Abstract:
PURPOSE:To evaluate components of the integrated ocular surface/lacrimal gland unit in a series of patients before and after undergoing bilateral laser in situ keratomileusis (LASIK). DESIGN:Prospective, noncomparative case series. PARTICIPANTS:Forty-eight eyes of 14 men and 34 women (age range, 26-54; mean, 39.2 years) who underwent bilateral LASIK for myopia or myopic astigmatism. METHODS:LASIK was performed using a VISX Star Excimer Laser (Santa Clara, CA). Patients completed a questionnaire containing 11 questions that evaluated the character and severity of ocular irritation symptoms. Snellen visual acuity, tear fluorescein clearance, corneal fluorescein staining, aqueous tear production by the Schirmer 1 test, and corneal and conjunctival sensitivity were measured in each eye. Corneal surface regularity (SRI) was evaluated with the Tomey TMS-1 (Tomey, Cambridge, MA) topography instrument. Each randomly chosen eye was evaluated 1 to 2 days (T0) before LASIK and 7 days (T1), 1 (T2), 2 (T3), 6 (T4), 12 (T5), and 16 (T6) months postoperatively. A Wilcoxon test, two-tailed paired t test, Friedman test, or analysis of variance were used for statistical comparisons. MAIN OUTCOME MEASURES:Components of the integrated ocular surface/lacrimal gland unit. RESULTS:Both corneal and conjunctival sensitivity were noted to be significantly decreased from preoperative levels at 1week, 1 month, 12 months, and 16 months postoperatively (P < 0.0002 at each time point). Symptom severity scores were significantly increased at 1 week, 12 months, and 16 months postoperatively (P < 0.007 at all time points). The mean Schirmer 1 test scores were 24 +/- 14 mm preoperatively, and they decreased to 18 +/- 14 mm by 1 month postoperatively (P < 0.001). Tear fluorescein clearance showed a linear increase postoperatively and was significantly greater than baseline (P < 0.001) at each time point. There was a significant increase in punctate corneal fluorescein staining at 1 week postoperatively (P < 0.0001), but staining returned to baseline by 12 months. There was a statistically significant increase in SRI 1 week postoperatively (P < 0.007) with return to baseline levels by 6 months. CONCLUSIONS:Sensory denervation of the ocular surface after bilateral LASIK disrupts ocular surface tear dynamics and causes irritation symptoms. Patients undergoing LASIK should be informed of these risks.
journal_name
Ophthalmologyjournal_title
Ophthalmologyauthors
Battat L,Macri A,Dursun D,Pflugfelder SCdoi
10.1016/s0161-6420(01)00623-6subject
Has Abstractpub_date
2001-07-01 00:00:00pages
1230-5issue
7eissn
0161-6420issn
1549-4713pii
S0161-6420(01)00623-6journal_volume
108pub_type
杂志文章相关文献
OPHTHALMOLOGY文献大全abstract:PURPOSE:The aim of this study was to describe a new technique for transscleral suturing of posterior chamber intraocular lenses (PCIOLs) without intraocular knots. DESIGN:Retrospective noncomparative case series. PARTICIPANTS:Twenty-four eyes underwent implantation of PCIOLs with this new technique. METHODS:Suture f...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/S0161-6420(03)00467-6
更新日期:2003-07-01 00:00:00
abstract:PURPOSE:The authors evaluated the relative nerve fiber layer height changes in glaucomatous eyes after reduction of intraocular pressure (IOP) after trabeculectomy using image analysis techniques. METHODS:Optic disc topography and relative nerve fiber layer height of 12 eyes of 12 patients with chronic open-angle glau...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(93)31497-1
更新日期:1993-08-01 00:00:00
abstract:OBJECTIVE:To investigate associations between dietary intake, including modest supplement intake, of antioxidant vitamins and zinc at baseline and the 5-year incidence of early age-related maculopathy (ARM). DESIGN:Population-based cohort study. PARTICIPANTS:From 1992 through 1994, 3654 persons aged 49 years or more ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(02)01263-0
更新日期:2002-12-01 00:00:00
abstract:PURPOSE:To evaluate the efficacy and toxicity of subconjunctival carboplatin for intraocular retinoblastoma. DESIGN:A phase I/II clinical trial (noncomparative case series). PARTICIPANTS:Eleven children with bilateral retinoblastoma who had 13 eyes containing active tumor. METHODS:Subconjunctival carboplatin (1.4-2....
