Abstract:
:The effect of two putative probiotic strains, Lactobacillus rhamnosus BFE5264 and Lactobacillus plantarum NR74, on the control of cholesterol efflux in enterocytes was assessed by focusing on the promotion of ATP-binding cassette sub-family G members 5 and 8 (ABCG5 and ABCG8). Differentiated Caco-2 enterocytes were treated with live bacteria, heat-killed bacteria, a bacterial cell wall fraction, and metabolites and were subjected to cholesterol uptake assay, mRNA analysis, and protein analyses. Following LXR-transfection by incubation with CHO-K1 cells in DNA-lipofectin added media, the luciferase assay was conducted for LXR analysis. Treatment of Caco-2 cells with L. rhamnosus BFE5264 (isolated from traditional fermented Maasai milk) and L. plantarum NR74 (isolated from Korean kimchi) resulted in the up-regulation of LXR, concomitantly with the elevated expression of ABCG5 and ABCG8. This was associated with the promotion of cholesterol efflux at significantly higher levels compared to the positive control strain L. rhamnosus GG (LGG). The experiment with CHO-K1 cells confirmed up-regulation of LXR-beta by the test strains, and treatment with the live L. rhamnosus BFE5264 and L. plantarum NR74 strains significantly increased cholesterol efflux. Heat-killed cells and cell wall fractions of both LAB strains induced the upregulation of ABCG5/8 through LXR activation. By contrast, LAB metabolites did not show any effect on ABCG5/8 and LXR expression. Data from this study suggest that LAB strains, such as L. rhamnosus BFE5264 and L. plantarum NR74, may promote cholesterol efflux in enterocytes, and thus potentially contribute to the prevention of hypercholesterolemia and atherosclerosis.
journal_name
Probiotics Antimicrob Proteinsjournal_title
Probiotics and antimicrobial proteinsauthors
Yoon HS,Ju JH,Kim H,Lee J,Park HJ,Ji Y,Shin HK,Do MS,Lee JM,Holzapfel Wdoi
10.1007/s12602-011-9086-3subject
Has Abstractpub_date
2011-12-01 00:00:00pages
194-203issue
3-4eissn
1867-1306issn
1867-1314pii
10.1007/s12602-011-9086-3journal_volume
3pub_type
杂志文章abstract::We studied as hydrogen peroxide, lactic acid, or surfactants from clinical isolates of vaginal lactobacilli and cell-free supernatants from probiotic strain LCR35 can influence on the sensitivity of opportunistic bacteria to antibiotics. We found that the most effective in increasing sensitivity to antibiotics were hy...
journal_title:Probiotics and antimicrobial proteins
pub_type: 杂志文章
doi:10.1007/s12602-016-9238-6
更新日期:2017-06-01 00:00:00
abstract::The aim of this work is to characterize the potential probiotic properties of 14 antifungal Lactobacillus strains isolated from traditional fermenting Moroccan green olives. The molecular identification of strains indicated that they are composed of five Lactobacillus brevis, two Lactobacillus pentosus, and seven Lact...
journal_title:Probiotics and antimicrobial proteins
pub_type: 杂志文章
doi:10.1007/s12602-019-09543-8
更新日期:2020-06-01 00:00:00
abstract::It has been recently shown, that certain strains/isolates of Bacillus subtilis can be used as a probiotic for humans. The production of the macrocyclic sactibiotic subtilosin in B. subtilis ATCC 6633 is highly regulated. To improve the subtilosin productivity of B. subtilis, different growth conditions were compared f...
journal_title:Probiotics and antimicrobial proteins
pub_type: 杂志文章
doi:10.1007/s12602-019-09547-4
更新日期:2020-06-01 00:00:00
abstract::The neutral outcome of the recently reported school-based trial of probiotic K12 (The effect of the oral probiotic Streptococcus salivarius K12 on group A streptococcus pharyngitis: a pragmatic trial in schools) can be attributed at least partially to several readily identifiable confounding factors. Mainly, the execu...
