Abstract:
PURPOSE:The mechanism of cupping reversal seen after lowering intraocular pressure (IOP) in pediatric glaucoma is unknown. Theories include forward movement of the lamina cribrosa or shrinkage of a stretched scleral canal. Our study aimed to quantify changes in optic disc size occurring in children who had undergone glaucoma surgery. DESIGN:Retrospective, single-center, observational case series. PARTICIPANTS:Children undergoing incisional surgery for pediatric glaucoma at the University of California, Davis. METHODS:The electronic charts of all patients with pediatric glaucoma were reviewed for the presence of RetCam digital optic nerve photographs (Clarity Medical Systems, Pleasanton, CA). Cases in which the photographs (baseline and follow-up after surgical intervention) were of sufficient quality were analyzed. The optic disc margin was outlined manually using ImageJ software. Inter-session changes in magnification were accounted for by drawing a control polygon joining 4 or 5 fixed landmarks (e.g., vessel crossings) to include a second larger area containing the optic nerve. The optic disc area (in pixels adjusted with the control polygon) was compared between baseline and follow-up images. MAIN OUTCOME MEASURES:Change in disc area between baseline and follow-up after surgery. RESULTS:We identified 29 eyes for which baseline and follow-up images were available for analysis. Fifteen eyes of 9 children showed clinically obvious cupping reversal. Fourteen eyes of 12 children showed no cupping reversal. Disc area decreased by 6.8% (95% confidence interval [CI], -10.0 to -3.3) in the obvious reversal group and increased by 4.3% (95% CI, +1.0 to +7.6) in the no reversal group after surgery (P < 0.0001; Student t test). Percent change in disc area is correlated to percent change in IOP (r=0.540; P=0.0025) and axial length (r=0.534; P=0.0028). CONCLUSIONS:When cupping reversal is clinically apparent after successful IOP-lowering surgery for congenital glaucoma, the scleral canal shrinks in area. In contrast, when cupping reversal is not observed, the scleral ring continues to enlarge, indicating ongoing stress on the optic nerve. Clinically obvious cupping reversal is less frequently observed in adults after surgery, which may reflect a lower elasticity of the scleral ring in adults compared with children. FINANCIAL DISCLOSURE(S):The author(s) have no proprietary or commercial interest in any materials discussed in this article.
journal_name
Ophthalmologyjournal_title
Ophthalmologyauthors
Mochizuki H,Lesley AG,Brandt JDdoi
10.1016/j.ophtha.2011.02.041subject
Has Abstractpub_date
2011-10-01 00:00:00pages
2008-13issue
10eissn
0161-6420issn
1549-4713pii
S0161-6420(11)00228-4journal_volume
118pub_type
杂志文章相关文献
OPHTHALMOLOGY文献大全abstract:OBJECTIVE:Cataracts are a frequent complication after silicone oil infusion for the repair of complicated retinal detachments, occurring in up to 100% of eyes retaining silicone oil for 6 months or more. The authors devised a combined procedure for cataract and silicone oil removal with intraocular lens (IOL) implantat...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/S0161-6420(98)91119-8
更新日期:1998-11-01 00:00:00
abstract::Preliminary investigations of optimal target distribution patterns of automated perimetry were conducted. In the first study, frequency distributions of visual field defects were determined in glaucoma (260 scotomata) and optic nerve disease (110 scotomata) for approximately 30,000 visual field locations. The frequenc...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(81)80037-1
更新日期:1981-10-01 00:00:00
abstract:PURPOSE:The expression of cellular adhesion molecules in 31 penetrating keratoplasty specimens from a broad range of corneal inflammatory diseases was studied using monoclonal antibodies and an immunoperoxidase technique. METHODS:Corneas were divided into noninflamed, mild to moderately inflamed, and severely inflamed...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(94)31370-4
更新日期:1994-01-01 00:00:00
abstract:PURPOSE:Diabetic patients have a greater risk of nonarteritic anterior ischemic optic neuropathy (NAION) than nondiabetic patients. We compare visual outcomes, prevalence of bilateral/sequential ION, and predictors of visual outcomes in NAION between diabetic and nondiabetic patients. DESIGN:Case-control study. PARTI...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2016.11.029
更新日期:2017-04-01 00:00:00
abstract:OBJECTIVE:To review the published literature on safety and outcomes of the Boston type I keratoprosthesis (BI-KPro) for the surgical treatment of corneal opacification not amenable to human cadaveric corneal transplantation. METHODS:Searches of peer-reviewed literature were conducted in PubMed and the Cochrane Library...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2015.03.025
更新日期:2015-07-01 00:00:00
