Enteric-coated alendronate sodium nanoliposomes: a novel formula to overcome barriers for the treatment of osteoporosis.

Abstract:

BACKGROUND AND OBJECTIVES:Alendronate sodium (ALS) is the most common drug used for the treatment of osteoporosis. The challenges facing ALS use include: very poor oral bioavailability (0.6%), esophageal ulcers, and complicated instructions for its use. The objective of this research is to utilize nanotechnology to formulate ALS into enteric-coated nanoliposomes (NLS) to overcome the previously mentioned drawbacks. METHODS:NLS were prepared with lipid components of phosphatidylcholine (PC), cholesterol (CH), and lecithin (Lec) in ratios 4:1:1, 4:2:1, 4:3:1, and 4:4:1, respectively. Formulas that showed the highest entrapment efficiency were prepared either alone or mixed with positive and negative charge-inducing agents and coated with Eudragit L100. Eudragit-coated NLS (EuC-NLS) were evaluated for particle size, zeta potential, morphological examination, and drug release in pH 1.2 and pH 7.4 media. The pharmacokinetic study was carried out in rabbits. RESULTS:Spherical NLS were successfully developed with a mean size range from 70 to 150 nm. EuC-NLS with PC:CH:Lec:dicetyl phosphate (4:3:1:1) successfully resist the release of ALS in acidic environments and enhanced the bioavailability in rabbits 12-fold compared with the marketed tablets. CONCLUSIONS:EuC-NLS is a promising novel formula for ALS with higher bioavailability and a lower dose, avoiding the side effects of esophageal ulceration.

journal_name

Expert Opin Drug Deliv

authors

Hosny KM,Ahmed OA,Al-Abdali RT

doi

10.1517/17425247.2013.799136

subject

Has Abstract

pub_date

2013-06-01 00:00:00

pages

741-6

issue

6

eissn

1742-5247

issn

1744-7593

journal_volume

10

pub_type

杂志文章
  • Solid lipid nanoparticles and nanostructured lipid carrier-based nanotherapeutics in treatment of psoriasis: a comparative study.

    abstract:BACKGROUND:The present work focuses on the development of ultra-small solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) encapsulating cyclosporine and calcipotriol, further incorporated into gel, increasing their penetration through the skin. RESEARCH DESIGN AND METHODS:Developed SLN and NLC were...

    journal_title:Expert opinion on drug delivery

    pub_type: 杂志文章

    doi:10.1080/17425247.2017.1264386

    authors: Arora R,Katiyar SS,Kushwah V,Jain S

    更新日期:2017-02-01 00:00:00

  • Delivery methods for drugs used in the treatment of overactive bladder.

    abstract:INTRODUCTION:Overactive bladder affects a significant portion of the population and results in prescribing of numerous medications for its treatment. Traditional drug delivery systems used in therapy are associated with multiple commonly reported side effects. Adherence rates with use of these medications are low. It i...

    journal_title:Expert opinion on drug delivery

    pub_type: 杂志文章,评审

    doi:10.1517/17425247.2016.1130033

    authors: Scott K,Dmochowski RR,Padmanabhan P

    更新日期:2016-01-01 00:00:00

  • Microarrays and microneedle arrays for delivery of peptides, proteins, vaccines and other applications.

    abstract:INTRODUCTION:Peptide and protein microarray and microneedle array technology provides direct information on protein function and potential drug targets in drug discovery and delivery. Because of this unique ability, these arrays are well suited for protein profiling, drug target identification/validation and studies of...

    journal_title:Expert opinion on drug delivery

    pub_type: 杂志文章,评审

    doi:10.1517/17425247.2013.797405

    authors: Chandrasekhar S,Iyer LK,Panchal JP,Topp EM,Cannon JB,Ranade VV

    更新日期:2013-08-01 00:00:00

  • Biointerfacial phenomena of amlodipine buccomucosal tablets of HPMC matrix system containing polyacrylate polymer/β-cyclodextrin: Correlation of swelling and drug delivery performance.

    abstract:OBJECTIVES:This study focuses on the development of amlodipine bilayer buccal tablets of hydroxypropyl methylcellulose (HPMC) matrix system containing polyacrylate polymer (Carbopol(®))/β-cyclodextrin as the drug layer and ethylcellulose as the non-swellable backing layer, and their biointerfacial phenomena. METHODS:T...

