Abstract：
:High-density ERPs were recorded in eight adults with persistent developmental stuttering (PERS) and eight matched normally fluent (CONT) control volunteers while participants either repeatedly uttered the vowel 'ah' or listened to their own previously recorded vocalizations. The fronto-central N1 auditory wave was reduced in response to spoken vowels relative to heard vowels (auditory-vocal gating), but no difference in the extent of such modulation was found in the PERS group. Abnormalities in the PERS group were restricted to the LISTEN condition, in the form of early N1 and late N3 amplitude changes. Voltage of the N1 wave was significantly reduced over right inferior temporo-occipital scalp in the PERS group. A laterality index derived from N1 voltage moderately correlated with the PERS group's assessed pre-experiment stuttering frequency. Source localization with sLORETA (Pascual-Marqui, R. D. (2002). Standardized low-resolution brain electromagnetic tomography (sLORETA): Technical details. Methods & Findings in Experimental & Clinical Pharmacology, 24, 5-12.) revealed that at the peak of the N1 the PERS group displayed significantly greater current density in right primary motor cortex than the CONT group, suggesting abnormal early speech-motor activation. Finally, the late N3 wave was reduced in amplitude over inferior temporo-occipital scalp, more so over the right hemisphere. sLORETA revealed that in the time window of the N3 the PERS group showed significantly less current density in right secondary auditory cortex than the CONT group, suggesting abnormal speech sound perception. These results point to a deficit in auditory processing of speech sounds in persistent developmental stuttering, stemming from early increased activation of right rolandic area and late reduced activation in right auditory cortex.
journal_name
Brain Langjournal_title
Brain and languageauthors
Liotti M,Ingham JC,Takai O,Paskos DK,Perez R,Ingham RJdoi
10.1016/j.bandl.2010.07.007subject
Has Abstractpub_date
2010-11-01 00:00:00pages
141-7issue
2eissn
0093-934Xissn
1090-2155pii
S0093-934X(10)00134-3journal_volume
115pub_type
杂志文章abstract：:Progressive visual processing decline is a known factor in aging. The present study investigates the evolution of visual expertise for printed stimuli with aging. Fifty-five participants of increasing age (20-30, 40-50, 60-70, 75-85years old) were recruited. Behavioral and EEG data were collected during a lexical deci...
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journal_title：Brain and language
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doi：10.1016/j.bandl.2013.05.005
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journal_title：Brain and language
pub_type： 杂志文章
doi：10.1016/j.bandl.2005.03.004
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journal_title：Brain and language
pub_type： 杂志文章
doi：10.1016/j.bandl.2006.08.003
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pub_type： 杂志文章
doi：10.1006/brln.1996.0037
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journal_title：Brain and language
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journal_title：Brain and language
pub_type： 杂志文章,评审
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journal_title：Brain and language
pub_type： 杂志文章
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journal_title：Brain and language
pub_type： 杂志文章
doi：10.1016/j.bandl.2019.104694
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