An Experimental Animal Model of Photodynamic Optic Nerve Head Injury (PONHI).

abstract：:The 'fast PIII' rod mediated photoreceptor response to flashes of monochromatic light has been investigated in isolated retinae of the RCS rat at age 30 days. A loss of both sensitivity and maximum response amplitude were found, with a concurrent slowing of the response kinetics. These observations indicate a rod abno...

journal_title：Current eye research

authors： Low JC

更新日期：1984-09-01 00:00:00

abstract：:Calf gamma-crystallins were separated by preparative flat-bed isoelectric focusing and characterized according to their immunological properties, molecular weights and isoelectric points. Immunologically 4 different groups of gamma-crystallins (gamma 1a-1d-crystallin) could be detected. The main immunological componen...

journal_title：Current eye research

authors： Bours J,Vornhagen R,Herlt M,Rink H

更新日期：1981-01-01 00:00:00

abstract：:Forty-five patients with virologically confirmed dendritic keratitis were treated in a randomized, double-blind controlled study with a basic therapy of trifluorothymidine (TFT) eye drops. In addition they received different human recombinant interferon (rHu IFN) eye drops. The following results were obtained for aver...

journal_title：Current eye research

authors： Sundmacher R,Mattes A,Neumann-Haefelin D,Adolf G,Kruss B

更新日期：1987-01-01 00:00:00

abstract：PURPOSE:To evaluate the clinical outcomes of laser in situ keratomileusis (LASIK) using a new approach for the calculation of the ablation profile based on wavefront vertexing from pupil plane to corneal. METHODS:One hundred eyes of 50 patients (age, 21-41 years) with low and moderate myopia were enrolled in this pros...

journal_title：Current eye research

authors： Uceda-Montañés A,Rogers M,Piñero DP

更新日期：2020-09-16 00:00:00

abstract：:Using phosphorus-31 nuclear magnetic resonance (P-31 NMR) spectroscopy the rat crystalline lens was evaluated as a potential animal model for the study of lens metabolic processes relevant to the human. The P-31 NMR spectra of intact rat lenses and rat lens PCA extracts provided comparable qualitative and quantitative...

journal_title：Current eye research

authors： Kopp SJ,Greiner JV,Glonek T

更新日期：1981-01-01 00:00:00

abstract：PURPOSE:Maintaining mature and viable retinal pigment epithelial cells (RPE) in vitro has proven challenging. Investigating compounds that can promote RPE-viability and maturation is motivated by RPE transplantation research, the quest to understand RPE physiology, and a desire to modulate RPE in pathological states. W...

journal_title：Current eye research

authors： Khan AZ,Utheim TP,Moe MC,Aass HCD,Sapkota D,Vallenari EM,Eidet JR

更新日期：2020-09-01 00:00:00

abstract：:The corneal endothelium is known to contain gap junctions on its lateral borders. Here we show that the endothelial cells of the rabbit cornea are highly dye coupled. Lucifer Yellow CH introduced into a single cell through either an intracellular glass microelectrode or a patch electrode rapidly spreads into its neigh...

journal_title：Current eye research

authors： Rae JL,Lewno AW,Cooper K,Gates P

更新日期：1989-08-01 00:00:00

abstract：PURPOSE:To evaluate "in vivo" the effect of topical travoprost on the central corneal thickness (CCT) of rabbit eyes, and the changes in the CCT after acute increases of intraocular pressure (IOP) in these eyes. MATERIALS AND METHODS:This is an interventional, prospective, case-control, masked study. Topical travopros...

journal_title：Current eye research

authors： Bolívar G,Teus M,Arranz-Marquez E

更新日期：2011-11-01 00:00:00

abstract：PURPOSE:To study the effect of cataract surgery with intraocular lens (IOL) on frequency doubling perimetry (FDP). METHODS:Patients aged 40 years or above seen at our outpatient clinic with no ocular pathology except for visually significant cataract and visual acuity 6/24 or better were eligible. They underwent FDP b...

journal_title：Current eye research

authors： Arvind H,George R,Baskaran M,Raju P,Ramesh SV,Paul PG,Vijaya L

更新日期：2005-02-01 00:00:00

abstract：:The content of rhodopsin in the eyes of 15 donors (30 eyes) was determined. Both retinal and pigment epithelial fractions were collected from each globe, extracted using 1% CTAB, and the rhodopsin difference spectrum of each fraction was obtained separately. The total amount of rhodopsin, obtained by summing the amoun...

journal_title：Current eye research

authors： Fulton AB,Dodge J,Schremser JL,Armstrong A,Lanier F,Dawson WW,Williams TP

更新日期：1990-12-01 00:00:00

abstract：:Free radicals and oxidative damage play roles in aging and age-related ocular diseases such as cataracts, so defensive mechanisms become important factors for protection. Because N-acetylation is involved in a wide variety of detoxification processes, this study was conducted to examine the relationship between the ac...

