Abstract:
PURPOSE:To investigate whether building a knowledge-based planning (KBP) model with prostate bed plans constructed from constrained hierarchical optimization (CHO) would result in more efficient model construction with more consistent output than a model built using plans from a traditional, trial-and-error-based optimization (TEO) technique. METHODS:Three KBP models were constructed from plans from subsets of 58 post-prostatectomy patients treated with intensity-modulated radiation therapy. TEO54 was built from 54 TEO plans, selected to represent typical clinical variations in target and organ-at-risk sizes and shapes. CHO30 and TEO30 were built from the same 30 patients populated with CHO and TEO plans, respectively. The three models were each applied to a new set of 18 patient scans and dose-volume histogram estimates (DVHEs) were generated for rectal and bladder walls and compared for each patient. RESULTS:CHO30 resulted in a significantly tighter range in DVHEs (P < 0.01) for both the rectal and bladder walls compared with either of the TEO models, indicating less uncertainty in the dose estimation. Plans resulting from KBP optimization using each model were very similar. CONCLUSION:Populating a KBP model with CHO data resulted in a high quality model. Since CHO plans can be generated automatically offline in a process that necessitates little to no user interaction, a CHO-KBP model can quickly adapt to changes in plan evaluation criteria or planning techniques without the need to wait to accrue sufficient numbers of clinical TEO plans. This may facilitate the use of KBP approaches for initial or ongoing quality assurance procedures and plan quality audits.
journal_name
Med Physjournal_title
Medical physicsauthors
Lin YH,Hong LX,Hunt MA,Berry SLdoi
10.1002/mp.13163subject
Has Abstractpub_date
2018-10-01 00:00:00pages
4364-4369issue
10eissn
0094-2405issn
2473-4209journal_volume
45pub_type
杂志文章相关文献
MEDICAL PHYSICS文献大全abstract:PURPOSE:We have investigated the dosimetric errors caused by the interplay between the motions of the LINAC and the tumor during the delivery of a volume modulated arc therapy treatment. This includes the development of an IMRT QA technique, applied here to evaluate RapidArc plans of varying complexity. METHODS:An IMR...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.3263614
更新日期:2010-01-01 00:00:00
abstract:PURPOSE:A commonly used beam quality index (Q) for high-energy photon beams is the tissue phantom ratio (TPR20,10) for a square field of 10 x 10 cm2 and SDD of 100 cm. On some specialized radiotherapy treatment equipment such a reference collimator setting is not achievable. Likewise a flat beam profile, not explicitly...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.3197062
更新日期:2009-09-01 00:00:00
abstract:PURPOSE:The purpose of this study was to assess, using an anthropomorphic digital phantom, the accuracy of algorithms in registering precontrast and contrast-enhanced computed tomography (CT) chest images for generation of iodine maps of the pulmonary parenchyma via temporal subtraction. MATERIALS AND METHODS:The XCAT...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1002/mp.13496
更新日期:2019-05-01 00:00:00
abstract:PURPOSE:Determine the effective point of measurement (EPOM) of 12 thimble ion chambers, including miniature chambers and three models widely used for clinical reference dosimetry. The EPOM is the point at which the measured dose would arise in the measurement medium in the absence of the probe: For cylindrical chambers...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.3266750
更新日期:2010-01-01 00:00:00
abstract::The Radiological Physics Center (RPC) developed two heterogeneous anthropomorphic quality assurance phantoms for use in verifying the accuracy of radiation delivery: one for intensity-modulated radiation therapy (IMRT) to the pelvis and the other for stereotactic body radiation therapy (SBRT) to the thorax. The purpos...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.2737158
更新日期:2007-06-01 00:00:00
abstract:PURPOSE:To overcome the problem of organ motion in intensity-modulated radiation therapy (IMRT), gated IMRT is often used for the treatment of lung cancer. In this study, the authors investigated the accuracy of the delivered monitor units (MUs) from each segment during gated IMRT using a two-dimensional detector array...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.3310806
更新日期:2010-03-01 00:00:00
abstract:PURPOSE:Radiopharmaceutical applications in nuclear medicine require a detailed dosimetry estimate of the radiation energy delivered to the human tissues. Over the past years, several publications addressed the problem of internal dose estimate in volumes of several sizes considering photon and electron sources. Most o...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.3242304
