Abstract:
:Oxidative stress plays an important role in exacerbating neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and Huntington's disease. In a previous study, Lactobacillus plantarum 200655 was shown to possess probiotic and antioxidant potential. The current study aimed to evaluate the neuroprotective effects of heat-killed L. plantarum 200655. We incubated intestinal cells (HT-29) with heat-killed L. plantarum 200655 in a conditioned medium (CM) and found that the brain-derived neurotrophic factor (BDNF) mRNA level was elevated in the HT-29 cells and the CM contained high concentrations of BDNF. The CM protected neuroblastoma cells (SH-SY5Y) from hydrogen peroxide (H2O2)-induced toxicity. Moreover, the CM increased BDNF and tyrosine hydroxylase (TH) mRNA expression and significantly reduced the apoptosis-related Bax/Bcl-2 ratio in H2O2-treated SH-SY5Y cells. At the protein level, the CM resulted in downregulation of caspase-3. These results indicate that L. plantarum 200655 might be used as a prophylactic functional ingredient to prevent neurodegenerative disease.
journal_name
Probiotics Antimicrob Proteinsjournal_title
Probiotics and antimicrobial proteinsauthors
Cheon MJ,Lee NK,Paik HDdoi
10.1007/s12602-020-09740-wsubject
Has Abstractpub_date
2021-01-17 00:00:00eissn
1867-1306issn
1867-1314pii
10.1007/s12602-020-09740-wpub_type
杂志文章abstract::Antimicrobial peptides (AMPs) are compounds widely distributed in nature that display activity against a broad spectrum of pathogens. Amphibian skin, as an organ rich in pharmacologically active peptides, appears to be an interesting source of novel AMPs. Aurein 1.2 (GLFDIIKKIAESF-NH2) is a short 13-residue antimicrob...
journal_title:Probiotics and antimicrobial proteins
pub_type: 杂志文章
doi:10.1007/s12602-018-9501-0
更新日期:2019-09-01 00:00:00
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journal_title:Probiotics and antimicrobial proteins
pub_type: 杂志文章
doi:10.1007/s12602-010-9042-7
更新日期:2010-12-01 00:00:00
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journal_title:Probiotics and antimicrobial proteins
pub_type: 杂志文章
doi:10.1007/s12602-018-9462-3
更新日期:2019-09-01 00:00:00
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journal_title:Probiotics and antimicrobial proteins
pub_type: 杂志文章
doi:10.1007/s12602-016-9219-9
更新日期:2016-09-01 00:00:00
abstract::A total of 145 lactic acid bacteria isolated from a variety of Turkish red wines during malolactic fermentation were screened to find bacteriocin-producing strains. Among them, 14 isolates of Enterococcus faecium were identified to produce bacteriocins. PCR screening revealed that some isolates harbored entA and entB ...
journal_title:Probiotics and antimicrobial proteins
pub_type: 杂志文章
doi:10.1007/s12602-016-9222-1
更新日期:2016-09-01 00:00:00
abstract::Artisanal fermented beverages have been associated with beneficial effects for a long time. In Mexico, there are a wide variety of artisanal fermented beverages such as Tepache, where the fermentation is initiated by the addition of grains of a polysaccharide-containing biofilm matrix formed by a symbiotic association...
journal_title:Probiotics and antimicrobial proteins
pub_type: 杂志文章
doi:10.1007/s12602-018-9471-2
更新日期:2019-09-01 00:00:00
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journal_title:Probiotics and antimicrobial proteins
pub_type: 杂志文章
doi:10.1007/s12602-019-09596-9
更新日期:2020-09-01 00:00:00
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journal_title:Probiotics and antimicrobial proteins
pub_type: 杂志文章
doi:10.1007/s12602-009-9021-z
更新日期:2010-03-01 00:00:00
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journal_title:Probiotics and antimicrobial proteins
pub_type: 杂志文章
doi:10.1007/s12602-016-9238-6
更新日期:2017-06-01 00:00:00
abstract::The original version of this article contained mistakes, and the authors would like to correct them. The correct details are given below. ...
