Abstract:
:The aim of this study was to investigate the effects of probiotic and synbiotic supplementation on serum inflammatory markers, endotoxin, and anti-HSP70 in hemodialysis (HD) patients. This study was a randomized, double-blind, placebo-controlled trial. Seventy-five hemodialysis patients who met the inclusion and exclusion criteria were randomly assigned for 12 weeks to one of the three arms: synbiotics [n = 23; 15 g of prebiotics, 5 g of probiotic powder containing Lactobacillus acidophilus T16, Bifidobacterium bifidum BIA-6, Bifidobacterium lactis BIA-6, and Bifidobacterium longum LAF-5 (2.7 × 107 CFU/g each)], probiotics [n = 23; 5 g probiotics as in synbiotic group with 15 g of maltodextrin in the sachet as placebo], and placebo [n = 19; 20 g of maltodextrin in the sachet]. Blood and feces were collected at baseline and after intervention. Serum high sensitive C-reactive protein (hs-CRP), interleukin-6, endotoxin, and anti-heat shock protein 70 antibodies (anti-HSP70) were measured. The number of fecal colonies was determined using the plate-counting method. The mean serum level of hs-CRP, anti-HSP70, and endotoxin decreased significantly between groups (p = 0.007, p = 0.037, and p = 0.036, respectively). For the synbiotic group, the mean changes in hs-CRP and IL-6 were significantly lower than for the placebo (p < 0.001 and p < 0.001, respectively) and probiotic group (p = 0.011 and p = 0.008, respectively). Anti-HSP70 mean changes in the synbiotic and probiotic groups differed from the placebo group (p = 0.002 and p = 0.013, respectively). Administration of synbiotics was more effective than probiotics for improvement of inflammatory markers, endotoxin and anti-HSP70 serum levels. Trial registration number: IRCT2017041233393N1.
journal_name
Probiotics Antimicrob Proteinsjournal_title
Probiotics and antimicrobial proteinsauthors
Haghighat N,Mohammadshahi M,Shayanpour S,Haghighizadeh MHdoi
10.1007/s12602-018-9509-5subject
Has Abstractpub_date
2020-03-01 00:00:00pages
144-151issue
1eissn
1867-1306issn
1867-1314pii
10.1007/s12602-018-9509-5journal_volume
12pub_type
杂志文章abstract::To screen Bacillus clausii UBBC07 as a putative probiotic strain and to examine the protective effect of probiotic-B. clausii UBBC07 spore on uremia on rats induced by acetaminophen. In vitro tests performed to screen potential probiotic strains were gastric and bile acid resistance and ability to reduce pathogen adhe...
journal_title:Probiotics and antimicrobial proteins
pub_type: 杂志文章
doi:10.1007/s12602-019-09540-x
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abstract::The probiotic effect of Enterococcus faecalis-1 (isolated from healthy chickens) on growth performance, immune response, and modulation of the intestinal microbiota of broilers was assessed with a total of 100-day-old commercial Cobb chicks. The chicks were randomly divided into two equal groups. The control group rec...
journal_title:Probiotics and antimicrobial proteins
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abstract::Dental diseases are among the common health issues experienced around the world. Dental caries is one of the most predominant oral diseases worldwide. Major factors associated with caries development include poor oral hygiene, the content of specific carbohydrates in the diet, dental biofilm formation, the cariogenic ...
journal_title:Probiotics and antimicrobial proteins
pub_type: 杂志文章,评审
doi:10.1007/s12602-020-09652-9
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abstract::Lactic acid bacteria (LAB) are important microorganisms for the food industry due to their functional activity, as starters and potential probiotic strains. With that in mind, we explored the LAB diversity in raw buffalo milk, screening for novel potential probiotic strains. A total of 11 strains were identified by co...
journal_title:Probiotics and antimicrobial proteins
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doi:10.1007/s12602-020-09700-4
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abstract::The bactericidal activities of cattle and swine platelet microbicidal proteins (PMPs) with their comparison with human PMP were studied. Activities of PMP were tested against Bacillus subtilis, Bacillus cereus, Staphylococcus aureus, Staphylococcus epidermidis, Micrococcus lysodeikticus and Escherichia coli. B. subtil...
journal_title:Probiotics and antimicrobial proteins
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doi:10.1007/s12602-009-9016-9
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abstract::The administration of probiotics is a promising approach to reduce the prevalence of colon cancer, a multifactorial disease, with hereditary factors, as well as environmental lifestyle-related risk factors. Biogenic polyamines, putrescine, spermidine, and spermine are small cationic molecules with great roles in cell ...
journal_title:Probiotics and antimicrobial proteins
pub_type: 杂志文章
doi:10.1007/s12602-017-9253-2
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abstract::The study reports the growth, acidification and proteolysis of eight selected lactic acid bacteria in skim and soy milk. Angiotensin-converting enzyme inhibition and antimicrobial profiles of skim and soy milk fermented by the lactic acid bacteria were also determined. Among eight lactic cultures (S. thermophilus MD2,...
