Abstract：
:Emerging evidence suggests that probiotic therapy can play a role in the prevention and management of oral inflammatory diseases through immunomodulation and down-regulation of the inflammatory cascade. The aim of this in vitro study was to investigate the viability of human gingival fibroblasts (HGF) and its production of prostaglandin E2 (PGE2), when exposed to supernatants of two mixed Lactobacillus reuteri strains (ATCC PTA 5289 and DSM 17938). The experiments were conducted in the presence and absence of the pro-inflammatory cytokine IL-1β. L. reuteri strains were grown and the bacterial supernatant was collected. The cell-free supernatant was diluted to concentrations equivalent to the ones produced by 0.5 to 5.0 × 107 CFU/mL bacteria. Cell viability was assessed with the MTT colorimetric assay and the amount of PGE2 in the cell culture medium was determined using the monoclonal enzyme immune assay kits. Our findings showed that none of the L. reuteri supernatants were cytotoxic or affected the viability of HGF. The most concentrated bacterial supernatant stimulated the production of PGE2 by the gingival cells in a significant way in the presence of IL-1β (p < 0.05), suggesting that bacterial products secreted from L. reuteri might play a role in the resolution of inflammation in HGF. Thus, our findings justify further investigations on the influence of probiotic bacteria on gingival inflammatory reactions.
journal_name
Probiotics Antimicrob Proteinsjournal_title
Probiotics and antimicrobial proteinsauthors
A Castiblanco G,Yucel-Lindberg T,Roos S,Twetman Sdoi
10.1007/s12602-016-9246-6subject
Has Abstractpub_date
2017-09-01 00:00:00pages
278-283issue
3eissn
1867-1306issn
1867-1314pii
10.1007/s12602-016-9246-6journal_volume
9pub_type
杂志文章abstract：:In the present study, the ability of bovine lactoferrin hydrolysate (LfH) to disrupt the cytoplasmic membrane of Escherichia coli O157:H7 was investigated. Lactoferrin and LfH antimicrobial activities were compared against E. coli O157:H7 and E. coli O157:H7 spheroplasts. The effect of LfH on the cytoplasmic membrane ...
journal_title：Probiotics and antimicrobial proteins
pub_type： 杂志文章
doi：10.1007/s12602-010-9039-2
更新日期：2010-06-01 00:00:00
abstract：:A specific strain of naturally occurring oral lactobacilli was isolated and identified based on morphological, biochemical, and 16S rRNA gene sequencing. The phylogenetic affiliation of the isolate confirmed that the NK02 strain had close association with the Lactobacillus salivarius. An effective mouthwash was develo...
journal_title：Probiotics and antimicrobial proteins
pub_type： 杂志文章,随机对照试验
doi：10.1007/s12602-017-9296-4
更新日期：2018-09-01 00:00:00
abstract：:The bactericidal activities of cattle and swine platelet microbicidal proteins (PMPs) with their comparison with human PMP were studied. Activities of PMP were tested against Bacillus subtilis, Bacillus cereus, Staphylococcus aureus, Staphylococcus epidermidis, Micrococcus lysodeikticus and Escherichia coli. B. subtil...
journal_title：Probiotics and antimicrobial proteins
pub_type： 杂志文章
doi：10.1007/s12602-009-9016-9
更新日期：2009-12-01 00:00:00
abstract：:The fate of dietary protein in the gut is determined by microbial and host digestion and utilization. Fermentation of proteins generates bioactive molecules that have wide-ranging health effects on the host. The type of protein can affect amino acid absorption, with animal proteins generally being more efficiently abs...
journal_title：Probiotics and antimicrobial proteins
pub_type： 杂志文章
doi：10.1007/s12602-020-09656-5
更新日期：2020-12-01 00:00:00
abstract：:Alcoholic liver disease (ALD) encompasses a broad spectrum of disorders including steatosis, steatohepatitis, fibrosis, and cirrhosis. Despite intensive research in the last two decades, there is currently no Food and Drug Administration-approved therapy for treating ALD. Several studies have demonstrated the importan...
journal_title：Probiotics and antimicrobial proteins
pub_type： 杂志文章
doi：10.1007/s12602-018-9419-6
更新日期：2019-06-01 00:00:00
abstract：:The aim of this study was to investigate the effects of probiotic and synbiotic supplementation on serum inflammatory markers, endotoxin, and anti-HSP70 in hemodialysis (HD) patients. This study was a randomized, double-blind, placebo-controlled trial. Seventy-five hemodialysis patients who met the inclusion and exclu...
journal_title：Probiotics and antimicrobial proteins
pub_type： 杂志文章
doi：10.1007/s12602-018-9509-5
更新日期：2020-03-01 00:00:00
abstract：:The present study was conducted to evaluate the effects of dietary supplementation of recombinant plectasin (Ple) on the growth performance, intestinal health, and serum immune parameters in broilers. A total of 288 1-day-old male broilers (Arbor Acres) were randomly allotted to four dietary treatments including the b...
