Abstract:
BACKGROUND:Antibody-mediated rejection (AMR) remains associated with reduced kidney graft survival and no clear prognostic marker is available. METHODS:We investigated whether donor-specific antibodies (DSA) ability to bind C1q in comparison with AMR C4d status, both indirect signs of complement activation, improve risk stratification at time of AMR. Hence, among 467 patients in whom 1 or more graft biopsies were performed between 2008 and 2015, we included 56 with AMR according to Banff '15 criteria. Using concurrent sera, we prospectively identified DSA by single-antigen beads (IgG and C1q) assays. RESULTS:Antibody-mediated rejection C4d (+) (n = 28) was associated with preformed DSA (P = 0.007), whereas DSA C1q (+) (n = 25) cases had stronger IgG-DSA (P < 0.001). At AMR, graft function was similar between DSA C1q groups, but in the first year after, it improved in DSA C1q (-), whereas a steady decline was observed in DSA C1q (+) cases, remaining significantly lower from 1 year until 4 years after AMR. DSA C1q (+) was significantly associated with reduced graft survival (P = 0.021), whereas AMR C4d (+) was not (P = 0.550). Importantly, a similar negative impact of DSA C1q (+) on graft survival was observed within AMR C4d (+) (P = 0.040) and (-) (P = 0.036), cases. In multivariable analysis, DSA C1q (+) (hazard ratio, 3.939, P = 0.005) and de novo DSA (hazard ratio, 4.409, P = 0.033) were independent predictors of graft failure, but stronger IgG-DSA was not. Similar results were obtained considering C1q-DSA and IgG-DSA strength as continuous variables. CONCLUSIONS:C1q-DSA assessment at AMR can be a valuable tool in detecting patients with higher risk of graft failure.
journal_name
Transplantationjournal_title
Transplantationauthors
Malheiro J,Santos S,Tafulo S,Dias L,Martins S,Fonseca I,Almeida M,Pedroso S,Beirão I,Castro-Henriques A,Cabrita Adoi
10.1097/TP.0000000000002265subject
Has Abstractpub_date
2018-11-01 00:00:00pages
1943-1954issue
11eissn
0041-1337issn
1534-6080journal_volume
102pub_type
杂志文章相关文献
TRANSPLANTATION文献大全abstract:BACKGROUND:Preexisting IgG antibodies to donor human leukocyte antigens (HLA) are a risk factor for rapid allograft rejection. However, non-HLA antibodies, of the IgM class, also called autoreactive antibodies, are not believed to affect graft survival. The aim of this study was to determine the incidence and clinical ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31819a65fa
更新日期:2009-03-27 00:00:00
abstract::Since June 1979, percutaneous transluminal angioplasty (PTA) has been the procedure of choice for renal transplant artery stenosis (RTAS) at the Hospital of the University of Pennsylvania. Of 241 renal allograft recipients, 17 (7%) when studied by arteriogram because of suspected RTAS proved to have significant stenos...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198212000-00005
更新日期:1982-12-01 00:00:00
abstract::Comparative experiments were performed on 41 allogenic rat kidney transplants to determine the mitotic behaviour and proliferative metabolism (application of 3H-thymidine) in the first 6 days after recirculation. Three days after transplantation, DNA synthesis in the tubular epithelial cells of the cortex and the medu...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197807010-00003
更新日期:1978-07-01 00:00:00
abstract::In vitro pretreatment of islets of Langerhans with deoxyguanosine (dGuo) has been shown to be effective for the prolongation of islet allograft survival in rats. [This study evaluates the effect of pretreatment of islets with dGuo transplanted into CsA-treated recipients.] Transplantation of dGuo-treated islets from W...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199105000-00007
更新日期:1991-05-01 00:00:00
abstract::To determine the extent to which pretransplant immunity resulting from natural infection protects against cytomegalovirus (CMV) disease, we analyzed CMV serology on 153 kidney donor and recipient pairs and followed transplant patients to determine incidence and severity of CMV disease. The overall incidence of CMV dis...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198508000-00010
更新日期:1985-08-01 00:00:00
abstract:BACKGROUND:Previous studies have shown that posttransplant total lymphoid irradiation, anti-thymocyte globulin, and an intravenous donor blood cell infusion induce tolerance to ACI heart allografts in Lewis rat hosts. METHODS:In the current study, fresh ACI monocytes and dendritic cell precursors, derived from short-t...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199811270-00004
更新日期:1998-11-27 00:00:00
abstract:BACKGROUND:One of the earliest prerequisites for the development of inflammation after ischemia-reperfusion (I/R) is local chemokine expression. We recently demonstrated that apoptosis, characterized by intracellular caspase-activation, contributes to the development of inflammation after I/R. METHODS:The contribution...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200104150-00032
更新日期:2001-04-15 00:00:00
abstract:BACKGROUND:The novel agent sirolimus (SRL; Rapamune; rapamycin) inhibits the immune response by a mechanism distinct from those of calcineurin antagonists or antimetabolites. This randomized, controlled, multicenter, single blind, phase II trial examined the combination of SRL, steroids, and full versus reduced doses o...
