Abstract:
OBJECTIVE:To obtain prevalence estimates of age-related macular degeneration (AMD; late, geographic atrophy, neovascular) by age and gender amongst populations of European ancestry taking into account study design and time trends. DESIGN:Systematic review of population-based studies published by September 2010 with quantitative estimates of geographic atrophy (GA), neovascular (NV), and late AMD prevalence. Studies were identified by a literature search of MEDLINE (from 1950), EMBASE (from 1980), and Web of Science (from 1980) databases. PARTICIPANTS:Data from 25 published studies (57 173 subjects: 455 with GA, 464 with NVAMD, and 1571 with late AMD). METHODS:Bayesian meta-regression of the log odds of AMD with age, gender, and year of study allowing for differences in study design characteristics, to estimate prevalences of AMD (late, GA, NVAMD) along with 95% credible intervals (CrI). MAIN OUTCOME MEASURES:Log odds and prevalence of AMD. RESULTS:There was considerable heterogeneity in prevalence rates between studies; for late AMD, 20% of the variability in prevalence rates was explained by differences in age and 50% by study characteristics. The prevalence of AMD increased exponentially with age (odds ratio [OR], 4.2 per decade; 95% CrI, 3.8-4.6), which did not differ by gender. There was some evidence to suggest higher risk of NVAMD in women compared with men (OR, 1.2; 95% CrI, 1.0-1.5). Compared with studies using fundus imaging and international classification systems, studies using fundus imaging with alternative classifications were more likely (OR, 2.7; 95% CrI, 1.1-2.8), and studies using alternative classifications without fundus imaging most likely to diagnose late AMD (OR, 2.9; 95% CrI, 1.3-7.8). There was no good evidence of trends in AMD prevalence over time. Estimated prevalence of late AMD is 1.4% (95% CrI, 1.0%-2.0%) at 70 years of age, rising to 5.6% (95% CrI, 3.9%-7.7%) at age 80 and 20% (95% CrI, 14%-27%) at age 90. CONCLUSIONS:Studies using recognized classifications systems with fundus photography reported the lowest prevalences of AMD taking account of age and gender, and were stable over time, with a potentially higher risk of NVAMD for women. These prevalence estimates can be used to guide health service provision in populations of European ancestry.
journal_name
Ophthalmologyjournal_title
Ophthalmologyauthors
Rudnicka AR,Jarrar Z,Wormald R,Cook DG,Fletcher A,Owen CGdoi
10.1016/j.ophtha.2011.09.027subject
Has Abstractpub_date
2012-03-01 00:00:00pages
571-80issue
3eissn
0161-6420issn
1549-4713pii
S0161-6420(11)00883-9journal_volume
119pub_type
杂志文章,meta分析,评审相关文献
OPHTHALMOLOGY文献大全abstract:PURPOSE:To examine the decrease in the intraocular concentration of intravitreally injected triamcinolone acetonide over an 8-month period in a rabbit model. DESIGN:Experimental study. PARTICIPANTS:The study included 18 white New Zealand rabbits. METHODS:The animals received an intravitreal injection of 6 mg triamci...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2008.01.019
更新日期:2008-08-01 00:00:00
abstract::Hidradenoma papilliferum is derived from apocrine sweat glands and was originally described as a tumor located in the anogenital area. The authors recently examined a 78-year-old man with a hidradenoma papilliferum at the margin of the upper eyelid. While the tumor was located in the dermis, serial sections showed a c...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(90)32373-4
更新日期:1990-12-01 00:00:00
abstract::Immunologic differences exist between the peripheral and central cornea. The peripheral cornea is closer to the conjunctiva, which has all of the immunologic machinery necessary to generate an immune response. The peripheral cornea has more Langerhans' cells and IgM than the central cornea. The peripheral cornea also ...
journal_title:Ophthalmology
pub_type: 杂志文章,评审
doi:10.1016/s0161-6420(88)33164-7
更新日期:1988-04-01 00:00:00
abstract:BACKGROUND:The Blue Mountains Eye Study is a population-based study of vision and the causes of visual impairment and blindness in a well-defined urban, Australian population 49 years of age and older. METHODS:The logarithm of the minimum angle of resolution (logMAR) visual acuity was measured before and after refract...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(96)30684-2
更新日期:1996-03-01 00:00:00
abstract::A 29-year-old woman presented with marked variations in refraction. A few minutes of physical exertion or reading at a close distance induced up to 2D of myopia and 2D of myopic astigmatism, which regressed upon resting with closed eyes. Cycloplegic agents did not affect the refractive changes, which were shown to be ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(84)34314-7
更新日期:1984-02-01 00:00:00
abstract:PURPOSE:To describe the association of demographic, behavioral, medical, and nonretinal ocular factors with the incidence of neovascular age-related macular degeneration (AMD) and central geographic atrophy (CGA) in the Age-Related Eye Disease Study (AREDS), a randomized trial of antioxidants and zinc supplementation p...
