Risk factors for microbial keratitis with contemporary contact lenses: a case-control study.


OBJECTIVE:To assess the relative risks (RR) of microbial keratitis (MK) for contemporary contact lens (CL) types and wearing schedules. DESIGN:A 2-year prospective case-control study begun in December 2003. PARTICIPANTS:Cases were 367 CL wearers attending Moorfields Eye Hospital with proven or presumed MK. Controls were 1069 hospital controls, who were CL wearers with a disorder unrelated to CL wear, and 639 population-based controls who were CL wearers randomly selected from the Moorfields catchment area. Hospital patients completed a self-administered questionnaire; population-based controls were interviewed by telephone. TESTING:Multivariate analysis was done both for all cases of MK, and for the moderate and severe MK subgroups alone. MAIN OUTCOME MEASURES:The RR for developing MK, and vision loss, for all lens types compared with planned replacement soft lenses (the referent). RESULTS:Compared with planned replacement soft lenses (the referent), the RR of MK was significantly increased with daily disposable (DD) CLs (RR, 1.56x [95% confidence interval (CI), 1.1-2.1]; P = 0.009) and differed between different brands of DD lens, was reduced for rigid lenses (RR, 0.16x [95% CI, 0.06-0.4]; P<0.001), and no different for silicone hydrogel or other types of soft lens. Although the risk of MK was higher overall among DD lens users, the risk of vision loss was less than for planned replacement soft CL users (P = 0.05); no DD lens users lost vision to the level of >or=20/40. The RR for overnight wear, for any lens type, was 5.4 times higher (95% CI, 3.3-10.9; P<0.001). Comparison of the DD soft CL types with planned replacement soft lenses (the referent), showed significant differences between brands for the risk of MK. CONCLUSIONS:The risk of MK has not been reduced in users of DD and silicone hydrogel CLs. However, vision loss is less likely to occur in DD than in reusable soft CL users. Different brands of CL may be associated with significantly different risks of keratitis; understanding these differences should lead to the development of safer soft lenses. These findings suggest that lens/ocular surface interactions may be more important in the development of corneal infection than oxygen levels and CL case contamination.






Dart JK,Radford CF,Minassian D,Verma S,Stapleton F




Has Abstract


2008-10-01 00:00:00


1647-54, 1654.e1-3












  • Bilateral retinal artery and choriocapillaris occlusion following the injection of long-acting corticosteroid suspensions in combination with other drugs: II. Animal experimental studies.

    abstract::An experimental dog model was used to reproduce the clinical picture of bilateral arteriole and choriocapillaris occlusion from a unilateral intracarotid injection of long-acting corticosteroids combined with other drugs including lidocaine, epinephrine, and penicillin. All five known long-acting corticosteroids, when...


    pub_type: 杂志文章


    authors: Wilson RS,McGrew RN,White HJ

    更新日期:1978-09-01 00:00:00

  • Modern instruments for subjective refraction. A comparative study.

    abstract::In a comparative study, subjective refractions were carried out on 115 normal subjects and 118 patients with four instruments (Humphrey Vision Analyzer, Möller/CooperVision Visutron, Reichert SR-IV, Rodenstock/Coburn Phoromat). The accuracy of the prescriptions obtained, the visual acuity results and the measurement t...


    pub_type: 杂志文章


    authors: Wesemann W,Rassow B

    更新日期:1986-09-01 00:00:00

  • Choroideremia: variability of clinical and electrophysiological characteristics and first report of a negative electroretinogram.

    abstract:PURPOSE:To analyze the variability of clinical and electrophysiological characteristics in X-linked choroideremia and provide the first report of a negative electroretinogram in choroideremia. DESIGN:Retrospective study. PARTICIPANTS:The records of 18 male patients with choroideremia and 8 female carriers were evalua...


    pub_type: 杂志文章


    authors: Renner AB,Kellner U,Cropp E,Preising MN,MacDonald IM,van den Hurk JA,Cremers FP,Foerster MH