journal_title:Ophthalmology
pub_type: 临床试验,杂志文章
doi:10.1016/S0161-6420(99)90406-2
更新日期:1999-10-01 00:00:00
abstract:PURPOSE:To investigate the long-term outcome of keratolimbal allograft (KLAL) for the treatment of severe ocular surface disorders. DESIGN:Retrospective, noncomparative case series. PARTICIPANTS:Twenty patients (23 eyes) with severe ocular surface disorders. INTERVENTION:Thirty-three KLAL procedures were performed. ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(02)01081-3
更新日期:2002-07-01 00:00:00
abstract::Ten patients, all younger than 50 years of age, had a temporal cilioretinal artery occlusion associated with a nonischemic central retinal vein occlusion. On fluorescein angiography, the cilioretinal artery eventually filled in all but one eye. The cilioretinal artery showed pulsations on fluorescein angiography in fi...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(91)32245-0
更新日期:1991-05-01 00:00:00
abstract:OBJECTIVE:The authors measured functional status after bilateral implantation of a multifocal versus a monofocal intraocular lens (IOL). METHODS:A retrospective, case-control study was done on 100 subjects implanted bilaterally with a silicone-optic foldable zonal progressive IOL under United States Food and Drug Admi...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(97)30265-6
更新日期:1997-04-01 00:00:00
abstract:PURPOSE:Although the impact of vision-related quality of life (VRQoL) is assessed optimally using binocular visual acuity (VA), uniocular VA remains the preferred measurement method in clinic-based and epidemiologic studies. We compared the impact of distance presenting binocular VA and uniocular VA in the better-seein...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2020.01.056
更新日期:2020-09-01 00:00:00
abstract:PURPOSE:To evaluate the clinical features, treatment, and prognosis in patients with metastatic retinoblastoma. DESIGN:Retrospective interventional case series. PARTICIPANTS:Eighteen consecutive patients with metastatic retinoblastoma who were diagnosed and managed at the Oncology Service of Ankara University, Turkey...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2006.03.039
更新日期:2006-09-01 00:00:00
abstract::A review was undertaken of nine eyes of nine patients who suffered tightly bound dense premacular hemorrhage as a complication of proliferative diabetic retinopathy. Patients who did not receive vitrectomy within four weeks of the onset of the hemorrhage all progressed to late macular traction and visual acuity no bet...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(85)34014-9
更新日期:1985-04-01 00:00:00
abstract:PURPOSE:To describe variations in retinal nerve fiber layer (RNFL) thickness based on spectral-domain (SD) OCT in a multiethnic Asian population. DESIGN:Population-based, cross-sectional study. PARTICIPANTS:Ethnic Chinese, Malay, and Indian adults older than 48 years without glaucoma who were recruited from the Singa...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2018.11.031
更新日期:2019-05-01 00:00:00
abstract:PURPOSE:To examine the outcomes of vitreoretinal surgery for retinal disorders at Tilganga Eye Centre in Kathmandu, Nepal. DESIGN:Retrospective noncomparative case series. PARTICIPANTS:Records of 255 patients undergoing vitreoretinal surgery from December 2000 to January 2003 were reviewed. METHODS:Demographics, dia...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2004.08.018
更新日期:2005-02-01 00:00:00
abstract:PURPOSE:To evaluate bone spicule pigmentation, a fundus feature in retinitis pigmentosa (RP) formed by migration of pigment-containing cells to perivascular sites in the inner retina. METHODS:The authors performed light and electron microscopy, including immunocytochemistry, on the retinas from ten patients with RP an...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(95)30953-0
更新日期:1995-05-01 00:00:00
abstract:OBJECTIVE:To evaluate the safety and tolerability of a single subconjunctival (SCJ) or intravitreal (IVT) injection of an ophthalmic sirolimus formulation in eyes with diabetic macular edema (DME). DESIGN:Randomized, open-label, dose-escalating phase I study. PARTICIPANTS:Fifty eyes among 50 patients with DME, retina...
journal_title:Ophthalmology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ophtha.2011.07.034
更新日期:2012-01-01 00:00:00
abstract::The successful management of suppurative microbial keratitis requires five steps: (1) make the clinical diagnosis, (2) perform the proper laboratory procedures, (3) initiate antimicrobial therapy, (4) modify the initial therapy, and (5) terminate therapy. The most helpful guidelines to decision-making in these steps a...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(81)34943-4
更新日期:1981-08-01 00:00:00
abstract:PURPOSE:To determine the frequency of exposure to Helicobacter pylori infection in glaucoma patients. DESIGN:Prospective case-control study. PARTICIPANTS:Ninety-seven consecutive patients attending a glaucoma clinic. These included 38 patients with primary open-angle glaucoma (POAG), 19 with normal pressure glaucoma ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/S0161-6420(03)00093-9
更新日期:2003-05-01 00:00:00
abstract:PURPOSE:To quantify factors affecting test-retest variability of threshold measurements over a series of 3 serial visual fields (VF). DESIGN:Prospective comparative observational study. PARTICIPANTS:Forty-one normals, 10 suspects and 35 stable glaucoma patients. METHODS:All subjects performed 3 standard and 3 short-...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/S0161-6420(03)00541-4
更新日期:2003-10-01 00:00:00
abstract::Iris (eye) color was examined for its effect on eye disease in a population-based study of diabetic retinopathy in Wisconsin. Eye color was determined by comparing the iris in a red reflex photograph with standard photographs. In younger-onset diabetic persons (N = 996), macular edema was more prevalent in persons wit...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(87)80004-0
更新日期:1987-10-01 00:00:00
abstract::A retrospective clinicopathologic review of 105 cases of sympathetic ophthalmia showed histologic features of prognostic significance and evaluated the role of therapy. Classic descriptions omit retinal changes, but 58.0% of our cases had retinal detachment and 42.2% showed intraretinal inflammation. The optic nerve a...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(80)35270-6
更新日期:1980-02-01 00:00:00
abstract:PURPOSE:To investigate the anatomic relation between the optic nerve and the adjacent intracranial internal carotid artery (ICA) in patients with unexplained optic neuropathy. METHODS:Coronal magnetic resonance images (MRIs) of 20 patients with unexplained optic neuropathy and 20 age-matched controls were evaluated wi...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(96)30664-7
更新日期:1996-03-01 00:00:00
abstract:OBJECTIVE:To describe characteristics of participants in the Complications of Age-Related Macular Degeneration Prevention Trial (CAPT) at baseline and to investigate associations among visual function, fundus features, and vision-related quality of life. DESIGN:Cross-sectional study. PARTICIPANTS:The 1052 participant...
