Abstract:
:Bacterial quorum sensing (QS) is a cell-to-cell communication in which specific signals are activated to coordinate pathogenic behaviors and help bacteria acclimatize to the disadvantages. The QS signals in the bacteria mainly consist of acyl-homoserine lactone, autoinducing peptide, and autoinducer-2. QS signaling activation and biofilm formation lead to the antimicrobial resistance of the pathogens, thus increasing the therapy difficulty of bacterial diseases. Anti-QS agents can abolish the QS signaling and prevent the biofilm formation, therefore reducing bacterial virulence without causing drug-resistant to the pathogens, suggesting that anti-QS agents are potential alternatives for antibiotics. This review focuses on the anti-QS agents and their mediated signals in the pathogens and conveys the potential of QS targeted therapy for bacterial diseases.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Jiang Q,Chen J,Yang C,Yin Y,Yao Kdoi
10.1155/2019/2015978subject
Has Abstractpub_date
2019-04-04 00:00:00pages
2015978eissn
2314-6133issn
2314-6141journal_volume
2019pub_type
杂志文章,评审abstract:INTRODUCTION:Human mesenchymal stromal cells (hMSCs) exhibit the potential to accelerate bone healing by enhanced osteogenic differentiation. Interleukin-1β is highly expressed during fracture healing and has been demonstrated to exert a significant impact on the differentiation behaviour of hMSCs. Here, we investigate...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/714230
更新日期:2015-01-01 00:00:00
abstract::Autophagy is a highly regulated-cell pathway for degrading long-lived proteins as well as for clearing cytoplasmic organelles. Autophagy is a key contributor to cellular homeostasis and metabolism. Warburg hypothesized that cancer growth is frequently associated with a deviation of a set of energy generation mechanism...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/926729
更新日期:2014-01-01 00:00:00
abstract::In the biomedical field, there is growing interest in using human stem cell-derived neurons as in vitro models for pharmacological and toxicological screening of bioactive compounds extracted from natural products. Lignosus rhinocerus (Tiger Milk Mushroom) is used by indigenous communities in Malaysia as a traditional...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/3126376
更新日期:2019-08-19 00:00:00
abstract::Viscosupplementation with hyaluronic acid is safe and effective in the management of osteoarthritis, but its use in the treatment of tendon disorders has received less attention. The aim of this review is to summarize the current knowledge on this topic, evaluating experimental and clinical trials. A search of English...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/783632
更新日期:2014-01-01 00:00:00
abstract::Bone integrity abnormality and imbalance between bone formation by osteoblasts and bone resorption by osteoclasts are known to result in metabolic bone diseases such as osteoporosis. Silymarin-rich milk thistle extract (MTE) and its component silibinin enhanced alkaline phosphatase activity of osteoblasts but reduced ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/919374
更新日期:2013-01-01 00:00:00
abstract::Tissue regeneration has become a promising treatment for craniomaxillofacial bone defects such as alveolar clefts. This study sought to assess the efficacy of lateral ramus cortical plate with buccal fat pad derived mesenchymal stem cells (BFSCs) in treatment of human alveolar cleft defects. Ten patients with unilater...
journal_title:BioMed research international
pub_type: 杂志文章,随机对照试验
doi:10.1155/2017/6560234
更新日期:2017-01-01 00:00:00
abstract::Helicobacter pylori colonization of gastric mucosa causes pain of unknown etiology in about 15-20% of infected subjects. The aim of the present work was to determine the level of expression of enzymes involved in the synthesis of melatonin in gastric mucosa of asymptomatic and symptomatic H. pylori infected patients. ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/845032
更新日期:2013-01-01 00:00:00
abstract::Atherosclerosis remains the most common cause of deaths worldwide. Endothelial cell apoptosis is an important process in the progress of atherosclerosis, as it can cause the endothelium to lose their capability in regulating the lipid homeostasis, inflammation, and immunity. Endothelial cell injury can disrupt the int...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/2819658
更新日期:2020-06-20 00:00:00
abstract::Coronary artery diseases (CAD) and heart failure have high mortality rate in the world, although much progress has been made in this field in last two decades. There is still a clinical need for a novel diagnostic approach and a therapeutic strategy to decrease the incidence of CAD. MicroRNAs (miRNAs) are highly conse...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/682857
更新日期:2015-01-01 00:00:00
abstract:Objective:We compared the prostate cancer (PCa) detection rates of targeted biopsy (TB) and saturation biopsy (SB) in patients with previous negative biopsy and the accuracy of TB and SB stratified by different serum prostate-specific antigen (PSA) levels. Materials and Methods:Overall 185 patients were enrolled. In t...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/7617148
更新日期:2017-01-01 00:00:00
abstract::The rapid development of picture archiving and communication systems (PACSs) thoroughly changes the way of medical informatics communication and management. However, as the scale of a hospital's operations increases, the large amount of digital images transferred in the network inevitably decreases system efficiency. ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/657417
更新日期:2014-01-01 00:00:00
abstract::Alzheimer's disease (AD) is a progressive neurodegenerative disorder with two hallmarks: β-amyloid plagues and neurofibrillary tangles. It is one of the most alarming illnesses to elderly people. No effective drugs and therapies have been developed, while mechanism-based explorations of therapeutic approaches have bee...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/837157
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVE:This study mainly aimed to explore the association between brain-derived neurotropic factor (BDNF) Val66Met polymorphism and posttraumatic stress disorder (PTSD) among flood survivors in China. METHODS:Individuals who experienced the 1998 Dongting Lake flood in Southeast Huarong, China, were enrolled in this...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2017/4569698
更新日期:2017-01-01 00:00:00
abstract::The receptor activator of NF-κB (RANK) pathway is involved in bone health as well as breast cancer (BC) pathogenesis and progression. Whereas the therapeutic implication of this pathway is established for the treatment of osteoporosis and bone metastases, the application in adjuvant BC is currently investigated. As ge...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1155/2014/842452