journal_title:Probiotics and antimicrobial proteins
pub_type: 杂志文章
doi:10.1007/s12602-018-9398-7
更新日期:2019-03-01 00:00:00
abstract::The present study was conducted to investigate the effects of probiotic and encapsulated Lactobacillus bulgaricus on hematological and immunological factors after lead toxicity in rainbow trout (Oncorhynchus mykiss). Two hundred and forty fish weighing about 16 ± 3.8 g were divided randomly in to four groups including...
journal_title:Probiotics and antimicrobial proteins
pub_type: 杂志文章
doi:10.1007/s12602-019-09544-7
更新日期:2020-06-01 00:00:00
abstract::Axone (Akhuni) is a homemade synbiotic (Nagamese fermented soybean product) served as side dish in North Eastern India. In this study, effects of Axone feeding on growth, weight gain, sexual maturity and egg production on Vanaraja birds (a strain of poultry bird developed at PDP Hyderabad for villages and backyard pou...
journal_title:Probiotics and antimicrobial proteins
pub_type: 杂志文章
doi:10.1007/s12602-014-9160-8
更新日期:2014-06-01 00:00:00
abstract::IL-17A is a cytokine which is produced by several immune and non-immune cells. The cytokine plays dual roles from protection from microbes and protection from pro-inflammatory based diseases to induction of the pro-inflammatory based diseases. The main mechanisms which lead to the controversial roles of IL-17A are yet...
journal_title:Probiotics and antimicrobial proteins
pub_type: 杂志文章,评审
doi:10.1007/s12602-017-9329-z
更新日期:2019-03-01 00:00:00
abstract::The ability of a probiotic strain (Weissella cibaria) to adhere on tissue and the effect of its topical application in nipples of lactating cows on physicochemical characteristics of milk were evaluated. An ex vivo model was used to demonstrate the adhesion capacity of W. cibaria. Tissue samples were randomly distribu...
journal_title:Probiotics and antimicrobial proteins
pub_type: 杂志文章
doi:10.1007/s12602-018-9481-0
更新日期:2019-12-01 00:00:00
abstract::Dental diseases are among the common health issues experienced around the world. Dental caries is one of the most predominant oral diseases worldwide. Major factors associated with caries development include poor oral hygiene, the content of specific carbohydrates in the diet, dental biofilm formation, the cariogenic ...
journal_title:Probiotics and antimicrobial proteins
pub_type: 杂志文章,评审
doi:10.1007/s12602-020-09652-9
更新日期:2020-12-01 00:00:00
abstract::The aim of this study was to investigate the effects of probiotic and synbiotic supplementation on serum inflammatory markers, endotoxin, and anti-HSP70 in hemodialysis (HD) patients. This study was a randomized, double-blind, placebo-controlled trial. Seventy-five hemodialysis patients who met the inclusion and exclu...
journal_title:Probiotics and antimicrobial proteins
pub_type: 杂志文章
doi:10.1007/s12602-018-9509-5
更新日期:2020-03-01 00:00:00
abstract::Ovarian cancer (OC) is a leading cause of death among women worldwide. Various evidences suggest that oncomiRs and Toll-like receptor 4 (TLR-4) signaling pathways appear to be key players in the initiation and progression of OC. It seems there exists a continuous intercommunication between cancer cells and normal micr...
journal_title:Probiotics and antimicrobial proteins
pub_type: 杂志文章
doi:10.1007/s12602-019-09596-9
更新日期:2020-09-01 00:00:00
abstract::A specific strain of naturally occurring oral lactobacilli was isolated and identified based on morphological, biochemical, and 16S rRNA gene sequencing. The phylogenetic affiliation of the isolate confirmed that the NK02 strain had close association with the Lactobacillus salivarius. An effective mouthwash was develo...
journal_title:Probiotics and antimicrobial proteins
pub_type: 杂志文章,随机对照试验
doi:10.1007/s12602-017-9296-4
更新日期:2018-09-01 00:00:00
abstract::High-fat diet (HFD) consumption induces obesity and increases blood glucose, insulin resistance, and metabolic disorders. Recent studies suggest that probiotics might be a novel approach to counteract these effects in the treatment of obesity. Here, we evaluated the effect of Leuconostoc mesenteroides subsp. mesentero...
