in pharmacological mobiliza...

journal_title：Stem cell reviews and reports

authors： Adamiak M,Abdelbaset-Ismail A,Moore JB 4th,Zhao J,Abdel-Latif A,Wysoczynski M,Ratajczak MZ

更新日期：2017-02-01 00:00:00

abstract：:Schwann cells (SC), the glial cells of peripheral nerves, are involved in many diseases including Charcot Marie Tooth and neurofibromatosis, and play a pivotal role in peripheral nerve regeneration. Although it is possible to obtain human SC from nerve biopsies, they are difficult to maintain and expand in culture. He...

journal_title：Stem cell reviews and reports

authors： Ziegler L,Grigoryan S,Yang IH,Thakor NV,Goldstein RS

更新日期：2011-06-01 00:00:00

abstract：:Angiotensin-converting enzyme 2 (ACE2) plays an important role as a member of the renin-angiotensin-aldosterone system (RAAS) in regulating the conversion of angiotensin II (Ang II) into angiotensin (1-7) (Ang [1-7]). But at the same time, while expressed on the surface of human cells, ACE2 is the entry receptor for S...

journal_title：Stem cell reviews and reports

authors： Ratajczak MZ,Bujko K,Ciechanowicz A,Sielatycka K,Cymer M,Marlicz W,Kucia M

更新日期：2020-07-20 00:00:00

abstract：:Pre-clinical studies have supported the use of mesenchymal stem cells (MSC) to treat highly prevalent neurodegenerative diseases such as Parkinson's disease (PD) but preliminary trials have reported controversial results. In a rat model of PD induced by MPTP neurotoxin, we first observed a significant bilateral preser...

journal_title：Stem cell reviews and reports

authors： Pereira MC,Secco M,Suzuki DE,Janjoppi L,Rodini CO,Torres LB,Araújo BH,Cavalheiro EA,Zatz M,Okamoto OK

更新日期：2011-11-01 00:00:00

abstract：:Converting adult cells from one cell type to another is a particularly interesting idea for regenerative medicine. Terminally differentiated cells can be induced to de-differentiate in vitro to become multipotent progenitors. In mammals these changes do not occur naturally, however exposing differentiated adult cells ...

journal_title：Stem cell reviews and reports

authors： Brevini TA,Pennarossa G,Rahman MM,Paffoni A,Antonini S,Ragni G,deEguileor M,Tettamanti G,Gandolfi F

更新日期：2014-10-01 00:00:00

abstract：:Zinc-finger nucleases (ZFNs) are sequence-specific genome engineering tools with great potential for the development of gene therapies. The achievement of permanent cures through gene therapy requires targeting of stem cells but the effects and/or side effects of ZFN treatment on adult stem cell potency are largely un...

journal_title：Stem cell reviews and reports

authors： Höher T,Wallace L,Khan K,Cathomen T,Reichelt J

更新日期：2012-06-01 00:00:00

abstract：:Motor neuron loss or degeneration is the typical characteristic of amyotrophic lateral sclerosis (ALS), which often leads to weakness, paralysis, or even death. The underlying mechanisms of motor neuron degeneration and ALS progression remain elusive, and there is no effective treatment for ALS. The advances of stem c...

journal_title：Stem cell reviews and reports

authors： Zhao A,Pan Y,Cai S

更新日期：2020-06-01 00:00:00

abstract：:Human embryonic stem cells (hESCs) are especially resistant to several cellular stresses, but the existence and induction of Endoplasmic Reticulum (ER) stress by culture conditions are unknown. Using qPCR, here, we investigated the behavior of the principal sensors of ER stress and their relation with the feeder layer...

journal_title：Stem cell reviews and reports

authors： Blanco-Gelaz MA,Suarez-Alvarez B,Ligero G,Sanchez L,Vidal-Castiñeira JR,Coto E,Moore H,Menendez P,Lopez-Larrea C

