当前位置： SCI文献检索 > OPHTHALMOLOGY期刊下所有文献 > Genetic and Dietary Factors Influencing the Progression of Nuclear Cataract.

Genetic and Dietary Factors Influencing the Progression of Nuclear Cataract.

Abstract：

PURPOSE:To determine the heritability of nuclear cataract progression and to explore prospectively the effect of dietary micronutrients on the progression of nuclear cataract. DESIGN:Prospective cohort study. PARTICIPANTS:Cross-sectional nuclear cataract and dietary measurements were available for 2054 white female twins from the TwinsUK cohort. Follow-up cataract measurements were available for 324 of the twins (151 monozygotic and 173 dizygotic twins). METHODS:Nuclear cataract was measured using a quantitative measure of nuclear density obtained from digital Scheimpflug images. Dietary data were available from EPIC food frequency questionnaires. Heritability was modeled using maximum likelihood structural equation twin modeling. Association between nuclear cataract change and micronutrients was investigated using linear and multinomial regression analysis. The mean interval between baseline and follow-up examination was 9.4 years. MAIN OUTCOME MEASURES:Nuclear cataract progression. RESULTS:The best-fitting model estimated that the heritability of nuclear cataract progression was 35% (95% confidence interval [CI], 13-54), and individual environmental factors explained the remaining 65% (95% CI, 46-87) of variance. Dietary vitamin C was protective against both nuclear cataract at baseline and nuclear cataract progression (β = -0.0002, P = 0.01 and β = -0.001, P = 0.03, respectively), whereas manganese and intake of micronutrient supplements were protective against nuclear cataract at baseline only (β = -0.009, P = 0.03 and β = -0.03, P = 0.01, respectively). CONCLUSIONS:Genetic factors explained 35% of the variation in progression of nuclear cataract over a 10-year period. Environmental factors accounted for the remaining variance, and in particular, dietary vitamin C protected against cataract progression assessed approximately 10 years after baseline.

journal_name

Ophthalmology

journal_title

Ophthalmology

authors

Yonova-Doing E,Forkin ZA,Hysi PG,Williams KM,Spector TD,Gilbert CE,Hammond CJ

doi

10.1016/j.ophtha.2016.01.036

subject

Has Abstract

pub_date

2016-06-01 00:00:00

pages

1237-44

issue

6

eissn

0161-6420

issn

1549-4713

pii

S0161-6420(16)00114-7

journal_volume

123

pub_type

杂志文章

相关文献

OPHTHALMOLOGY文献大全
  • Enophthalmos: a clinical review.

    abstract：:Twenty-six cases of enophthalmos were reviewed. The causes in order of frequency were: orbital asymmetry (8); trauma (5); orbital metastasis (4); microphthalmos (2); orbital varix (2); maxillary mucocele (2); localized scleroderma (1); absence of sphenoid wing (neurofibromatosis) (1); post irradiation atrophy (1). Onl...

    journal_title：Ophthalmology

    pub_type： 杂志文章

    doi：10.1016/s0161-6420(84)34299-3

    authors： Cline RA,Rootman J

    更新日期：1984-03-01 00:00:00

  • Eyelid involvement in multicentric reticulohistiocytosis.

    abstract：CASE REPORT:The authors report the first biopsy-confirmed ocular adnexal involvement by multicentric reticulohistiocytosis. The patient was a 28-year-old black woman with a 15-year history of well-documented multicentric reticulohistiocytosis who had multiple dermal nodules and severe mutilating arthritis that had prod...

    journal_title：Ophthalmology

    pub_type： 杂志文章

    doi：10.1016/s0161-6420(95)31005-6

    authors： Eagle RC Jr,Penne RA,Hneleski IS Jr

    更新日期：1995-03-01 00:00:00

  • Lipemic diabetic retinopathy.

    abstract：:A study group of eight patients with diabetic retinopathy and marked accumulation of hard exudates in the fundi is described. There was a significant increase in serum triglyceride levels (P less than 0.05) in the study group as compared to a control group of 23 consecutive patients with diabetic retinopathy. This exu...

    journal_title：Ophthalmology

    pub_type： 杂志文章

    doi：10.1016/s0161-6420(84)34098-2

    authors： Brown GC,Ridley M,Haas D,Lucier AC,Sarin LK

    更新日期：1984-12-01 00:00:00

  • Implantation of Kelman-style, open-loop anterior chamber lenses during keratoplasty for aphakic and pseudophakic bullous keratopathy. A comparison with iris-sutured posterior chamber lenses.