    更新日期:2006-11-01 00:00:00

  • The barrier function in extracapsular cataract surgery.

    abstract::The distribution of fluorescein between the anterior chamber and the anterior vitreous was measured in two groups of patients after oral administration: group I, extracapsular cataract extraction (ECCE) patients with intact capsule and posterior chamber intraocular lens (PC IOL) (n = 12); group II, intracapsular catar...


    pub_type: 杂志文章


    authors: Smith RT,Campbell CJ,Koester CJ,Trokel S,Anderson A

    更新日期:1990-01-01 00:00:00

  • Efficacy of cimetidine/pyrilamine eyedrops. A dose response study with histamine challenge.

    abstract::Eighteen healthy volunteers participated in a histamine challenge, dose response study of cimetidine (H2 antagonist)/pyrilamine (H1 antagonist) eyedrops. This was a randomized, double-masked, multiple-crossover trial, consisting of six visits spaced 48 hours apart. At each visit, subjects were pretreated with one of s...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Leon J,Charap A,Duzman E,Shen CD

    更新日期:1986-01-01 00:00:00

  • Foldable Artiflex phakic intraocular lens for the correction of myopia: two-year follow-up results of a prospective European multicenter study.

    abstract:OBJECTIVE:To evaluate the safety, efficacy, predictability, stability, and complications of the foldable Artiflex iris-fixated intraocular lens (Ophtec BV, Groningen, The Netherlands) for the correction of myopia in phakic eyes. DESIGN:Prospective, nonrandomized, open-label, multicenter trial. PARTICIPANTS:Two hundre...


    pub_type: 临床试验,杂志文章,多中心研究


    authors: Dick HB,Budo C,Malecaze F,Güell JL,Marinho AA,Nuijts RM,Luyten GP,Menezo JL,Kohnen T

    更新日期:2009-04-01 00:00:00

  • Massive mycobacterial choroiditis during highly active antiretroviral therapy: another immune-recovery uveitis?

    abstract:PURPOSE:To describe the ocular presentation of disseminated mycobacterial disease occurring during immune-recovery in a patient with acquired immune deficiency syndrome (AIDS). STUDY DESIGN:Case report and literature review. PARTICIPANTS:A 41-year-old AIDS patient with a prior diagnosis of cytomegalovirus retinitis. ...


    pub_type: 杂志文章


    authors: Zamir E,Hudson H,Ober RR,Kumar SK,Wang RC,Read RW,Rao NA

    更新日期:2002-11-01 00:00:00

  • Association between corneal allograft reactions and HLA compatibility.

    abstract::The purpose of this follow-up study is to measure the association between corneal allograft reactions and donor-recipient HLA-A and HLA-B compatibility. Four hundred thirty-eight consecutive adult recipients of corneal grafts with known donor-recipient HLA matching were observed for allograft reactions and failures. M...


    pub_type: 杂志文章


    authors: Boisjoly HM,Roy R,Bernard PM,Dubé I,Laughrea PA,Bazin R

    更新日期:1990-12-01 00:00:00

  • Early Treatment Diabetic Retinopathy Study design and baseline patient characteristics. ETDRS report number 7.

    abstract::The Early Treatment Diabetic Retinopathy Study (ETDRS), a multicenter collaborative clinical trial supported by the National Eye Institute, was designed to assess whether argon laser photocoagulation or aspirin treatment can reduce the risk of visual loss or slow the progression of diabetic retinopathy in patients wit...


