Abstract：
:The authors examined the relationship of change in tumor height after proton beam irradiation with the risk of metastasis in 700 patients treated for uveal melanoma before July 1, 1986. Rates of change in tumor height were computed for each patient using follow-up ultrasonographic measures during the first 2 years after treatment. Risk of metastasis was evaluated separately in the first 2 years after treatment when tumor decline was assessed (concurrent metastasis), and 2 years or later after treatment (subsequent metastasis). Using Cox proportional hazards models to adjust for other known risk factors, tumors regressing rapidly were significantly more likely to metastasize concurrently with their regression (P less than 0.05). The opposite was found for subsequent metastasis: tumors with a slow annual decline were more likely to metastasize after 2 years after treatment (P less than 0.05). Substantial changes also were noted in the ability of previously described prognostic factors (largest tumor diameter, tumor height, ciliary body involvement, and patient's age) to predict early and late metastasis. Characteristics placing individuals at high risk of metastasis may change markedly with time after treatment.
journal_name
Ophthalmologyjournal_title
Ophthalmologyauthors
Glynn RJ,Seddon JM,Gragoudas ES,Egan KM,Hart LJdoi
10.1016/s0161-6420(89)32685-6subject
Has Abstractpub_date
1989-10-01 00:00:00pages
1566-73issue
10eissn
0161-6420issn
1549-4713pii
S0161-6420(89)32685-6journal_volume
96pub_type
杂志文章相关文献
OPHTHALMOLOGY文献大全abstract：OBJECTIVE:To report the outcomes of ipsilateral rotational autokeratoplasty (RAK) for nonprogressive paracentral corneal opacities in children <16 years of age. DESIGN:Retrospective, consecutive, interventional case series. PARTICIPANTS:Thirty-three eyes of 33 children aged <16 years undergoing RAK for nonprogressive...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2012.06.045
更新日期：2012-12-01 00:00:00
abstract：OBJECTIVE:To determine the safety and efficacy of subconjunctival triamcinolone (Kenalog) in treating nonnecrotizing anterior scleritis. DESIGN:The authors conducted a retrospective review of all patients treated with depot subconjunctival corticosteroid injection for scleritis from January 1988 to May 1993. Response ...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(95)30963-3
更新日期：1995-05-01 00:00:00
abstract：PURPOSE:To apply lessons learned in the treatment of systemic hypertension to the problem of nonadherence in glaucoma medical therapy. CLINICAL RELEVANCE:Although physicians recognize that nonadherence with glaucoma medication is a problem, most lack the skill set to identify nonadherent patients, to identify the caus...
journal_title：Ophthalmology
pub_type： 杂志文章,实务指引,评审
doi：10.1016/j.ophtha.2009.06.022
更新日期：2009-11-01 00:00:00
abstract：OBJECTIVE:To compare pathologic changes in photoreceptors in eyes with resolved central serous chorioretinopathy (CSC) seen on high-resolution images obtained by adaptive optics scanning laser ophthalmoscopy (AO SLO) with visual acuity (VA) and findings on spectral-domain optical coherence tomography (SD OCT). DESIGN:...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2010.01.042
更新日期：2010-09-01 00:00:00
abstract：OBJECTIVE:To investigate the risk factors and control mechanisms used to control the outbreak of diffuse lamellar keratitis (DLK) associated with laser in situ keratomileusis (LASIK) and examine the relationship between DLK and endotoxins released from sterilizer biofilm reservoirs. DESIGN:Clinic-based cohort and labo...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(00)00246-3
更新日期：2000-07-01 00:00:00
abstract：PURPOSE:The authors determine if specific features of the clinical presentation of acute postoperative endophthalmitis correlated with the microbiologic culture results. METHODS:A total of 420 patients who had clinical evidence of endophthalmitis within 6 weeks after cataract surgery or secondary intraocular lens impl...
journal_title：Ophthalmology
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1016/s0161-6420(97)30326-1
更新日期：1997-02-01 00:00:00
abstract：PURPOSE:To assess whether sequential or simultaneous ptosis repair yields a better postoperative outcome in patients with documented preoperative Hering's dependency. DESIGN:Retrospective, case-control study. PARTICIPANTS AND CONTROLS:Of the 216 patients who underwent bilateral ptosis surgery, 109 patients with docum...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2011.07.008
更新日期：2012-02-01 00:00:00
abstract：PURPOSE:To investigate if previous intravitreal therapy is a predictor of posterior capsule rupture (PCR) during cataract surgery. DESIGN:Multicenter, national electronic medical record (EMR) database study with univariate and multivariate regression modeling. PARTICIPANTS:A total of 65 836 eyes of 44 635 patients un...