更新日期:2009-11-01 00:00:00
abstract::When parallel-plate chambers are used for dosimetry in electron fields, the AAPM dosimetry protocol recommends a value of 1.0 for the replacement correction factor, P(repl),pp,E, until further data become available. Here, P(repl),pp,E for five commercially available parallel-plate chambers was measured as a function o...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.596740
更新日期:1991-11-01 00:00:00
abstract::Subsecond single-slice, multi-slice or cone-beam spiral computed tomography (SSCT, MSCT, CBCT) offer great potential for improving heart imaging. Together with the newly developed phase-correlated cardiac reconstruction algorithms 180 degrees MCD and 180 degrees MCI [Med. Phys. 27, 1881-1902 (2000)] or related algorit...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.1487861
更新日期:2002-07-01 00:00:00
abstract:PURPOSE:Our aim was to compare different magnet arrangements for magnetic cell delivery to human lower leg arteries and investigate the theoretical targeting efficiency under realistic flow conditions as a possible treatment after angioplasty. Additionally the potential of scaling down or translating the magnetic actua...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.3593363
更新日期:2011-07-01 00:00:00
abstract:PURPOSE:To investigate the effect of energy (kVp) and filters (no filter, half Bowtie, and full Bowtie) on the dose response curves of the Gafchromic XRQA2 film and nanoDot optical stimulated luminescence dosimeters (OSLDs) in CBCT dose fields. To measure surface and internal doses received during x-ray volume imager (...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.4803466
更新日期:2013-06-01 00:00:00
abstract:PURPOSE:For the purpose of size-specific dose estimation, information regarding patient attenuation is required. The purpose of this work is to describe a method for measuring patient attenuation and expressing the results in terms of a water cylinder, with cross sectional area A(w), which would absorb the same average...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.4754303
更新日期:2012-11-01 00:00:00
abstract:PURPOSE:4d cone-beam computed tomography (CBCT) scans are usually reconstructed by extracting the motion information from the 2d projections or an external surrogate signal, and binning the individual projections into multiple respiratory phases. In this "after-the-fact" binning approach, however, projections are uneve...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.4817479
更新日期:2013-09-01 00:00:00
abstract:PURPOSE:Photon counting arrays (PCAs), capable of measuring the spectral information of individual x-ray photons and recording that information digitally, provide a number of advantages compared to conventional, energy-integrating active matrix flat-panel imagers - such as reducing the undesirable effects of electronic...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1002/mp.13128
更新日期:2018-10-01 00:00:00
abstract:PURPOSE:An optimized air ventilation system design for a treatment room in Heavy-ion Medical Facility is an important issue in the aspects of nuclear safety because the activated air produced in a treatment room can directly affect the medical staff and the general public in the radiation-free area. METHODS:Optimized ...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1002/mp.12914
更新日期:2018-06-01 00:00:00
abstract:PURPOSE:To characterize the radiation dose and three-dimensional (3D) imaging performance of a recently developed mobile, isocentric C-arm equipped with a flat-panel detector (FPD) for intraoperative cone-beam computed tomography (CBCT) (Cios Spin 3D, Siemens Healthineers) and to identify potential improvements in 3D i...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1002/mp.13983
更新日期:2020-03-01 00:00:00
abstract:PURPOSE:Transcranial focused ultrasound is an emerging therapeutic modality that can be used to perform noninvasive neurosurgical procedures. The current clinical transcranial phased array operates at 650 kHz, however the development of a higher frequency array would enable more precision, while reducing the risk of st...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.4829510
更新日期:2013-12-01 00:00:00
abstract:PURPOSE:A three-dimensional finite element analysis based canine heart model is introduced that would enable the assessment of cardiac function. METHODS:The three-dimensional canine heart model is based on the cardiac deformation and motion model obtained from the Cardiac Mechanics Research Group at UCSD. The canine h...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.3496326
更新日期:2010-11-01 00:00:00