    journal_title:Expert opinion on drug delivery

    pub_type: 杂志文章

    doi:10.1517/17425247.2016.1154038

    authors: Panda B,Subhadarsini R,Mallick S

    更新日期:2016-01-01 00:00:00

  • Design and in vitro release study of siRNA loaded Layer by Layer nanoparticles with sustained gene silencing effect.

    abstract:OBJECTIVES:Clinical translation of siRNA therapeutics has been severely limited due to the lack of stable and sustained siRNA delivery systems. Furthermore, when nanocarrier systems with siRNA are administered systemically to treat diseases, insufficient doses reach the target tissue. Here we report the successful deve...

    journal_title:Expert opinion on drug delivery

    pub_type: 杂志文章

    doi:10.1080/17425247.2018.1518426

    authors: Tan YF,Lee YS,Seet LF,Ng KW,Wong TT,Venkatraman S

    更新日期:2018-10-01 00:00:00

  • Nanocarriers: more than tour de force for thymoquinone.

    abstract::Introduction: Thymoquinone (TQ), 2-isopropyl-5-methylbenzo-1, 4-quinone, the main active constituent of Nigella sativa (NS) plant, has been proven to be of great therapeutic aid in various in vitro and in vivo conditions. Despite the promising therapeutic activities of TQ, this molecule is not yet in the clinical tria...

    journal_title:Expert opinion on drug delivery

    pub_type: 杂志文章,评审

    doi:10.1080/17425247.2020.1730808

    authors: Rathore C,Rathbone MJ,Chellappan DK,Tambuwala MM,Pinto TJA,Dureja H,Hemrajani C,Gupta G,Dua K,Negi P

    更新日期:2020-04-01 00:00:00

  • Nucleic acid-loaded lipid-polymer nanohybrids as novel nanotherapeutics in anticancer therapy.

    abstract:INTRODUCTION:Since decades, cancer is a major public health problem worldwide. The increasing knowledge of molecular and tumor biology has significantly changed the cancer treatment paradigms during the past few years. AREA COVERED:Conventionally, the first-line treatment of solid tumors is their surgical removal foll...

    journal_title:Expert opinion on drug delivery

    pub_type: 杂志文章,评审

    doi:10.1080/17425247.2020.1757645

    authors: Rahman M,Alharbi KS,Alruwaili NK,Anfinan N,Almalki WH,Padhy I,Sambamoorthy U,Swain S,Beg S

    更新日期:2020-06-01 00:00:00

  • Photosensitiser delivery for photodynamic therapy. Part 1: Topical carrier platforms.

    abstract:BACKGROUND:Photodynamic therapy (PDT) is a medical treatment in which a combination of a photosensitising drug and visible light causes destruction of selected cells. Due to the lack of true selectivity of preformed photosensitisers for neoplastic tissue and their high molecular weights, PDT of superficial skin lesions...

    journal_title:Expert opinion on drug delivery

    pub_type: 杂志文章,评审

    doi:10.1517/17425247.5.7.757

    authors: Donnelly RF,McCarron PA,Morrow DI,Sibani SA,Woolfson AD

    更新日期:2008-07-01 00:00:00

  • Gemcitabine-loaded innovative nanocarriers vs GEMZAR: biodistribution, pharmacokinetic features and in vivo antitumor activity.

    abstract:INTRODUCTION:Gemcitabine, an anticancer drug, is a nucleoside analog deoxycytidine antimetabolite, which acts against a wide range of solid tumors. The limitation of gemcitabine is its rapid inactivation by the deoxycytidine deaminase enzyme following its in vivo administration. AREAS COVERED:One of the most promising...

    journal_title:Expert opinion on drug delivery

    pub_type: 杂志文章,评审

    doi:10.1517/17425247.2011.632630

    authors: Celia C,Cosco D,Paolino D,Fresta M

    更新日期:2011-12-01 00:00:00

  • Liposomes for targeted delivery of antithrombotic drugs.

    abstract:BACKGROUND:Targeted delivery of antithrombotic (thrombolytic) drugs is expected to increase their efficacy and decrease side effects, especially in the case of thrombolytic enzymes. Liposomes, phospholipid nanosized bubbles with a bilayered membrane structure, have drawn a lot of interest as pharmaceutical carriers for...

    journal_title:Expert opinion on drug delivery

    pub_type: 杂志文章,评审

    doi:10.1517/17425240802497457

    authors: Elbayoumi TA,Torchilin VP

    更新日期:2008-11-01 00:00:00

  • Current status and the future of buccal drug delivery systems.

