Abstract：
:Compared to conventional deep brain stimulation (DBS) for patients with Parkinson's Disease (PD), the newer approach of adaptive DBS (aDBS), regulating stimulation on the basis of the patient's clinical state, promises to achieve better clinical outcomes, avoid adverse-effects and save time for tuning parameters. A remaining challenge before aDBS comes into practical use is to prove its feasibility and its effectiveness in larger groups of patients and in more ecological conditions. We developed an external portable aDBS system prototype designed for clinical testing in freely-moving PD patients with externalized DBS electrodes. From a single-channel bipolar artifact-free recording, it analyses local field potentials (LFPs), during ongoing DBS for tuning stimulation parameters, independent from the specific feedback algorithm implemented. We validated the aDBS system in vitro, by testing both its sensing and closed-loop stimulation capabilities, and then tested it in vivo, focusing on the sensing capabilities. By applying the aDBS system prototype in a patient with PD, we provided evidence that it can track levodopa and DBS-induced LFP spectral power changes among different patient's clinical states. Our system, intended for testing LFP-based feedback strategies for aDBS, should help understanding how and whether aDBS therapy works in PD and indicating future technical and clinical advances.
journal_name
Med Eng Physjournal_title
Medical engineering & physicsauthors
Arlotti M,Rossi L,Rosa M,Marceglia S,Priori Adoi
10.1016/j.medengphy.2016.02.007subject
Has Abstractpub_date
2016-05-01 00:00:00pages
498-505issue
5eissn
1350-4533issn
1873-4030pii
S1350-4533(16)30001-7journal_volume
38pub_type
杂志文章abstract：:The Fit4Purpose project aims to develop upper limb prosthetic devices which are suitable for deployment in lower- and middle-income countries (LMIC's). Open-frame trans-radial socket designs are being considered, formed of several, linked components, including pads which interface directly with the skin surface. A mec...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2020.08.003
更新日期：2020-10-01 00:00:00
abstract：:In robotic and conventional minimally invasive surgery the risk of complications caused by collateral tissue damage remains high. This paper studies the concept of imposing damage thresholds on surgical instruments to avoid tissue overload. More specifically, the correlation between mechanical loading and damage in ca...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2010.04.002
更新日期：2010-06-01 00:00:00
abstract：:Ultrasonic scalers are used in dentistry for removing mineralised plaque, known as calculus, from tooth surfaces. Though there is much information relating to the longitudinal vibrations of scaler probes, corresponding lateral data is limited. Understanding the lateral motion of ultrasonic probes is essential as, when...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2010.02.010
更新日期：2010-07-01 00:00:00
abstract：:This study proposes semi-automatic determination of geometrical features in hip magnetic resonance (MR) images in order to evaluate the Legg-Calvé-Perthes disease (LCPD). Nine anatomical points on a hip image are selected by a clinician; then eight geometrical indexes of the hip joint are calculated: acetabulum head i...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2004.10.003
更新日期：2005-06-01 00:00:00
abstract：:In case of large segmental defects in load-bearing bones, an external fixator is used to provide mechanical stability to the defect site. The overall stiffness of the bone-fixator system is determined not only by the fixator design but also by the way the fixator is mounted to the bone. This stiffness is an important ...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2012.10.006
更新日期：2013-07-01 00:00:00
abstract：:The internal carotid artery (ICA) has been proposed as an alternative site to the middle cerebral artery (MCA) to measure dynamic cerebral autoregulation (dCA) using transcranial Doppler ultrasound (TCD). Our aim was to test the inter-operator reproducibility of dCA assessment in the ICA and the effect of interaction ...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2016.03.007
更新日期：2016-07-01 00:00:00
abstract：:This study introduced a shape memory alloy (SMA)-based smart knee spacer for total knee arthroplasty (TKA). Subsequently, a 3D CAD model of a smart tibial component of TKA was designed in Solidworks software, and verified using a finite element analysis in ANSYS Workbench. The two major properties of the SMA (NiTi), t...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2018.03.001
更新日期：2018-05-01 00:00:00
abstract：:Bone defects can occur in various forms and present challenges to performing a standard micro-CT evaluation of bone quality because most measures are suited to homogeneous structures rather than ones with spatially focal abnormalities. Such defects are commonly associated with pain and fragility. Research involving bo...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2013.05.016
更新日期：2013-11-01 00:00:00
abstract：:The purpose of this study was to determine the use and feasibility of accelerometry-based monitoring and to examine a discrete multi-resolution signal analysis technique to determine motoric subtypes in patients with DSM-IV delirium. Forty consecutive patients receiving palliative care (23 male, 17 female, mean age+/-...
