Advances in non-invasive drug delivery for atherosclerotic heart disease.

abstract：INTRODUCTION:In situ gel systems refer to a class of novel delivery vehicles, composed of natural, semisynthetic or synthetic polymers, which present the unique property of sol-gel conversion on receipt of biological stimulus. AREAS COVERED:The present review summarizes the latest developments in in situ gel technolog...

journal_title：Expert opinion on drug delivery

authors： Agrawal AK,Das M,Jain S

更新日期：2012-04-01 00:00:00

abstract：:Introduction: Current therapies of neurodegenerative or neurometabolic diseases are, to a large extent, hampered by the inability of drugs to cross the blood-brain barrier (BBB). This very tight barrier severely restricts the entrance of molecules from the blood into the brain, especially macromolecular substances (i....

journal_title：Expert opinion on drug delivery

authors： Tosi G,Duskey JT,Kreuter J

更新日期：2020-01-01 00:00:00

abstract：INTRODUCTION:With the incorporation of edge activators into the lipid bilayer structure, elasticity properties are given to liposomes. Regardless of the debate over the precise permeation mechanism of elastic liposomes, these vesicles have been proven to enhance drug permeation into or through skin in most cases. AREA...

journal_title：Expert opinion on drug delivery

authors： Chen J,Lu WL,Gu W,Lu SS,Chen ZP,Cai BC

更新日期：2013-06-01 00:00:00

abstract：:Objective: Conventional chloramphenicol (CHL) eye drops are widely used anti-infection formulations for acute bacterial conjunctivitis. However, the therapeutic effects are limited by insufficient concentration in the conjunctival sac. Hence, the objective of this study is to formulate and develop novel CHL eye drops ...

journal_title：Expert opinion on drug delivery

authors： Xu Y,Zhang C,Zhu X,Wang X,Wang H,Hu G,Fu Q,He Z

更新日期：2019-06-01 00:00:00

abstract：:Skin diseases are prevalent and can significantly affect quality of life. Empirical mathematical models retrospectively analyse data to predict skin permeation from the physico-chemical properties of drugs. Quantitative structure permeability relationships are discussed, along with alternatives to linear modelling. Me...

journal_title：Expert opinion on drug delivery

authors： Russell LM,Guy RH

更新日期：2009-04-01 00:00:00

abstract：INTRODUCTION:Rapid clearance of drugs from the body results in short therapeutic half-life and is an integral property of many protein and peptide-based drugs. To maintain the desired therapeutic effect patients are required to administer higher doses more frequently, which is inconvenient and risks undesirable side ef...

journal_title：Expert opinion on drug delivery

authors： Sleep D

更新日期：2015-05-01 00:00:00

abstract：:Introduction: Poloxamer based in situ gelling systems offer numerous advantages in drug delivery; however, their application as prolonged-release delivery platforms is limited mainly due to their weak mechanical properties and the interconnected aqueous network causing fast gel erosion and drug diffusion.Area covered:...

journal_title：Expert opinion on drug delivery

authors： Abdeltawab H,Svirskis D,Sharma M

更新日期：2020-04-01 00:00:00

abstract：INTRODUCTION:Glioblastoma is a type of brain cancer arises from glial cells. Glioblastoma multiforme (GBM), a subtype of glioblastoma, is the most common and most aggressive primary brain tumor. Currently, GBM therapy includes surgery and post-operative high-doses of radiation and chemotherapy. This therapeutic strateg...

journal_title：Expert opinion on drug delivery

authors： Gutkin A,Cohen ZR,Peer D

更新日期：2016-11-01 00:00:00

abstract：INTRODUCTION:Interest in mesoporous silica nanoparticles for drug delivery has resulted in a good understanding of the impact of size and surface chemistry of these nanoparticles on their performance as drug carriers. Shape has emerged as an additional factor that can have a significant effect on delivery efficacy. Rod...

journal_title：Expert opinion on drug delivery

authors： Cong VT,Gaus K,Tilley RD,Gooding JJ

更新日期：2018-09-01 00:00:00

abstract：INTRODUCTION:A nanosuspension or nanocrystal suspension is a versatile formulation combining conventional and innovative features. It comprises 100% pure drug nanoparticles with sizes in the nano-scale range, generally stabilized by surfactants or polymers. Nanosuspensions are usually obtained in liquid media with bott...

