Abstract:
PURPOSE:To investigate the prevalence, features, associated factors, and reproducibility of segmentation errors in macular ganglion cell inner plexiform layer (GCIPL) thickness measurement as determined by optical coherence tomography (OCT). DESIGN:Cross-sectional study. PARTICIPANTS:Five hundred thirty-eight glaucomatous and healthy eyes from 290 subjects with OCT-measured macular GCIPL thickness were enrolled. Eyes with macular disorders, including epiretinal membrane, macular degeneration, macular hole, and myopic maculopathy, were excluded. METHODS:By inspecting 128 cross-sectional OCT B-scan images per eye, the presence (yes vs. no), layer (anterior vs. posterior border), location (quadrants), and area (diffuse vs. focal) of macular GCIPL segmentation error were investigated. The effects of age, refractive error, mean deviation of visual field test, circumpapillary retinal nerve fiber layer thickness obtained by OCT, and signal strength of OCT scan on the presence of macular GCIPL segmentation errors were evaluated. In eyes with segmentation errors, repeated OCT examinations were performed to investigate the reproducibility of the segmentation errors. MAIN OUTCOME MEASURES:The prevalence, features, associated factors, and reproducibility of macular GCIPL segmentation errors were assessed. RESULTS:Among the 538 eyes, 52 eyes (9.7%) showed segmentation errors in macular GCIPL thickness measurement. The most common features of segmentation errors were that they affected both the anterior and posterior borders, were located at the nasal quadrant (centered to the fovea), and were diffuse. In univariate analysis, the presence of segmentation error was associated significantly with younger age (P < 0.001), higher degree of myopia (P < 0.001), and lower signal strength of OCT scan (P = 0.038). In multivariate analysis, only higher degree of myopia was associated significantly with the presence of segmentation error (P < 0.001). In repeated examinations, segmentation errors were reproducible in 24 eyes (46.2%). In other cases, the features of segmentation errors changed or disappeared. CONCLUSIONS:Although the OCT segmentation algorithm accurately detected macular GCIPL thickness in most eyes without macular disorders, in some cases, segmentation errors were found, especially in myopic eyes. In repeated examinations, approximately half of the errors were nonreproducible. These findings should be considered when assessing macular GCIPL thickness using OCT.
journal_name
Ophthalmologyjournal_title
Ophthalmologyauthors
Hwang YH,Kim MK,Kim DWdoi
10.1016/j.ophtha.2015.12.032subject
Has Abstractpub_date
2016-05-01 00:00:00pages
950-8issue
5eissn
0161-6420issn
1549-4713pii
S0161-6420(15)01556-0journal_volume
123pub_type
杂志文章相关文献
OPHTHALMOLOGY文献大全abstract:PURPOSE:To evaluate prospectively the efficacy of a single sub-Tenon's capsule injection of triamcinolone acetonide (TA) against panretinal photocoagulation (PRP)-induced macular thickening and visual disturbance in patients with severe diabetic retinopathy and good vision. DESIGN:Prospective, comparative, interventio...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2005.10.035
更新日期:2006-03-01 00:00:00
abstract:PURPOSE:Although the impact of vision-related quality of life (VRQoL) is assessed optimally using binocular visual acuity (VA), uniocular VA remains the preferred measurement method in clinic-based and epidemiologic studies. We compared the impact of distance presenting binocular VA and uniocular VA in the better-seein...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2020.01.056
更新日期:2020-09-01 00:00:00
abstract::A 42-year-old man who was human immunodeficiency virus (HIV)-positive complained of floaters in his right eye, which had existed for 1 week, followed by loss of central vision. Results of ophthalmoscopic examination disclosed confluent yellowish-white retinochoroidal infiltrates with perivascular sheathing, which were...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(91)32335-2
更新日期:1991-01-01 00:00:00
abstract:OBJECTIVE:Cataracts are a frequent complication after silicone oil infusion for the repair of complicated retinal detachments, occurring in up to 100% of eyes retaining silicone oil for 6 months or more. The authors devised a combined procedure for cataract and silicone oil removal with intraocular lens (IOL) implantat...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/S0161-6420(98)91119-8
更新日期:1998-11-01 00:00:00
