Abstract:
:The wide spread of antimicrobial resistance has urged the need of alternative therapeutic approach. In this context, probiotic lactobacilli have been reported for the prevention and treatment of many gastrointestinal and urogenital infections. However, very little is known about their antagonistic activity against skin pathogens. Accordingly, the present study aimed to investigate the potential of lactobacilli to interfere with pathogenesis features of two antibiotic-resistant skin pathogens, namely methicillin-resistant Staphylococcus aureus and multiple-resistant Pseudomonas aeruginosa. A total of 49 lactobacilli were recovered, identified and tested for their antagonistic activities against the aforementioned pathogens. Of these, eight isolates were capable of blocking the adherence of pathogens to mammalian cells independent of the skin pathogen tested or model adopted. Moreover, three Lactobacillus isolates (LRA4, LC2 and LR5) effectively prevented the pathogen internalization into epithelial cells in addition to potentiating phagocyte-mediated pathogen killing. Interestingly, the lactobacilli LC2, LF9 and LRA4 markedly inhibited the growth of P. aeruginosa and S. aureus isolates in coculture experiments. Besides, the lactobacilli LRA4, LC2, LR5 and LF9 have counteracted pathogen cytotoxicity. Taken together, the present study revealed some inhibitory activities of lactobacilli against two antibiotic-resistant skin pathogens. Moreover, it revealed two lactobacilli, namely LC2 and LRA4, with antagonistic capacity against different virulence determinants of skin pathogens. These lactobacilli are considered promising probiotic candidates that may represent an alternative therapeutic approach for skin infections.
journal_name
Probiotics Antimicrob Proteinsjournal_title
Probiotics and antimicrobial proteinsauthors
Hafez MM,Maghrabi IA,Zaki NMdoi
10.1007/s12602-013-9137-zsubject
Has Abstractpub_date
2013-09-01 00:00:00pages
216-26issue
3eissn
1867-1306issn
1867-1314pii
10.1007/s12602-013-9137-zjournal_volume
5pub_type
杂志文章abstract::Urinary tract infections (UTIs) are the most common infectious diseases in infants and the elderly; they are also the most common among nosocomial infections. The treatment of UTIs usually involves a short-term course of antibiotics. The purpose of this study was to identify the strains of lactic acid bacteria (LAB) t...
journal_title:Probiotics and antimicrobial proteins
pub_type: 杂志文章
doi:10.1007/s12602-017-9302-x
更新日期:2018-06-01 00:00:00
abstract::In this paper, the antibacterial effects of the Bacillus amyloliquefaciens-produced bacteriocin subtilosin, both alone and in combination with curcumin, ε-poly-L-lysine (poly-lysine), or zinc lactate, were examined against Listeria monocytogenes. Results indicated that subtilosin inhibits both of the studied bacterial...
journal_title:Probiotics and antimicrobial proteins
pub_type: 杂志文章
doi:10.1007/s12602-010-9042-7
更新日期:2010-12-01 00:00:00
abstract::In the present study, the ability of bovine lactoferrin hydrolysate (LfH) to disrupt the cytoplasmic membrane of Escherichia coli O157:H7 was investigated. Lactoferrin and LfH antimicrobial activities were compared against E. coli O157:H7 and E. coli O157:H7 spheroplasts. The effect of LfH on the cytoplasmic membrane ...
journal_title:Probiotics and antimicrobial proteins
pub_type: 杂志文章
doi:10.1007/s12602-010-9039-2
更新日期:2010-06-01 00:00:00
abstract::The ability of a probiotic strain (Weissella cibaria) to adhere on tissue and the effect of its topical application in nipples of lactating cows on physicochemical characteristics of milk were evaluated. An ex vivo model was used to demonstrate the adhesion capacity of W. cibaria. Tissue samples were randomly distribu...
journal_title:Probiotics and antimicrobial proteins
pub_type: 杂志文章
doi:10.1007/s12602-018-9481-0
更新日期:2019-12-01 00:00:00
abstract::The fate of dietary protein in the gut is determined by microbial and host digestion and utilization. Fermentation of proteins generates bioactive molecules that have wide-ranging health effects on the host. The type of protein can affect amino acid absorption, with animal proteins generally being more efficiently abs...