journal_title:Probiotics and antimicrobial proteins
pub_type: 杂志文章
doi:10.1007/s12602-017-9279-5
更新日期:2018-06-01 00:00:00
abstract::A specific strain of naturally occurring oral lactobacilli was isolated and identified based on morphological, biochemical, and 16S rRNA gene sequencing. The phylogenetic affiliation of the isolate confirmed that the NK02 strain had close association with the Lactobacillus salivarius. An effective mouthwash was develo...
journal_title:Probiotics and antimicrobial proteins
pub_type: 杂志文章,随机对照试验
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更新日期:2018-09-01 00:00:00
abstract::In this study, we have investigated the effect of probiotic Lactobacillus helveticus CD6 supplemented into simple laboratory fish feed (LFF) and complex, multi-ingredient market fish feed (MFF) on growth performance, antioxidant levels, and essential trace element absorption in goldfish (Carassius auratus). Twenty-fou...
journal_title:Probiotics and antimicrobial proteins
pub_type: 杂志文章
doi:10.1007/s12602-018-9428-5
更新日期:2019-06-01 00:00:00
abstract::Bacterial vaginosis (BV) is a commonly occurring vaginal infection that is associated with a variety of serious risks related to the reproductive health of women. Conventional antibiotic treatment for this condition is frequently ineffective because the antibiotics tend to inhibit healthy vaginal microflora along with...
journal_title:Probiotics and antimicrobial proteins
pub_type: 杂志文章
doi:10.1007/s12602-008-9003-6
更新日期:2009-01-20 00:00:00
abstract::The purpose of this article is to reveal the role of the lactic acid bacteria (LAB) in the beebread transformation/preservation, biochemical properties of 25 honeybee endogenous LAB strains, particularly: antifungal, proteolytic, and amylolytic activities putatively expressed in the beebread environment have been stud...
journal_title:Probiotics and antimicrobial proteins
pub_type: 杂志文章
doi:10.1007/s12602-017-9379-2
更新日期:2018-12-01 00:00:00
abstract::The present study was conducted to evaluate the effects of dietary supplementation of recombinant plectasin (Ple) on the growth performance, intestinal health, and serum immune parameters in broilers. A total of 288 1-day-old male broilers (Arbor Acres) were randomly allotted to four dietary treatments including the b...
journal_title:Probiotics and antimicrobial proteins
pub_type: 杂志文章
doi:10.1007/s12602-019-9515-2
更新日期:2020-03-01 00:00:00
abstract::Urinary tract infections (UTIs) are the most common infectious diseases in infants and the elderly; they are also the most common among nosocomial infections. The treatment of UTIs usually involves a short-term course of antibiotics. The purpose of this study was to identify the strains of lactic acid bacteria (LAB) t...
journal_title:Probiotics and antimicrobial proteins
pub_type: 杂志文章
doi:10.1007/s12602-017-9302-x
更新日期:2018-06-01 00:00:00
abstract::Emerging evidence suggests that probiotic therapy can play a role in the prevention and management of oral inflammatory diseases through immunomodulation and down-regulation of the inflammatory cascade. The aim of this in vitro study was to investigate the viability of human gingival fibroblasts (HGF) and its producti...
journal_title:Probiotics and antimicrobial proteins
pub_type: 杂志文章
doi:10.1007/s12602-016-9246-6
更新日期:2017-09-01 00:00:00
abstract::The effects of treatment with probiotics on the immunological and hematobiochemical changes in Trypanosoma brucei infection were investigated. Probiotic strains used are Bifidobacterium BB-12, Lactobacillus acidophilus LA-5, Lactobacillus delbrueckii LBY-27, Lactobacillus paracasei LC-01, and Streptococcus thermophilu...
journal_title:Probiotics and antimicrobial proteins
pub_type: 杂志文章
doi:10.1007/s12602-019-09592-z
更新日期:2020-09-01 00:00:00
abstract::Ovarian cancer (OC) is a leading cause of death among women worldwide. Various evidences suggest that oncomiRs and Toll-like receptor 4 (TLR-4) signaling pathways appear to be key players in the initiation and progression of OC. It seems there exists a continuous intercommunication between cancer cells and normal micr...
journal_title:Probiotics and antimicrobial proteins
pub_type: 杂志文章
doi:10.1007/s12602-019-09596-9
更新日期:2020-09-01 00:00:00
abstract::The effect of two putative probiotic strains, Lactobacillus rhamnosus BFE5264 and Lactobacillus plantarum NR74, on the control of cholesterol efflux in enterocytes was assessed by focusing on the promotion of ATP-binding cassette sub-family G members 5 and 8 (ABCG5 and ABCG8). Differentiated Caco-2 enterocytes were tr...
journal_title:Probiotics and antimicrobial proteins
pub_type: 杂志文章
doi:10.1007/s12602-011-9086-3
更新日期:2011-12-01 00:00:00
abstract::Probiotics offer numerous health benefits, including digestive and immune health. Improved digestive health is linked to a more efficient absorption of important nutrients from our diet. This review focused on the rationale of using the probiotic Bacillus coagulans GBI-30, 6086 to aid protein absorption and utilizatio...