journal_title:Ophthalmology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1016/j.ophtha.2004.10.047
更新日期:2005-04-01 00:00:00
abstract:PURPOSE:Accommodation of the eye can adversely affect optical tomography of the retina using a confocal scanning laser ophthalmoscope (cSLO). This study measured the dynamic accommodative response of young adult eyes while acquiring static retinal images with a cSLO without cycloplegia and also examined whether a scann...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2006.08.047
更新日期:2007-06-01 00:00:00
abstract:PURPOSE:To expand understanding of presentation, diagnosis, and outcomes of hemorrhagic occlusive retinal vasculitis (HORV). DESIGN:Retrospective case series. PARTICIPANTS:Thirty-six eyes of 23 patients. METHODS:The American Society of Cataract and Refractive Surgery (ASCRS) and the American Society of Retina Specia...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2016.11.042
更新日期:2017-05-01 00:00:00
abstract:PURPOSE:To evaluate the intraocular pressure (IOP)-lowering efficacy and safety of 10- and 15-μg bimatoprost implant in subjects with open-angle glaucoma (OAG) and ocular hypertension (OHT) after initial and repeated administrations. DESIGN:Randomized, 20-month, multicenter, subject- and efficacy evaluator-masked, par...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2020.06.018
更新日期:2020-12-01 00:00:00
abstract::An immunoperoxidase technique was utilized to identify herpes simplex type I viral antigens in the retina, optic nerve and brain of an adult with herpetic retinitis and encephalitis. Viral antigens were demonstrated in all layers of retina, retinal pigment epithelium and to a lesser extent, in choroid. Oligodendroglia...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(85)34077-0
更新日期:1985-01-01 00:00:00
abstract:OBJECTIVE:To describe the initial experience and to evaluate the safety and feasibility of using the 25-gauge Transconjunctival Sutureless Vitrectomy System (TSV) for a variety of vitreoretinal procedures. DESIGN:Retrospective review of a consecutive interventional case series. PARTICIPANTS:Thirty-five eyes of 33 pat...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(02)01119-3
更新日期:2002-10-01 00:00:00
abstract:OBJECTIVE:To determine the histopathologic effects of transpupillary thermotherapy (TTT) on the normal human retina. DESIGN:Prospective, noncomparative small case series. PARTICIPANTS:Three patients with eyes scheduled for enucleation because of the presence of a malignant intraocular tumor. INTERVENTION:Application...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/S0161-6420(02)01561-0
更新日期:2003-02-01 00:00:00
abstract:OBJECTIVE:This study aimed to examine the characteristics of intraretinal changes associated with macular holes and epiretinal membranes by scanning retinal thickness analysis. STUDY DESIGN:The study design was a nonconsecutive case series. PATIENTS:Fifty-six eyes of patients who had either a suspected or clinically ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(98)91274-x
更新日期:1998-01-01 00:00:00
abstract:OBJECTIVE:To assess the safety and efficacy of the Artisan/Verisyse phakic intraocular lens (IOL) for the correction of high myopia. DESIGN:Prospective, open-label, noncomparative, multicenter clinical trial. PARTICIPANTS:A total of 684 adults with axial myopia from -4.5 diopters (D) to -22 D were enrolled: 662 in th...
journal_title:Ophthalmology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ophtha.2007.08.039
更新日期:2008-03-01 00:00:00
abstract:PURPOSE:To compare clinical outcomes using 20% sulfur hexafluoride (SF6) versus 100% air as a tamponade for graft attachment in Descemet membrane endothelial keratoplasty (DMEK). DESIGN:Retrospective, comparative, interventional case series. PARTICIPANTS:Pseudophakic patients with Fuchs' endothelial dystrophy or pseu...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2015.05.013
更新日期:2015-09-01 00:00:00
abstract:PURPOSE:To report treatment outcomes in malignant glaucoma. DESIGN:Retrospective case series. PARTICIPANTS:Twenty-eight eyes of 26 patients who were treated for malignant glaucoma between 1991 and 2009. METHODS:Malignant glaucoma was diagnosed based on the presence of a shallow or flat central and peripheral anterio...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2012.10.024
更新日期:2013-05-01 00:00:00
abstract:PURPOSE:To describe macular thickness measured by optical coherence tomography (OCT) in healthy eyes of adult Chinese persons. DESIGN:Population-based cross-sectional study. PARTICIPANTS:Chinese adults aged 30+ years who were residents of Handan, North China. METHODS:The Handan Eye Study is a population-based study ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2009.12.036
更新日期:2010-08-01 00:00:00
abstract:OBJECTIVE:To investigate associations between dietary intake, including modest supplement intake, of antioxidant vitamins and zinc at baseline and the 5-year incidence of early age-related maculopathy (ARM). DESIGN:Population-based cohort study. PARTICIPANTS:From 1992 through 1994, 3654 persons aged 49 years or more ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(02)01263-0