    abstract:BACKGROUND:The delivery of drugs through the buccal mucosa has received a great deal of attention over the last two decades, and yet there are not many buccal delivery products available on the market. OBJECTIVE:This review outlines the advantages and disadvantages of buccal drug delivery, provides a historical perspe...

    journal_title:Expert opinion on drug delivery

    pub_type: 杂志文章,评审

    doi:10.1517/17425247.5.5.531

    authors: Pather SI,Rathbone MJ,Senel S

    更新日期:2008-05-01 00:00:00

  • Overcoming the barriers in micellar drug delivery: loading efficiency, in vivo stability, and micelle-cell interaction.

    abstract:IMPORTANCE OF THE FIELD:Spontaneously constructed from block copolymers in aqueous media, the polymer micelle has been extensively studied as a potential carrier of poorly water-soluble drugs, but cellular uptake pathways and stability of micelles in blood have not yet been clearly understood. An in-depth insight into ...

    journal_title:Expert opinion on drug delivery

    pub_type: 杂志文章,评审

    doi:10.1517/17425240903380446

    authors: Kim S,Shi Y,Kim JY,Park K,Cheng JX

    更新日期:2010-01-01 00:00:00

  • Transdermal delivery of beta-blockers.

    abstract::Beta-adrenoceptor blocking drugs (beta-blockers) are one of the most frequently used class of cardiovascular drugs that are mainly used in conventional dosage forms., which have their own limitations including hepatic first-pass metabolism, high incidence of adverse effects due to variable absorption profiles, higher ...

    journal_title:Expert opinion on drug delivery

    pub_type: 杂志文章,评审

    doi:10.1517/17425247.3.3.405

    authors: Aqil M,Sultana Y,Ali A

    更新日期:2006-05-01 00:00:00

  • Recent advance of nanoparticle-based topical drug delivery to the posterior segment of the eye.

    abstract:INTRODUCTION:Considering that the number of patients afflicted by posterior eye diseases is increasing, effective drug delivery is currently in high clinical demand. Topical administration has been identified as the preferred option, while sufferingfrom multiple barriers. The development of nanoparticle-based drug deli...

    journal_title:Expert opinion on drug delivery

    pub_type: 杂志文章,评审

    doi:10.1080/17425247.2018.1496080

    authors: Wang Y,Xu X,Gu Y,Cheng Y,Cao F

    更新日期:2018-07-01 00:00:00

  • The interaction of nanoparticles with plasma proteins and the consequent influence on nanoparticles behavior.

    abstract:INTRODUCTION:Plasma protein binding with nanoparticles (NPs) occurs immediately upon their introduction into a physiological environment and is affected by the characteristics of NPs, including their composition, size, shape and surface properties. According to their specific functions, adsorbed proteins can be divided...

    journal_title:Expert opinion on drug delivery

    pub_type: 杂志文章,评审

    doi:10.1517/17425247.2014.877442

    authors: Gao H,He Q

    更新日期:2014-03-01 00:00:00

  • Nanoparticles as carriers for drug delivery of macromolecules across the blood-brain barrier.

    abstract::Introduction: Current therapies of neurodegenerative or neurometabolic diseases are, to a large extent, hampered by the inability of drugs to cross the blood-brain barrier (BBB). This very tight barrier severely restricts the entrance of molecules from the blood into the brain, especially macromolecular substances (i....

    journal_title:Expert opinion on drug delivery

    pub_type: 杂志文章,评审

    doi:10.1080/17425247.2020.1698544

    authors: Tosi G,Duskey JT,Kreuter J

    更新日期:2020-01-01 00:00:00

  • An update on the contribution of hot-melt extrusion technology to novel drug delivery in the twenty-first century: part I.

    abstract:INTRODUCTION:Currently, hot melt extrusion (HME) is a promising technology in the pharmaceutical industry, as evidenced by its application to manufacture various FDA-approved commercial products in the market. HME is extensively researched for enhancing the solubility and bioavailability of poor water-soluble drugs, ta...

    journal_title:Expert opinion on drug delivery

    pub_type: 杂志文章,评审

    doi:10.1080/17425247.2019.1609448

    authors: Kallakunta VR,Sarabu S,Bandari S,Tiwari R,Patil H,Repka MA

    更新日期:2019-05-01 00:00:00

  • Cutaneous immunization: an evolving paradigm in influenza vaccines.