更新日期：2010-09-01 00:00:00

abstract：:Since its early days, stem cell research, particularly human embryonic stem cell research, has been the focus of intense social debate, and the question of the moral status of the embryo has been a central issue in the controversy. Despite this friction, and while it has yet to obtain widespread success in clinical ap...

journal_title：Stem cell reviews and reports

authors： Zarzeczny A,Caulfield T

更新日期：2009-06-01 00:00:00

abstract：:Endothelial progenitors are a population of cells with the inherent capacity to differentiate into mature endothelial cells and proangiogenic paracrine action. These characteristics have led to extensive studies being performed and tested in the treatment of tissue ischemia. The natural course of diabetes mellitus (DM...

journal_title：Stem cell reviews and reports

authors： Pyšná A,Bém R,Němcová A,Fejfarová V,Jirkovská A,Hazdrová J,Jude EB,Dubský M

更新日期：2019-04-01 00:00:00

abstract：:Brain injury continues to be one of the leading causes of disability worldwide. Despite decades of research, there is currently no pharmacologically effective treatment for preventing neuronal loss and repairing the brain. As a result, novel therapeutic approaches, such as cell-based therapies, are being actively purs...

journal_title：Stem cell reviews and reports

authors： Jezierski A,Rennie K,Zurakowski B,Ribecco-Lutkiewicz M,Haukenfrers J,Ajji A,Gruslin A,Sikorska M,Bani-Yaghoub M

更新日期：2014-04-01 00:00:00

abstract：:Orthotopic liver transplant (OLT) remains the standard of care for end stage liver disease. To circumvent allo-rejection, OLT subjects receive gluococorticoids (GC). We investigated the effects of GC on endogenous mesenchymal stem (stromal) cells (MSCs) in OLT. This question is relevant because MSCs have regenerative ...

journal_title：Stem cell reviews and reports

authors： Walker ND,Mourad Y,Liu K,Buxhoeveden M,Schoenberg C,Eloy JD,Wilson DJ,Brown LG,Botea A,Chaudhry F,Greco SJ,Ponzio NM,Pyrsopoulos N,Koneru B,Gubenko Y,Rameshwar P

更新日期：2017-10-01 00:00:00

abstract：:Epicardial resident stem cells are known to differentiate into cardiomyocytes during cardiac development, amongst other cell types. Whether epicardium-derived progenitor cells (EPDCs) retain this plasticity in the adult heart has been the topic of heated scientific debate. Priming with thymosin beta 4, a peptide which...

journal_title：Stem cell reviews and reports

authors： Gajzer DC,Balbin J,Chaudhry HW

更新日期：2013-06-01 00:00:00

abstract：:There is a need for physiologically relevant assay platforms to provide functionally relevant models of diabetes, to accelerate the discovery of new treatment options and boost developments in drug discovery. In this review, we compare several 3D-strategies that have been used to increase the functional relevance of e...

journal_title：Stem cell reviews and reports

authors： Ribeiro D,Kvist AJ,Wittung-Stafshede P,Hicks R,Forslöw A

更新日期：2018-04-01 00:00:00

abstract：:In this report we review the concept of standardization and propose an exhaustive framework for the proper management of technology on pluripotent stem cells based on studies of global and regional initiatives. We demonstrated detailed observational analysis on global initiatives for the standardization of related tec...

journal_title：Stem cell reviews and reports

authors： Sengoku S,Sumikura K,Oki T,Nakatsuji N

更新日期：2011-06-01 00:00:00

abstract：:Recent advances on human pluripotent stem cells (hPSCs), including human embryonic stem cells (hESCs) and induced pluripotent stem cells (hiPSCs) have brought us closer to the realization of their clinical potential. Nonetheless, tissue engineering and regenerative medicine applications will require the generation of ...