journal_title：Ophthalmology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.ophtha.2016.02.014
更新日期：2016-06-01 00:00:00
abstract：OBJECTIVES:To determine the proportion of all Myocilin coding mutations responsible for advanced primary open-angle glaucoma (POAG) in early-age-at-onset individuals and to investigate the prevalence of exon 3 Myocilin mutations in advanced POAG at any age at onset in a large Australasian cohort. DESIGN:Cross-sectiona...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2012.11.029
更新日期：2013-06-01 00:00:00
abstract：PURPOSE:To identify effective methods to increase the number of cataract surgeries in a rural setting in Pucheng County of Shaanxi Province, northwestern China. DESIGN:Community-based randomized interventional study. PARTICIPANTS:Four hundred thirty-two patients 50 years of age or older with operable cataract who had...
journal_title：Ophthalmology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.ophtha.2012.07.087
更新日期：2013-02-01 00:00:00
abstract：OBJECTIVE:To obtain prevalence estimates of age-related macular degeneration (AMD; late, geographic atrophy, neovascular) by age and gender amongst populations of European ancestry taking into account study design and time trends. DESIGN:Systematic review of population-based studies published by September 2010 with qu...
journal_title：Ophthalmology
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.ophtha.2011.09.027
更新日期：2012-03-01 00:00:00
abstract：PURPOSE:To investigate the associations of genetic variants in the high-density lipoprotein (HDL) metabolism pathway with neovascular age-related macular degeneration (AMD) and polypoidal choroidal vasculopathy (PCV). DESIGN:Cross-sectional, case-control association study. PARTICIPANTS:A Chinese case-control group of...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2013.10.042
更新日期：2014-04-01 00:00:00
abstract：PURPOSE:Geographic atrophy (GA) may cause significant compromise of visual function, even when there still is good visual acuity (VA), because of parafoveal scotomas and foveal function abnormalities antedating visible atrophy. This study evaluates the visual function abnormalities at baseline and the 2-year worsening ...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(97)30079-7
更新日期：1997-10-01 00:00:00
abstract：:The clinical features of 290 patients with scleral inflammation were reviewed to determine whether a classification based on the anatomical site and clinical appearance of the disease at presentation reflected its natural history. The authors' results confirm that the majority of patients remain in the same clinical c...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(91)32269-3
更新日期：1991-04-01 00:00:00
abstract：PURPOSE:To define and characterize a novel pre-Descemet's layer in the human cornea. DESIGN:Clinical and experimental study. PARTICIPANTS:We included 31 human donor sclerocorneal discs, including 6 controls (mean age, 77.7 years). METHODS:Air was injected into the stroma of donor whole globes (n = 4) and sclerocorne...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2013.01.018
更新日期：2013-09-01 00:00:00
abstract：:One hundred twelve patients with vitiligo were examined for ocular abnormalities. Discrete areas of depigmentation with associated pigment hyperplasia clinically appearing to involve the choroid and retinal pigment epithelium were observed in 44 patients, and active uveitis was seen in nine patients. The changes obser...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(79)35413-6
更新日期：1979-06-01 00:00:00
abstract：OBJECTIVE:To describe a simple and noninvasive technique to manage conjunctival prolapse and to report its efficacy. DESIGN:Noncomparative, retrospective case series. PARTICIPANTS:Ten consecutive patients encountered over a span of 13 years developed postoperative conjunctival prolapse as a complication from various ...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/S0161-6420(99)00520-5
更新日期：1999-05-01 00:00:00
abstract：OBJECTIVE:The purpose of the study was to evaluate the results of retreatment for low myopia after primary photorefractive keratectomy (PRK). DESIGN:A prospective study. PARTICIPANTS:A total of 48 eyes of 37 patients from 566 eyes of 331 patients originally treated for myopia of up to -6 diopters (D) were studied. I...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/S0161-6420(98)97018-X
更新日期：1998-07-01 00:00:00
abstract：:Recent studies have suggested that diffuse field loss and localized visual field loss in glaucomatous patients may have different pathophysiologic mechanisms. Testing that hypothesis requires that some patients present with purely localized field loss and other patients with purely diffuse loss. This article describes...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(91)32092-x