更新日期:2014-01-01 00:00:00
abstract::Alterations in pancreatic milieu to adapt to physiological shifts occurring in conditions of obesity and metabolic syndrome (MS) have been documented, though mechanisms leading to such a state have remained elusive so far. The data presented here tries to look at the gravity of metabolic insult during the early and pr...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/617569
更新日期:2013-01-01 00:00:00
abstract::Robot-Assisted Rehabilitation (RAR) is relevant for treating patients affected by nervous system injuries (e.g., stroke and spinal cord injury). The accurate estimation of the joint angles of the patient limbs in RAR is critical to assess the patient improvement. The economical prevalent method to estimate the patient...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/2581924
更新日期:2016-01-01 00:00:00
abstract::Gold nanorods (GNRs) are considered one of the most promising forms of nanoparticles for nanobiotechnology; however, the problem of their toxicity is currently not resolved. We synthesised GNRs, modified with linear polyethyleneimine (PEI-GNRs), and examined their physicochemical and some biological properties in comp...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/908175
更新日期:2014-01-01 00:00:00
abstract::With the development of nanotechnology, nanocarriers have been increasingly used for curative drug/gene delivery. Various nanocarriers are being introduced and assessed, such as polymer nanoparticles, liposomes, and micelles. As a novel theranostic system, nanocarriers hold great promise for ultrasound molecular imagi...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/963891
更新日期:2014-01-01 00:00:00
abstract::Polymethylmethacrylate (PMMA) bone cement is a popular bone void filler for vertebroplasty. However, the use of PMMA has some drawbacks, including the material's excessive stiffness, exothermic polymerization, and short handling time. This study aimed to create an ideal modified bone cement to solve the above-mentione...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/7901562
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVE:Conventional surgical techniques of laryngomicrosurgery (LMS) on hemorrhagic vocal polyps are often difficult due to obscuration of the surgical field by inadvertent bleeding from the lesion, and there are often significant amounts of mucosal epithelium loss. Here, we introduce our surgical technique using pu...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/820654
更新日期:2015-01-01 00:00:00
abstract:Purpose:We aimed to identify prognostic factors for survival and recurrence of hepatocellular carcinoma (HCC) after liver transplantation (LT) for patients with HCC and hepatitis C virus-related cirrhosis (HCV-cirrhosis). Methods:This retrospective cohort study followed all adult patients with HCV-cirrhosis who underw...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/1487593
更新日期:2020-10-17 00:00:00
abstract::Among the different signaling molecules released during reactive gliosis occurring in Alzheimer's disease (AD), the astrocyte-derived S100B protein plays a key role in neuroinflammation, one of the hallmarks of the disease. The use of pharmacological tools targeting S100B may be crucial to embank its effects and some ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/508342
更新日期:2015-01-01 00:00:00
abstract::GHK (glycyl-L-histidyl-L-lysine) is present in human plasma, saliva, and urine but declines with age. It is proposed that GHK functions as a complex with copper 2+ which accelerates wound healing and skin repair. GHK stimulates both synthesis and breakdown of collagen and glycosaminoglycans and modulates the activity ...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/648108
更新日期:2015-01-01 00:00:00
abstract:Background:Preeclampsia (PE) is a pregnancy-specific hypertension syndrome and is one of the leading causes of maternal and perinatal morbidity and mortality. Long noncoding RNAs (lncRNAs) have been reported to be abnormally expressed in many diseases, including preeclampsia. The present study is aimed at identifying t...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/1673486
更新日期:2020-06-05 00:00:00
abstract::Tongue diagnosis is a noninvasive diagnosis and is traditionally one of the most important tools for physicians who practice Kampo (traditional Japanese) medicine. However, it is a subjective process, and its results can depend on the experience of the physician performing it. Previous studies have reported how to mea...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/249609
更新日期:2015-01-01 00:00:00
abstract::The large-scale production of cardiomyocytes is a key step in the development of cell therapy and tissue engineering to treat cardiovascular diseases, particularly those caused by ischemia. The main objective of this study was to establish a procedure for the efficient production of cardiomyocytes by reprogramming mes...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/390789
更新日期:2013-01-01 00:00:00
abstract::Uveitic glaucoma (UG) typically is associated with very high intraocular pressure (IOP) and more intense optic nerve damage than other glaucoma types. This secondary glaucoma requires an early diagnosis and adequate management of both uveitis and glaucoma. It is mandatory to identify the mechanisms of IOP elevation th...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/742792
更新日期:2015-01-01 00:00:00
abstract::Long noncoding RNAs play an essential role in bladder cancer progression. The role of long noncoding RNA EGFR-AS1 in bladder cancer needs further study. We used clinical specimens to analyze the relationship between EGFR-AS1 and bladder cancer patients' characteristics. The functional experiments and mechanism studies...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/6665974
更新日期:2020-12-22 00:00:00
abstract:Background:The mechanism of inflammatory reaction after intracerebral hemorrhage remains unclear, which to some extent restrains the therapeutic development of hemorrhagic stroke. The present study attempts to verify whether NLRP6 plays an important role in inflammatory reaction after intracerebral hemorrhage and ident...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/6182464
更新日期:2020-06-07 00:00:00
abstract::Epithelial Cl(-) secretion plays important roles in water secretion preventing bacterial/viral infection and regulation of body fluid. We previously suggested that quercetin would be a useful compound for maintaining epithelial Cl(-) secretion at a moderate level irrespective of cAMP-induced stimulation. However, we n...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/902735
更新日期:2014-01-01 00:00:00