journal_title:Probiotics and antimicrobial proteins
pub_type: 杂志文章
doi:10.1007/s12602-020-09656-5
更新日期:2020-12-01 00:00:00
abstract::Twenty-nine Lactobacillus plantarum strains isolated from different types of Polish regional cheeses (Oscypek and Korycinski) were assessed for selected probiotic properties and anti-staphylococcal activity. Most of the tested L. plantarum strains were considered safe. Whole bacterial cultures (WBC) and cell-free supe...
journal_title:Probiotics and antimicrobial proteins
pub_type: 杂志文章
doi:10.1007/s12602-019-09587-w
更新日期:2020-09-01 00:00:00
abstract::The probiotic effect of Enterococcus faecalis-1 (isolated from healthy chickens) on growth performance, immune response, and modulation of the intestinal microbiota of broilers was assessed with a total of 100-day-old commercial Cobb chicks. The chicks were randomly divided into two equal groups. The control group rec...
journal_title:Probiotics and antimicrobial proteins
pub_type: 杂志文章
doi:10.1007/s12602-019-09557-2
更新日期:2020-06-01 00:00:00
abstract::The purpose of this article is to reveal the role of the lactic acid bacteria (LAB) in the beebread transformation/preservation, biochemical properties of 25 honeybee endogenous LAB strains, particularly: antifungal, proteolytic, and amylolytic activities putatively expressed in the beebread environment have been stud...
journal_title:Probiotics and antimicrobial proteins
pub_type: 杂志文章
doi:10.1007/s12602-017-9379-2
更新日期:2018-12-01 00:00:00
abstract::The present study was conducted to investigate the effects of probiotic and encapsulated Lactobacillus bulgaricus on hematological and immunological factors after lead toxicity in rainbow trout (Oncorhynchus mykiss). Two hundred and forty fish weighing about 16 ± 3.8 g were divided randomly in to four groups including...
journal_title:Probiotics and antimicrobial proteins
pub_type: 杂志文章
doi:10.1007/s12602-019-09544-7
更新日期:2020-06-01 00:00:00
abstract::Lactiplantibacillus plantarum subsp. plantarum 299v (L. plantarum 299v) is one of the most important probiotic strains in animal health, but the molecular mechanisms of how it exerts health benefits remain unclear. The purpose of this study was to explore the changes in miRNA expression profiles in the intestinal tiss...
journal_title:Probiotics and antimicrobial proteins
pub_type: 杂志文章
doi:10.1007/s12602-021-09743-1
更新日期:2021-01-24 00:00:00
abstract::Probiotics offer numerous health benefits, including digestive and immune health. Improved digestive health is linked to a more efficient absorption of important nutrients from our diet. This review focused on the rationale of using the probiotic Bacillus coagulans GBI-30, 6086 to aid protein absorption and utilizatio...
journal_title:Probiotics and antimicrobial proteins
pub_type: 杂志文章,评审
doi:10.1007/s12602-017-9354-y
更新日期:2018-12-01 00:00:00
abstract::We studied as hydrogen peroxide, lactic acid, or surfactants from clinical isolates of vaginal lactobacilli and cell-free supernatants from probiotic strain LCR35 can influence on the sensitivity of opportunistic bacteria to antibiotics. We found that the most effective in increasing sensitivity to antibiotics were hy...
journal_title:Probiotics and antimicrobial proteins
pub_type: 杂志文章
doi:10.1007/s12602-016-9238-6
更新日期:2017-06-01 00:00:00
abstract::The administration of probiotics is a promising approach to reduce the prevalence of colon cancer, a multifactorial disease, with hereditary factors, as well as environmental lifestyle-related risk factors. Biogenic polyamines, putrescine, spermidine, and spermine are small cationic molecules with great roles in cell ...