更新日期:2002-12-01 00:00:00
abstract:PURPOSE:To identify susceptibility genes associated with hereditary predisposition to uveal melanoma (UM) in patients with no detectable germline BAP1 alterations. DESIGN:Retrospective case series from academic referral centers. PARTICIPANTS:Cohort of 154 UM patients with high risk of hereditary cancer defined as pat...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2019.11.009
更新日期:2020-05-01 00:00:00
abstract:PURPOSE:To assess the long-term success rate and to determine factors that predict survival after 5-fluorouracil-augmented needling revision of poorly functioning trabeculectomy blebs. DESIGN:Prospective observational cohort study. PARTICIPANTS:Eighty-one consecutive patients undergoing bleb needling. METHODS:Surviv...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2007.10.023
更新日期:2008-07-01 00:00:00
abstract::In a comparative study, subjective refractions were carried out on 115 normal subjects and 118 patients with four instruments (Humphrey Vision Analyzer, Möller/CooperVision Visutron, Reichert SR-IV, Rodenstock/Coburn Phoromat). The accuracy of the prescriptions obtained, the visual acuity results and the measurement t...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(86)33586-3
更新日期:1986-09-01 00:00:00
abstract:PURPOSE:To quantify the vitreous traction created by pneumatic (20-, 23-, and 25-gauge) and electric cutters (20- and 25-gauge) during vitrectomy. DESIGN:Experimental study. PARTICIPANTS:This is a preclinical study, and no patients were involved. METHODS:Five separate cutters for each drive mechanism and gauge (20-,...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2009.11.004
更新日期:2010-07-01 00:00:00
abstract:PURPOSE:To determine the frequency of exposure to Helicobacter pylori infection in glaucoma patients. DESIGN:Prospective case-control study. PARTICIPANTS:Ninety-seven consecutive patients attending a glaucoma clinic. These included 38 patients with primary open-angle glaucoma (POAG), 19 with normal pressure glaucoma ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/S0161-6420(03)00093-9
更新日期:2003-05-01 00:00:00
abstract:OBJECTIVE:To determine the incidence and associations of glaucoma after pars plana vitrectomy (PPV) and silicone oil injection (SOI) for complicated retinal detachments and the response to treatment. DESIGN:Retrospective noncomparative case series. PARTICIPANTS:A total of 150 eyes of 150 patients who had completed a ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/S0161-6420(99)90017-9
更新日期:1999-01-01 00:00:00
abstract::Eighty-two survivors of acute lymphoblastic leukemia (ALL) had prospective eye evaluations to determine the ocular sequelae of the disease and its treatment. All patients had completed or nearly completed a 25- to 31-month protocol which included either 3.4 or 10.2 g of systemic prednisone/m2 per year and cranial irra...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(88)33198-2
更新日期:1988-02-01 00:00:00
abstract:OBJECTIVE:To compare baseline characteristics, treatment frequency, visual acuity (VA), and morphologic outcomes of eyes with >50% of the lesion composed of blood (B50 group) versus all other eyes (Other group) enrolled in the Comparison of Age-Related Macular Degeneration Treatments Trials (CATT). DESIGN:Prospective ...
journal_title:Ophthalmology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.ophtha.2014.08.020
更新日期:2015-02-01 00:00:00
abstract:OBJECTIVE:To evaluate the reproducibility of optical coherence tomograph (OCT) retinal nerve fiber layer (RNFL) measurements in normal and glaucomatous eyes by means of the commercially available OCT 2000 instrument (Humphrey Systems, Dublin, CA). DESIGN:Prospective instrument validation study. PARTICIPANTS:One eye e...
journal_title:Ophthalmology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0161-6420(00)00341-9
更新日期:2000-12-01 00:00:00
abstract:PURPOSE:To report the longitudinal change in axial length (AL) from the time of unilateral cataract surgery at age 1 to 7 months to age 5 years, and to compare AL growth of operated eyes with that of fellow unoperated eyes. DESIGN:Comparative case series. PARTICIPANTS:Infants enrolled in the Infant Aphakia Treatment ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2017.01.010
更新日期:2017-05-01 00:00:00
abstract::We encountered two clinically similar but genetically unrelated cases of a disorder characterized by an unusual white pupillary-iris-lens membrane with extension to a prominent Schwalbe's line, the membranes were vascularized and their appearance changed over time. In both cases the abnormality was unilateral. Anomalo...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(86)33659-5
更新日期:1986-06-01 00:00:00
abstract::The degree of retinal involvement of 20 patients (ages 3-21) with mucopolysaccharidosis (MPS) types I, II, and III was assessed using electroretinography (ERG) under standardized conditions. ERG evidence of retinal dysfunction ranged from none to severe in MPS I and II, and from moderate to severe in MPS III. The ERG ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(86)33537-1
更新日期:1986-12-01 00:00:00