    abstract：:The clinical and specular microscopic results of 40 cases (39 patients) of penetrating keratoplasty during which a Kelman-style anterior chamber intraocular lens was implanted were reviewed retrospectively. Thirty-one pseudophakic eyes received an intraocular lens exchange and nine aphakic eyes received a secondary in...

    journal_title：Ophthalmology

    pub_type： 杂志文章

    doi：10.1016/s0161-6420(91)32206-1

    authors： Hassan TS,Soong HK,Sugar A,Meyer RF

    更新日期：1991-06-01 00:00:00

  • Long-term effects of tocilizumab therapy for refractory uveitis-related macular edema.

    abstract：OBJECTIVE:To report the long-term efficacy and safety of the interleukin-6 receptor antagonist tocilizumab for refractory uveitis-related macular edema (ME). DESIGN:Retrospective cohort study. PARTICIPANTS:Eyes with uveitis seen at a single tertiary referral center for which ME was the principal cause of reduced visu...

    journal_title：Ophthalmology

    pub_type： 杂志文章

    doi：10.1016/j.ophtha.2014.06.050

    authors： Mesquida M,Molins B,Llorenç V,Sainz de la Maza M,Adán A

    更新日期：2014-12-01 00:00:00

  • Long-term follow-up of Intacs for post-LASIK corneal ectasia.

    abstract：OBJECTIVE:To report long-term follow-up of Intacs microthin prescription inserts for the management of post-LASIK corneal ectasia. DESIGN:Long-term (5 years), retrospective, nonrandomized study. PARTICIPANTS:Eight eyes of 5 patients with post-LASIK corneal ectasia (3 men and 2 women) ages 31 to 54 years (mean age+/-s...

    journal_title：Ophthalmology

    pub_type： 杂志文章

    doi：10.1016/j.ophtha.2006.05.043

    authors： Kymionis GD,Tsiklis NS,Pallikaris AI,Kounis G,Diakonis VF,Astyrakakis N,Siganos CS

    更新日期：2006-11-01 00:00:00

  • Incidence and rates of visual field progression after longitudinally measured optic disc change in glaucoma.

    abstract：OBJECTIVE:To determine whether glaucoma patients with progressive optic disc change have subsequent visual field progression earlier and at a faster rate compared with those without disc change. DESIGN:Prospective, longitudinal, cohort study. PARTICIPANTS AND CONTROLS:Eighty-one patients with open-angle glaucoma. ME...

    journal_title：Ophthalmology

    pub_type： 杂志文章

    doi：10.1016/j.ophtha.2009.04.031

    authors： Chauhan BC,Nicolela MT,Artes PH

    更新日期：2009-11-01 00:00:00

  • Evaluation of tumor regression and other prognostic factors for early and late metastasis after proton irradiation of uveal melanoma.

    abstract：:The authors examined the relationship of change in tumor height after proton beam irradiation with the risk of metastasis in 700 patients treated for uveal melanoma before July 1, 1986. Rates of change in tumor height were computed for each patient using follow-up ultrasonographic measures during the first 2 years aft...

    journal_title：Ophthalmology

    pub_type： 杂志文章

    doi：10.1016/s0161-6420(89)32685-6

    authors： Glynn RJ,Seddon JM,Gragoudas ES,Egan KM,Hart LJ

    更新日期：1989-10-01 00:00:00

  • Apocrine adenocarcinoma arising in Moll gland cystadenoma.

    abstract：CASE REPORT:An 85-year-old woman had a bluish tumor medially on the margin of the left upper eyelid. Malignant melanoma of the conjunctiva was presumed; the lesion was excised and submitted for routine histopathologic examination. There are no signs of recurrence or metastatic disease after follow-up for 1 year. METHO...

    journal_title：Ophthalmology

    pub_type： 杂志文章

    doi：10.1016/s0161-6420(93)31412-0

    authors： Seregard S

    更新日期：1993-11-01 00:00:00

  • Prospective study of sub-Tenon's versus retrobulbar anesthesia for inpatient and day-surgery trabeculectomy.

    abstract：PURPOSE:Several retrospective studies have demonstrated the safety and efficacy of sub-Tenon's anesthesia in ocular surgery. This is the first prospective randomized study comparing sub-Tenon's versus retrobulbar anesthesia for glaucoma surgery. METHODS:Thirty-nine patients undergoing both inpatient and day surgery tr...

    journal_title：Ophthalmology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0161-6420(93)31440-5

    authors： Buys YM,Trope GE

    更新日期：1993-10-01 00:00:00

  • Diffuse lamellar keratitis related to endotoxins released from sterilizer reservoir biofilms.

