Abstract:
:At the behavioral level one of the primary disturbances involved in congenital dyslexia concerns phonological processing. At the neuroarchitectural level autopsies have revealed ectopies, e.g., a reduced number of neurons in the upper layers of the cortex and an increased number in the lower ones. In dynamic models of interacting neuronal populations the behavioral level can be related to the neurophysiological level. In this study an attempt is made to do so at the cortical level. The first focus of this model study are the results of a Finnish experiment assessing geminate stop perception in quasi speech stimuli by 6 month old infants using a head turning paradigm and evoked potentials. The second focus of this study are the results of a Dutch experiment assessing discrimination of transients in speech stimuli, by adult dyslexics and controls and 2 month old infants. There appears to be a difference in the phonemic perceptual boundaries of children at genetic risk for dyslexia and control children as revealed in the Finnish study. Assuming a lowered neuronal density in the 'dyslexic' model, reflecting ectopies, it may be postulated that less neuronal surface is available for synaptic connections resulting in a lowered synaptic density and thus a lowered amount of available neurotransmitter. A lowered synaptic density also implies a reduced amount of membrane surface available for neurotransmitter metabolism. By assuming both, a reduced upper bound of neurotransmitter and a reduced metabolic transmitter rate in the dynamic model, the Finnish experimental results can be approximated closely. This applies both to data from behavioral head turning and that of the evoked potential study. In the Dutch study adult dyslexics show poor performance in discriminating transients in the speech signal compared to the controls. The same stimuli were used in a a study comparing infants from dyslexic families and controls. Using the same transmitter parameters as in modeling the results of the Finnish study, also in this case the experimental results for adults and infants can be approximated closely. Simulation of behavioral and pharmaceutical interventions with the model provide predictions which can be put to the test in experiments.
journal_name
Brain Langjournal_title
Brain and languageauthors
Been PH,Zwarts Fdoi
10.1016/s0093-934x(02)00592-8subject
Has Abstractpub_date
2003-09-01 00:00:00pages
395-412issue
3eissn
0093-934Xissn
1090-2155pii
S0093934X02005928journal_volume
86pub_type
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