Drug delivery to macrophages: a review of nano-therapeutics targeted approach for inflammatory disorders and cancer.

abstract：OBJECTIVES:The aim of this work is to synthesize a novel stable and biodegradable nitric oxide (NO) donor polymer based on a chitosan backbone. This polymer needed to be linked to glutathione (GSH), which was nitrosated in a second step. This polymer has been developed as an NO delivery platform that could be further e...

journal_title：Expert opinion on drug delivery

authors： Shah SU,Martinho N,Socha M,Pinto Reis C,Gibaud S

更新日期：2015-08-01 00:00:00

abstract：INTRODUCTION:Nasal drug delivery that exploits the olfactory and trigeminal neuronal pathways to deliver drugs to the brain is being widely explored by pharmaceutical companies, for the delivery of challenging drugs. Low-molecular-weight and lipophilic drugs are effectively absorbed by the intranasal route for efficaci...

journal_title：Expert opinion on drug delivery

authors： Bahadur S,Pathak K

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:The advent of therapeutic proteins highlights the need for delivery systems that protect and extend the duration of its action. Ranibizumab-VEGF is one such drug used for treating wet AMD. This paper describes a facile method to sustain bioactive ranibizumab release from PLGA-based particles. METHODS:Two em...

journal_title：Expert opinion on drug delivery

authors： Chua HY,Lui YS,Bhuthalingam R,Agrawal R,Wong T,Preiser PR,Venkatraman S

更新日期：2018-12-01 00:00:00

abstract：BACKGROUND:Pulmonary cell culture models for the development of new aerosol medicines are attracting increasing interest. Ease of handling, ethical acceptance and high explanatory power are the main advantages of cell culture systems in pulmonary drug research. OBJECTIVE:Pulmonary cell culture models are described and...

journal_title：Expert opinion on drug delivery

authors： Bur M,Lehr CM

更新日期：2008-06-01 00:00:00

abstract：BACKGROUND:Targeted delivery of antithrombotic (thrombolytic) drugs is expected to increase their efficacy and decrease side effects, especially in the case of thrombolytic enzymes. Liposomes, phospholipid nanosized bubbles with a bilayered membrane structure, have drawn a lot of interest as pharmaceutical carriers for...

journal_title：Expert opinion on drug delivery

authors： Elbayoumi TA,Torchilin VP

更新日期：2008-11-01 00:00:00

abstract：INTRODUCTION:Polymers can be designed to modify their features as a function of the level and nature of the surrounding microorganisms. Such responsive polymers can endow drug delivery systems and drug-medical device combination products with improved performance against intracellular infections and biofilms. AREAS CO...

journal_title：Expert opinion on drug delivery

authors： Alvarez-Lorenzo C,Garcia-Gonzalez CA,Bucio E,Concheiro A

更新日期：2016-08-01 00:00:00

abstract：INTRODUCTION:Respiratory infections and diseases are accompanied by or exhibit inflammation. Recent advances in nanoparticle engineering technology, together with the increased knowledge of inflammatory pathophysiology, have ignited interest in the pulmonary delivery of anti-inflammatory agents (AIAs) to achieve local ...

journal_title：Expert opinion on drug delivery

authors： Ali ME,McConville JT,Lamprecht A

更新日期：2015-06-01 00:00:00

abstract：INTRODUCTION:Development of efficient in vivo delivery systems remains a major challenge en route to clinical application of antisense technology, including RNA-cleaving molecules such as deoxyribozymes (DNAzymes). The mechanisms of oligonucleotide uptake and trafficking are clearly dependent on cell type and the type ...

journal_title：Expert opinion on drug delivery

authors： Fokina AA,Chelobanov BP,Fujii M,Stetsenko DA

更新日期：2017-09-01 00:00:00

abstract：INTRODUCTION:Most vaccines are administered by intramuscular injection using a hypodermic needle and syringe. Some limitations of this procedure include reluctance to be immunized because of fear of needlesticks, and concerns associated with the safe disposal of needles after their use. Skin delivery is an alternate ro...

journal_title：Expert opinion on drug delivery

authors： Gill HS,Kang SM,Quan FS,Compans RW

更新日期：2014-04-01 00:00:00

abstract：INTRODUCTION:The work presents the development of acellular scaffolds extemporaneously embedded with platelet lysate (PL), as an innovative approach in the field of tissue regeneration/reparation. PL embedded scaffolds should have a tridimensional architecture to support cell migration and growth, in order to restore s...