journal_title:Probiotics and antimicrobial proteins
pub_type: 杂志文章
doi:10.1007/s12602-019-09556-3
更新日期:2020-06-01 00:00:00
abstract::Thaumatin-like proteins (TLPs) are the products of a large, highly complex gene family involved in host defense. TLPs also belong to the pathogenesis-related family 5 (PR-5) of plant defense proteins. Most TLPs exhibit potential antifungal activities, and their accumulation in the plant is related to many physiologica...
journal_title:Probiotics and antimicrobial proteins
pub_type: 杂志文章
doi:10.1007/s12602-018-9422-y
更新日期:2019-03-01 00:00:00
abstract::Antimicrobial peptides (AMPs) are compounds widely distributed in nature that display activity against a broad spectrum of pathogens. Amphibian skin, as an organ rich in pharmacologically active peptides, appears to be an interesting source of novel AMPs. Aurein 1.2 (GLFDIIKKIAESF-NH2) is a short 13-residue antimicrob...
journal_title:Probiotics and antimicrobial proteins
pub_type: 杂志文章
doi:10.1007/s12602-018-9501-0
更新日期:2019-09-01 00:00:00
abstract::Helicobacter pylori is an infectious agent commonly associated with gastrointestinal diseases. The use of probiotics to treat this infection has been documented, however, their potential antimicrobial metabolites have not yet been investigated. In the present study, the effect of reuterin produced by Lactobacillus reu...
journal_title:Probiotics and antimicrobial proteins
pub_type: 杂志文章
doi:10.1007/s12602-017-9342-2
更新日期:2018-06-01 00:00:00
abstract::The effects of treatment with probiotics on the immunological and hematobiochemical changes in Trypanosoma brucei infection were investigated. Probiotic strains used are Bifidobacterium BB-12, Lactobacillus acidophilus LA-5, Lactobacillus delbrueckii LBY-27, Lactobacillus paracasei LC-01, and Streptococcus thermophilu...
journal_title:Probiotics and antimicrobial proteins
pub_type: 杂志文章
doi:10.1007/s12602-019-09592-z
更新日期:2020-09-01 00:00:00
abstract::The reduction in the use of antibiotics in the poultry industry has considerably increased the appearance of Clostridium perfringens (CP)-induced subclinical necrotic enteritis (SNE), forcing researchers to search alternatives to antibiotic growth promoters (AGP) like probiotics. This study aimed to investigate the ef...
journal_title:Probiotics and antimicrobial proteins
pub_type: 杂志文章
doi:10.1007/s12602-019-09597-8
更新日期:2020-09-01 00:00:00
abstract::A total of 32 lactic acid bacteria (LAB) were isolated from Khanom-jeen, a Thai traditional fermented rice noodle. They belonged to the genus Leuconostoc (Ln), Lactobacillus (Lb), Enterococcus (E), Lactococcus (Lc), and Weissella (W), based on their phenotypic characteristics and 16S rRNA gene sequence analyses. The s...
journal_title:Probiotics and antimicrobial proteins
pub_type: 杂志文章
doi:10.1007/s12602-018-9385-z
更新日期:2019-03-01 00:00:00
abstract::Bacillus cereus strain F, collected from relict permafrost located in Siberia, was analyzed for probiotic activity in the mouse Salmonella enterica model. Viable bacterial cells were found in frozen soils taken at Mammoth Mountain in Yakutia from a depth below the level of seasonal thawing. Geological data indicated t...
journal_title:Probiotics and antimicrobial proteins
pub_type: 杂志文章
doi:10.1007/s12602-012-9105-z
更新日期:2012-09-01 00:00:00
abstract::Food-grade yeasts make significant contributions to flavor development in fermented foods. Some yeast species also inhibit undesirable bacteria, yeasts and molds, apparently by producing antimicrobial compounds called mycocins. The aim of this study was to evaluate the ability of wild yeasts, isolated from raw milk an...
journal_title:Probiotics and antimicrobial proteins
pub_type: 杂志文章
doi:10.1007/s12602-012-9109-8
更新日期:2013-03-01 00:00:00
abstract::It is well established that bacteria communicate between each other by using different mechanisms; among which, quorum sensing (QS) is the best known one. Indeed, intra- and intercellular communications of microorganisms, as well as the regulation of metabolism and reaction to the surrounding environmental conditions,...
