Abstract：
:High-fat diet (HFD) consumption induces obesity and increases blood glucose, insulin resistance, and metabolic disorders. Recent studies suggest that probiotics might be a novel approach to counteract these effects in the treatment of obesity. Here, we evaluated the effect of Leuconostoc mesenteroides subsp. mesenteroides SD23 on obesity-related metabolic dysfunction. In the present study, mice were randomly divided into four dietary groups: standard diet (C), HFD (OB), standard diet with L. mesenteroides SD23 (CP), and HFD with L. mesenteroides SD23 (OBP). Diets were maintained for 14 weeks. Animal weight was monitored and biochemical and histological analyses were performed after intervention. OB showed metabolic dysfunction, and increased the number of larger adipocytes compared to C. OB induced liver tumor necrosis factor-α (TNF-α) expression, increased cholesterol, leptin, and glucose levels compared to C. OBP reduced body weight, glucose, cholesterol, and leptin levels and improved glucose tolerance compared to OB. OBP also reduced liver steatosis, the number of larger adipocytes in adipose tissue, and reduced the villus height in the small intestine. OBP decreased expression of TNF-α and increased expression of IL-10 in liver. The parameters evaluated in the CP were similar to the C. This study provides novel evidence that dietary intervention with L. mesenteroides SD23 improves metabolic dysfunction related to obesity in HFD-fed mice.
journal_name
Probiotics Antimicrob Proteinsjournal_title
Probiotics and antimicrobial proteinsauthors
Castro-Rodríguez DC,Reyes-Castro LA,Vega CC,Rodríguez-González GL,Yáñez-Fernández J,Zambrano Edoi
10.1007/s12602-019-09556-3subject
Has Abstractpub_date
2020-06-01 00:00:00pages
505-516issue
2eissn
1867-1306issn
1867-1314pii
10.1007/s12602-019-09556-3journal_volume
12pub_type
杂志文章abstract：:In the present study, the ability of bovine lactoferrin hydrolysate (LfH) to disrupt the cytoplasmic membrane of Escherichia coli O157:H7 was investigated. Lactoferrin and LfH antimicrobial activities were compared against E. coli O157:H7 and E. coli O157:H7 spheroplasts. The effect of LfH on the cytoplasmic membrane ...
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journal_title：Probiotics and antimicrobial proteins
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journal_title：Probiotics and antimicrobial proteins
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journal_title：Probiotics and antimicrobial proteins
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journal_title：Probiotics and antimicrobial proteins
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journal_title：Probiotics and antimicrobial proteins
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journal_title：Probiotics and antimicrobial proteins
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