    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验



    更新日期:1991-05-01 00:00:00

  • The relation of cardiovascular disease and its risk factors to the 5-year incidence of age-related maculopathy: the Beaver Dam Eye Study.

    abstract:OBJECTIVE:The purpose of the study is to examine the association between cardiovascular disease and its risk factors and the incidence of age-related maculopathy. PARTICIPANTS:A population of 3583 adults (range, 43-86 years of age at baseline) living in Beaver Dam, Wisconsin, was studied at baseline and 5 years later....


    pub_type: 杂志文章


    authors: Klein R,Klein BE,Jensen SC

    更新日期:1997-11-01 00:00:00

  • In vivo laser confocal microscopy findings and mutational analysis for Schnyder's crystalline corneal dystrophy.

    abstract:OBJECTIVE:To identify any mutation of the UbiA prenyltransferase domain-containing protein 1 (UBIAD1) gene in Japanese patients with Schnyder's crystalline corneal dystrophy (SCCD) and to investigate in vivo microstructural phenotype and genotype correlations using laser scanning confocal microscopy (Heidelberg Retina ...


    pub_type: 杂志文章


    authors: Kobayashi A,Fujiki K,Murakami A,Sugiyama K

    更新日期:2009-06-01 00:00:00

  • Some factors governing the efficacy of positional pseudoaccommodative intraocular lenses.

    abstract:PURPOSE:To examine the effects of ametropia (spherocylindrical), corneal curvature, target anterior chamber depth (ACD), misplacement, and some design features on the performance of positional pseudoaccommodative intraocular lenses (PPAIOLs). DESIGN:Theoretical investigation based on computer models to determine the p...


    pub_type: 杂志文章


    authors: Alió JL,Patel S

    更新日期:2005-11-01 00:00:00

  • Subperiosteal midface lift with or without a hard palate mucosal graft for correction of lower eyelid retraction.

    abstract:PURPOSE:To compare functional and surgical outcomes of a subperiosteal midface lift with and without the placement of a hard palate mucosal graft (HPMG) in patients with lower eyelid retraction. DESIGN:Retrospective, comparative, interventional case series. PARTICIPANTS:Thirty-four patients with lower eyelid retracti...


    pub_type: 杂志文章


    authors: Ben Simon GJ,Lee S,Schwarcz RM,McCann JD,Goldberg RA

    更新日期:2006-10-01 00:00:00

  • Effectiveness of nonpharmacologic treatments for acute seasonal allergic conjunctivitis.

    abstract:OBJECTIVE:To investigate whether artificial tears and cold compress alone or in combination provide a treatment benefit and whether they were as effective as or could enhance topical antiallergic medication. DESIGN:Randomized, masked clinical trial. PARTICIPANTS:Eighteen subjects (mean age, 29.5±11.0 years) allergic ...


    pub_type: 杂志文章,随机对照试验


    authors: Bilkhu PS,Wolffsohn JS,Naroo SA,Robertson L,Kennedy R

    更新日期:2014-01-01 00:00:00

  • Management of strabismus with botulinum A toxin.

    abstract::Three hundred eight patients with strabismus were treated with botulinum A toxin (Oculinum) chemodenervation; 153 were followed by the authors for at least 6 months. In this study group, 97 received botulinum A toxin injections as the primary method of treatment of their ocular deviation. Fifty-six received injections...


    pub_type: 杂志文章


    authors: Biglan AW,Burnstine RA,Rogers GL,Saunders RA

    更新日期:1989-07-01 00:00:00

  • Comparison and evaluation of ocular biometry using a new noncontact optical low-coherence reflectometer.

    abstract:PURPOSE:To evaluate a new high-resolution noncontact biometer (Lenstar; Haag-Streit AG, Koeniz, Switzerland) using optical low-coherence reflectometry and to compare the clinical measurements with those obtained from the IOLMaster (Carl Zeiss, Jena, Germany) and the Pachmumeter (Haag-Streit AG). DESIGN:Exploratory eva...


    pub_type: 临床试验,杂志文章


    authors: Rohrer K,Frueh BE,Wälti R,Clemetson IA,Tappeiner C,Goldblum D

    更新日期:2009-11-01 00:00:00

  • Retinopathy of prematurity in assisted versus natural conception and singleton versus multiple births.

    abstract:OBJECTIVES:To determine whether the incidence and severity of retinopathy of prematurity (ROP) differs between infants conceived naturally and those born after assisted conception, and to analyze the impact of singleton versus multiple gestation on ROP. DESIGN:Comparative case series. PARTICIPANTS:The study group con...