abstract::Fifty-eight patients with keratitis sicca were enrolled in a long-term study to test the effectiveness of slow-release artificial tears (SRAT). The average follow up period of 39 weeks, with a range of 9 to 136 weeks. Forty-six (79%) are still being followed. Almost all of these patients have had marked relief from th...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(81)35074-x
更新日期:1981-01-01 00:00:00
abstract:PURPOSE:To evaluate whether confocal scanning laser ophthalmoscopy (Heidelberg Retina Tomograph II [HRT II], Heidelberg Engineering, Heidelberg, Germany) is a valid tool for the detection of glaucomatous optic nerve damage. DESIGN:Observational, cross-sectional, nonconsecutive study in Montreal, Canada. PARTICIPANTS:...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2005.09.009
更新日期:2005-12-01 00:00:00
abstract:PURPOSE:Indocyanine green (ICG) dye is known to remain selectively in and around choroidal neovascularization (CNV) associated with age-related macular degeneration, and is thought to be cleared from the overlying retinal circulation without leakage. This is the basis of ICG dye-enhanced laser photocoagulation. The aut...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(94)31323-6
更新日期:1994-03-01 00:00:00
abstract:PURPOSE:Autosomal-dominant optic atrophy (DOA) is one of the most common inherited optic neuropathies, and it is genetically heterogeneous, with mutations in both OPA1 and OPA3 known to cause disease. Approximately 60% of cases harbor OPA1 mutations, whereas OPA3 mutations have been reported in only 2 pedigrees with DO...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2010.07.029
更新日期:2011-03-01 00:00:00
abstract:PURPOSE:Sjögren-Larsson syndrome (SLS), an autosomal recessive hereditary disorder with congenital ichthyosis, spastic diplegia or tetraplegia, and mental retardation, reveals a characteristic macular dystrophy with intraretinal crystals and foveal pseudocysts. Ophthalmic symptoms in SLS are reduced visual acuity and p...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2009.10.019
更新日期:2010-05-01 00:00:00
abstract::A 13-year-old boy presented with a 2-month history of swelling of the right upper eyelid and displacement of the right eye. Computed tomography (CT) showed a tumor in the right orbit and a large osteolytic defect of the orbital frontal bone. At surgery a yellowish-tan mass was found replacing the orbital roof and abut...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(87)33352-4
更新日期:1987-08-01 00:00:00
abstract::Perfluoropropane (C3F8) was injected into nine eyes of six cynomolgus monkeys. In all nine eyes, macular changes consistent with the development of a macular cyst were noted within 3 months after injection. On fluorescein angiography, there was no evidence of retinal vascular leakage associated with the macular cysts....
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(91)32259-0
更新日期:1991-04-01 00:00:00
abstract::Sixty-four consecutive patients with aphakic penetrating keratoplasty and penetrating keratoplasty combined with intracapsular cataract extraction were reviewed in a prospective fashion with a minimum of a one-year follow-up. Five were lost to follow-up. There were seven graft failures at the end of one year. Five of ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(80)35187-7
更新日期:1980-07-01 00:00:00
abstract:PURPOSE:The human orbit is an environment that is vulnerable to inflammation and edema in the setting of autoimmune thyroid disease. Our study investigated the tenet that orbital adipose tissue lacks lymphatic vessels and analyzed the clinicopathologic differences between patients with acute and chronic thyroid eye dis...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2016.05.052
更新日期:2016-09-01 00:00:00
abstract:PURPOSE/BACKGROUND:Retinal arteriovenous malformations can be seen in a variety of ways and have multiple, associated, ocular changes that can affect vision. The authors report two cases of retinal arteriovenous malformation. In each case, a central retinal vein occlusion developed. METHODS:Each patient underwent clin...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(93)31701-x
更新日期:1993-01-01 00:00:00
abstract:OBJECTIVE:To compare the reliability and the agreement in measuring central corneal thickness (CCT) using the following technologies: RTVue Fourier-domain optical coherence tomography (Optovue, Inc., Fremont, CA), Pentacam (Oculus, Inc., Wetzlar, Germany), and ultrasonic pachymetry (USP; Pocket-II; Quantel Medical, Inc...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2010.03.002
更新日期:2010-11-01 00:00:00
abstract:OBJECTIVE:The authors compared two methods, the Marcus Gunn test and the alternating light test, for detecting a relative afferent pupillary defect. DESIGN:A randomized, prospective clinical trial. PARTICIPANTS:Fourteen patients with unilateral optic neuropathy. INTERVENTION:The Marcus Gunn and alternating light tes...