journal_title：Stem cell reviews and reports

authors： Fan Y,Wu J,Ashok P,Hsiung M,Tzanakakis ES

更新日期：2015-02-01 00:00:00

abstract：:Chemotherapy constitutes one of the key treatment modalities for solid and hematological malignancies. Albeit being an effective treatment, chemotherapy application is often limited by its damage to healthy tissues, and curative treatment options for chemotherapy-related side effects are largely missing. As mesenchyma...

journal_title：Stem cell reviews and reports

authors： Rühle A,Lopez Perez R,Zou B,Grosu AL,Huber PE,Nicolay NH

更新日期：2019-06-01 00:00:00

abstract：:The Networks of Centres of Excellence (NCE) is an innovative model of large-scale research networks that began in Canada in 1989, and has since been adopted by numerous countries around the globe. The Canadian Stem Cell Network (SCN), an NCE that has fostered stem cell research and innovation in Canada, has supported ...

journal_title：Stem cell reviews and reports

authors： Jacob KJ,Roskams-Edris D,Illes J

更新日期：2015-12-01 00:00:00

abstract：:The practice of travelling abroad to receive unproven and unregulated stem cell treatments has become an increasingly problematic global phenomenon known as 'stem cell tourism'. In this paper, we examine representations of nine major clinics and providers of such treatments on the microblogging network Twitter. We col...

journal_title：Stem cell reviews and reports

authors： Kamenova K,Reshef A,Caulfield T

更新日期：2014-12-01 00:00:00

abstract：:Cerebral ischemia induces death of all neural cell types within the region affected by the loss of blood flow. We have shown that administering human umbilical cord blood cells after a middle cerebral artery occlusion in rats significantly reduces infarct size, presumably by rescuing cells within the penumbra. In this...

journal_title：Stem cell reviews and reports

authors： Jiang L,Saporta S,Chen N,Sanberg CD,Sanberg P,Willing A

更新日期：2010-12-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) are promising tools for studying the mechanisms of development and for the regeneration of injured tissues. Correct selection of the MSCs source is crucial in order to obtain a more efficient treatment and, in this respect Periosteum-Derived Cells (PDPCs) may represent an interesting alte...

journal_title：Stem cell reviews and reports

authors： Ferretti C,Borsari V,Falconi M,Gigante A,Lazzarini R,Fini M,Di Primio R,Mattioli-Belmonte M

更新日期：2012-09-01 00:00:00

abstract：:Trithorax group (TrxG) proteins play critical roles in transcriptional activation by promoting methylation of histone H3 Lysine 4 (H3K4), but the precise functions of the individual TrxG members during embryonic differentiation are not fully understood. Here we show that Mll2, a TrxG member, is required for proliferat...

journal_title：Stem cell reviews and reports

authors： Wan X,Liu L,Ding X,Zhou P,Yuan X,Zhou Z,Hu P,Zhou H,Li Q,Zhang S,Xiong S,Zhang Y

更新日期：2014-10-01 00:00:00

abstract：:Surface topography of Titanium (Ti) dental implants strongly influences osseointegration. In the present work, we have analyzed the influence of two Ti implant surfaces characterized by similar microtopography but different nanotopography and chemistry on the osteoblastic phenotype of Dental Pulp Stem Cells (DPSCs). T...

journal_title：Stem cell reviews and reports

authors： Gardin C,Ferroni L,Piattelli A,SIvolella S,Zavan B,Mijiritsky E

更新日期：2016-10-01 00:00:00

abstract：:Factors responsible for the rapid proliferative properties of embryonic stem (ES) cells are largely unknown. MicroRNA-221/222 (miR-221/222) regulate proliferation in many somatic cells, however, their roles in proliferation of ES cells are unclear. In this study, E14 mouse ES cells proliferation was determined by tota...

journal_title：Stem cell reviews and reports

authors： Li J,Bei Y,Liu Q,Lv D,Xu T,He Y,Chen P,Xiao J

更新日期：2015-02-01 00:00:00