更新日期：1991-10-01 00:00:00
abstract：OBJECTIVE:To evaluate the ocular effects of blunt trauma due to injury from a paintball pellet. DESIGN:Noncomparative case series. PARTICIPANTS:Thirteen patients who suffered ocular injury from paintballs are described. The patients presented to six different civilian and military emergency departments in tertiary ca...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/S0161-6420(99)90112-4
更新日期：1999-03-01 00:00:00
abstract：:The clinical efficacy was investigated of fibronectin eyedrops on the nonhealing corneal epithelial defect after herpetic keratitis. Fibronectin eyedrops were prepared from the patient's own blood plasma by an affinity chromatography using gelatin-coupled agarose gel and by gel filtration technique. Twenty eyes with m...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(85)34050-2
更新日期：1985-02-01 00:00:00
abstract：BACKGROUND:Several forms of retinal pigment epithelial detachment have been reported. The authors used indocyanine green (ICG) videoangiography, which is useful to study the choroidal vasculature and Bruch membrane, to study pigment epithelial detachments. METHODS:Ninety-eight pigment epithelial detachments in 75 eyes...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(95)30990-6
更新日期：1995-04-01 00:00:00
abstract：OBJECTIVE:To study the prevalence of undercorrected refractive error and associated sociodemographic factors among Singaporean Chinese adults. DESIGN:Cross-sectional, population-based survey. PARTICIPANTS:Singaporean Chinese adults aged 40 to 79 years (n = 1152). METHODS:The Singapore electoral register of Tanjong P...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2004.05.032
更新日期：2004-12-01 00:00:00
abstract：PURPOSE:The aim of this study was to describe a new technique for transscleral suturing of posterior chamber intraocular lenses (PCIOLs) without intraocular knots. DESIGN:Retrospective noncomparative case series. PARTICIPANTS:Twenty-four eyes underwent implantation of PCIOLs with this new technique. METHODS:Suture f...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/S0161-6420(03)00467-6
更新日期：2003-07-01 00:00:00
abstract：:The Academy finds in its preliminary review of keratomileusis in situ and ALK reason for more rigorous evaluation of the safety, refractive accuracy, stability, and optical quality of these microkeratome-based procedures. To understand these issues more thoroughly, the ophthalmic community needs continued access to pe...
journal_title：Ophthalmology
pub_type： 杂志文章,评审
doi：
更新日期：1996-05-01 00:00:00
abstract：OBJECTIVE:To develop a clinical classification system for age-related macular degeneration (AMD). DESIGN:Evidence-based investigation, using a modified Delphi process. PARTICIPANTS:Twenty-six AMD experts, 1 neuro-ophthalmologist, 2 committee chairmen, and 1 methodologist. METHODS:Each committee member completed an o...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2012.10.036
更新日期：2013-04-01 00:00:00
abstract：:Thirteen cases of rhegmatogenous retinal detachment repaired by pneumatic retinopexy were reviewed retrospectively. All patients were followed for a minimum of 6 months after surgery. At the end of follow-up, retinal detachment repair by pneumatic retinopexy succeeded in nine cases (70%) and failed in four (30%). With...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(87)33445-1
更新日期：1987-04-01 00:00:00
abstract：PURPOSE:To report a patient with Neisseria meningitidis endophthalmitis without associated meningitis with full visual recovery, with early detection of the microorganism using polymerase chain reaction (PCR) analysis. DESIGN:Retrospective, observational case report. PARTICIPANTS:One patient with endogenous endophtha...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/S0161-6420(03)00834-0
更新日期：2003-11-01 00:00:00
abstract：:Intraocular lenses have been regulated by the Food and Drug Administration since February 9, 1978. Data reported through August 9, 1979 reveal 177,503 lenses of four different classes have been implanted. The anterior chamber intraocular lens appears to have a higher incidence of certain postoperative complications co...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(80)35239-1
更新日期：1980-04-01 00:00:00
abstract：PURPOSE:To assess the prevalence of subretinal drusenoid deposits (SDD) in older adults with healthy maculas and early and intermediate age-related macular degeneration (AMD) using multimodal imaging. DESIGN:Cross-sectional study. PARTICIPANTS:A total of 651 subjects aged ≥60 years enrolled in the Alabama Study of Ea...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2015.12.034
更新日期：2016-05-01 00:00:00