journal_title：Expert opinion on drug delivery

authors： Sandri G,Bonferoni MC,Rossi S,Ferrari F,Mori M,Cervio M,Riva F,Liakos I,Athanassiou A,Saporito F,Marini L,Caramella C

更新日期：2015-04-01 00:00:00

abstract：INTRODUCTION:Sixty years since its introduction, 5-FU still forms the core of chemotherapy regimens for many types of malignancies. 5-FU is a time-dependent drug but is rapidly degraded in plasma by dihydropyrimidine dehydrogenase (DPD). Although originally developed in an intravenous form, 5-FU oral prodrugs were deve...

journal_title：Expert opinion on drug delivery

authors： Miura K,Shima H,Takebe N,Rhie J,Satoh K,Kakugawa Y,Satoh M,Kinouchi M,Yamamoto K,Hasegawa Y,Kawai M,Kanazawa K,Fujiya T,Unno M,Katakura R

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:Photodynamic therapy (PDT) is a medical treatment in which a combination of a photosensitising drug and visible light causes destruction of selected cells. Due to the lack of true selectivity of preformed photosensitisers for neoplastic tissue and their high molecular weights, PDT of superficial skin lesions...

journal_title：Expert opinion on drug delivery

authors： Donnelly RF,McCarron PA,Morrow DI,Sibani SA,Woolfson AD

更新日期：2008-07-01 00:00:00

abstract：:Among the strategies developed for drug delivery into the CNS, locally controlled drug release by the way of an implantable polymeric device has been developed in recent years. The first polymeric devices developed were macroscopic implants needing open surgery for implantation. Over the last few years, poly(lactide-c...

journal_title：Expert opinion on drug delivery

authors： Menei P,Montero-Menei C,Venier MC,Benoit JP

更新日期：2005-03-01 00:00:00

abstract：:The pressurised metered-dose inhaler (pMDI) has now been available for 50 years. Once regarded as an inefficient and difficult-to-use device, the technology has evolved significantly over the last few years, particularly since the introduction of novel formulations containing hydrofluoroalkane (HFA) propellants. Many ...

journal_title：Expert opinion on drug delivery

authors： Bell J,Newman S

更新日期：2007-05-01 00:00:00

abstract：INTRODUCTION:Calcium channel blockers are a very important class of antihypertensive drugs. Most calcium channel blockers (CCBs) exhibiting low oral bioavailability are required to be taken more than once a day due to their short half-lives which result in poor patient compliance. There is an ineluctable requirement fo...

journal_title：Expert opinion on drug delivery

authors： Ahad A,Al-Jenoobi FI,Al-Mohizea AM,Aqil M,Kohli K

更新日期：2013-08-01 00:00:00

abstract：INTRODUCTION:Biopolymers have been used extensively in the pharmaceutical field. Pectin, a biopolymer, has several unique properties that enable it to be used as an excipient or carrier for oral drug delivery systems. Accordingly, several investigators have identified the benefits of pectin-based delivery systems for o...

journal_title：Expert opinion on drug delivery

authors： Sriamornsak P

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND:Pressurized metered-dose inhalers (pMDIs) include hydrofluoroalkane (HFA) propellant to generate a drug aerosol upon actuation and drugs can be formulated as solution or suspension. Suspended particles can cream or sediment depending on density differences between drug and propellant and shaking the pMDI is ...

journal_title：Expert opinion on drug delivery

authors： Chierici V,Cavalieri L,Piraino A,Paleari D,Quarta E,Sonvico F,Melani AS,Buttini F

更新日期：2020-07-01 00:00:00

abstract：INTRODUCTION:The utility of controlled and sustained release of drugs from polymeric systems, both bulk (hydrogels) and colloids (nanoparticles), is a key point that should be addressed. Unfortunately, classic delivery systems are essentially driven by diffusion, which is very quick due to the high concentration gradie...

journal_title：Expert opinion on drug delivery

authors： Mauri E,Papa S,Masi M,Veglianese P,Rossi F

更新日期：2017-11-01 00:00:00

abstract：INTRODUCTION:Long circulating liposomal drug carriers are widely used in experimental cancer therapy because they avoid excretion and benefit from the enhanced permeability and retention-effect to accumulate at the tumor site while simultaneously limiting systemic exposure to the cytotoxic drug due to their high stabil...

journal_title：Expert opinion on drug delivery

authors： Oude Blenke E,Mastrobattista E,Schiffelers RM

更新日期：2013-10-01 00:00:00

abstract：INTRODUCTION:Polymer-drug conjugates are an important part of polymer therapeutics. Recently, they have been used as an appealing platform for drug delivery. As a delivery vector, the route of administration performs a serious impact on the accessibility of drug molecules to their respective target site and therapeutic...