journal_title:Probiotics and antimicrobial proteins
pub_type: 杂志文章
doi:10.1007/s12602-017-9253-2
更新日期:2017-06-01 00:00:00
abstract::The effect of dietary supplementation with a synbiotic mixture of galacto-oligosaccharides (GOS) and Bacillus spp. was examined in Caspian salmon, Salmo trutta caspius (Kessler, 1877) fingerlings. Caspian salmon fed with the synbiotic diet had significantly higher weight gain rate, protein efficiency ratio, and surviv...
journal_title:Probiotics and antimicrobial proteins
pub_type: 杂志文章
doi:10.1007/s12602-018-9498-4
更新日期:2019-12-01 00:00:00
abstract::In this work, we performed the rational design of a cationic antimicrobial peptide, GIBIMPY4, using the software DEPRAMPs developed at the GIBIM research group. GIBIMPY4 has a length of 17 amino acids, it is amphipathic, its structure is α-helix and it has a net charge of (+5). Solid-phase peptide synthesis was perfor...
journal_title:Probiotics and antimicrobial proteins
pub_type: 杂志文章
doi:10.1007/s12602-016-9219-9
更新日期:2016-09-01 00:00:00
abstract::Oxidative stress plays an important role in exacerbating neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and Huntington's disease. In a previous study, Lactobacillus plantarum 200655 was shown to possess probiotic and antioxidant potential. The current study aimed to evaluate the neuropro...
journal_title:Probiotics and antimicrobial proteins
pub_type: 杂志文章
doi:10.1007/s12602-020-09740-w
更新日期:2021-01-17 00:00:00
abstract::Hepcidins are small cysteine-rich antimicrobial peptides that play an important role in fish immunity against pathogens. Most fish species have two or more hepcidin homologs that have distinct functions. This study investigated the immune functions of mudskipper (Boleophthalmus pectinirostris) hepcidin-1 (BpHep-1) and...
journal_title:Probiotics and antimicrobial proteins
pub_type: 杂志文章
doi:10.1007/s12602-017-9352-0
更新日期:2018-06-01 00:00:00
abstract::The reduction in the use of antibiotics in the poultry industry has considerably increased the appearance of Clostridium perfringens (CP)-induced subclinical necrotic enteritis (SNE), forcing researchers to search alternatives to antibiotic growth promoters (AGP) like probiotics. This study aimed to investigate the ef...
journal_title:Probiotics and antimicrobial proteins
pub_type: 杂志文章
doi:10.1007/s12602-019-09597-8
更新日期:2020-09-01 00:00:00
abstract::The effect of two putative probiotic strains, Lactobacillus rhamnosus BFE5264 and Lactobacillus plantarum NR74, on the control of cholesterol efflux in enterocytes was assessed by focusing on the promotion of ATP-binding cassette sub-family G members 5 and 8 (ABCG5 and ABCG8). Differentiated Caco-2 enterocytes were tr...
journal_title:Probiotics and antimicrobial proteins
pub_type: 杂志文章
doi:10.1007/s12602-011-9086-3
更新日期:2011-12-01 00:00:00
abstract::It is well established that bacteria communicate between each other by using different mechanisms; among which, quorum sensing (QS) is the best known one. Indeed, intra- and intercellular communications of microorganisms, as well as the regulation of metabolism and reaction to the surrounding environmental conditions,...
journal_title:Probiotics and antimicrobial proteins
pub_type: 杂志文章,评审
doi:10.1007/s12602-019-09555-4
更新日期:2020-03-01 00:00:00
abstract::Lactobacillus plantarum ST8Sh, isolated from Bulgarian salami "shpek" and previously characterized as bacteriocin producer, was evaluated for its beneficial properties. Based on the PCR analysis, Lb. plantarum ST8Sh was shown to host a gene related to the production of adhesion proteins such as Mab, Mub, EF, and PrgB....
journal_title:Probiotics and antimicrobial proteins
pub_type: 杂志文章
doi:10.1007/s12602-016-9245-7
更新日期:2017-06-01 00:00:00
abstract::Axone (Akhuni) is a homemade synbiotic (Nagamese fermented soybean product) served as side dish in North Eastern India. In this study, effects of Axone feeding on growth, weight gain, sexual maturity and egg production on Vanaraja birds (a strain of poultry bird developed at PDP Hyderabad for villages and backyard pou...