    abstract：OBJECTIVE:To investigate the risk factors and control mechanisms used to control the outbreak of diffuse lamellar keratitis (DLK) associated with laser in situ keratomileusis (LASIK) and examine the relationship between DLK and endotoxins released from sterilizer biofilm reservoirs. DESIGN:Clinic-based cohort and labo...

    journal_title：Ophthalmology

    pub_type： 杂志文章

    doi：10.1016/s0161-6420(00)00246-3

    authors： Holland SP,Mathias RG,Morck DW,Chiu J,Slade SG

    更新日期：2000-07-01 00:00:00

  • A survey of blindness and cataract surgery in Doumen County, China.

    abstract：PURPOSE:To assess blindness prevalence and that caused specifically by cataract in rural southern China. DESIGN:Population-based, cross-sectional study. PARTICIPANTS:A total of 5342 persons older than 50 years of age. METHODS:Visual acuity and eye examinations were performed in the summer of 1997 in a random sample ...

    journal_title：Ophthalmology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/S0161-6420(99)90459-1

    authors： Li S,Xu J,He M,Wu K,Munoz SR,Ellwein LB

    更新日期：1999-08-01 00:00:00

  • Toxocara canis infestation. Clinical and epidemiological associations with seropositivity in kindergarten children.

    abstract：:We studied a cohort of 333 children in kindergarten to determine the prevalence of seropositivity to Toxocara canis, and to detect and measure chronic health effects that might be attributable to past infection. We found that 23.1% of the children had serologic evidence of infection (antibody titer greater than or equ...

    journal_title：Ophthalmology

    pub_type： 杂志文章

    doi：10.1016/s0161-6420(86)33625-x

    authors： Ellis GS Jr,Pakalnis VA,Worley G,Green JA,Frothingham TE,Sturner RA,Walls KW

    更新日期：1986-08-01 00:00:00

  • Ocular motor and sensory function in Parkinson's disease.

    abstract：PURPOSE:To evaluate the effect of dopaminergic medication and deep brain stimulation on ocular function in Parkinson's disease (PD) and to measure vision-related quality of life in subjects with PD. DESIGN:Prospective, comparative case series. PARTICIPANTS AND CONTROLS:Twenty-seven PD and 16 control subjects were rec...

    journal_title：Ophthalmology

    pub_type： 杂志文章

    doi：10.1016/j.ophtha.2011.06.040

    authors： Almer Z,Klein KS,Marsh L,Gerstenhaber M,Repka MX

    更新日期：2012-01-01 00:00:00

  • Diffuse iris melanoma: a report of 25 cases.

    abstract：BACKGROUND:Diffuse iris melanoma is a rare variant of iris melanoma that has a flat growth pattern and often presents as unilateral hyperchromic heterochromia and glaucoma. There have been no large clinical reports of diffuse iris melanoma. DESIGN:Single-center retrospective case series. PARTICIPANTS:Twenty-five cons...

    journal_title：Ophthalmology

    pub_type： 杂志文章,评审

    doi：10.1016/s0161-6420(02)01104-1

    authors： Demirci H,Shields CL,Shields JA,Eagle RC Jr,Honavar SG

    更新日期：2002-08-01 00:00:00

  • Anterior clear spaces in keratoconus.

    abstract：:Anterior clear spaces were observed prospectively at slit-lamp examination in 26 of 69 consecutive eyes (38%) with keratoconus. Two corneal buttons with this finding were examined by light and electron microscopy and revealed breaks in Bowman's layer. Anterior clear spaces should be considered in the spectrum of clini...

    journal_title：Ophthalmology

    pub_type： 杂志文章

    doi：10.1016/s0161-6420(86)33571-1

    authors： Shapiro MB,Rodrigues MM,Mandel MR,Krachmer JH

    更新日期：1986-10-01 00:00:00

  • Rabbit ocular reactivity to bacterial endotoxin contained in aqueous solution and ophthalmic viscosurgical devices.

    abstract：OBJECTIVE:To describe the ocular reactivity of the rabbit to bacterial endotoxin contained in an aqueous medium and in a cohesive and a dispersive ophthalmic viscosurgical device (OVD). DESIGN:Experimental, randomized animal study. PARTICIPANTS:Seventy-five New Zealand white rabbits. METHODS:This study was performed...

    journal_title：Ophthalmology

    pub_type： 杂志文章

    doi：10.1016/j.ophtha.2012.04.006

    authors： Buchen SY,Calogero D,Hilmantel G,Eydelman MB

    更新日期：2012-07-01 00:00:00

  • Responsiveness of health-related quality-of-life questionnaires in adults undergoing Strabismus surgery.