journal_title：Current eye research

authors： Tamer L,Yilmaz A,Yildirim H,Ayaz L,Ates NA,Karakas S,Oz O,Yildirim O,Atik U

更新日期：2005-10-01 00:00:00

abstract：PURPOSE:To determine the effectiveness of topically applied fluoroquinolones for experimental Pseudomonas or Serratia keratitis. METHODS:Bacteria were injected intrastromally (10(3) colony forming units [CFU]). From 16 to 22 hours post-infection (PI), a single topical drop of moxifloxacin (Vigamox, 0.545%), levofloxac...

journal_title：Current eye research

authors： Thibodeaux BA,Dajcs JJ,Caballero AR,Marquart ME,Girgis DO,O'Callaghan RJ

更新日期：2004-05-01 00:00:00

abstract：PURPOSE:To evaluate 24-hr intraocular pressure (IOP) and blood pressure (BP) with timolol or latanoprost/timolol fixed combination (LTFC). METHODS:Patients with primary open-angle glaucoma or ocular hypertension with normal blood pressure were randomized to LTFC, dosed each evening, or timolol dosed twice daily in a c...

journal_title：Current eye research

authors： Konstas AG,Pikilidou MI,Tsironi S,Mikropoulos D,Kozobolis VP,Sarafidis PA,Lasaridis AN,Nelson LA,Stewart WC

更新日期：2009-05-01 00:00:00

abstract：:We assessed in vitro the antimicrobial activity of four agents (vancomycin, teicoplanin, mupirocin, and imipenem) which are effective against Gram-positive cocci causally associated with bacterial keratitis, as well as their corneal epithelial cytotoxicity. Minimal inhibitory concentrations inhibiting 90% of strains (...

journal_title：Current eye research

authors： Cutarelli PE,Lazarus HM,Jacobs MR,Lass JH

更新日期：1993-07-01 00:00:00

abstract：:Water-soluble (WS) and water-insoluble (WI) crystallins were prepared from calf and bovine lenses. The WS-crystallins were analyzed by capillary isotachophoresis and by immunoelectrophoresis with polyvalent and alpha-, beta-, gamma-crystallin specific antisera. The WI-crystallins were first solubilized in formamide an...

journal_title：Current eye research

authors： Bours J

更新日期：1984-05-01 00:00:00

abstract：:Two different measures of response to therapy were evaluated in a model of keratitis caused by Aspergillus fumigatus in Dutch-belted rabbits. Combined pre and post-inoculation treatment with oral fluconazole 37.5 mg/kg bid or itraconazole 40 mg/kg bid was compared to post-inoculation treatment only and untreated contr...

journal_title：Current eye research

authors： O'Day DM,Head WS,Robinson RD,Williams TE,Gedde S

更新日期：1992-01-01 00:00:00

abstract：:The objective of this study was to determine if 20:5n-3 or 22:6n-3 is the primary precursor of very-long-chain fatty acids (VLCFAs; C24-C36) synthesized in retina. Rats were fed semisynthetic, nutritionally complete diet containing 20% (w/w) fat with 3% (w/w) of 22:6n-3. After 6 weeks feeding, the vitreal fluid of eac...

journal_title：Current eye research

authors： Suh M,Clandinin MT

更新日期：2005-11-01 00:00:00

abstract：:The effects of light damage were studied in four inbred strains of albino rats, Fischer (F344), Lewis (L), Wistar (W), and Buffalo (BUF). Thirty-five-day-old rats (3 from each strain) were kept in cyclic light for two weeks, after which they were exposed to constant fluorescent light (180-190 foot-candles, 490-580 nm)...

journal_title：Current eye research

authors： Borges JM,Edward DP,Tso MO

更新日期：1990-08-01 00:00:00

abstract：PURPOSE:Due to a possible link in humans between atherosclerosis, a high-fat diet, and the development of age-related retinal degenerations, we investigated retinal changes with age and diet in high-fat-fed C57BL/6 mice, a mouse model of human atherosclerosis. METHODS:We fed C57BL/6J mice either a normal chow diet or ...

journal_title：Current eye research

authors： Miceli MV,Newsome DA,Tate DJ Jr,Sarphie TG

更新日期：2000-01-01 00:00:00

abstract：PURPOSE:This study identifies the prevalence and risk factors of sensorineural hearing loss and primary open-angle glaucoma (POAG). MATERIALS AND METHODS:Patients aged 19 years or older who had undergone both ophthalmologic examination and audiometry as part of the Korea National Health and Nutrition Examination Surve...

