Abstract：
:An immunoperoxidase technique was utilized to identify herpes simplex type I viral antigens in the retina, optic nerve and brain of an adult with herpetic retinitis and encephalitis. Viral antigens were demonstrated in all layers of retina, retinal pigment epithelium and to a lesser extent, in choroid. Oligodendroglia in the right optic nerve and neuronal and glial cells in the grey and white matter of the left frontal, inferior parietal and temporal lobes of the brain also expressed herpes simplex antigens. The sensitive immunoperoxidase method allowed detection of viral antigens in many cells without intranuclear inclusions or surrounding inflammation, and thereby added valuable information regarding the anatomic and cellular localization of herpetic infection. The clinicopathologic features that characterize herpes simplex retinitis in the adult are compared to cytomegalovirus retinopathy.
journal_name
Ophthalmologyjournal_title
Ophthalmologyauthors
Pepose JS,Kreiger AE,Tomiyasu U,Cancilla PA,Foos RYdoi
10.1016/s0161-6420(85)34077-0subject
Has Abstractpub_date
1985-01-01 00:00:00pages
160-6issue
1eissn
0161-6420issn
1549-4713pii
S0161-6420(85)34077-0journal_volume
92pub_type
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