journal_title:Probiotics and antimicrobial proteins
pub_type: 已发布勘误
doi:10.1007/s12602-018-9412-0
更新日期:2019-06-01 00:00:00
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journal_title:Probiotics and antimicrobial proteins
pub_type: 杂志文章
doi:10.1007/s12602-018-9509-5
更新日期:2020-03-01 00:00:00
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journal_title:Probiotics and antimicrobial proteins
pub_type: 杂志文章
doi:10.1007/s12602-009-9024-9
更新日期:2010-03-01 00:00:00
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journal_title:Probiotics and antimicrobial proteins
pub_type: 杂志文章
doi:10.1007/s12602-014-9160-8
更新日期:2014-06-01 00:00:00
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journal_title:Probiotics and antimicrobial proteins
pub_type: 杂志文章
doi:10.1007/s12602-018-9475-y
更新日期:2019-12-01 00:00:00
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journal_title:Probiotics and antimicrobial proteins
pub_type: 杂志文章
doi:10.1007/s12602-019-09576-z
更新日期:2020-06-01 00:00:00
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journal_title:Probiotics and antimicrobial proteins
pub_type: 杂志文章
doi:10.1007/s12602-018-9422-y
更新日期:2019-03-01 00:00:00
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journal_title:Probiotics and antimicrobial proteins
pub_type: 杂志文章
doi:10.1007/s12602-018-9481-0
更新日期:2019-12-01 00:00:00
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journal_title:Probiotics and antimicrobial proteins
pub_type: 杂志文章
doi:10.1007/s12602-011-9086-3
更新日期:2011-12-01 00:00:00
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journal_title:Probiotics and antimicrobial proteins
pub_type: 杂志文章
doi:10.1007/s12602-019-09540-x
更新日期:2020-03-01 00:00:00
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journal_title:Probiotics and antimicrobial proteins
pub_type: 杂志文章
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更新日期:2013-09-01 00:00:00
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journal_title:Probiotics and antimicrobial proteins
pub_type: 杂志文章
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更新日期:2009-01-20 00:00:00
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journal_title:Probiotics and antimicrobial proteins
pub_type: 杂志文章
doi:10.1007/s12602-019-09557-2
更新日期:2020-06-01 00:00:00
abstract::The aim of this work is to characterize the potential probiotic properties of 14 antifungal Lactobacillus strains isolated from traditional fermenting Moroccan green olives. The molecular identification of strains indicated that they are composed of five Lactobacillus brevis, two Lactobacillus pentosus, and seven Lact...
journal_title:Probiotics and antimicrobial proteins
pub_type: 杂志文章
doi:10.1007/s12602-019-09543-8
更新日期:2020-06-01 00:00:00
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journal_title:Probiotics and antimicrobial proteins
pub_type: 杂志文章
doi:10.1007/s12602-017-9253-2
更新日期:2017-06-01 00:00:00
abstract::Alcoholic liver disease (ALD) encompasses a broad spectrum of disorders including steatosis, steatohepatitis, fibrosis, and cirrhosis. Despite intensive research in the last two decades, there is currently no Food and Drug Administration-approved therapy for treating ALD. Several studies have demonstrated the importan...
journal_title:Probiotics and antimicrobial proteins
pub_type: 杂志文章
doi:10.1007/s12602-018-9419-6
更新日期:2019-06-01 00:00:00
abstract::Three halotolerant lactobacilli (Lactobacillus plantarum, L. pentosus, and L. acidipiscis) isolated from a ripened Mexican tropical cheese (double cream Chiapas cheese) were evaluated as potential probiotics and compared with two commercial probiotic strains (L. casei Shirota and L. plantarum 299v) from human origin. ...
journal_title:Probiotics and antimicrobial proteins
pub_type: 杂志文章
doi:10.1007/s12602-013-9144-0
更新日期:2013-12-01 00:00:00
abstract::Oysters hold a unique place within the field of aquaculture as one of the only organisms that is regularly shipped live to be consumed whole and raw. The microbiota of oysters is capable of adapting to a wide range of environmental conditions within their dynamic estuarine environments; however, human aquaculture prac...
journal_title:Probiotics and antimicrobial proteins
pub_type: 杂志文章,评审
doi:10.1007/s12602-019-09629-3
更新日期:2020-06-01 00:00:00
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journal_title:Probiotics and antimicrobial proteins
pub_type: 杂志文章
doi:10.1007/s12602-016-9246-6
更新日期:2017-09-01 00:00:00
abstract::Probiotics are a nutritional tool for disease prevention. It has been proposed that stimulation of immune response could affect the growth-promoting properties of antimicrobial growth promoters as well as the control of foodborne pathogens. The current study compares immune response in the blood of 280 non-infected an...
journal_title:Probiotics and antimicrobial proteins
pub_type: 杂志文章
doi:10.1007/s12602-010-9054-3
更新日期:2010-10-01 00:00:00
abstract::The effect of a prebiotic (fructooligosaccharides) or a synbiotic components (prebiotic and probiotic) on the viability, proteolysis and antioxidant properties of probiotic and synbiotic yogurt during 28 days of storage at 4 °C has been investigated. Yogurt starters in conjunction with either probiotic bacteria Lactob...
journal_title:Probiotics and antimicrobial proteins
pub_type: 杂志文章
doi:10.1007/s12602-012-9099-6
更新日期:2012-06-01 00:00:00