journal_title：Probiotics and antimicrobial proteins
pub_type： 杂志文章
doi：10.1007/s12602-019-9515-2
更新日期：2020-03-01 00:00:00
abstract：:Bacillus cereus strain F, collected from relict permafrost located in Siberia, was analyzed for probiotic activity in the mouse Salmonella enterica model. Viable bacterial cells were found in frozen soils taken at Mammoth Mountain in Yakutia from a depth below the level of seasonal thawing. Geological data indicated t...
journal_title：Probiotics and antimicrobial proteins
pub_type： 杂志文章
doi：10.1007/s12602-012-9105-z
更新日期：2012-09-01 00:00:00
abstract：:We studied as hydrogen peroxide, lactic acid, or surfactants from clinical isolates of vaginal lactobacilli and cell-free supernatants from probiotic strain LCR35 can influence on the sensitivity of opportunistic bacteria to antibiotics. We found that the most effective in increasing sensitivity to antibiotics were hy...
journal_title：Probiotics and antimicrobial proteins
pub_type： 杂志文章
doi：10.1007/s12602-016-9238-6
更新日期：2017-06-01 00:00:00
abstract：:Bacterial vaginosis (BV) is a commonly occurring vaginal infection that is associated with a variety of serious risks related to the reproductive health of women. Conventional antibiotic treatment for this condition is frequently ineffective because the antibiotics tend to inhibit healthy vaginal microflora along with...
journal_title：Probiotics and antimicrobial proteins
pub_type： 杂志文章
doi：10.1007/s12602-008-9003-6
更新日期：2009-01-20 00:00:00
abstract：:Three halotolerant lactobacilli (Lactobacillus plantarum, L. pentosus, and L. acidipiscis) isolated from a ripened Mexican tropical cheese (double cream Chiapas cheese) were evaluated as potential probiotics and compared with two commercial probiotic strains (L. casei Shirota and L. plantarum 299v) from human origin. ...
journal_title：Probiotics and antimicrobial proteins
pub_type： 杂志文章
doi：10.1007/s12602-013-9144-0
更新日期：2013-12-01 00:00:00
abstract：:Lipopolysaccharide (LPS) is a toxic and immunogenic agent for human. Additionally, LPS is a good target for some antimicrobial compounds, including antimicrobial peptides (AMPs). LPS-binding peptides (LBPs) can recognize and neutralize LPS. Rabbit and human cathelicidins are AMPs with LPS-binding activity. In this stu...
journal_title：Probiotics and antimicrobial proteins
pub_type： 杂志文章
doi：10.1007/s12602-020-09648-5
更新日期：2020-12-01 00:00:00
abstract：:Probiotics are a nutritional tool for disease prevention. It has been proposed that stimulation of immune response could affect the growth-promoting properties of antimicrobial growth promoters as well as the control of foodborne pathogens. The current study compares immune response in the blood of 280 non-infected an...
journal_title：Probiotics and antimicrobial proteins
pub_type： 杂志文章
doi：10.1007/s12602-010-9054-3
更新日期：2010-10-01 00:00:00
abstract：:In this work, we performed the rational design of a cationic antimicrobial peptide, GIBIMPY4, using the software DEPRAMPs developed at the GIBIM research group. GIBIMPY4 has a length of 17 amino acids, it is amphipathic, its structure is α-helix and it has a net charge of (+5). Solid-phase peptide synthesis was perfor...
journal_title：Probiotics and antimicrobial proteins
pub_type： 杂志文章
doi：10.1007/s12602-016-9219-9
更新日期：2016-09-01 00:00:00
abstract：:The effect of two putative probiotic strains, Lactobacillus rhamnosus BFE5264 and Lactobacillus plantarum NR74, on the control of cholesterol efflux in enterocytes was assessed by focusing on the promotion of ATP-binding cassette sub-family G members 5 and 8 (ABCG5 and ABCG8). Differentiated Caco-2 enterocytes were tr...
journal_title：Probiotics and antimicrobial proteins
pub_type： 杂志文章
doi：10.1007/s12602-011-9086-3
更新日期：2011-12-01 00:00:00
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journal_title：Probiotics and antimicrobial proteins
pub_type： 杂志文章
doi：10.1007/s12602-017-9302-x
更新日期：2018-06-01 00:00:00
abstract：:The purpose of this article is to reveal the role of the lactic acid bacteria (LAB) in the beebread transformation/preservation, biochemical properties of 25 honeybee endogenous LAB strains, particularly: antifungal, proteolytic, and amylolytic activities putatively expressed in the beebread environment have been stud...