    abstract:INTRODUCTION:Most vaccines are administered by intramuscular injection using a hypodermic needle and syringe. Some limitations of this procedure include reluctance to be immunized because of fear of needlesticks, and concerns associated with the safe disposal of needles after their use. Skin delivery is an alternate ro...

    journal_title:Expert opinion on drug delivery

    pub_type: 杂志文章,评审

    doi:10.1517/17425247.2014.885947

    authors: Gill HS,Kang SM,Quan FS,Compans RW

    更新日期:2014-04-01 00:00:00

  • Preparation of sterile long-acting injectable medroxyprogesterone acetate microcrystals based on anti-solvent precipitation and crystal habit control.

    abstract::Background: To overcome the rigorous aseptic process widely adopted by commercial long-acting injections, this work aimed to prepare a sterile MPA injection by manipulating the crystal habit through a bottom-up method. Methods: The habit of the precipitated crystals was modified by changing the process conditions. Whe...

    journal_title:Expert opinion on drug delivery

    pub_type: 杂志文章

    doi:10.1080/17425247.2019.1662394

    authors: Sun R,Guo Y,Yin N,Yin J,Yin T,He H,Gou J,Zhang Y,Tang X

    更新日期:2019-10-01 00:00:00

  • Current status of non-viral gene therapy for CNS disorders.

    abstract:INTRODUCTION:Viral and non-viral vectors have been used as methods of delivery in gene therapy for many CNS diseases. Currently, viral vectors such as adeno-associated viruses (AAV), retroviruses, lentiviruses, adenoviruses and herpes simplex viruses (HHV) are being used as successful vectors in gene therapy at clinica...

    journal_title:Expert opinion on drug delivery

    pub_type: 杂志文章,评审

    doi:10.1080/17425247.2016.1188802

    authors: Jayant RD,Sosa D,Kaushik A,Atluri V,Vashist A,Tomitaka A,Nair M

    更新日期:2016-10-01 00:00:00

  • Nanocarrier-based antioxidant therapy: promise or delusion?

    abstract:INTRODUCTION:Oxidative stress has generally been recognized as an important factor in the pathogenesis of human diseases, making antioxidant therapy a plausible strategy to either prevent or treat human disorders. Yet so far, numerous antioxidant-based clinical trials aimed at developing clinically approved protocols h...

    journal_title:Expert opinion on drug delivery

    pub_type: 杂志文章,评审

    doi:10.1517/17425247.2015.1063611

    authors: Weissig V,Guzman-Villanueva D

    更新日期:2015-01-01 00:00:00

  • New biomaterials for the sustained release of nitric oxide: past, present and future.

    abstract::Nitric oxide (NO), the 1992 'Molecule of the Year', is the focus of immense medical and scientific exploration. Interest in NO has grown exponentially since the initial and relatively recent discovery that NO is the long sought after endothelial relaxing factor. There is intense research that is continuing to expose t...

    journal_title:Expert opinion on drug delivery

    pub_type: 杂志文章,评审

    doi:10.1517/17425240903196743

    authors: Friedman A,Friedman J

    更新日期:2009-10-01 00:00:00

  • Starch microparticles as vaccine adjuvant.

    abstract::The demand for new vaccine adjuvants is well documented. New purified antigens from parasites, bacterial or viral pathogens, as well as recombinant subunit antigens and synthetic peptides, are often inherently weak immunogens; therefore, they need some kind of adjuvant to help initiate an immune response. In addition,...

    journal_title:Expert opinion on drug delivery

    pub_type: 杂志文章,评审

    doi:10.1517/17425247.2.5.807

    authors: Rydell N,Stertman L,Sjöholm I

    更新日期:2005-09-01 00:00:00

  • Development of thermosensitive chitosan/glicerophospate injectable in situ gelling solutions for potential application in intraoperative fluorescence imaging and local therapy of hepatocellular carcinoma: a preliminary study.

    abstract:OBJECTIVES:Thermosensitive chitosan/glycerophosphate (C/GP) solutions exhibiting sol-gel transition around body temperature were prepared to develop a class of injectable hydrogel platforms for the imaging and loco-regional treatment of hepatocellular carcinoma (HCC). Indocyanine green (ICG) was loaded in the thermosen...