journal_title：Expert opinion on drug delivery

authors： Pang X,Yang X,Zhai G

更新日期：2014-07-01 00:00:00

abstract：:Functionalised carbon nanotubes (f-CNTs) are emerging as new tools in the field of nanobiotechnology and nanomedicine. This is because they can be easily manipulated and modified by encapsulation with biopolymers or by covalent linking of solubilising groups to the external walls and tips. The possibility of incorpora...

journal_title：Expert opinion on drug delivery

authors： Bianco A

更新日期：2004-11-01 00:00:00

abstract：:Objective: Conventional chloramphenicol (CHL) eye drops are widely used anti-infection formulations for acute bacterial conjunctivitis. However, the therapeutic effects are limited by insufficient concentration in the conjunctival sac. Hence, the objective of this study is to formulate and develop novel CHL eye drops ...

journal_title：Expert opinion on drug delivery

authors： Xu Y,Zhang C,Zhu X,Wang X,Wang H,Hu G,Fu Q,He Z

更新日期：2019-06-01 00:00:00

abstract：:The treatment of genetic diseases using therapeutic gene transfer is considered to be a significant development. This development has brought with it certain limitations, and the process of overcoming these barriers has seen a drastic change in gene delivery. Many metal ions such as Mg2+, Mn2+, Ba2+ and, most importan...

journal_title：Expert opinion on drug delivery

authors： Kulkarni VI,Shenoy VS,Dodiya SS,Rajyaguru TH,Murthy RR

更新日期：2006-03-01 00:00:00

abstract：OBJECTIVES:To develop orodispersible films (ODF) based on hydrophobic polymers with higher stability to ordinary environmental humidity conditions without compromising their fast disintegration time. METHODS:A quality by design approach was applied to screen three different formulations each one based on a different h...

journal_title：Expert opinion on drug delivery

authors： Borges AF,Silva BM,Silva C,Coelho JF,Simões S

更新日期：2016-10-01 00:00:00

abstract：INTRODUCTION:Peptide and protein microarray and microneedle array technology provides direct information on protein function and potential drug targets in drug discovery and delivery. Because of this unique ability, these arrays are well suited for protein profiling, drug target identification/validation and studies of...

journal_title：Expert opinion on drug delivery

authors： Chandrasekhar S,Iyer LK,Panchal JP,Topp EM,Cannon JB,Ranade VV

更新日期：2013-08-01 00:00:00

abstract：INTRODUCTION:Cancer initiating or stem cells (CSCs) are a small population of cells in the tumor mass, which have been reported to be present in different types of cancers. CSCs usually reside within the tumor and are responsible for reoccurrence of cancer. The imprecise, inaccessible nature and increased efflux of con...

journal_title：Expert opinion on drug delivery

authors： Ahmad G,Amiji MM

更新日期：2017-08-01 00:00:00

abstract：:Introduction: Making selective inhibitors of novel Gram-negative targets is not a substantial challenge - getting them into Gram-negative bacteria to reach their lethal target is the bottleneck. Poor permeability of the antibiotic requires high concentration causing off target activity. The lack of simple experimental...

journal_title：Expert opinion on drug delivery

authors： Winterhalter M

更新日期：2020-11-13 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Alendronate sodium (ALS) is the most common drug used for the treatment of osteoporosis. The challenges facing ALS use include: very poor oral bioavailability (0.6%), esophageal ulcers, and complicated instructions for its use. The objective of this research is to utilize nanotechnology to for...

journal_title：Expert opinion on drug delivery

authors： Hosny KM,Ahmed OA,Al-Abdali RT

更新日期：2013-06-01 00:00:00

abstract：INTRODUCTION:The renaissance in drug delivery research during the past decade led to several new approaches toward vaccine development. Transdermal immunization (TI) is a promising modality with both practical and immunological merits. Compared with conventional routes of administration, this needle-free delivery appro...

journal_title：Expert opinion on drug delivery

authors： Mishra DK,Dhote V,Mishra PK

更新日期：2013-02-01 00:00:00

abstract：INTRODUCTION:Recent advances in pharmacological therapies to treat ocular diseases such as glaucoma, age-related macular degeneration, diabetic macular edema and retinal vascular occlusions have greatly improved the prognosis for these diseases. Due to these advances in pharmacological therapy, there is a great deal of...

journal_title：Expert opinion on drug delivery

authors： Kang-Mieler JJ,Osswald CR,Mieler WF

更新日期：2014-10-01 00:00:00