Abstract:
:The purpose of this study was to examine the association between aphasia severity and neurocognitive function, disease duration and temporoparietal atrophy in 21 individuals with the logopenic variant of primary progressive aphasia (lvPPA). We found significant correlations between aphasia severity and degree of neurocognitive impairment as well as temporoparietal atrophy; but not disease duration. Cluster analysis identified three variants of lvPPA: (1) subjects with mild aphasia and short disease duration (mild typical lvPPA); (2) subjects with mild aphasia and long disease duration (mild atypical lvPPA); and, (3) subjects with severe aphasia and relatively long disease duration (severe typical lvPPA). All three variants showed temporoparietal atrophy, with the mild atypical group showing the least atrophy despite the longest disease duration. The mild atypical group also showed mild neuropsychological impairment. The subjects with mild aphasia and neuropsychological impairment despite long disease duration may represent a slowly progressive variant of lvPPA.
journal_name
Brain Langjournal_title
Brain and languageauthors
Machulda MM,Whitwell JL,Duffy JR,Strand EA,Dean PM,Senjem ML,Jack CR Jr,Josephs KAdoi
10.1016/j.bandl.2013.02.007subject
Has Abstractpub_date
2013-11-01 00:00:00pages
139-44issue
2eissn
0093-934Xissn
1090-2155pii
S0093-934X(13)00050-3journal_volume
127pub_type
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