    abstract：OBJECTIVE:To evaluate the responsiveness of 2 health-related quality-of-life (HRQOL) questionnaires, the Adult Strabismus-20 (AS-20) and National Eye Institute Visual Function Questionnaire-25 (VFQ-25), to changes in HRQOL after strabismus surgery. DESIGN:Cohort study. PARTICIPANTS:We included 106 adults (aged 18-84 ...

    journal_title：Ophthalmology

    pub_type： 杂志文章

    doi：10.1016/j.ophtha.2010.03.042

    authors： Hatt SR,Leske DA,Holmes JM

    更新日期：2010-12-01 00:00:00

  • Demographic-related variations in posterior segment ocular sarcoidosis.

    abstract：OBJECTIVE:To compare the frequency of posterior segment involvement (PSI), the prevalence of specific posterior segment signs, and visual acuity in ocular sarcoidosis by patient race, sex, and age. DESIGN:Retrospective, cross-sectional observational study. PARTICIPANTS:Seventy-six consecutive patients with biopsy-pro...

    journal_title：Ophthalmology

    pub_type： 杂志文章

    doi：10.1016/S0161-6420(03)00793-0

    authors： Khalatbari D,Stinnett S,McCallum RM,Jaffe GJ

    更新日期：2004-02-01 00:00:00

  • Objective and subjective evaluation of photic phenomena after monofocal and multifocal intraocular lens implantation.

    abstract：OBJECTIVE:To objectively measure and compare halo, flicker, and glare disability in pseudophakic eyes with monofocal (MONO) and multifocal (MULTI) intraocular lenses (IOLs) with respect to the influence of corneal surface quality, astigmatism, and age. DESIGN:Prospective case series. PARTICIPANTS:This clinical trial ...

    journal_title：Ophthalmology

    pub_type： 临床试验,杂志文章

    doi：10.1016/S0161-6420(99)90396-2

    authors： Dick HB,Krummenauer F,Schwenn O,Krist R,Pfeiffer N

    更新日期：1999-10-01 00:00:00

  • Malignant rhabdoid tumor of the orbit.

    abstract：:Malignant rhabdoid tumor (MRT), originally described as a sarcomatous variant of Wilms' tumor, is now recognized as a distinct, highly malignant entity. The authors describe, for the first time, a primary tumor of the orbit with histologic, immunohistochemical, and ultrastructural features of MRT. Their findings sugge...

    journal_title：Ophthalmology

    pub_type： 杂志文章

    doi：10.1016/s0161-6420(89)32666-2

    authors： Rootman J,Damji KF,Dimmick JE

    更新日期：1989-11-01 00:00:00

  • Dietary antioxidants and age-related maculopathy: the Blue Mountains Eye Study.

    abstract：OBJECTIVE:To assess associations between the stages of age-related maculopathy (ARM) and dietary intake of carotene, vitamin C, retinol, and zinc. DESIGN:Cross-sectional, population-based study. PARTICIPANTS:A total of 3654 subjects 49 years of age and older from a defined area, west of Sydney, Australia, participate...

    journal_title：Ophthalmology

    pub_type： 杂志文章

    doi：10.1016/S0161-6420(99)90164-1

    authors： Smith W,Mitchell P,Webb K,Leeder SR

    更新日期：1999-04-01 00:00:00

  • Intraocular pressure variations after diode laser photocoagulation for threshold retinopathy of prematurity.

    abstract：PURPOSE:To investigate the intraocular pressure (IOP) variations occurring after indirect diode laser photocoagulation for threshold retinopathy of prematurity. DESIGN:Prospective, nonrandomized, comparative study. PARTICIPANTS:A study group-21 consecutive premature babies (42 eyes) undergoing diode laser photocoagul...

    journal_title：Ophthalmology

    pub_type： 杂志文章

    doi：10.1016/j.ophtha.2004.03.024

    authors： Axer-Siegel R,Bourla D,Friling R,Shalev B,Sirota L,Benjamini Y,Weinberger D,Snir M

    更新日期：2004-09-01 00:00:00

  • An evaluation of image quality and accuracy of eye bank measurement of donor cornea endothelial cell density in the Specular Microscopy Ancillary Study.

    abstract：PURPOSE:The Specular Microscopy Ancillary Study was designed to examine donor corneal endothelial specular image quality, compare the central endothelial cell density determined by eye banks with the endothelial cell density determined by a central specular microscopy reading center, and evaluate donor factors that may...

    journal_title：Ophthalmology

    pub_type： 杂志文章

    doi：10.1016/j.ophtha.2004.10.045

    authors： Lass JH,Gal RL,Ruedy KJ,Benetz BA,Beck RW,Baratz KH,Holland EJ,Kalajian A,Kollman C,Manning FJ,Mannis MJ,McCoy K,Montoya M,Stulting D,Xing D,Cornea Donor Study Group.

