Cancer stem cells: lessons from melanoma.

abstract：:Various strategies have been published enabling cardiomyocyte differentiation of human induced pluripotent stem (iPS) cells. However the complex nature of signaling pathways involved as well as line-to-line variability compromises the application of a particular protocol to robustly obtain cardiomyocytes from multiple...

journal_title：Stem cell reviews and reports

authors： Kadari A,Mekala S,Wagner N,Malan D,Köth J,Doll K,Stappert L,Eckert D,Peitz M,Matthes J,Sasse P,Herzig S,Brüstle O,Ergün S,Edenhofer F

更新日期：2015-08-01 00:00:00

abstract：:Neural progenitor cells (NPCs) are multipotent cells that have the potential to produce neurons and glial cells in the neural system. NPCs undergo identity maintenance or differentiation regulated by different kinds of transcription factors. Here we present evidence that ETV5, which is an ETS transcription factor, pro...

journal_title：Stem cell reviews and reports

authors： Liu Y,Zhang Y

更新日期：2019-10-01 00:00:00

abstract：:Traumatic injuries are a leading cause of death and disability in both military and civilian populations. Given the complexity and diversity of traumatic injuries, novel and individualized treatment strategies are required to optimize outcomes. Cellular therapies have potential benefit for the treatment of acute or ch...

journal_title：Stem cell reviews and reports

authors： Lowry LE,Herzig MC,Christy BA,Schäfer R,Pati S,Cap AP,Bynum JA

更新日期：2021-01-08 00:00:00

abstract：:Osteoarthritis (OA) remains incurable in humans or horses and mesenchymal stromal/stem cells (MSCs) represent an attractive solution for producing a neocartilage substitute. However, the best MSC source still needs to be identified. This study compared the chondrogenic potential of equine MSCs derived from bone marrow...

journal_title：Stem cell reviews and reports

authors： Contentin R,Demoor M,Concari M,Desancé M,Audigié F,Branly T,Galéra P

更新日期：2020-02-01 00:00:00

abstract：:Mesenchymal stem cells (MSC) have been extensively studied over the past years for the treatment of different diseases. Most of the ongoing clinical trials currently involve the use of MSC derived from adult tissues. This source may have some limitations, particularly with therapies that may require extensive and repe...

journal_title：Stem cell reviews and reports

authors： Luzzani CD,Miriuka SG

更新日期：2017-02-01 00:00:00

abstract：:Factors responsible for the rapid proliferative properties of embryonic stem (ES) cells are largely unknown. MicroRNA-221/222 (miR-221/222) regulate proliferation in many somatic cells, however, their roles in proliferation of ES cells are unclear. In this study, E14 mouse ES cells proliferation was determined by tota...

journal_title：Stem cell reviews and reports

authors： Li J,Bei Y,Liu Q,Lv D,Xu T,He Y,Chen P,Xiao J

更新日期：2015-02-01 00:00:00

abstract：:Although bone marrow-derived mononuclear cells (BMNC) have been extensively used in cell therapy for cardiac diseases, little mechanistic information is available to support reports of their efficacy. To address this shortcoming, we compared structural and functional recovery and associated global gene expression prof...

journal_title：Stem cell reviews and reports

authors： Lachtermacher S,Esporcatte BL,Fortes Fda S,Rocha NN,Montalvão F,Costa PC,Belem L,Rabischoffisky A,Faria Neto HC,Vasconcellos R,Iacobas DA,Iacobas S,Spray DC,Thomas NM,Goldenberg RC,de Carvalho AC

更新日期：2012-03-01 00:00:00

abstract：:Orthotopic liver transplant (OLT) remains the standard of care for end stage liver disease. To circumvent allo-rejection, OLT subjects receive gluococorticoids (GC). We investigated the effects of GC on endogenous mesenchymal stem (stromal) cells (MSCs) in OLT. This question is relevant because MSCs have regenerative ...

journal_title：Stem cell reviews and reports

authors： Walker ND,Mourad Y,Liu K,Buxhoeveden M,Schoenberg C,Eloy JD,Wilson DJ,Brown LG,Botea A,Chaudhry F,Greco SJ,Ponzio NM,Pyrsopoulos N,Koneru B,Gubenko Y,Rameshwar P

更新日期：2017-10-01 00:00:00

abstract：:Trithorax group (TrxG) proteins play critical roles in transcriptional activation by promoting methylation of histone H3 Lysine 4 (H3K4), but the precise functions of the individual TrxG members during embryonic differentiation are not fully understood. Here we show that Mll2, a TrxG member, is required for proliferat...

journal_title：Stem cell reviews and reports

authors： Wan X,Liu L,Ding X,Zhou P,Yuan X,Zhou Z,Hu P,Zhou H,Li Q,Zhang S,Xiong S,Zhang Y

更新日期：2014-10-01 00:00:00

abstract：:Please note the following errors in the original version. ...