journal_title:Probiotics and antimicrobial proteins
pub_type: 杂志文章,评审
doi:10.1007/s12602-019-09555-4
更新日期:2020-03-01 00:00:00
abstract::The administration of probiotics is a promising approach to reduce the prevalence of colon cancer, a multifactorial disease, with hereditary factors, as well as environmental lifestyle-related risk factors. Biogenic polyamines, putrescine, spermidine, and spermine are small cationic molecules with great roles in cell ...
journal_title:Probiotics and antimicrobial proteins
pub_type: 杂志文章
doi:10.1007/s12602-017-9253-2
更新日期:2017-06-01 00:00:00
abstract::Present study is intended to assess the probiotic properties of Bacillus spp. isolated from idli batter, a traditional fermented food of Southern India and Sri Lanka. A total of 32 isolates were screened for potential pathogenic behaviour through haemolysis assay, DNase activity and antibiotics sensitivity. Two of the...
journal_title:Probiotics and antimicrobial proteins
pub_type: 杂志文章
doi:10.1007/s12602-020-09650-x
更新日期:2020-12-01 00:00:00
abstract::Lactobacillus plantarum ST8Sh, isolated from Bulgarian salami "shpek" and previously characterized as bacteriocin producer, was evaluated for its beneficial properties. Based on the PCR analysis, Lb. plantarum ST8Sh was shown to host a gene related to the production of adhesion proteins such as Mab, Mub, EF, and PrgB....
journal_title:Probiotics and antimicrobial proteins
pub_type: 杂志文章
doi:10.1007/s12602-016-9245-7
更新日期:2017-06-01 00:00:00
abstract::The present study was conducted to assess the effects of combined and singular dietary administration of PrimaLac® and potassium diformate (KDF) on growth performance, feed utilization, digestive enzymes activity, and some physiological parameters of rainbow trout (Oncorhynchus mykiss) juvenile. Three hundred sixty ra...
journal_title:Probiotics and antimicrobial proteins
pub_type: 杂志文章
doi:10.1007/s12602-019-9523-2
更新日期:2020-03-01 00:00:00
abstract::Probiotics offer numerous health benefits, including digestive and immune health. Improved digestive health is linked to a more efficient absorption of important nutrients from our diet. This review focused on the rationale of using the probiotic Bacillus coagulans GBI-30, 6086 to aid protein absorption and utilizatio...
journal_title:Probiotics and antimicrobial proteins
pub_type: 杂志文章,评审
doi:10.1007/s12602-017-9354-y
更新日期:2018-12-01 00:00:00
abstract::The purpose of this article is to reveal the role of the lactic acid bacteria (LAB) in the beebread transformation/preservation, biochemical properties of 25 honeybee endogenous LAB strains, particularly: antifungal, proteolytic, and amylolytic activities putatively expressed in the beebread environment have been stud...
journal_title:Probiotics and antimicrobial proteins
pub_type: 杂志文章
doi:10.1007/s12602-017-9379-2
更新日期:2018-12-01 00:00:00
abstract::In the present study, the ability of bovine lactoferrin hydrolysate (LfH) to disrupt the cytoplasmic membrane of Escherichia coli O157:H7 was investigated. Lactoferrin and LfH antimicrobial activities were compared against E. coli O157:H7 and E. coli O157:H7 spheroplasts. The effect of LfH on the cytoplasmic membrane ...
journal_title:Probiotics and antimicrobial proteins
pub_type: 杂志文章
doi:10.1007/s12602-010-9039-2
更新日期:2010-06-01 00:00:00
abstract::Bacterial vaginosis (BV) is a commonly occurring vaginal infection that is associated with a variety of serious risks related to the reproductive health of women. Conventional antibiotic treatment for this condition is frequently ineffective because the antibiotics tend to inhibit healthy vaginal microflora along with...
journal_title:Probiotics and antimicrobial proteins
pub_type: 杂志文章
doi:10.1007/s12602-008-9003-6
更新日期:2009-01-20 00:00:00