journal_title:Transplantation
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1097/00007890-199911270-00016
更新日期:1999-11-27 00:00:00
abstract::We developed and applied a quantitative competitive polymerase chain reaction method to study the expression of various cytokine genes in Con A-stimulated murine splenocytes. This method relies on the use of competitive templates that differ from the target cytokine cDNA templates only by the introduction of a unique ...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:1994-07-15 00:00:00
abstract::Increased susceptibility to bacterial infection is a recognized side-effect of sirolimus treatment after transplantation, which could be caused by inhibition of neutrophil activation. Blood from 24 healthy subjects was equilibrated with 0 to 50 ng/mL sirolimus or 60 microg/mL propofol. Blood was also collected from 23...
journal_title:Transplantation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/01.TP.0000093995.08240.49
更新日期:2003-12-27 00:00:00
abstract:BACKGROUND:Ischemia-reperfusion (I/R) injury is the major cause of delayed renal graft function in kidney transplantation. To date, there are no effective therapeutic approaches for preventing I/R injury. We previously reported that treatment of animals with small interference RNA (siRNA) would prevent warm I/R injury ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000960
更新日期:2016-04-01 00:00:00
abstract:BACKGROUND:The timing of an acute rejection may have a variable impact on renal allograft survival. To determine whether the time of first acute transplant rejection (ATR) is an independent predictor of long-term allograft survival, we studied 31,600 first cadaveric renal transplants that were functional on the first t...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199705150-00013
更新日期:1997-05-15 00:00:00
abstract:BACKGROUND:Elastase released from activated neutrophils is an important mediator of inflammatory tissue damage. We investigated the effect of human neutrophil elastase (NE) inhibitor (ONO-5046) on reperfusion injury after pancreaticoduodenal transplantation in rats by measuring the expression of intercellular adhesion ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199806270-00014
更新日期:1998-06-27 00:00:00
abstract::During acute rejection of rat renal allografts, numerous activated monocytes accumulate in the vasculature of the graft. These monocytes seem to be involved in allograft destruction. Proinflammatory and effector functions of monocytes and macrophages can be down-regulated by peroxisome proliferators, which are probabl...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000052591.91653.52
更新日期:2003-03-15 00:00:00
abstract:BACKGROUND:Only four centers have reported their results with renal transplantation in human immunodeficiency virus (HIV)+ recipients on highly active antiretroviral therapy, and acute rejection (AR) rates have consistently ranged from 43% to 67%. METHODS:We examined the outcomes of eight adult HIV+ primary renal allo...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e318177884e
更新日期:2008-07-27 00:00:00
abstract:BACKGROUND:Obliterative bronchiolitis poses a primary obstacle for long-term survival of lung transplant recipients and manifests clinically as bronchiolitis obliterans syndrome (BOS). Establishing a molecular level screening method to detect BOS-related proteome changes before its diagnosis by forced expiratory volume...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e318224c109
更新日期:2011-08-27 00:00:00
abstract:BACKGROUND:Pancreatic islets are avascular immediately after transplantation and depend on revascularization. Recently, the authors found decreased vascular density in mouse islets 1 month after implantation into nondiabetic recipients. This study investigated possible differences in revascularization between islets im...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000052592.92966.FE
更新日期:2003-03-15 00:00:00
abstract::Cyclosporine (CsA) dose adjustment after renal transplantation is generally based on serum, plasma, or whole-blood trough level values. In the face of increased levels, the dosage is reduced in order to prevent CsA-induced nephrotoxicity. There is a paucity of data, however, on the kinetics of CsA in association with ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198512000-00006
更新日期:1985-12-01 00:00:00
abstract::By means of double diffusion in gel reactions, "heterophile" antibodies were demonstrated in human renal transplantation sera. Of thirty-two recipients of renal allografts, 12 (37 per cent) had antibodies to extract of bovine erythrocyte stromata, and 5 (19 per cent) of 26 recipients produced antibodies to extract of ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197501000-00004