abstract::A 35-year-old white man, on immunosuppressive medications for 3 1/2 years following a renal transplant, presented with a whitish-yellow mass at the medial end of the left lower eyelid. An initial incisional biopsy was performed that was misinterpreted as granular cell myoblastoma. The mass was subsequently excised and...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(86)33633-9
更新日期:1986-08-01 00:00:00
abstract:BACKGROUND:The authors treated ten patients (13 eyelids) with visually significant blepharoptosis and compromised corneal protective mechanisms resulting from paresis of ocular motility and absent Bell phenomenon. METHODS:Traditional upper eyelid surgery consisting of frontalis suspension (6 eyelids) or levator aponeu...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(97)30356-x
更新日期:1997-01-01 00:00:00
abstract:PURPOSE:To evaluate whether confocal scanning laser ophthalmoscopy (Heidelberg Retina Tomograph II [HRT II], Heidelberg Engineering, Heidelberg, Germany) is a valid tool for the detection of glaucomatous optic nerve damage. DESIGN:Observational, cross-sectional, nonconsecutive study in Montreal, Canada. PARTICIPANTS:...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2005.09.009
更新日期:2005-12-01 00:00:00
abstract:PURPOSE:To compare the rotational stability of the 2 most commonly used toric intraocular lenses (TIOLs). DESIGN:Retrospective cohort study in a single private practice. SUBJECTS:The study included all patients receiving an Acrysof (n = 626) or Tecnis TIOL (n = 647) over an 18-month period from April 2015 to Septembe...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2018.02.012
更新日期:2018-09-01 00:00:00
abstract::Long-term management of cytomegalovirus (CMV) retinitis by intravitreal injection of ganciclovir was evaluated in ten patients with acquired immune deficiency syndrome (AIDS). Patients were unable to tolerate systemic ganciclovir because of severe neutropenia (8 cases), catheter-induced sepsis (1 case), or the need to...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(89)32900-9
更新日期:1989-03-01 00:00:00
abstract:PURPOSE:To describe the clinical and cytopathologic characteristics in patients with vitreous opacity of unknown cause or preceding inflammation, diagnosed cytopathologically as inflammation. DESIGN:Retrospective case series. PARTICIPANTS:Forty-three consecutive patients (61 eyes) who underwent vitrectomy for vitreou...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2011.10.020
更新日期:2012-04-01 00:00:00
abstract:PURPOSE:The mechanism of cupping reversal seen after lowering intraocular pressure (IOP) in pediatric glaucoma is unknown. Theories include forward movement of the lamina cribrosa or shrinkage of a stretched scleral canal. Our study aimed to quantify changes in optic disc size occurring in children who had undergone gl...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2011.02.041
更新日期:2011-10-01 00:00:00
abstract:PURPOSE:To determine an optimal sector pattern of the central 30 degrees visual field in glaucoma by mathematically analyzing the visual field data of primary open-angle glaucoma (POAG) without any assumption such as the retinal nerve fiber layer anatomy. METHODS:One hundred three visual fields of the 30-2 program of ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(93)31691-x
更新日期:1993-01-01 00:00:00
abstract::A CW YAG laser was used to coagulate retina and to produce an optical iridotomy in a human eye that was to be enucleated for malignant melanoma at the optic nerve head. Moderate coagulation with the CW YAG laser produced a deep choroidal reaction involving the outer portion of the retina. The inner structure of the fo...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(84)34185-9
更新日期:1984-09-01 00:00:00
abstract:OBJECTIVE:To evaluate the efficacy of a second year of pegaptanib sodium therapy in patients with neovascular age-related macular degeneration (AMD). DESIGN:Two concurrent, multicenter, randomized, double-masked, sham-controlled studies (V.I.S.I.O.N. [Vascular Endothelial Growth Factor Inhibition Study in Ocular Neova...
journal_title:Ophthalmology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.ophtha.2006.02.064
更新日期:2006-09-01 00:00:00
abstract::Immunologic differences exist between the peripheral and central cornea. The peripheral cornea is closer to the conjunctiva, which has all of the immunologic machinery necessary to generate an immune response. The peripheral cornea has more Langerhans' cells and IgM than the central cornea. The peripheral cornea also ...
