The rejuvenated pressurised metered dose inhaler.

abstract：INTRODUCTION:Liposomes are well-known as drug carriers, and are now critical components of two of six types of adjuvants present in licensed vaccines. The liposomal vaccine adjuvant field has long been dynamic and innovative, and research in this area is further examined as new commercial products appear in parallel wi...

journal_title：Expert opinion on drug delivery

authors： Alving CR,Beck Z,Matyas GR,Rao M

更新日期：2016-06-01 00:00:00

abstract：INTRODUCTION:Harnessing RNA interference as a therapeutic approach has the potential to significantly expand the druggable target space, offering new hope for treatment of diseases that cannot be addressed with existing classes of drugs. A number of siRNA therapeutics have already progressed into preclinical and clinic...

journal_title：Expert opinion on drug delivery

authors： Gindy ME,Leone AM,Cunningham JJ

更新日期：2012-02-01 00:00:00

abstract：INTRODUCTION:Cancer initiating or stem cells (CSCs) are a small population of cells in the tumor mass, which have been reported to be present in different types of cancers. CSCs usually reside within the tumor and are responsible for reoccurrence of cancer. The imprecise, inaccessible nature and increased efflux of con...

journal_title：Expert opinion on drug delivery

authors： Ahmad G,Amiji MM

更新日期：2017-08-01 00:00:00

abstract：INTRODUCTION:Oxidative stress has generally been recognized as an important factor in the pathogenesis of human diseases, making antioxidant therapy a plausible strategy to either prevent or treat human disorders. Yet so far, numerous antioxidant-based clinical trials aimed at developing clinically approved protocols h...

journal_title：Expert opinion on drug delivery

authors： Weissig V,Guzman-Villanueva D

更新日期：2015-01-01 00:00:00

abstract：IMPORTANCE OF THE FIELD:Vascular delivery of several classes of therapeutic agents may benefit from carriage by red blood cells (RBC), for example, drugs that require delivery into phagocytic cells and those that must act within the vascular lumen. The fact that several protocols of infusion of RBC-encapsulated drugs a...

journal_title：Expert opinion on drug delivery

authors： Muzykantov VR

更新日期：2010-04-01 00:00:00

abstract：:Introduction: Systemically administered non-viral gene delivery systems face multiple biological barriers that decrease their efficiency. These systems are rapidly cleared from the circulation and sufficient concentrations do not accumulate in diseased tissues. A number of targeting strategies can be used to provide f...

journal_title：Expert opinion on drug delivery

authors： Khalil IA,Sato Y,Harashima H

更新日期：2019-10-01 00:00:00

abstract：INTRODUCTION:Apart from statins, anti-platelet agents and invasive procedures, the anti-atherosclerotic medical weaponry for coronary heart disease (CHD) is scarce and only partially protects CHD patients from major adverse cardiac events. AREAS COVERED:Several novel non-invasive strategies are being developed to wide...

journal_title：Expert opinion on drug delivery

authors： Maranhão RC,Tavares ER

更新日期：2015-07-01 00:00:00

abstract：INTRODUCTION:Polymeric microspheres have been established as a valuable parenteral drug delivery system for sustained release of therapeutic agents via subcutaneous or intramuscular injection. AREAS COVERED:Biodegradable polymers which are either synthetic or from natural sources are reviewed with respect to recent ad...

journal_title：Expert opinion on drug delivery

authors： Mao S,Guo C,Shi Y,Li LC

更新日期：2012-09-01 00:00:00

abstract：INTRODUCTION:Plasma protein binding with nanoparticles (NPs) occurs immediately upon their introduction into a physiological environment and is affected by the characteristics of NPs, including their composition, size, shape and surface properties. According to their specific functions, adsorbed proteins can be divided...

journal_title：Expert opinion on drug delivery

authors： Gao H,He Q

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:Efficient and minimally invasive vector systems appear to be the most appropriate for both gene therapy and drug delivery. Numerous viral and non-viral vectors have been developed. Each vector has its own advantages and limitations. OBJECTIVE:New vectors have been required for overcoming the limitations of ...

journal_title：Expert opinion on drug delivery

authors： Kaneda Y

更新日期：2008-02-01 00:00:00

abstract：BACKGROUND:Inhalation of microparticulate dosage forms can be effectively used in the treatment of respiratory and systemic diseases. OBJECTIVE:Disease states investigated for treatment by inhalation of microparticles were reviewed along with the drugs' pharmacological, pharmacokinetic and physical chemical properties...