journal_title:Ophthalmology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/S0161-6420(98)95029-1
更新日期:1998-05-01 00:00:00
abstract:PURPOSE:To report a series of patients with ocular infections caused by the rarely described gram-negative bacterium, Providencia rettgeri. DESIGN:Retrospective case series. PARTICIPANTS:Five patients with ocular infections who grew P. rettgeri after culture (2 keratitis, 1 dacryocystitis, 1 conjunctivitis, 1 conjunc...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2006.03.047
更新日期:2006-08-01 00:00:00
abstract::An entire family (father, mother, and three daughters) were given thiabendazole because one of the children had acquired pinworm infestation. The mother and one daughter (non-infected) developed a sicca complex (keratoconjunctivitis sicca and xerostomia) accompanied by cholangiostatic jaundice. Sjögren's syndrome is a...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(79)35334-9
更新日期:1979-10-01 00:00:00
abstract:PURPOSE:To characterize the types and frequencies of image artifacts associated with macular scanning using 2 common spectral-domain optical coherence tomography (SD OCT) instruments and to evaluate the impact of artifacts on foveal thickness measurements. DESIGN:Retrospective, observational chart review. PARTICIPANT...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2009.10.029
更新日期:2010-06-01 00:00:00
abstract:PURPOSE:To define and characterize a novel pre-Descemet's layer in the human cornea. DESIGN:Clinical and experimental study. PARTICIPANTS:We included 31 human donor sclerocorneal discs, including 6 controls (mean age, 77.7 years). METHODS:Air was injected into the stroma of donor whole globes (n = 4) and sclerocorne...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2013.01.018
更新日期:2013-09-01 00:00:00
abstract::Twelve consecutive patients with optic neuritis of unknown etiology treated with 250 to 500 mg methylprednisolone every 6 hours are described. All patients improved, some dramatically and rapidly. Patients with swollen discs and visual loss for less than 6 weeks improved uniformly, rapidly, and completely. In some pat...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(88)33220-3
更新日期:1988-01-01 00:00:00
abstract::Enucleation is the beginning of a long-term relationship between the ophthalmologist and the patient to provide a comfortable, cosmetically acceptable, anophthalmic socket. The ideal socket should have a low risk of implant extrusion, normal volume, and normal motility of the prosthesis. Aspheric motility implants pro...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(83)80054-2
更新日期:1983-09-01 00:00:00
abstract::Autosomal dominant vitreoretinochoroidopathy (ADVIRC), a recently described disease, is clinically characterized by a slowly progressive or stationary circumferential peripheral pigmentary retinopathy with fibrillar condensation of the vitreous. Histopathologic study of an 88-year-old patient with this disease showed ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(89)32663-7
更新日期:1989-12-01 00:00:00
abstract::Superior sulcus deformity is a late sequela of surgical anophthalmos. Many methods have been proposed to treat this difficult problem. A technique using autogenous costal cartilage that has resulted in satisfactory repair is presented. In addition to standard photographs and exophthalmometry measurements to follow the...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(82)34772-7
更新日期:1982-05-01 00:00:00
abstract:PURPOSE:To analyze visual acuity (VA) outcomes before and after preplanned treatment regimen change in the VIEW studies at week 52 (W52). DESIGN:Multiple post hoc analyses for retrospectively defined subgroups in 2 multicenter, multinational, double-masked trials. PARTICIPANTS:Two thousand four hundred fifty-seven ne...
journal_title:Ophthalmology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.ophtha.2015.08.014
更新日期:2015-12-01 00:00:00
abstract:OBJECTIVE:To report the results of repeated intravitreal injections of triamcinolone acetonide for treatment of diffuse diabetic macular edema. DESIGN:Retrospective interventional comparative study. PARTICIPANTS:The investigation included a study group (the responders) of 19 patients (22 eyes) with diffuse diabetic m...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2006.01.002
更新日期:2006-05-01 00:00:00
abstract:PURPOSE:To study the clinicopathologic features of mantle cell lymphoma (MCL) in the ocular adnexal region. DESIGN:Retrospective review. METHODS:The slides of 23 suspect patients were reevaluated with a panel of monoclonal antibodies, including anti-CD20, cyclin-D1, CD5, CD3, and p53 immunostains. Patients confirmed ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2004.07.025
更新日期:2005-01-01 00:00:00
abstract:PURPOSE:The authors studied the etiology of acquired ptosis in the young to middle-aged adult population with specific attention to the role of rigid contact lens use. METHODS:The study consisted of all patients between the ages of 15 and 50 years with acquired ptosis who presented between April 1986 and May 1994. Pot...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(95)30933-5
更新日期:1995-06-01 00:00:00
abstract::Nabilone is a synthesized crystalline benzopyran that resembles the cannabinols but is not a tetrahydrocannabinol. Oral administration of 0.5 to 2 mg to patients with open-angle glaucoma reduced the intraocular pressure from 10% to 54% with an average of 28%. Administration of a topical ophthalmic nabilone solution (0...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(79)35539-7
更新日期:1979-01-01 00:00:00