    更新日期：2005-03-01 00:00:00

  • Results of early alignment of congenital esotropia.

    abstract：OBJECTIVE:To determine the long-term motor and sensory results after early surgical correction of patients with congenital esotropia. DESIGN:Noncomparative interventional case series. PARTICIPANTS:Ten infants with congenital esotropia. INTERVENTION:Patients had bimedial rectus recession between 83 and 159 days of ag...

    journal_title：Ophthalmology

    pub_type： 杂志文章

    doi：10.1016/S0161-6420(99)90337-8

    authors： Helveston EM,Neely DF,Stidham DB,Wallace DK,Plager DA,Sprunger DT

    更新日期：1999-09-01 00:00:00

  • Visual-evoked potential evidence of chiasmal hypoplasia.

    abstract：PURPOSE:To show that chiasmal hypoplasia or aplasia need not be an isolated developmental anomaly and to examine the spectrum of associated clinical findings to explore the possibility that these patients may represent a phenotypic manifestation of a developmental gene anomaly. DESIGN:An observational case series. PA...

    journal_title：Ophthalmology

    pub_type： 杂志文章

    doi：10.1016/S0161-6420(99)90539-0

    authors： Thompson DA,Kriss A,Chong K,Harris C,Russell-Eggitt I,Shawkat F,Neville BG,Aclimandos W,Taylor DS

    更新日期：1999-12-01 00:00:00

  • Ocular adnexal monoclonal lymphoid tumors with a favorable prognosis.

    abstract：:Fourteen patients with well- or intermediately differentiated monoclonal B-lymphocytic tumors of the conjunctiva or orbit had a favorable prognosis with follow-ups of 4 to 9 years (mean and median, 7.5 years). The lesions were, for the most part, diffuse proliferations of small lymphocytes, either with round or minima...

    journal_title：Ophthalmology

    pub_type： 杂志文章

    doi：10.1016/s0161-6420(86)33532-2

    authors： Jakobiec FA,Iwamoto T,Patell M,Knowles DM 2nd

    更新日期：1986-12-01 00:00:00

  • Management of advanced retinopathy of prematurity in the older patient.

    abstract：:The authors studied 11 eyes of 10 patients who complained of a recent decrease in vision and whose eyes had the clinical appearance of stage 5 retinopathy of prematurity (ROP) as diagnosed by the presence of a dense, opaque retrolenticular membrane. Patients ranged in age from 4 to 33 years, and birth weights ranged f...

    journal_title：Ophthalmology

    pub_type： 杂志文章

    doi：10.1016/s0161-6420(91)32170-5

    authors： Bradford JD,Trese MT

    更新日期：1991-07-01 00:00:00

  • Effects of laser in situ keratomileusis on tear production, clearance, and the ocular surface.

    abstract：PURPOSE:To evaluate components of the integrated ocular surface/lacrimal gland unit in a series of patients before and after undergoing bilateral laser in situ keratomileusis (LASIK). DESIGN:Prospective, noncomparative case series. PARTICIPANTS:Forty-eight eyes of 14 men and 34 women (age range, 26-54; mean, 39.2 yea...

    journal_title：Ophthalmology

    pub_type： 杂志文章

    doi：10.1016/s0161-6420(01)00623-6

    authors： Battat L,Macri A,Dursun D,Pflugfelder SC

    更新日期：2001-07-01 00:00:00

  • Successful Optimization of Adalimumab Therapy in Refractory Uveitis Due to Behçet's Disease.

    abstract：PURPOSE:To assess efficacy, safety, and cost-effectiveness of adalimumab (ADA) therapy optimization in a large series of patients with uveitis due to Behçet disease (BD) who achieved remission after the use of this biologic agent. DESIGN:Open-label multicenter study of ADA-treated patients with BD uveitis refractory t...

    journal_title：Ophthalmology

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.ophtha.2018.02.020

    authors： Martín-Varillas JL,Calvo-Río V,Beltrán E,Sánchez-Bursón J,Mesquida M,Adán A,Hernandez MV,Garfella MH,Pascual EV,Martínez-Costa L,Sellas-Fernández A,Cordero-Coma M,Díaz-Llopis M,Gallego R,Salom D,Ortego N,García-Serrano JL

    更新日期：2018-09-01 00:00:00