Abstract：
PURPOSE:To determine the frequency of exposure to Helicobacter pylori infection in glaucoma patients. DESIGN:Prospective case-control study. PARTICIPANTS:Ninety-seven consecutive patients attending a glaucoma clinic. These included 38 patients with primary open-angle glaucoma (POAG), 19 with normal pressure glaucoma (NPG), 16 with pseudoexfoliation glaucoma (PXE), and 24 with ocular hypertension (OHT). Ninety-four age-matched participants without glaucoma served as a control population. METHODS:Serum was analyzed for the presence of H. pylori-specific immunoglobulin G antibodies by enzyme-linked immunosorbent assay. MAIN OUTCOME MEASURES:Serologic analysis for H. pylori. RESULTS:Seropositivity for H. pylori was higher in patients with glaucoma (26.0%) than in controls (20.2%), but this did not achieve statistical significance (P = 0.46). A total of 26.3% of POAG patients, 26.3% of NPG patients, 25.0% of PXE patients, and 25.0% of OHT patients were seropositive. CONCLUSIONS:This study suggests that exposure to H. pylori infection is not associated with open-angle glaucoma.
journal_name
Ophthalmologyjournal_title
Ophthalmologyauthors
Galloway PH,Warner SJ,Morshed MG,Mikelberg FSdoi
10.1016/S0161-6420(03)00093-9subject
Has Abstractpub_date
2003-05-01 00:00:00pages
922-5issue
5eissn
0161-6420issn
1549-4713pii
S0161-6420(03)00093-9journal_volume
110pub_type
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