当前位置： SCI文献检索 > OPHTHALMOLOGY期刊下所有文献 > Follow-up to Age 4 Years of Treatment of Type 1 Retinopathy of Prematurity Intravitreal Bevacizumab Injection versus Laser: Fluorescein Angiographic Findings.

Follow-up to Age 4 Years of Treatment of Type 1 Retinopathy of Prematurity Intravitreal Bevacizumab Injection versus Laser: Fluorescein Angiographic Findings.

Abstract：

PURPOSE:To compare structural outcome at age 4 years of eyes treated with intravitreal injection of bevacizumab with fellow eyes treated with conventional laser photoablation in type 1 retinopathy of prematurity (ROP). DESIGN:Single, randomized, controlled trial. PARTICIPANTS:All inborn babies with type 1 zone 1 ROP at the Neonatal Intensive Care Unit of the Catholic University, Rome, from September 1, 2009, to March 31, 2012. METHODS:In 21 infants (42 eyes), 1 eye was randomized to receive an intravitreal injection of 0.5 mg bevacizumab; the fellow eye underwent conventional laser photoablation. Digital retinal imaging and fluorescein angiography (FA) were performed at an average of 4 years after treatment in follow-up after these studies performed at treatment and 9 months. MAIN OUTCOME MEASURES:Fluorescein angiograms were examined by 2 experts to document retinal and choroidal findings. RESULTS:Among the 20 bevacizumab-treated eyes available at 4 years of age, all showed abnormalities at the periphery (avascular area, vessel leakage, shunts, abnormal vessel branching, and tangles) or the posterior pole (hyperfluorescent lesions, absence of foveal avascular zone). These lesions were not observed in the majority of the lasered eyes. Among the 19 laser-treated eyes, leakage was noted in 1 eye, shunts and tangles were noted in 3 eyes, and macular abnormalities were noted in 3 eyes. CONCLUSIONS:Fluorescein angiography has shown potentially serious and long-term ocular effects that are present more commonly after treatment with bevacizumab for acute-phase ROP than after laser.

journal_name

Ophthalmology

journal_title

Ophthalmology

authors

Lepore D,Quinn GE,Molle F,Orazi L,Baldascino A,Ji MH,Sammartino M,Sbaraglia F,Ricci D,Mercuri E

doi

10.1016/j.ophtha.2017.08.005

subject

Has Abstract

pub_date

2018-02-01 00:00:00

pages

218-226

issue

2

eissn

0161-6420

issn

1549-4713

pii

S0161-6420(17)31224-1

journal_volume

125

pub_type

杂志文章,随机对照试验

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