Anterior shift of zonular insertion onto the anterior surface of human crystalline lens with age.

Abstract:

OBJECTIVE:This study aimed to investigate the age-related changes in the position of zonular insertion onto the anterior lens capsule. DESIGN:The study design was an experimental cadaveric eye study. PARTICIPANTS:Two hundred twenty-three cadaveric eyes (range, 16-100 years old) from eye banks in the United States were studied. INTERVENTION:The zonular insertion onto the anterior capsule was detected using a modified posterior photographic technique. MAIN OUTCOME MEASURES:The distances from the anterior zonular insertion (AZI) to the lens equator and to the ciliary sulcus, size of zonular-free zone, lens diameter, ciliary sulcus diameter, and axial length of the globe were measured. RESULTS:Multiple regression analysis showed that age, lens diameter, and axial length of the globe had significant correlations with AZI (r2 = 0.748), among which age showed the highest relevance with AZI. Multiple regression equation was expressed as AZI = (0.0079 x age) + (0.202 x lens diameter) - (0.041 x axial length of the globe) + 0.0114. The increase in AZI was accompanied by a decrease in the size of zonular-free zone with age (r = -0.206, P < 0.001). CONCLUSION:Aging correlates with an increase in the distance from the anterior zonular insertion to the lens equator and a decrease in zonular-free zone.

journal_name

Ophthalmology

journal_title

Ophthalmology

authors

Sakabe I,Oshika T,Lim SJ,Apple DJ

doi

10.1016/s0161-6420(98)93172-4

subject

Has Abstract

pub_date

1998-02-01 00:00:00

pages

295-9

issue

2

eissn

0161-6420

issn

1549-4713

pii

S0161-6420(98)93172-4

journal_volume

105

pub_type

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