journal_title：Expert opinion on drug delivery

authors： Leone F,Cavalli R

更新日期：2015-01-01 00:00:00

abstract：INTRODUCTION:Fueled by a growing global expectation of the health and medical fields, billions of dollars/euros/pounds are invested every year in the research of new biological and chemical entities. However, little interest is seen in the development of novel drug delivery systems. One such system, pre-filled syringe ...

journal_title：Expert opinion on drug delivery

authors： Ingle RG,Agarwal AS

更新日期：2014-09-01 00:00:00

abstract：:Introduction: Sativex® spray is clinically utilized to deliver delta9-tetrahydrocannabinol and cannabidiol to oral mucosa for systemic absorption. We challenge the consensus that the mechanism of absorption following the oro-mucosal application occurs via the buccal tissue. Areas covered: Correctness of the consensus ...

journal_title：Expert opinion on drug delivery

authors： Itin C,Domb AJ,Hoffman A

更新日期：2019-10-01 00:00:00

abstract：INTRODUCTION:Polymer-drug conjugates are an important part of polymer therapeutics. Recently, they have been used as an appealing platform for drug delivery. As a delivery vector, the route of administration performs a serious impact on the accessibility of drug molecules to their respective target site and therapeutic...

journal_title：Expert opinion on drug delivery

authors： Pang X,Yang X,Zhai G

更新日期：2014-07-01 00:00:00

abstract：INTRODUCTION:Utilizing the prodrug approach as a method to overcome various pharmaceutical and pharmacokinetic barriers to drug delivery is significantly accelerating and achieving successes. In contrast to the older traditional prodrugs which suffer from decreased bioavailability and a high profile of side effects, du...

journal_title：Expert opinion on drug delivery

authors： Amly W,Karaman R

更新日期：2016-01-01 00:00:00

abstract：INTRODUCTION:Currently, hot melt extrusion (HME) is a promising technology in the pharmaceutical industry, as evidenced by its application to manufacture various FDA-approved commercial products in the market. HME is extensively researched for enhancing the solubility and bioavailability of poor water-soluble drugs, ta...

journal_title：Expert opinion on drug delivery

authors： Kallakunta VR,Sarabu S,Bandari S,Tiwari R,Patil H,Repka MA

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND:Pulmonary cell culture models for the development of new aerosol medicines are attracting increasing interest. Ease of handling, ethical acceptance and high explanatory power are the main advantages of cell culture systems in pulmonary drug research. OBJECTIVE:Pulmonary cell culture models are described and...

journal_title：Expert opinion on drug delivery

authors： Bur M,Lehr CM

更新日期：2008-06-01 00:00:00

abstract：INTRODUCTION:Peptide and protein microarray and microneedle array technology provides direct information on protein function and potential drug targets in drug discovery and delivery. Because of this unique ability, these arrays are well suited for protein profiling, drug target identification/validation and studies of...

journal_title：Expert opinion on drug delivery

authors： Chandrasekhar S,Iyer LK,Panchal JP,Topp EM,Cannon JB,Ranade VV

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND:Liposomes, phospholipids, nanosized bubbles with a bilayered membrane structure, have drawn a lot of interest as pharmaceutical carriers for drugs and genes. In particular, liposomes are widely used for drug delivery into tumors. OBJECTIVE:In many cases, to enhance the efficacy of the liposomal drugs, drug-...

journal_title：Expert opinion on drug delivery

authors： Torchilin V

更新日期：2008-09-01 00:00:00

abstract：BACKGROUND:The lung comprises an interesting route of administration not only for topical drugs but also for systemically acting drugs. Over the last years, several models have been developed in order to study the efficacy and safety of pulmonary drug delivery. OBJECTIVE:This review describes relevant drug delivery mo...

journal_title：Expert opinion on drug delivery

authors： Fernandes CA,Vanbever R

更新日期：2009-11-01 00:00:00

abstract：:Due to the poor solvent properties of hydrofluoroalkanes, suspension is often the only formulation option for respiratory drug delivery. Research in this area has focussed mainly on two main themes over the past 5 years: new design of stabilisers and particle engineering. Among the most important advances, the introdu...

journal_title：Expert opinion on drug delivery

authors： Rogueda P

更新日期：2005-07-01 00:00:00

abstract：IMPORTANCE OF THE FIELD:Visceral leishmaniasis (VL) is the most overwhelming type of leishmaniasis associated with the poverty of developing countries and usually mortal if untreated. Most of the conventionally used dosage forms offer us the shortcomings of toxic side effects and emergence of drug resistance. Several e...