journal_title：Expert opinion on drug delivery

authors： Xie Y,Zeng P,Wiedmann TS

更新日期：2008-03-01 00:00:00

abstract：:Many agents used to treat cancer are toxic to normal tissues. Thus, treatments delivering drug specifically to tumour, while minimising exposure to normal tissue, may be advantageous over non-targeted treatments. The exquisite specificity of the immune system has been used successfully to help develop targeted antican...

journal_title：Expert opinion on drug delivery

authors： Brumlik MJ,Daniel BJ,Waehler R,Curiel DT,Giles FJ,Curiel TJ

更新日期：2008-01-01 00:00:00

abstract：INTRODUCTION:Drug release and oral absorption of drugs with pH-dependent solubility are influenced by the conditions in the gastrointestinal tract. In some cases, poor oral absorption has been observed for these drugs, causing insufficient drug efficacy. The pH-modification of a formulation could be a promising approac...

journal_title：Expert opinion on drug delivery

authors： Taniguchi C,Kawabata Y,Wada K,Yamada S,Onoue S

更新日期：2014-04-01 00:00:00

abstract：IMPORTANCE OF THE FIELD:Since the 1950s, ultrasonic nebulizers have played an important role in pulmonary drug delivery. As the process in which aerosol droplets are generated is independent and does not require breath-actuation, ultrasonic nebulizers, in principle, offer the potential for instantaneously fine-tuning t...

journal_title：Expert opinion on drug delivery

authors： Yeo LY,Friend JR,McIntosh MP,Meeusen EN,Morton DA

更新日期：2010-06-01 00:00:00

abstract：INTRODUCTION:Peptide and protein microarray and microneedle array technology provides direct information on protein function and potential drug targets in drug discovery and delivery. Because of this unique ability, these arrays are well suited for protein profiling, drug target identification/validation and studies of...

journal_title：Expert opinion on drug delivery

authors： Chandrasekhar S,Iyer LK,Panchal JP,Topp EM,Cannon JB,Ranade VV

更新日期：2013-08-01 00:00:00

abstract：IMPORTANCE OF THE FIELD:The prediction of the in vivo drug release characteristics of modified release (MR) oral dosage forms by in vitro dissolution tests is a prerequisite for successful product development. AREAS COVERED IN THIS REVIEW:To improve the predictive power of dissolution testing, the authors recently dev...

journal_title：Expert opinion on drug delivery

authors： Garbacz G,Klein S,Weitschies W

更新日期：2010-11-01 00:00:00

abstract：AIM:Spacer devices are inhalation aids of varying dimension and complexity, specifically designed to overcome problems with the use of pressurised metered dose inhalers (pMDIs). The aim of this review is to examine the current understanding about these inhalation devices and discuss their advantages and disadvantages. ...

journal_title：Expert opinion on drug delivery

authors： Lavorini F,Fontana GA

更新日期：2009-01-01 00:00:00

abstract：INTRODUCTION:Reversible Addition Fragmentation Chain Transfer (RAFT) polymerisation is now an established tool for polymer chemists to create various polymer architectures with precise control over the molecular weight, and to install a variety of different moieties onto the polymer chain ends. Recently, there seems to...

journal_title：Expert opinion on drug delivery

authors： Gregory A,Stenzel MH

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND:Therapeutic peptides have great potential as anticancer agents owing to their ease of rational design and target specificity. However, their utility in vivo is limited by low stability and poor tumor penetration. OBJECTIVE:The authors review the development of peptide inhibitors with potential for cancer th...

journal_title：Expert opinion on drug delivery

authors： Bidwell GL 3rd,Raucher D

更新日期：2009-10-01 00:00:00

abstract：BACKGROUND:We hypothesized if phagocytosis of liposomes by macrophages could be mitigated through incorporation of a CD47 mimicry peptide (Self peptide: SP) on the surface of liposomes. METHODS:Thin film hydration method followed by extrusion was used to prepare nanoliposomes, and Dox encapsulation in liposomes was do...

journal_title：Expert opinion on drug delivery

authors： Gheibi Hayat SM,Jaafari MR,Hatamipour M,Jamialahmadi T,Sahebkar A

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND:The advent of therapeutic proteins highlights the need for delivery systems that protect and extend the duration of its action. Ranibizumab-VEGF is one such drug used for treating wet AMD. This paper describes a facile method to sustain bioactive ranibizumab release from PLGA-based particles. METHODS:Two em...