journal_title：Stem cell reviews and reports

authors： Cai X,Lin Y,Friedrich CC,Neville C,Pomerantseva I,Sundback CA,Zhang Z,Vacanti JP,Hauschka PV,Grottkau BE

更新日期：2019-02-01 00:00:00

abstract：:There is a need for physiologically relevant assay platforms to provide functionally relevant models of diabetes, to accelerate the discovery of new treatment options and boost developments in drug discovery. In this review, we compare several 3D-strategies that have been used to increase the functional relevance of e...

journal_title：Stem cell reviews and reports

authors： Ribeiro D,Kvist AJ,Wittung-Stafshede P,Hicks R,Forslöw A

更新日期：2018-04-01 00:00:00

abstract：:Chronic articular cartilage defects are the most common disabling conditions of humans in the western world. The incidence for cartilage defects is increasing with age and the most prominent risk factors are overweight and sports associated overloading. Damage of articular cartilage frequently leads to osteoarthritis ...

journal_title：Stem cell reviews and reports

authors： Preitschopf A,Zwickl H,Li K,Lubec G,Joo G,Rosner M,Hengstschläger M,Mikula M

更新日期：2012-12-01 00:00:00

abstract：:The combination of cell therapy with growth factors could be a useful approach to treat progressive muscular dystrophies. Here, we demonstrate, for the first time, that IGF-1 considerably enhances the myogenesis of human umbilical cord (UC) mesenchymal stromal cells (MSCs) in vitro and that IGF-1 enhances interaction ...

journal_title：Stem cell reviews and reports

authors： Secco M,Bueno C Jr,Vieira NM,Almeida C,Pelatti M,Zucconi E,Bartolini P,Vainzof M,Miyabara EH,Okamoto OK,Zatz M

更新日期：2013-02-01 00:00:00

abstract：:Stem cells in the endometrium and myometrium possess an immense regenerative potential which is necessary to maintain the menstrual cycle and support pregnancy. These cells, as well as bone marrow stem cells, have also been implicated in the development of common benign gynecological disorders including leiomyomas, en...

journal_title：Stem cell reviews and reports

authors： El Sabeh M,Afrin S,Singh B,Miyashita-Ishiwata M,Borahay M

更新日期：2020-11-05 00:00:00

abstract：BACKGROUND:Bone marrow-derived mononuclear cells (BM-MNC) consist of a heterogeneous mix of mesenchymal stem cells (MSC), hematopoietic progenitor cells (HPC), endothelial progenitor cells (EPC), monocytes, lymphocytes and pluripotent stem cells. Whereas the importance of MSC and EPC has been well documented in bone he...

journal_title：Stem cell reviews and reports

authors： Leppik L,Sielatycka K,Henrich D,Han Z,Wang H,Eischen-Loges MJ,Oliveira KMC,Bhavsar MB,Ratajczak MZ,Barker JH

更新日期：2020-02-01 00:00:00

abstract：:Stem cell research has generated considerable attention for its potential to remediate many disorders of the central nervous system including neurodevelopmental disorders such as autism spectrum disorder (ASD) and cerebral palsy (CP) that place a high burden on individual children, families and society. Here we charac...

journal_title：Stem cell reviews and reports

authors： Sharpe K,Di Pietro N,Illes J

更新日期：2016-02-01 00:00:00

abstract：:The propensity of induced pluripotent stem (iPS) cells to differentiate into specific lineages may be influenced by a number of factors, including the selection of the somatic cell type used for reprogramming. Herein we report the generation of new iPS cells, which we derived from human articular chondrocytes and from...

journal_title：Stem cell reviews and reports

authors： Guzzo RM,Scanlon V,Sanjay A,Xu RH,Drissi H

更新日期：2014-12-01 00:00:00

abstract：:Epicardial resident stem cells are known to differentiate into cardiomyocytes during cardiac development, amongst other cell types. Whether epicardium-derived progenitor cells (EPDCs) retain this plasticity in the adult heart has been the topic of heated scientific debate. Priming with thymosin beta 4, a peptide which...

journal_title：Stem cell reviews and reports

authors： Gajzer DC,Balbin J,Chaudhry HW

更新日期：2013-06-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) represent a population of cells which have the ability to regulate reactivity of T and B lymphocytes by multiple mechanisms. The immunoregulatory activities of MSCs are strictly influenced by the cytokine environment. Here we show that two functionally distinct cytokines, interleukin-4 (I...

journal_title：Stem cell reviews and reports

authors： Holan V,Hermankova B,Bohacova P,Kossl J,Chudickova M,Hajkova M,Krulova M,Zajicova A,Javorkova E

更新日期：2016-12-01 00:00:00

abstract：:The majority of patients survive an acute myocardial infarction (AMI). Their outcome is negatively influenced by post-AMI events, such as loss of viable cardiomyocytes due to a post-AMI inflammatory response, eventually resulting in heart failure and/or death. Recent pre-clinical animal studies indicate that mesenchym...