journal_title：Current eye research

authors： Kim JM,Lee MY,Kim JW,Lee J,Kim HJ,Cha SC,Kim NR

更新日期：2020-08-01 00:00:00

abstract：PURPOSE:To investigate orbital biomechanical properties in patients with thyroid orbitopathy and in age- and gender-matched healthy subjects using the Corvis-ST (CST, Oculus Wetzlar, Germany). METHODS:The CST allows a non-contact tonometry with an ultra-high-speed Scheimpflug device to record the deformation of the co...

journal_title：Current eye research

authors： Leszczynska A,Moehler K,Spoerl E,Ramm L,Herber R,Pillunat LE,Terai N

更新日期：2018-03-01 00:00:00

abstract：:Purpose: To evaluate the correlation between pain during cataract surgery and preoperative anxiety.Methods: This prospective observational masked study included 103 eyes of 103 consecutive patients who underwent routine clear corneal incision phacoemulsification surgery at the Department of Ophthalmology, Rambam Healt...

journal_title：Current eye research

authors： Socea SD,Abualhasan H,Magen O,Zayit-Soudry S,Blumenthal EZ,Duvdevan N,Mimouni M

更新日期：2020-04-01 00:00:00

abstract：PURPOSE:We investigated the impact of target properties on vertical fusion amplitude (VFA) using a 3D display platform; the performance of the subjects allowed us to assess how central and peripheral retina regions interact during the fusion process. MATERIAL AND METHODS:Fourteen subjects were involved in the test. VF...

journal_title：Current eye research

authors： Zhang D,Neveu P,Fattakhova Y,Ferragut S,Lamard M,Cochener B,de Bougrenet de la Tocnaye JL

更新日期：2017-03-01 00:00:00

abstract：PURPOSE:In the limbo-corneal epithelium the stem and early precursor epithelial cell pool is confined to the limbal rim. Among the features associated with this spatial segregation is the general paucity of connexin43 (Cx43) within the limbal basal cell population and its complete absence in resident stem cells. The li...

journal_title：Current eye research

authors： Wolosin JM,Schütte M,Zieske JD,Budak MT

更新日期：2002-06-01 00:00:00

abstract：:Sixteen adult New Zealand white rabbits with previously confirmed herpes simplex virus type 1 (HSV-1) infections were stimulated by iontophoresis of 6-hydroxydopamine into the cornea and were followed-up by topical epinephrine treatment to confirm latency. A total of 224 ocular cultures were obtained, of which 73 were...

journal_title：Current eye research

authors： Trousdale MD,Robin JB,Willey DE,De Clercq E

更新日期：1987-12-01 00:00:00

abstract：PURPOSE:To compare the efficacy and tolerability of diclofenac and bromfenac ophthalmic solutions as adjunctive therapy after cataract surgery. MATERIALS AND METHODS:This prospective randomized controlled study included 130 patients who underwent cataract surgery. One hundred patients were randomized to receive postop...

journal_title：Current eye research

authors： Giannaccare G,Finzi A,Sebastiani S,Greco F,Versura P,Campos EC

更新日期：2018-12-01 00:00:00

abstract：PURPOSE:To evaluate the toxicity of indocyanine green (ICG) in combination with light. METHODS:Human retinal pigment epithelial cells (ARPE-19) and rat neurosensory retinal cells (R28) were treated with four different concentrations of ICG in combination with light exposure. Cell viability, mitochondrial function, and...

journal_title：Current eye research

authors： Narayanan R,Kenney MC,Kamjoo S,Trinh TH,Seigel GM,Resende GP,Kuppermann BD

更新日期：2005-06-01 00:00:00

abstract：PURPOSE:The repair of the corneal epithelium is modulated by matrix metalloproteinases. The present study examined the effects of recombinant (r-) tissue inhibitors of metalloproteinases-1 and -2 (TIMP-1 and -2) on the proliferation of cultured epithelial cells from rabbit cornea, and on the spreading of a sheet of squ...

journal_title：Current eye research

authors： Saika S,Kawashima Y,Okada Y,Tanaka SI,Yamanaka O,Ohnishi Y,Ooshima A

更新日期：1998-01-01 00:00:00

abstract：:Previous attempts to prepare monoclonal antibodies (MAbs) against S-antigen, a photoreceptor cell protein involved in the visual process and a potent autoantigen for the induction of experimental autoimmune uveitis (EAU), have yielded MAbs which define only carboxyl terminal epitopes. In this study we devised alternat...

journal_title：Current eye research

authors： Donoso LA,Gregerson DS,Smith L,Robertson S,Knospe V,Vrabec T,Kalsow CM

更新日期：1990-04-01 00:00:00

abstract：PURPOSE:To examine the morphological changes in the meibomian glands of eyes of patients with dry eye disease using the non-contact infrared meibography system and to assess their relationship with meibomian dropout, signs, and tear-film function. METHODS:Subjects included 264 randomly selected patients (528 eyes) suf...

journal_title：Current eye research

authors： Feng Y,Gao Z,Feng K,Qu H,Hong J

更新日期：2014-10-01 00:00:00