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Clinical classification of age-related macular degeneration.

Abstract：

OBJECTIVE:To develop a clinical classification system for age-related macular degeneration (AMD). DESIGN:Evidence-based investigation, using a modified Delphi process. PARTICIPANTS:Twenty-six AMD experts, 1 neuro-ophthalmologist, 2 committee chairmen, and 1 methodologist. METHODS:Each committee member completed an online assessment of statements summarizing current AMD classification criteria, indicating agreement or disagreement with each statement on a 9-step scale. The group met, reviewed the survey results, discussed the important components of a clinical classification system, and defined new data analyses needed to refine a classification system. After the meeting, additional data analyses from large studies were provided to the committee to provide risk estimates related to the presence of various AMD lesions. MAIN OUTCOME MEASURES:Delphi review of the 9-item set of statements resulting from the meeting. RESULTS:Consensus was achieved in generating a basic clinical classification system based on fundus lesions assessed within 2 disc diameters of the fovea in persons older than 55 years. The committee agreed that a single term, age-related macular degeneration, should be used for the disease. Persons with no visible drusen or pigmentary abnormalities should be considered to have no signs of AMD. Persons with small drusen (<63 μm), also termed drupelets, should be considered to have normal aging changes with no clinically relevant increased risk of late AMD developing. Persons with medium drusen (≥ 63-<125 μm), but without pigmentary abnormalities thought to be related to AMD, should be considered to have early AMD. Persons with large drusen or with pigmentary abnormalities associated with at least medium drusen should be considered to have intermediate AMD. Persons with lesions associated with neovascular AMD or geographic atrophy should be considered to have late AMD. Five-year risks of progressing to late AMD are estimated to increase approximately 100 fold, ranging from a 0.5% 5-year risk for normal aging changes to a 50% risk for the highest intermediate AMD risk group. CONCLUSIONS:The proposed basic clinical classification scale seems to be of value in predicting the risk of late AMD. Incorporating consistent nomenclature into the practice patterns of all eye care providers may improve communication and patient care.

journal_name

Ophthalmology

journal_title

Ophthalmology

authors

Ferris FL 3rd,Wilkinson CP,Bird A,Chakravarthy U,Chew E,Csaky K,Sadda SR,Beckman Initiative for Macular Research Classification Committee.

doi

10.1016/j.ophtha.2012.10.036

subject

Has Abstract

pub_date

2013-04-01 00:00:00

pages

844-51

issue

eissn

0161-6420

issn

1549-4713

pii

S0161-6420(12)01055-X

journal_volume

120

pub_type

杂志文章

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Clinical classification of age-related macular degeneration.