journal_title:Probiotics and antimicrobial proteins
pub_type: 杂志文章,评审
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更新日期:2018-12-01 00:00:00
abstract::It is well established that bacteria communicate between each other by using different mechanisms; among which, quorum sensing (QS) is the best known one. Indeed, intra- and intercellular communications of microorganisms, as well as the regulation of metabolism and reaction to the surrounding environmental conditions,...
journal_title:Probiotics and antimicrobial proteins
pub_type: 杂志文章,评审
doi:10.1007/s12602-019-09555-4
更新日期:2020-03-01 00:00:00
abstract::Microbial diseases in fish, plant, animal and human are rising constantly; thus, discovery of their antidote is imperative. The use of antibiotic in aquaculture further compounds the problem by development of resistance and consequent consumer health risk by bio-magnification. Antimicrobial peptides (AMPs) have been h...
journal_title:Probiotics and antimicrobial proteins
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更新日期:2016-09-01 00:00:00
abstract::Bacillus cereus strain F, collected from relict permafrost located in Siberia, was analyzed for probiotic activity in the mouse Salmonella enterica model. Viable bacterial cells were found in frozen soils taken at Mammoth Mountain in Yakutia from a depth below the level of seasonal thawing. Geological data indicated t...
journal_title:Probiotics and antimicrobial proteins
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abstract::Alcoholic liver disease (ALD) encompasses a broad spectrum of disorders including steatosis, steatohepatitis, fibrosis, and cirrhosis. Despite intensive research in the last two decades, there is currently no Food and Drug Administration-approved therapy for treating ALD. Several studies have demonstrated the importan...
journal_title:Probiotics and antimicrobial proteins
pub_type: 杂志文章
doi:10.1007/s12602-018-9419-6
更新日期:2019-06-01 00:00:00
abstract::Food-grade yeasts make significant contributions to flavor development in fermented foods. Some yeast species also inhibit undesirable bacteria, yeasts and molds, apparently by producing antimicrobial compounds called mycocins. The aim of this study was to evaluate the ability of wild yeasts, isolated from raw milk an...
journal_title:Probiotics and antimicrobial proteins
pub_type: 杂志文章
doi:10.1007/s12602-012-9109-8
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abstract::Lactobacillus rhamnosus GG (L. rhamnosus GG) cells were encapsulated in buttermilk proteins by spray drying, alone (E), or with Agave tequilana fructans (CEF). Buttermilk proteins acted as a thermo-protector for the probiotic cells undergoing the spray-dried process. The addition of Agave fructans in CEF microcapsules...
journal_title:Probiotics and antimicrobial proteins
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abstract::The reduction in the use of antibiotics in the poultry industry has considerably increased the appearance of Clostridium perfringens (CP)-induced subclinical necrotic enteritis (SNE), forcing researchers to search alternatives to antibiotic growth promoters (AGP) like probiotics. This study aimed to investigate the ef...
journal_title:Probiotics and antimicrobial proteins
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更新日期:2020-09-01 00:00:00
abstract::The ability of a probiotic strain (Weissella cibaria) to adhere on tissue and the effect of its topical application in nipples of lactating cows on physicochemical characteristics of milk were evaluated. An ex vivo model was used to demonstrate the adhesion capacity of W. cibaria. Tissue samples were randomly distribu...
journal_title:Probiotics and antimicrobial proteins
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abstract::The present study was conducted to assess the effects of combined and singular dietary administration of PrimaLac® and potassium diformate (KDF) on growth performance, feed utilization, digestive enzymes activity, and some physiological parameters of rainbow trout (Oncorhynchus mykiss) juvenile. Three hundred sixty ra...
journal_title:Probiotics and antimicrobial proteins
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abstract::In this work, we performed the rational design of a cationic antimicrobial peptide, GIBIMPY4, using the software DEPRAMPs developed at the GIBIM research group. GIBIMPY4 has a length of 17 amino acids, it is amphipathic, its structure is α-helix and it has a net charge of (+5). Solid-phase peptide synthesis was perfor...
journal_title:Probiotics and antimicrobial proteins
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更新日期:2016-09-01 00:00:00
abstract::Unveiling and understanding differences in physiological features below the species level may serve as an essential fast-screening tool for selecting strains that can promote a specific probiotic effect. To study the intra-species diversity of Bacillus, a genus with a wide range of enzyme activities and specificity, 1...
journal_title:Probiotics and antimicrobial proteins
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abstract::Thaumatin-like proteins (TLPs) are the products of a large, highly complex gene family involved in host defense. TLPs also belong to the pathogenesis-related family 5 (PR-5) of plant defense proteins. Most TLPs exhibit potential antifungal activities, and their accumulation in the plant is related to many physiologica...
journal_title:Probiotics and antimicrobial proteins
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