journal_title：Stem cell reviews and reports

authors： Naaijkens BA,van Dijk A,Kamp O,Krijnen PA,Niessen HW,Juffermans LJ

更新日期：2014-06-01 00:00:00

abstract：:During the process of development, neural crest cells migrate out from their niche between the newly formed ectoderm and the neural tube. Thereafter, they give rise not only to ectodermal cell types, but also to mesodermal cell types. Cell types with neural crest ancestry consequently comprise a number of specialized ...

journal_title：Stem cell reviews and reports

authors： Kaltschmidt B,Kaltschmidt C,Widera D

更新日期：2012-09-01 00:00:00

abstract：:Xenografting of normal and transformed mammalian tissues and cells to chick embryos has been performed for almost 100 years. Embryonic stem cells, derived more than 25 years ago from murine, and more than 10 years ago from human blastocysts, have transformed many fields of biological research. There is a growing body ...

journal_title：Stem cell reviews and reports

authors： Goldstein RS

更新日期：2010-09-01 00:00:00

abstract：:Since its early days, stem cell research, particularly human embryonic stem cell research, has been the focus of intense social debate, and the question of the moral status of the embryo has been a central issue in the controversy. Despite this friction, and while it has yet to obtain widespread success in clinical ap...

journal_title：Stem cell reviews and reports

authors： Zarzeczny A,Caulfield T

更新日期：2009-06-01 00:00:00

abstract：:Schwann cells (SC), the glial cells of peripheral nerves, are involved in many diseases including Charcot Marie Tooth and neurofibromatosis, and play a pivotal role in peripheral nerve regeneration. Although it is possible to obtain human SC from nerve biopsies, they are difficult to maintain and expand in culture. He...

journal_title：Stem cell reviews and reports

authors： Ziegler L,Grigoryan S,Yang IH,Thakor NV,Goldstein RS

更新日期：2011-06-01 00:00:00

abstract：:The original version of this article unfortunately contained a mistake. In the author group, the correct family name of Dr. Rebeca is "Blázquez" and the correct family name of Dr. Francisco Miguel is "Sánchez-Margallo." ...

journal_title：Stem cell reviews and reports

authors： López E,Blázquez R,Marinaro F,Álvarez V,Blanco V,Báez C,González I,Abad A,Moreno B,Sánchez-Margallo FM,Crisóstomo V,Casado JG

更新日期：2020-06-01 00:00:00

abstract：:Human pluripotent stem cells (PSCs) are critical in vitro tools for understanding mechanisms that regulate lineage differentiation in the human embryo as well as a potentially unlimited supply of stem cells for regenerative medicine. Pluripotent human and mouse embryonic stem cells (ESCs) derived from the inner cell m...

journal_title：Stem cell reviews and reports

authors： Gkountela S,Li Z,Chin CJ,Lee SA,Clark AT

更新日期：2014-04-01 00:00:00

abstract：:Converting adult cells from one cell type to another is a particularly interesting idea for regenerative medicine. Terminally differentiated cells can be induced to de-differentiate in vitro to become multipotent progenitors. In mammals these changes do not occur naturally, however exposing differentiated adult cells ...

journal_title：Stem cell reviews and reports

authors： Brevini TA,Pennarossa G,Rahman MM,Paffoni A,Antonini S,Ragni G,deEguileor M,Tettamanti G,Gandolfi F

更新日期：2014-10-01 00:00:00

abstract：:Recent advances on human pluripotent stem cells (hPSCs), including human embryonic stem cells (hESCs) and induced pluripotent stem cells (hiPSCs) have brought us closer to the realization of their clinical potential. Nonetheless, tissue engineering and regenerative medicine applications will require the generation of ...

journal_title：Stem cell reviews and reports

authors： Fan Y,Wu J,Ashok P,Hsiung M,Tzanakakis ES

更新日期：2015-02-01 00:00:00

abstract：:Angiotensin-converting enzyme 2 (ACE2) plays an important role as a member of the renin-angiotensin-aldosterone system (RAAS) in regulating the conversion of angiotensin II (Ang II) into angiotensin (1-7) (Ang [1-7]). But at the same time, while expressed on the surface of human cells, ACE2 is the entry receptor for S...

journal_title：Stem cell reviews and reports

authors： Ratajczak MZ,Bujko K,Ciechanowicz A,Sielatycka K,Cymer M,Marlicz W,Kucia M

更新日期：2020-07-20 00:00:00

abstract：:The molecular profile of human mesenchymal stem cells (MSCs) have emerged as a key factor in defining their identity. Nevertheless, the effect of fetal bovine serum (FBS) batches or origin on MSC molecular signature has been neglected. In this frame, chemical fingerprint of FBS batches from unrelated countries showed ...

journal_title：Stem cell reviews and reports

authors： Banfi F,Colombini A,Perucca Orfei C,Parazzi V,Ragni E

更新日期：2018-12-01 00:00:00