Abstract:
:Naming treatment outcomes in post-stroke aphasia are variable and the factors underlying this variability are incompletely understood. In this study, 26 patients with chronic aphasia completed a semantic judgment fMRI task before receiving up to 12 weeks of naming treatment. Global (i.e., network-wide) and local (i.e., regional) graph theoretic measures of pre-treatment functional connectivity were analyzed to identify differences between patients who responded most and least favorably to treatment (i.e., responders and nonresponders) and determine if network measures predicted naming improvements. Responders had higher levels of global integration (i.e., average network strength and global efficiency) than nonresponders, and these measures predicted treatment effects after controlling for lesion volume and age. Group differences in local measures were identified in several regions associated with a variety of cognitive functions. These results suggest there is a meaningful and possibly prognostically-informative relationship between patients' functional network properties and their response to naming therapy.
journal_name
Brain Langjournal_title
Brain and languageauthors
Johnson JP,Meier EL,Pan Y,Kiran Sdoi
10.1016/j.bandl.2020.104809subject
Has Abstractpub_date
2020-08-01 00:00:00pages
104809eissn
0093-934Xissn
1090-2155pii
S0093-934X(20)30068-7journal_volume
207pub_type
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