journal_title:Ophthalmology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1016/j.ophtha.2003.10.031
更新日期:2004-07-01 00:00:00
abstract::A clinicopathologic study of multiple extramacular drusen (MED) was performed on 784 eyes of 412 consecutive autopsies and on 100 eyes of 50 consecutive patients with MED. The clinical and histopathologic characteristics of MED and its correlation with reticular degeneration of the pigment epithelium (RDPE) and with m...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(86)33615-7
更新日期:1986-08-01 00:00:00
abstract:BACKGROUND:Sterile corneal ulceration is a rare complication of rheumatoid arthritis and may lead to corneal perforation. Surgical management for visual restoration frequently is unsuccessful. The authors analyze the factors that may determine the failure of corneal surgery in perforations associated with rheumatoid ar...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(95)30867-6
更新日期:1995-09-01 00:00:00
abstract:PURPOSE:To evaluate the use of a peripheral stromal support to facilitate and improve the outcomes of Descemet's membrane endothelial keratoplasty (DMEK). DESIGN:Prospective case series. PARTICIPANTS:Ten patients with Fuchs' endothelial dystrophy. INTERVENTION:Pneumatic dissection was used to detach the central part...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2010.03.038
更新日期:2010-12-01 00:00:00
abstract:BACKGROUND/PURPOSE:To assess the potential of a new diagnostic technique called optical coherence tomography for imaging macular disease. Optical coherence tomography is a novel noninvasive, noncontact imaging modality which produces high depth resolution (10 microns) cross-sectional tomographs of ocular tissue. It is ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(95)31032-9
更新日期:1995-02-01 00:00:00
abstract::The authors used the Humphrey Retinal Analyzer to study the effect of acute changes in intraocular pressure (IOP) on the topography of the optic nerve head in normotensive and hypertensive eyes of cynomolgus monkeys. Chronically elevated IOP was produced monocularly in monkeys by argon laser angle treatment. In 8 hype...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(91)32345-5
更新日期:1991-01-01 00:00:00
abstract::In a long-term study of 252 eyes that had initial glaucoma filtration surgery, there was an overall success rate of 85%. Rigid criteria for success included an intraocular pressure equal to or less than 19 mmHg, no further visual field loss or disc damage, and no glaucomatous etiology for a decrease in visual acuity. ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(86)33771-0
更新日期:1986-01-01 00:00:00
abstract:PURPOSE:To report the long-term outcomes of patients with iridocorneal endothelial (ICE) syndrome who required surgery for glaucoma. DESIGN:Retrospective, noncomparative case series. PARTICIPANTS:Twenty-six patients with ICE syndrome who underwent surgery for glaucoma at one institution between January 1987 and Janua...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(01)00725-4
更新日期:2001-10-01 00:00:00
abstract:OBJECTIVE:To evaluate the incidence and extent of visual recovery in patients with giant cell arteritis (GCA) treated with high doses of systemic corticosteroids. DESIGN:Multicenter prospective case series. PARTICIPANTS:Thirty-four consecutive patients with biopsy-proven GCA and visual loss seen at either Wills Eye H...
journal_title:Ophthalmology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ophtha.2005.01.036
更新日期:2005-06-01 00:00:00
abstract:OBJECTIVE:To evaluate risk factors for astigmatism in a population-based sample of preschool children. DESIGN:Population-based cross-sectional study. PARTICIPANTS:Population-based samples of 9970 children ages 6 to 72 months from Los Angeles County, California, and Baltimore, Maryland. METHODS:A cross-sectional stud...
journal_title:Ophthalmology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ophtha.2011.06.031
更新日期:2011-10-01 00:00:00