journal_title：Expert opinion on drug delivery

authors： Gupta S,Pal A,Vyas SP

更新日期：2010-03-01 00:00:00

abstract：INTRODUCTION:Reversible Addition Fragmentation Chain Transfer (RAFT) polymerisation is now an established tool for polymer chemists to create various polymer architectures with precise control over the molecular weight, and to install a variety of different moieties onto the polymer chain ends. Recently, there seems to...

journal_title：Expert opinion on drug delivery

authors： Gregory A,Stenzel MH

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND:Although various injected peptide and protein therapeutics have been developed successfully over the past 25 years, several pharmacokinetic and immunological challenges are still encountered that can limit the efficacy of both novel and established biotech molecules. OBJECTIVE AND METHOD:PEGylation is a pop...

journal_title：Expert opinion on drug delivery

authors： Ryan SM,Mantovani G,Wang X,Haddleton DM,Brayden DJ

更新日期：2008-04-01 00:00:00

abstract：INTRODUCTION:Calcium channel blockers are a very important class of antihypertensive drugs. Most calcium channel blockers (CCBs) exhibiting low oral bioavailability are required to be taken more than once a day due to their short half-lives which result in poor patient compliance. There is an ineluctable requirement fo...

journal_title：Expert opinion on drug delivery

authors： Ahad A,Al-Jenoobi FI,Al-Mohizea AM,Aqil M,Kohli K

更新日期：2013-08-01 00:00:00

abstract：INTRODUCTION:Oral delivery of therapeutic peptide hormones offers the promise of greater patient compliance when compared to parenteral administration routes. However, it is a huge challenge in the pharmaceutical field. Due to increasing demand for oral delivery of peptide hormones such as insulin, gonadotropin-releasi...

journal_title：Expert opinion on drug delivery

authors： Varamini P,Toth I

更新日期：2016-01-01 00:00:00

abstract：INTRODUCTION:Respiratory infections and diseases are accompanied by or exhibit inflammation. Recent advances in nanoparticle engineering technology, together with the increased knowledge of inflammatory pathophysiology, have ignited interest in the pulmonary delivery of anti-inflammatory agents (AIAs) to achieve local ...

journal_title：Expert opinion on drug delivery

authors： Ali ME,McConville JT,Lamprecht A

更新日期：2015-06-01 00:00:00

abstract：:Introduction: Pulmonary drug delivery is a complex field of research combining physics which drive aerosol transport and deposition and biology which underpins efficacy and toxicity of inhaled drugs. A myriad of preclinical methods, ranging from in-silico to in-vitro, ex-vivo and in-vivo, can be implemented.Areas cove...

journal_title：Expert opinion on drug delivery

authors： Ehrmann S,Schmid O,Darquenne C,Rothen-Rutishauser B,Sznitman J,Yang L,Barosova H,Vecellio L,Mitchell J,Heuze-Vourc'h N

更新日期：2020-04-01 00:00:00

abstract：AIM:Spacer devices are inhalation aids of varying dimension and complexity, specifically designed to overcome problems with the use of pressurised metered dose inhalers (pMDIs). The aim of this review is to examine the current understanding about these inhalation devices and discuss their advantages and disadvantages. ...

journal_title：Expert opinion on drug delivery

authors： Lavorini F,Fontana GA

更新日期：2009-01-01 00:00:00

abstract：:Nitric oxide (NO), the 1992 'Molecule of the Year', is the focus of immense medical and scientific exploration. Interest in NO has grown exponentially since the initial and relatively recent discovery that NO is the long sought after endothelial relaxing factor. There is intense research that is continuing to expose t...

journal_title：Expert opinion on drug delivery

authors： Friedman A,Friedman J

更新日期：2009-10-01 00:00:00

abstract：INTRODUCTION:In any manufacturing process, the success of producing an end product with the desired properties and yield depends on a range of factors that include the equipment, process and formulation variables. It is the interest of manufacturers and researchers to understand each manufacturing process better and as...

journal_title：Expert opinion on drug delivery

authors： Oh CM,Guo Q,Wan Sia Heng P,Chan LW

更新日期：2014-07-01 00:00:00