journal_title:Probiotics and antimicrobial proteins
pub_type: 杂志文章
doi:10.1007/s12602-014-9160-8
更新日期:2014-06-01 00:00:00
abstract::The bactericidal activities of cattle and swine platelet microbicidal proteins (PMPs) with their comparison with human PMP were studied. Activities of PMP were tested against Bacillus subtilis, Bacillus cereus, Staphylococcus aureus, Staphylococcus epidermidis, Micrococcus lysodeikticus and Escherichia coli. B. subtil...
journal_title:Probiotics and antimicrobial proteins
pub_type: 杂志文章
doi:10.1007/s12602-009-9016-9
更新日期:2009-12-01 00:00:00
abstract::The original version of this article contained mistakes, and the authors would like to correct them. The correct details are given below. ...
journal_title:Probiotics and antimicrobial proteins
pub_type: 已发布勘误
doi:10.1007/s12602-018-9412-0
更新日期:2019-06-01 00:00:00
abstract::Lactic acid bacteria (LAB) are important microorganisms for the food industry due to their functional activity, as starters and potential probiotic strains. With that in mind, we explored the LAB diversity in raw buffalo milk, screening for novel potential probiotic strains. A total of 11 strains were identified by co...
journal_title:Probiotics and antimicrobial proteins
pub_type: 杂志文章
doi:10.1007/s12602-020-09700-4
更新日期:2020-08-23 00:00:00
abstract::Artisanal fermented beverages have been associated with beneficial effects for a long time. In Mexico, there are a wide variety of artisanal fermented beverages such as Tepache, where the fermentation is initiated by the addition of grains of a polysaccharide-containing biofilm matrix formed by a symbiotic association...
journal_title:Probiotics and antimicrobial proteins
pub_type: 杂志文章
doi:10.1007/s12602-018-9471-2
更新日期:2019-09-01 00:00:00
abstract::Food-grade yeasts make significant contributions to flavor development in fermented foods. Some yeast species also inhibit undesirable bacteria, yeasts and molds, apparently by producing antimicrobial compounds called mycocins. The aim of this study was to evaluate the ability of wild yeasts, isolated from raw milk an...
journal_title:Probiotics and antimicrobial proteins
pub_type: 杂志文章
doi:10.1007/s12602-012-9109-8
更新日期:2013-03-01 00:00:00
abstract::The present study was conducted to evaluate the effects of dietary supplementation of recombinant plectasin (Ple) on the growth performance, intestinal health, and serum immune parameters in broilers. A total of 288 1-day-old male broilers (Arbor Acres) were randomly allotted to four dietary treatments including the b...
journal_title:Probiotics and antimicrobial proteins
pub_type: 杂志文章
doi:10.1007/s12602-019-9515-2
更新日期:2020-03-01 00:00:00
abstract::The effect of a prebiotic (fructooligosaccharides) or a synbiotic components (prebiotic and probiotic) on the viability, proteolysis and antioxidant properties of probiotic and synbiotic yogurt during 28 days of storage at 4 °C has been investigated. Yogurt starters in conjunction with either probiotic bacteria Lactob...
journal_title:Probiotics and antimicrobial proteins
pub_type: 杂志文章
doi:10.1007/s12602-012-9099-6
更新日期:2012-06-01 00:00:00
abstract::A total of 32 lactic acid bacteria (LAB) were isolated from Khanom-jeen, a Thai traditional fermented rice noodle. They belonged to the genus Leuconostoc (Ln), Lactobacillus (Lb), Enterococcus (E), Lactococcus (Lc), and Weissella (W), based on their phenotypic characteristics and 16S rRNA gene sequence analyses. The s...
journal_title:Probiotics and antimicrobial proteins
pub_type: 杂志文章
doi:10.1007/s12602-018-9385-z
更新日期:2019-03-01 00:00:00