    pub_type: 杂志文章


    authors: Friling R,Axer-Siegel R,Hersocovici Z,Weinberger D,Sirota L,Snir M

    更新日期:2007-02-01 00:00:00

  • Accommodation during static retinal imaging with a confocal scanning laser ophthalmoscope.

    abstract:PURPOSE:Accommodation of the eye can adversely affect optical tomography of the retina using a confocal scanning laser ophthalmoscope (cSLO). This study measured the dynamic accommodative response of young adult eyes while acquiring static retinal images with a cSLO without cycloplegia and also examined whether a scann...


    pub_type: 杂志文章


    authors: Kelly JP,Seibel EJ

    更新日期:2007-06-01 00:00:00

  • Corneal endothelial changes in primary acute angle-closure glaucoma.

    abstract::In 20 patients, corneal endothelium was examined by specular microscopy after acute angle-closure glaucoma, and before any surgical treatment in order to assess possible damage during pressure induced abnormal hydration of the cornea. The mean intraocular pressure was elevated to 55 mm Hg and had lasted, on an average...


    pub_type: 杂志文章


    authors: Bigar F,Witmer R

    更新日期:1982-06-01 00:00:00

  • Optic nerve head circulation in nonarteritic anterior ischemic optic neuropathy and optic neuritis.

    abstract:PURPOSE:To quantify optic nerve head circulatory abnormalities in patients with unilateral nonarteritic anterior ischemic optic neuropathy (NAION) or optic neuritis (ON), and to assess the potential of such measurements to differentiate NAION from ON. DESIGN:Prospective, cross-sectional, observational study. PARTICIP...


    pub_type: 杂志文章


    authors: Collignon-Robe NJ,Feke GT,Rizzo JF 3rd

    更新日期:2004-09-01 00:00:00

  • Anterior ciliary sclerotomy for treatment of presbyopia: a prospective controlled study.

    abstract:PURPOSE:To examine the safety and efficacy of anterior ciliary sclerotomy to restore accommodation in the presbyopic eye. DESIGN:Prospective nonrandomized comparative single-center clinical trial. PARTICIPANTS:Nine presbyopic subjects with no prior ocular surgery except corneal refractive procedures were enrolled. M...


    pub_type: 临床试验,杂志文章


    authors: Hamilton DR,Davidorf JM,Maloney RK

    更新日期:2002-11-01 00:00:00

  • Merkel cell carcinoma of the eyelid review of the literature and report of patients with Merkel cell carcinoma showing spontaneous regression.

    abstract:PURPOSE:To evaluate the clinical and histopathologic characteristics of Merkel cell carcinoma (MCC) of the eyelid. DESIGN:Retrospective case series and literature review. PARTICIPANTS:Three consecutive patients with MCC of the eyelid who were referred to the Ocular Oncology Unit of Leiden University Medical Center, N...


    pub_type: 杂志文章


    authors: Missotten GS,de Wolff-Rouendaal D,de Keizer RJ

    更新日期:2008-01-01 00:00:00

  • Implantation of Kelman-style, open-loop anterior chamber lenses during keratoplasty for aphakic and pseudophakic bullous keratopathy. A comparison with iris-sutured posterior chamber lenses.

    abstract::The clinical and specular microscopic results of 40 cases (39 patients) of penetrating keratoplasty during which a Kelman-style anterior chamber intraocular lens was implanted were reviewed retrospectively. Thirty-one pseudophakic eyes received an intraocular lens exchange and nine aphakic eyes received a secondary in...


    pub_type: 杂志文章


    authors: Hassan TS,Soong HK,Sugar A,Meyer RF

    更新日期:1991-06-01 00:00:00

  • Effect of laser trabeculoplasty on nocturnal intraocular pressure in medically treated glaucoma patients.

