Abstract:
:There is a need for physiologically relevant assay platforms to provide functionally relevant models of diabetes, to accelerate the discovery of new treatment options and boost developments in drug discovery. In this review, we compare several 3D-strategies that have been used to increase the functional relevance of ex vivo human primary pancreatic islets and developments into the generation of stem cell derived pancreatic beta-cells (β-cells). Special attention will be given to recent approaches combining the use of extracellular matrix (ECM) scaffolds with pancreatic molecular memory, which can be used to improve yield and functionality of in vitro stem cell-derived pancreatic models. The ultimate goal is to develop scalable cell-based platforms for diabetes research and drug screening. This article will critically assess key aspects related to in vitro pancreatic 3D-ECM models and highlight the most promising approaches for future research.
journal_name
Stem Cell Rev Repjournal_title
Stem cell reviews and reportsauthors
Ribeiro D,Kvist AJ,Wittung-Stafshede P,Hicks R,Forslöw Adoi
10.1007/s12015-017-9783-8subject
Has Abstractpub_date
2018-04-01 00:00:00pages
177-188issue
2eissn
2629-3269issn
2629-3277pii
10.1007/s12015-017-9783-8journal_volume
14pub_type
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journal_title:Stem cell reviews and reports
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更新日期:2010-12-01 00:00:00
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journal_title:Stem cell reviews and reports
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journal_title:Stem cell reviews and reports
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journal_title:Stem cell reviews and reports
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journal_title:Stem cell reviews and reports
pub_type: 杂志文章,评审
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journal_title:Stem cell reviews and reports
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doi:10.1007/s12015-013-9483-y
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abstract:PURPOSE:Evaluation of potential tropic effects of vascular endothelial growth factor (VEGF) on the incorporation and differentiation of bone-marrow-derived stem cells (BMSCs) in a murine model of anterior ischemic optic neuropathy (AION). METHODS:In the first approach, small-sized subset of BMCs were isolated from GFP...
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journal_title:Stem cell reviews and reports
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abstract::Islet transplantation has been hampered by the shortage of islet donors available for diabetes therapy. However, pluripotent stem cells (PSCs) can be an alternative source of insulin-producing cells (IPCs) because of their capacity for self-renewal and differentiation. We described a method to efficiently differentiat...
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