journal_title：Expert opinion on drug delivery

authors： Chua HY,Lui YS,Bhuthalingam R,Agrawal R,Wong T,Preiser PR,Venkatraman S

更新日期：2018-12-01 00:00:00

abstract：INTRODUCTION:Bisphosphonates (BPs) were introduced 45 years ago as anti-osteoporotic drugs and during the last decade have been utilized as bone-targeting groups in systemic treatment of bone diseases. Very recently, strategies of chemical immobilization of BPs in hydrogels and nanocomposites for bone tissue engineerin...

journal_title：Expert opinion on drug delivery

authors： Ossipov DA

更新日期：2015-01-01 00:00:00

abstract：INTRODUCTION:Transdermal drug delivery has several known advantages over the oral route and hypodermic injections. The number of drugs that can be taken up transdermally is, however, limited owing to the innate barrier function of the skin. New transdermal drug candidates need to be tested extensively before being used...

journal_title：Expert opinion on drug delivery

authors： Van Gele M,Geusens B,Brochez L,Speeckaert R,Lambert J

更新日期：2011-06-01 00:00:00

abstract：IMPORTANCE OF THE FIELD:Efficient systemic delivery of low-molecular-mass therapeutics to neuronal tissue remains a central issue not only to drug development but also to the chronic treatment of a range of neurodegenerative disorders. AREAS COVERED IN THIS REVIEW:This review discusses the potential of using RNA inter...

journal_title：Expert opinion on drug delivery

authors： Campbell M,Ozaki E,Humphries P

更新日期：2010-07-01 00:00:00

abstract：OBJECTIVES:This study focuses on the development of amlodipine bilayer buccal tablets of hydroxypropyl methylcellulose (HPMC) matrix system containing polyacrylate polymer (Carbopol(®))/β-cyclodextrin as the drug layer and ethylcellulose as the non-swellable backing layer, and their biointerfacial phenomena. METHODS:T...

journal_title：Expert opinion on drug delivery

authors： Panda B,Subhadarsini R,Mallick S

更新日期：2016-01-01 00:00:00

abstract：INTRODUCTION:Many drug candidates with high therapeutic efficacy have low water solubility, which limits the administration and transport across physiological barriers, for example, the tumor tissue barrier. Therefore, strategies are needed to permeabilize the physiological barriers safely so that hydrophobic drugs may...

journal_title：Expert opinion on drug delivery

authors： Wang G,Wang J,Wu W,Tony To SS,Zhao H,Wang J

更新日期：2015-01-01 00:00:00

abstract：:Targeting vaccines to the skin epidermis results in the activation of an immune inductive site that is rich in antigen-presenting cells. The superficial location of the skin makes it accessible to vaccine delivery. However, it is difficult to access the epidermis using needle and syringe delivery, and vaccine antigens...

journal_title：Expert opinion on drug delivery

authors： Dean HJ

更新日期：2005-03-01 00:00:00

abstract：AIM:The mechanical properties and compaction characteristics of different varieties of Assam Bora rice flours (ABRFs) were evaluated and compared with those of official Starch 1500®. METHODS:The material properties and compression characteristics of Assam Bora rice flours were studied by Heckel and Kawakita analysis. ...

journal_title：Expert opinion on drug delivery

authors： Ahmad MZ,Akhter S,Dhiman I,Sharma P,Verma R

更新日期：2013-02-01 00:00:00

abstract：IMPORTANCE OF THE FIELD:Drug combinations have been the standard of care in the treatment of cancer for > 50 years. Typically, combination chemotherapy uses agents with non-overlapping toxicities which are escalated to their maximum tolerated dose. However, emerging evidence indicates that this approach may not be prov...

journal_title：Expert opinion on drug delivery

authors： Dicko A,Mayer LD,Tardi PG

更新日期：2010-12-01 00:00:00

abstract：INTRODUCTION:Diseases of the inner ear include those of the auditory and vestibular systems, and frequently result in disabling hearing loss or vertigo. Despite a rapidly expanding pipeline of potential cochlear therapeutics, the inner ear remains a challenging organ for targeted drug delivery, and new technologies are...

journal_title：Expert opinion on drug delivery

authors： Ayoob AM,Borenstein JT

更新日期：2015-03-01 00:00:00