    abstract:PURPOSE:To evaluate the effects of laser trabeculoplasty on 24-hour intraocular pressure (IOP) in a group of medically treated open-angle glaucoma patients. DESIGN:Prospective experimental study. PARTICIPANTS:Eighteen open-angle glaucoma patients. METHODS:Laser trabeculoplasty (180 degrees ) was performed on 28 eyes...


    pub_type: 杂志文章


    authors: Lee AC,Mosaed S,Weinreb RN,Kripke DF,Liu JH

    更新日期:2007-04-01 00:00:00

  • Extended-wear contact lenses in patients with corneal grafts and aphakia.

    abstract::Extended-wear contact lenses (EWCL) were fitted successfully on 61 aphakic eyes with penetrating corneal grafts. In two- to 32-months follow-up there were 26 eyes that had varying amounts of superficial neovascularization of the grafts and one Staphylococcus epidermidis corneal graft ulcer. There were five homograft r...


    pub_type: 杂志文章


    authors: Cavanagh HD,Leveille AS

    更新日期:1982-06-01 00:00:00

  • Validity of self-report in type 1 diabetic subjects for laser treatment of retinopathy.

    abstract:PURPOSE:This study sought to determine the validity of self-report of prior panretinal photocoagulation (PRP) and focal photocoagulation (FP) compared with fundus photography. DESIGN:Prospective cohort study. PARTICIPANTS:One thousand three hundred sixty-three type 1 diabetic subjects from the Epidemiology of Diabete...


    pub_type: 临床试验,杂志文章,多中心研究


    authors: Grassi MA,Sun W,Gangaputra S,Cleary PA,Hubbard L,Lachin JM,Gao X,Kiss S,Barkmeier AJ,Almony A,Davis M,Klein R,Danis RP,DCCT\/EDIC Research Group.

    更新日期:2013-12-01 00:00:00

  • Intravitreal aflibercept for treatment-resistant neovascular age-related macular degeneration.

    abstract:OBJECTIVE:To assess the effectiveness of intravitreal aflibercept in patients with neovascular age-related macular degeneration (AMD) previously resistant to treatment with other anti-vascular endothelial growth factor agents. DESIGN:Prospective, open-label, noncontrolled, registered clinical trial. PARTICIPANTS:Fort...


    pub_type: 临床试验,杂志文章


    authors: Chang AA,Li H,Broadhead GK,Hong T,Schlub TE,Wijeyakumar W,Zhu M

    更新日期:2014-01-01 00:00:00

  • An improved technique for management of dislocated posterior chamber implants.

    abstract::Many techniques for repositioning dislocated posterior chamber implants described in the recent literature involve intricate intraocular manipulation of a needle or other sharp instrument. The author describes an improved sulcus fixation technique, which combines the best features of external and internal approaches. ...


    pub_type: 杂志文章


    authors: Chan CK

    更新日期:1992-01-01 00:00:00

  • Palpebral fissure height and downgaze in patients with Graves upper eyelid retraction and congenital blepharoptosis.

    abstract:PURPOSE:To compare the relation between vertical eyelid fissure height and downgaze in healthy subjects and in patients with Graves upper eyelid retraction and congenital blepharoptosis. METHODS:With a caliper rule, the authors measured the vertical eyelid fissure height of 25 patients with no previous history of eye ...


    pub_type: 杂志文章


    authors: Guimarães FC,Cruz AA

    更新日期:1995-08-01 00:00:00

  • Assessment of Confocal Microscopy for the Diagnosis of Polymerase Chain Reaction-Positive Acanthamoeba Keratitis: A Case-Control Study.

    abstract:PURPOSE:To determine in vivo confocal microscopy diagnostic criteria to diagnose Acanthamoeba keratitis (AK) using polymerase chain reaction (PCR) as the reference diagnostic technique. DESIGN:Retrospective case-control study. Data were recorded prospectively and analyzed retrospectively. PARTICIPANTS:Fifty patients ...


    pub_type: 杂志文章


    authors: De Craene S,Knoeri J,Georgeon C,Kestelyn P,Borderie VM

    更新日期:2018-02-01 00:00:00