更新日期:1975-01-01 00:00:00
abstract::Gliotoxin is an immunosuppressive secondary metabolite produced by several pathogenic fungi. It has previously been shown to prevent graft-versus-host disease in transplantation of allogeneic mouse bone marrow and to reduce the immunogenicity of human fetal pancreas. We here report on the effect of gliotoxin on the pr...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:1995-11-15 00:00:00
abstract::Liver-derived dendritic cell (DC) progenitors propagated in liquid culture in granulocyte/macrophage colony-stimulating factor exhibit low levels both of cell surface MHC class II antigens and of counter-receptors for CTLA-4/CD28. They fail to stimulate allogeneic T cells in mixed leukocyte cultures. To evaluate their...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:1995-12-15 00:00:00
abstract:BACKGROUND:Acute graft dysfunction caused by ischemia-reperfusion injury is recognized as a major source of morbidity and mortality following adult heart transplantation. The aim of this study was to determine whether treating the donor and recipient with cariporide, an inhibitor of the sodium-hydrogen exchanger, could...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000054619.13962.30
更新日期:2003-03-15 00:00:00
abstract::We describe four patients who suffered asystole, myocardial infarction (in two cases) and supraventricular tachycardia at the time of high-dose methylprednisolone infusion. One patient died during infusion. We measured the effects of methylprednisolone and placebo infusion on heart rate, blood pressure, and cardiac ou...
journal_title:Transplantation
pub_type: 临床试验,杂志文章
doi:10.1097/00007890-198304000-00017
更新日期:1983-04-01 00:00:00
abstract::IL-10 is a regulatory cytokine of both T cells and monocytes. We have investigated the ability of IL-10 to regulate responses to alloantigens in vitro and in vivo. Addition of IL-10 to mixed lymphocyte cultures profoundly decreased the proliferation and IL-2 production by donor B10.BR cells stimulated with CBA cells e...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:1994-12-15 00:00:00
abstract:OBJECTIVES:To retrospectively compare the accuracy of pretransplant panel of reactivity antibodies (PRA) and serum level of soluble CD30 (sCD30) in predicting early (<6 months) acute rejection (AR) in living-donor and deceased-donor kidney-transplant (KT) patients. METHODS:Pretransplant sera of 24 KT recipients were r...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:2005-05-15 00:00:00
abstract:BACKGROUND:The aim was to compare efficacy of multiple daily injections (MDI), continuous subcutaneous insulin infusion (CSII) and islet transplantation to reduce hypoglycemia and glycemic variability in type 1 diabetes subjects with severe hypoglycemia. METHODS:This was a within-subject, paired comparison of MDI and ...
journal_title:Transplantation
pub_type: 杂志文章,多中心研究
doi:10.1097/TP.0000000000001381
更新日期:2017-06-01 00:00:00
abstract:BACKGROUND:Little is known about associations between low physical activity (PA) and its correlates and outcomes in solid organ transplant recipients. This systematic review with meta-analysis examined correlates and outcomes associated with low PA (ie, not meeting individual study's definition of being physically acti...
journal_title:Transplantation
pub_type: 杂志文章,meta分析
doi:10.1097/TP.0000000000002543
更新日期:2019-04-01 00:00:00
abstract:BACKGROUND:It is unclear whether ischemic preconditioning (IPC) of solid organs induces remote IPC (RIPC) in donors after brain death (DBD). METHODS:Outcomes in kidney recipients from 163 DBD in two randomized trials of liver IPC (5 min=62 and 10 min=101) were obtained retrospectively from the Scientific Registry of T...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000436926.30897.56
更新日期:2014-02-15 00:00:00
abstract::Liver transplantation is currently the only established treatment of end-stage liver disease, but it is limited by a severe shortage of viable donor livers. Donors after cardiac death (DCD) are an untapped source that could significantly increase the pool of available livers. Preservation of these DCD livers by conven...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e318192df6b
更新日期:2009-01-27 00:00:00
abstract:BACKGROUND:Intracellular concentration of reactive oxygen species is held within tight physiological limits by enzymes with scavenging and repair functions. Under extreme conditions such as prolonged cold ischemia, these enzymes may be unable to adequately protect the organ, resulting in reperfusion injury that renders...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200209270-00013
更新日期:2002-09-27 00:00:00