journal_title：Medical engineering & physics
pub_type： 临床试验,杂志文章
doi：10.1016/j.medengphy.2009.10.012
更新日期：2010-03-01 00:00:00
abstract：:Pulse transit time (PTT) has emerged over the recent decades as a simple and non-invasive measure to quantify inspiratory effort changes in adults with sleep disordered breathing (SDB). Hence, this shows promise to be an effective screening tool for the paediatrics. However, little is known about its utility and suita...
journal_title：Medical engineering & physics
pub_type： 杂志文章,评审
doi：10.1016/j.medengphy.2006.01.006
更新日期：2007-01-01 00:00:00
abstract：:The formation of pressure ulcers can be exacerbated by a breakdown in the integrity of the patient's skin caused by poor maintenance of the skin microclimate. Patient support systems (PSSs-specialised beds, mattresses, chairs, cushions and pads) play an important role in the dissipation of heat and moisture away from ...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/s1350-4533(00)00003-5
更新日期：1999-12-01 00:00:00
abstract：OBJECTIVE:A novel methodology has been developed to evaluate regional alterations in arterial wall material properties with induced atheroma in an animal model. METHODS:Atheromatous lesions (fatty, fibro-fatty, and fibrous) were induced in the carotid arteries of a Yucatan miniswine model by endothelial cell denudatio...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2004.09.014
更新日期：2005-03-01 00:00:00
abstract：:This work proposes the use of miniature wireless inertial sensors as an objective tool for the diagnosis of ADHD. The sensors, consisting of both accelerometers and gyroscopes to measure linear and rotational movement, respectively, are used to characterize the motion of subjects in the setting of a psychiatric consul...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2014.02.023
更新日期：2014-07-01 00:00:00
abstract：:The BION (Bionic Neuron) is a single channel implantable neurostimulator of unique design that can be delivered by injection. The development of the BION injectable neurostimulators exemplifies a challenging, but well posed medical design problem addressed with a successful strategy for prioritizing and resolving the ...
journal_title：Medical engineering & physics
pub_type： 杂志文章,评审
doi：10.1016/j.medengphy.2010.08.010
更新日期：2011-01-01 00:00:00
abstract：:Small spaces make collision-free turns difficult for wheelchair users. Contrary to basic kinematic wheelchair modelling and not considered previously by engineers; when wheelchairs turn in small spaces, could lateral drift (sideways slipping) increase the risk of collisions with surrounding structures such as walls an...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2020.11.012
更新日期：2021-01-01 00:00:00
abstract：:Beat detection is a basic and fundamental step in electrocardiogram (ECG) processing. In many ECG applications strong artifacts from biological or technical sources could appear and cause distortion of ECG signals. Beat detection algorithm desired property is to avoid these distortions and detect beats in any situatio...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2012.07.017
更新日期：2013-06-01 00:00:00
abstract：:Stent implantation has become a widely accepted endovascular intervention for the treatment of stenosed arteries. This minimally invasive technique has shown excellent results in unbranched arteries. However, stenting bifurcation lesions remains a challenge in coronary intervention as it is associated with a lower suc...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2008.11.013
更新日期：2009-05-01 00:00:00
abstract：:Bone-attached robots and microstereotactic frames, intended for deep brain stimulation and minimally invasive cochlear implantation, typically attach to a patient's skull via bone anchors. A rigid and reliable link between such devices and the skull is mandatory in order to fulfill the high accuracy demands of minimal...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2015.02.012
更新日期：2015-05-01 00:00:00
abstract：:Children with severe physical disabilities often require a range of technological devices to aid them with the fundamental tasks carried out in everyday life. These tasks areas may include mobility, communication, environment control and computer access for education. The most efficient, and often the most cost-effect...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/1350-4533(94)90043-4
更新日期：1994-05-01 00:00:00