journal_title：Probiotics and antimicrobial proteins
pub_type： 杂志文章
doi：10.1007/s12602-017-9379-2
更新日期：2018-12-01 00:00:00
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journal_title：Probiotics and antimicrobial proteins
pub_type： 杂志文章
doi：10.1007/s12602-018-9475-y
更新日期：2019-12-01 00:00:00
abstract：:Antimicrobial peptides (AMPs) are compounds widely distributed in nature that display activity against a broad spectrum of pathogens. Amphibian skin, as an organ rich in pharmacologically active peptides, appears to be an interesting source of novel AMPs. Aurein 1.2 (GLFDIIKKIAESF-NH2) is a short 13-residue antimicrob...
journal_title：Probiotics and antimicrobial proteins
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journal_title：Probiotics and antimicrobial proteins
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doi：10.1007/s12602-019-09556-3
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journal_title：Probiotics and antimicrobial proteins
pub_type： 杂志文章
doi：10.1007/s12602-019-09587-w
更新日期：2020-09-01 00:00:00
abstract：:The effect of a prebiotic (fructooligosaccharides) or a synbiotic components (prebiotic and probiotic) on the viability, proteolysis and antioxidant properties of probiotic and synbiotic yogurt during 28 days of storage at 4 °C has been investigated. Yogurt starters in conjunction with either probiotic bacteria Lactob...
journal_title：Probiotics and antimicrobial proteins
pub_type： 杂志文章
doi：10.1007/s12602-012-9099-6
更新日期：2012-06-01 00:00:00
abstract：:A total of 145 lactic acid bacteria isolated from a variety of Turkish red wines during malolactic fermentation were screened to find bacteriocin-producing strains. Among them, 14 isolates of Enterococcus faecium were identified to produce bacteriocins. PCR screening revealed that some isolates harbored entA and entB ...
journal_title：Probiotics and antimicrobial proteins
pub_type： 杂志文章
doi：10.1007/s12602-016-9222-1
更新日期：2016-09-01 00:00:00
abstract：:IL-17A is a cytokine which is produced by several immune and non-immune cells. The cytokine plays dual roles from protection from microbes and protection from pro-inflammatory based diseases to induction of the pro-inflammatory based diseases. The main mechanisms which lead to the controversial roles of IL-17A are yet...
journal_title：Probiotics and antimicrobial proteins
pub_type： 杂志文章,评审
doi：10.1007/s12602-017-9329-z
更新日期：2019-03-01 00:00:00
abstract：:It is well established that bacteria communicate between each other by using different mechanisms; among which, quorum sensing (QS) is the best known one. Indeed, intra- and intercellular communications of microorganisms, as well as the regulation of metabolism and reaction to the surrounding environmental conditions,...
journal_title：Probiotics and antimicrobial proteins
pub_type： 杂志文章,评审
doi：10.1007/s12602-019-09555-4
更新日期：2020-03-01 00:00:00
abstract：:Hepcidins are small cysteine-rich antimicrobial peptides that play an important role in fish immunity against pathogens. Most fish species have two or more hepcidin homologs that have distinct functions. This study investigated the immune functions of mudskipper (Boleophthalmus pectinirostris) hepcidin-1 (BpHep-1) and...
journal_title：Probiotics and antimicrobial proteins
pub_type： 杂志文章
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更新日期：2018-06-01 00:00:00
abstract：:Newly hatched broiler chickens are the most susceptible to Salmonella infections, especially during the first 24 h. At this age, the gut microbiome is not fully developed and offers little protection in the form of competitive exclusion. In this study, one group of newly hatched, Salmonella-free broilers were colonise...
journal_title：Probiotics and antimicrobial proteins
pub_type： 杂志文章
doi：10.1007/s12602-019-09593-y
更新日期：2020-09-01 00:00:00
abstract：:The wide spread of antimicrobial resistance has urged the need of alternative therapeutic approach. In this context, probiotic lactobacilli have been reported for the prevention and treatment of many gastrointestinal and urogenital infections. However, very little is known about their antagonistic activity against ski...
journal_title：Probiotics and antimicrobial proteins
pub_type： 杂志文章
doi：10.1007/s12602-013-9137-z
更新日期：2013-09-01 00:00:00
abstract：:The administration of probiotics is a promising approach to reduce the prevalence of colon cancer, a multifactorial disease, with hereditary factors, as well as environmental lifestyle-related risk factors. Biogenic polyamines, putrescine, spermidine, and spermine are small cationic molecules with great roles in cell ...
journal_title：Probiotics and antimicrobial proteins
pub_type： 杂志文章
doi：10.1007/s12602-017-9253-2
更新日期：2017-06-01 00:00:00
abstract：:Present study is intended to assess the probiotic properties of Bacillus spp. isolated from idli batter, a traditional fermented food of Southern India and Sri Lanka. A total of 32 isolates were screened for potential pathogenic behaviour through haemolysis assay, DNase activity and antibiotics sensitivity. Two of the...
journal_title：Probiotics and antimicrobial proteins
pub_type： 杂志文章
doi：10.1007/s12602-020-09650-x
更新日期：2020-12-01 00:00:00