    journal_title:Expert opinion on drug delivery

    pub_type: 杂志文章

    doi:10.1517/17425247.2015.1042452

    authors: Salis A,Rassu G,Budai-Szűcs M,Benzoni I,Csányi E,Berkó S,Maestri M,Dionigi P,Porcu EP,Gavini E,Giunchedi P

    更新日期:2015-01-01 00:00:00

  • Therapeutic potential of carbohydrate-based polymeric and nanoparticle systems.

    abstract:INTRODUCTION:Carbohydrates are key participants in many biological processes including reproduction, inflammation, signal transmission and infection. Their biocompatibility and ability to be recognized by cell-surface receptors illustrate their potential therapeutic applications. αYet, they are not ideal candidates bec...

    journal_title:Expert opinion on drug delivery

    pub_type: 杂志文章,评审

    doi:10.1517/17425247.2014.902048

    authors: Sunasee R,Adokoh CK,Darkwa J,Narain R

    更新日期:2014-06-01 00:00:00

  • Noninvasive approach for enhancing small interfering RNA delivery percutaneously.

    abstract:INTRODUCTION:Topically applied small interfering RNA (siRNA) can be an effective treatment for skin disorders. Using noninvasive strategies can be a safe and effective siRNA-permeation-enhancement approach for facilitating skin delivery. It has been demonstrated that noninvasive approaches for enhancing siRNA transport...

    journal_title:Expert opinion on drug delivery

    pub_type: 杂志文章,评审

    doi:10.1517/17425247.2016.1121988

    authors: Aljuffali IA,Lin YK,Fang JY

    更新日期:2016-01-01 00:00:00

  • Technology-derived storage solutions for stabilizing insulin in extreme weather conditions I: the ViViCap-1 device.

    abstract:BACKGROUND:Injectable life-saving drugs should not be exposed to temperatures <4°C/39°F or >30°C/86°F. Frequently, weather conditions exceed these temperature thresholds in many countries. Insulin is to be kept at 4-8°C/~ 39-47°F until use and once opened, is supposed to be stable for up to 31 days at room temperature ...

    journal_title:Expert opinion on drug delivery

    pub_type: 杂志文章

    doi:10.1080/17425247.2017.1316261

    authors: Pfützner A,Pesach G,Nagar R

    更新日期:2017-06-01 00:00:00

  • The latest advances of cisplatin liposomal formulations: essentials for preparation and analysis.

    abstract::Introduction: Cisplatin has been indicated for several malignancies all over the world for many years. Increasing patient tolerance for high dose of chemotherapeutics and reducing side effects has been granted by drug encapsulated liposomal systems. There have been much efforts for improving cisplatin delivery to the ...

    journal_title:Expert opinion on drug delivery

    pub_type: 杂志文章,评审

    doi:10.1080/17425247.2020.1737672

    authors: Zahednezhad F,Zakeri-Milani P,Shahbazi Mojarrad J,Valizadeh H

    更新日期:2020-04-01 00:00:00

  • Progressive stent technologies: new approaches for the treatment of cardiovascular diseases.

    abstract::The CYPHER (Cordis, Johnson & Johnson) sirolimus-eluting stent and the TAXU (Boston Scientific) paclitaxel-eluting stent have been extensively evaluated and have been proven to be significant novel tools for the treatment of coronary artery disease. Several sirolimus derivatives have already emerged, receiving CE Mark...

    journal_title:Expert opinion on drug delivery

    pub_type: 杂志文章,评审

    doi:10.1517/17425247.3.6.783

    authors: Vaina S,Serruys PW

    更新日期:2006-11-01 00:00:00

  • Topically applied methotrexate is rapidly delivered into skin by fractional laser ablation.

    abstract:OBJECTIVES:Methotrexate (MTX) is a chemotherapeutic and anti-inflammatory drug that may cause systemic adverse effects. This study investigated kinetics and biodistribution of MTX delivered topically by ablative fractional laser (AFXL). METHODS:In vitro passive diffusion of 10 mg/ml MTX (1 w/v%) was measured from 0.25...

    journal_title:Expert opinion on drug delivery

    pub_type: 杂志文章

    doi:10.1517/17425247.2015.1031216

    authors: Taudorf EH,Lerche CM,Vissing AC,Philipsen PA,Hannibal J,D'Alvise J,Hansen SH,Janfelt C,Paasch U,Anderson RR,Haedersdal M

    更新日期:2015-07-01 00:00:00