abstract：:In this paper, we present a novel decentralized robust methodology for control of quiet upright posture during arm-free paraplegic standing using functional electrical stimulation (FES). Each muscle-joint complex is considered as a subsystem and individual controllers are designed for each one. Each controller operate...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2011.06.013
更新日期：2012-01-01 00:00:00
abstract：:The results from studies of wave propagation in large arteries carried out over the last 25 years have shown that there is a good agreement among values of the imaginary part of the complex propagation coefficient, as expressed by pressure or flow-rate wave propagation velocity. However, there is considerable disparit...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/s1350-4533(96)00073-2
更新日期：1997-04-01 00:00:00
abstract：:A major challenge during minimally invasive surgery is transfer of high forces through small, flexible instruments, such as needles and catheters, because of their low buckling resistance. In this study, we determined the feasibility of using a Newton's Cradle-inspired catheter (patented) to transfer high-force impuls...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2018.12.025
更新日期：2019-05-01 00:00:00
abstract：:Electromyography (EMG) has been widely used for the assessment of musculoskeletal functions and the control of electrical prostheses, which make use of the EMG signal generated by the contraction of the residual muscles. In spite of the successful applications of EMG in different fields, it has some inherent limitatio...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2005.07.012
更新日期：2006-06-01 00:00:00
abstract：OBJECTIVE:To evaluate whether outcomes based on stopwatch time and power output (PO) over a 15m-overground wheelchair sprint test can be used to assess wheelchair-specific anaerobic work capacity, by studying their relationship with outcomes on a Wingate-based 30s-wheelchair ergometer sprint (WAnT). METHODS:Able-bodie...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2014.01.003
更新日期：2014-04-01 00:00:00
abstract：:Understanding the load mechanics of orthopaedic implants is important to be able to predict their behaviour in-vivo. Much research, both mechanical and clinical, has been carried out on hip and knee implants, but less has been written about the mechanics of wrist implants. In this paper, the load mechanics of the Univ...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2016.02.008
更新日期：2016-06-01 00:00:00
abstract：:We suggest a new approach to peripheral vascular bypass surgery planning based on solving the one-dimensional (1D) governing equations of blood flow in patient-specific models. The aim of the present paper is twofold. First, we present the coupled 1D-0D model based on a discontinuous Galerkin method in a comprehensive...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2008.04.015
更新日期：2009-01-01 00:00:00
abstract：:Quantification in clinical, diagnostic electromyography (EMG) currently includes motor unit action potential (MUAP) analysis and interference pattern analysis. Early efforts to examine the frequency/power spectra of the interference pattern showed modest value but the technique was not developed further. This paper re...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2011.07.017
更新日期：2012-03-01 00:00:00
abstract：:We developed a device for an objective measurement of non-nutritive sucking (NNS). NNS is newborns' spontaneous action that is a predictor of their neural system development and can be adopted as an intervention to train oral feeding skills in preterms. Two miniaturized digital pressure sensors were embedded into a co...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2015.12.013
更新日期：2016-04-01 00:00:00
abstract：OBJECTIVE:Mathematical modeling of cerebral hemodynamics by descriptive equations can estimate the underlying pulsatile component of cerebral arterial blood volume (CaBV). This way, clinical monitoring of changes in cerebral compartmental compliances becomes possible. Our aim is to validate the most adequate method of ...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2019.07.019
更新日期：2019-12-01 00:00:00
abstract：:Comprehensive evaluation of results obtained using acoustic and contact microphones in screening for laryngeal disorders through analysis of sustained phonation is the main objective of this study. Aiming to obtain a versatile characterization of voice samples recorded using microphones of both types, 14 different set...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2014.12.005
更新日期：2015-02-01 00:00:00