abstract:PURPOSE:Carpal tunnel syndrome (CTS) is the common entrapment neuropathy that occurs due to compression of the median nerve at the wrist. Ultrasound images have been used to highlight anatomical variants of the median nerve, and CTS is thought to be associated to enlargement of the cross-sectional area (CSA) of the med...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.4767754
更新日期:2012-12-01 00:00:00
abstract::An important aspect of heavy charged particle radiotherapy is its ability to localize dose to the target volume. Current techniques generally employ beam delivery schemes which use range modulated beams in which the Bragg peak is spread out over a range of depths. The range modulation is constant over the entire beam ...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.595419
更新日期:1983-11-01 00:00:00
abstract::One limitation to the widespread implementation of Monte Carlo (MC) patient dose-calculation algorithms for radiotherapy is the lack of a general and accurate source model of the accelerator radiation source. Our aim in this work is to investigate the sensitivity of the photon-beam subsource distributions in a MC sour...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.1884385
更新日期:2005-04-01 00:00:00
abstract:PURPOSE:The authors use reduced-order constrained optimization (ROCO) to create clinically acceptable IMRT plans quickly and automatically for advanced lung cancer patients. Their new ROCO implementation works with the treatment planning system and full dose calculation used at Memorial Sloan-Kettering Cancer Center (M...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.3575416
更新日期:2011-05-01 00:00:00
abstract:PURPOSE:The purpose of this study is to evaluate the performance of a recently developed benchtop dual cone-beam computed tomography (CBCT) system with two orthogonally placed tube∕detector sets. METHODS:The benchtop dual CBCT system consists of two orthogonally placed 40 × 30 cm flat-panel detectors and two conventio...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.4788654
更新日期:2013-02-01 00:00:00
abstract:PURPOSE:To investigate the effect of the number of projection views on image noise in cone-beam CT (CBCT) with a flat-panel detector. METHODS:This fairly fundamental consideration in CBCT system design and operation was addressed experimentally (using a phantom presenting a uniform medium as well as statistically moti...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.4875688
更新日期:2014-06-01 00:00:00
abstract::Knowledge of the relative intensity distribution at the patient's surface is essential for pencil beam calculations of three-dimensional dose distributions for arbitrarily shaped electron beams. To calculate the relative intensity distribution, the spatial spread resulting from angular spread is convolved with a two-d...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.596252
更新日期:1988-03-01 00:00:00
abstract::A PTW Riga diamond detector and LiF TLDs have been evaluated for use in proton beam dosimetry by comparing results of proton beam calibration with those obtained using thimble ionization chambers. The thimble ionization chambers were calibrated in terms of exposure while the TLDs and diamond detector were calibrated i...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.597608
更新日期:1995-04-01 00:00:00
abstract:PURPOSE:Stereotactic body radiation therapy (SBRT) is a radiotherapy technique which uses high dose fractions with multiple coplanar and noncoplanar beams. Due to the large fractional doses, treatments are typically protracted and there are more fields than in conventional radiation treatment schemes. The effect of tem...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.4709605
更新日期:2012-06-01 00:00:00
abstract::Optical-resolution photoacoustic microscopy (OR-PAM) has been validated as a valuable tool for label-free volumetric microvascular imaging. More importantly, the advantages of noninvasiveness and measurement consistency suggest the use of OR-PAM for chronic imaging of intact microcirculation. Here, such chronic imagin...
journal_title:Medical physics
pub_type: 信件
doi:10.1118/1.3137572
更新日期:2009-06-01 00:00:00
abstract:PURPOSE:A prototype in-house program was developed to assist deriving image guidance shifts clinically using our 4DCT method for lung SBRT. METHODS:Our in-house prototype program was implemented in MATLAB. The 4D DICOM CT dataset of interest is imported by the program from AW and subsequently accepts input from the us...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.4735493
更新日期:2012-06-01 00:00:00
abstract::We present a theoretical development and experimental verification of a description of power loss and sample resistance for a lossy sample in a nuclear magnetic resonance radio frequency coil for a sample geometry where the eddy current streamlines are disrupted from their usually assumed circular paths. Specifically ...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.596336
更新日期:1989-09-01 00:00:00