当前位置： SCI文献检索 > OPHTHALMOLOGY期刊下所有文献 > Changes in Retinal Nonperfusion Associated with Suppression of Vascular Endothelial Growth Factor in Retinal Vein Occlusion.

Changes in Retinal Nonperfusion Associated with Suppression of Vascular Endothelial Growth Factor in Retinal Vein Occlusion.

Abstract：

PURPOSE:To assess changes in retinal nonperfusion (RNP) in patients with retinal vein occlusion (RVO) treated with ranibizumab. DESIGN:Secondary outcome measure in randomized double-masked controlled clinical trial. PARTICIPANTS:Thirty-nine patients with central RVO (CRVO) and 42 with branch RVO (BRVO). METHODS:Subjects were randomized to 0.5 or 2.0 mg ranibizumab every month for 6 months and then were re-randomized to pro re nata (PRN) groups receiving either ranibizumab plus scatter laser photocoagulation or ranibizumab alone for an additional 30 months. MAIN OUTCOME MEASURES:Comparison of percentage of patients with increased or decreased area of RNP in patients with RVO treated with 0.5 versus 2.0 mg ranibizumab, during monthly injections versus ranibizumab PRN, and in patients treated with ranibizumab PRN versus ranibizumab PRN plus laser. RESULTS:In RVO patients given monthly injections of 0.5 or 2.0 mg ranibizumab for 6 months, there was no significant difference in the percentage who showed reduction or increase in the area of RNP. However, regardless of dose, during the 6-month period of monthly injections, a higher percentage of patients showed a reduction in area of RNP and a lower percentage showed an increase in area of RNP compared with subsequent periods of ranibizumab PRN treatment. After the 6-month period of monthly injections, BRVO patients, but not CRVO patients, randomized to ranibizumab PRN plus laser showed significantly less progression of RNP compared with patients treated with ranibizumab PRN. CONCLUSIONS:Regardless of dose (0.5 or 2.0 mg), monthly ranibizumab injections promote improvement and reduce progression of RNP compared with PRN injections. The addition of scatter photocoagulation to ranibizumab PRN may reduce progression of RNP in patients with BRVO, but a statistically significant reduction was not seen in patients with CRVO.

journal_name

Ophthalmology

journal_title

Ophthalmology

authors

Mir TA,Kherani S,Hafiz G,Scott AW,Zimmer-Galler I,Wenick AS,Solomon S,Han I,Poon D,He L,Shah SM,Brady CJ,Meyerle C,Sodhi A,Linz MO,Sophie R,Campochiaro PA

doi

10.1016/j.ophtha.2015.10.030

subject

Has Abstract

pub_date

2016-03-01 00:00:00

pages

625-34.e1

issue

eissn

0161-6420

issn

1549-4713

pii

S0161-6420(15)01217-8

journal_volume

123

pub_type

杂志文章,随机对照试验

在线工具

Changes in Retinal Nonperfusion Associated with Suppression of Vascular Endothelial Growth Factor in Retinal Vein Occlusion.