journal_title:Ophthalmology
pub_type: 杂志文章,评审
doi:10.1016/s0161-6420(88)33164-7
更新日期:1988-04-01 00:00:00
abstract:PURPOSE:This study was undertaken to better characterize patients with multifocal choroiditis and panuveitis (MCP), punctate inner choroidopathy (PIC), multiple evanescent white dot syndrome (MEWDS), and diffuse subretinal fibrosis syndrome. The specific aim was to determine whether these disorders were different entit...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(96)30645-3
更新日期:1996-04-01 00:00:00
abstract:PURPOSE:The identification of healthy persons more susceptible to dry eye (DED) symptoms developing after surgery remains an unmet need. We performed this study to build a new Ocular Surface Frailty Index (OSFI) and assess its predictive value for DED symptom onset after cataract surgery. DESIGN:Single-center, observa...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2019.12.012
更新日期:2020-07-01 00:00:00
abstract:PURPOSE:To characterize quantitatively the configuration of the anterior ocular segment with ultrasound biomicroscopy (UBM) in a population-based setting. DESIGN:Cross-sectional study. PARTICIPANTS:Ten percent of 4632 residents aged > or =40 years of Kumejima, an island off southwest Japan, were randomly selected. M...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2010.01.045
更新日期:2010-09-01 00:00:00
abstract:PURPOSE:A MATLAB-based (The MathWorks, Inc, Natick, MA) computer program (the ganglion cell-inner plexiform layer [GCIPL] hemifield test) for automated detection of GCIPL thickness difference across the horizontal raphe was developed, and its glaucoma diagnostic performance was assessed. DESIGN:Cross-sectional study. ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2015.07.013
更新日期:2015-11-01 00:00:00
abstract:PURPOSE:To evaluate accuracy of intraocular lens (IOL) power calculation formulae (SRK II, SRK/T, Holladay 1, Hoffer Q) in pediatric eyes. DESIGN:Retrospective case series. PARTICIPANTS:One hundred thirty-five eyes of 96 children with congenital, developmental, or acquired cataracts who underwent uncomplicated catara...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2009.12.031
更新日期:2010-08-01 00:00:00
abstract:OBJECTIVE:To assess associations between health-related quality of life (HRQOL) and the decision to perform strabismus surgery for children with intermittent exotropia. DESIGN:Retrospective chart review. PARTICIPANTS:Children with intermittent exotropia. METHODS:Included subjects, identified in a clinical practice, ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2013.10.029
更新日期:2014-04-01 00:00:00
abstract::The zonules of 27 postmortem eyes were studied grossly using a histologic staining technique that allowed easy visualization of the zonules. Large disinsertions of the zonules were present in 5 of the 20 eyes that had undergone extracapsular cataract extraction (ECCE). ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(87)33423-2
更新日期:1987-05-01 00:00:00
abstract:OBJECTIVE:To investigate systematically the natural history of visual outcome in nonarteritic anterior ischemic optic neuropathy (NAION). DESIGN:Cohort study. PARTICIPANTS:Three hundred forty consecutive untreated patients (386 eyes) with NAION, first seen in our clinic from 1973 to 2000. METHODS:At first visit, all...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2007.05.027
更新日期:2008-02-01 00:00:00
abstract:OBJECTIVE:To report the incidence of macular hole reopening after initial successful surgery. DESIGN:A noncomparative retrospective case series. PARTICIPANTS:From a series of 137 consecutive cases of idiopathic macular holes operated on between August 1993 and May 1996, the authors analyzed the charts of 116 cases of...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(99)00182-7
更新日期:2000-04-01 00:00:00
abstract:PURPOSE:To assess changes in retinal nonperfusion (RNP) in patients with retinal vein occlusion (RVO) treated with ranibizumab. DESIGN:Secondary outcome measure in randomized double-masked controlled clinical trial. PARTICIPANTS:Thirty-nine patients with central RVO (CRVO) and 42 with branch RVO (BRVO). METHODS:Subj...
journal_title:Ophthalmology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ophtha.2015.10.030
更新日期:2016-03-01 00:00:00
abstract:PURPOSE:Recent studies have shown a relationship between elevated levels of homocysteine and vascular disease including cerebrovascular accidents and myocardial infarctions. We evaluated patients with a recent retinal vein occlusion to determine if there was an associated elevation of homocysteine. DESIGN:Age and gend...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(01)00923-x
更新日期:2002-02-01 00:00:00
abstract:PURPOSE:To characterize the demographics of patients with dacryolithiasis and to compare patients who have canalicular concretions with patients who have lacrimal sac and duct dacryoliths. DESIGN:Comparative case series study and literature review. PARTICIPANTS:A total of 327 consecutive patients undergoing external ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2009.04.029
更新日期:2009-11-01 00:00:00
abstract:PURPOSE:To report the 24-month anatomic and Early Treatment Diabetic Retinopathy Study (ETDRS) best-corrected visual acuity (BCVA) response after primary intravitreal bevacizumab (Avastin; Genentech, Inc., San Francisco, CA; 1.25 or 2.5 mg) in patients with diffuse diabetic macular edema (DDME). In addition, a comparis...
journal_title:Ophthalmology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ophtha.2009.03.016
更新日期:2009-08-01 00:00:00
abstract:OBJECTIVE:To compare the ice test with the rest test in subjects with myasthenic and nonmyasthenic ptosis. DESIGN:Randomized, noninterventional trial. PARTICIPANTS:(1) Ten subjects with ptosis from previously undiagnosed myasthenia gravis. (2) Fifteen subjects with nonmyasthenic ptosis. METHODS:Application of ice co...
journal_title:Ophthalmology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0161-6420(00)00458-9
更新日期:2000-11-01 00:00:00
abstract::Thirteen cases of rhegmatogenous retinal detachment repaired by pneumatic retinopexy were reviewed retrospectively. All patients were followed for a minimum of 6 months after surgery. At the end of follow-up, retinal detachment repair by pneumatic retinopexy succeeded in nine cases (70%) and failed in four (30%). With...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(87)33445-1
更新日期:1987-04-01 00:00:00