Formulation strategies to modulate drug release from poloxamer based in situ gelling systems.

abstract：INTRODUCTION:Lymphatic vessels are the preferential route of most solid tumors to spread their metastases in the body. The onset of metastatic nests in draining lymph nodes (LNs) are a significant indicator of cancer progression and a dismaying sign of worsen staging. Therefore, the individuation and elimination of can...

journal_title：Expert opinion on drug delivery

authors： Obinu A,Gavini E,Rassu G,Maestri M,Bonferoni MC,Giunchedi P

更新日期：2018-05-01 00:00:00

abstract：IMPORTANCE OF THE FIELD:Recently, there has been substantial progress in the development of integrin targeted pharmaceuticals and drug delivery systems. Integrin is an important member in the cell adhesion molecule family, which is involved in regulation of complex biological conditions, from keeping normal physiologic...

journal_title：Expert opinion on drug delivery

authors： Wang Z,Chui WK,Ho PC

更新日期：2010-02-01 00:00:00

abstract：INTRODUCTION:Harnessing RNA interference as a therapeutic approach has the potential to significantly expand the druggable target space, offering new hope for treatment of diseases that cannot be addressed with existing classes of drugs. A number of siRNA therapeutics have already progressed into preclinical and clinic...

journal_title：Expert opinion on drug delivery

authors： Gindy ME,Leone AM,Cunningham JJ

更新日期：2012-02-01 00:00:00

abstract：:Many agents used to treat cancer are toxic to normal tissues. Thus, treatments delivering drug specifically to tumour, while minimising exposure to normal tissue, may be advantageous over non-targeted treatments. The exquisite specificity of the immune system has been used successfully to help develop targeted antican...

journal_title：Expert opinion on drug delivery

authors： Brumlik MJ,Daniel BJ,Waehler R,Curiel DT,Giles FJ,Curiel TJ

更新日期：2008-01-01 00:00:00

abstract：OBJECTIVES:The aim of this work is to synthesize a novel stable and biodegradable nitric oxide (NO) donor polymer based on a chitosan backbone. This polymer needed to be linked to glutathione (GSH), which was nitrosated in a second step. This polymer has been developed as an NO delivery platform that could be further e...

journal_title：Expert opinion on drug delivery

authors： Shah SU,Martinho N,Socha M,Pinto Reis C,Gibaud S

更新日期：2015-08-01 00:00:00

abstract：:The treatment of genetic diseases using therapeutic gene transfer is considered to be a significant development. This development has brought with it certain limitations, and the process of overcoming these barriers has seen a drastic change in gene delivery. Many metal ions such as Mg2+, Mn2+, Ba2+ and, most importan...

journal_title：Expert opinion on drug delivery

authors： Kulkarni VI,Shenoy VS,Dodiya SS,Rajyaguru TH,Murthy RR

更新日期：2006-03-01 00:00:00

abstract：INTRODUCTION:Nanocarrier-based delivery systems offer multiple benefits to overcome limitations of the traditional drug dosage forms, such as protection of the drug, enhanced bioavailability, targeted delivery to disease site, etc. Nanocarriers have exhibited tremendous successes in targeted delivery of therapeutics to...

journal_title：Expert opinion on drug delivery

authors： Majumder J,Minko T

更新日期：2020-10-08 00:00:00

abstract：INTRODUCTION:Reversible Addition Fragmentation Chain Transfer (RAFT) polymerisation is now an established tool for polymer chemists to create various polymer architectures with precise control over the molecular weight, and to install a variety of different moieties onto the polymer chain ends. Recently, there seems to...

journal_title：Expert opinion on drug delivery

authors： Gregory A,Stenzel MH

更新日期：2011-02-01 00:00:00

abstract：:The CYPHER (Cordis, Johnson & Johnson) sirolimus-eluting stent and the TAXU (Boston Scientific) paclitaxel-eluting stent have been extensively evaluated and have been proven to be significant novel tools for the treatment of coronary artery disease. Several sirolimus derivatives have already emerged, receiving CE Mark...

journal_title：Expert opinion on drug delivery

authors： Vaina S,Serruys PW

更新日期：2006-11-01 00:00:00

abstract：INTRODUCTION:With the incorporation of edge activators into the lipid bilayer structure, elasticity properties are given to liposomes. Regardless of the debate over the precise permeation mechanism of elastic liposomes, these vesicles have been proven to enhance drug permeation into or through skin in most cases. AREA...

journal_title：Expert opinion on drug delivery

authors： Chen J,Lu WL,Gu W,Lu SS,Chen ZP,Cai BC

更新日期：2013-06-01 00:00:00

abstract：INTRODUCTION:Cancer initiating or stem cells (CSCs) are a small population of cells in the tumor mass, which have been reported to be present in different types of cancers. CSCs usually reside within the tumor and are responsible for reoccurrence of cancer. The imprecise, inaccessible nature and increased efflux of con...

journal_title：Expert opinion on drug delivery

authors： Ahmad G,Amiji MM

更新日期：2017-08-01 00:00:00

abstract：INTRODUCTION:The utility of controlled and sustained release of drugs from polymeric systems, both bulk (hydrogels) and colloids (nanoparticles), is a key point that should be addressed. Unfortunately, classic delivery systems are essentially driven by diffusion, which is very quick due to the high concentration gradie...

journal_title：Expert opinion on drug delivery

authors： Mauri E,Papa S,Masi M,Veglianese P,Rossi F

更新日期：2017-11-01 00:00:00

abstract：AIM:Spacer devices are inhalation aids of varying dimension and complexity, specifically designed to overcome problems with the use of pressurised metered dose inhalers (pMDIs). The aim of this review is to examine the current understanding about these inhalation devices and discuss their advantages and disadvantages. ...

journal_title：Expert opinion on drug delivery

authors： Lavorini F,Fontana GA

更新日期：2009-01-01 00:00:00

abstract：INTRODUCTION:Liposomes are well-known as drug carriers, and are now critical components of two of six types of adjuvants present in licensed vaccines. The liposomal vaccine adjuvant field has long been dynamic and innovative, and research in this area is further examined as new commercial products appear in parallel wi...

journal_title：Expert opinion on drug delivery

authors： Alving CR,Beck Z,Matyas GR,Rao M

更新日期：2016-06-01 00:00:00

abstract：:The introduction of insulin pens has helped improve adherence in Type 1 or 2 diabetes, and reduce inaccurate dosing, fear of injection, and social embarrassment associated with vial and syringe. This report presents the published evidence base for the accuracy, patient preference and economic evaluation of one prefill...

journal_title：Expert opinion on drug delivery

authors： Pfützner A,Asakura T,Sommavilla B,Lee W

更新日期：2008-08-01 00:00:00

abstract：BACKGROUND:The lung comprises an interesting route of administration not only for topical drugs but also for systemically acting drugs. Over the last years, several models have been developed in order to study the efficacy and safety of pulmonary drug delivery. OBJECTIVE:This review describes relevant drug delivery mo...

journal_title：Expert opinion on drug delivery

authors： Fernandes CA,Vanbever R

更新日期：2009-11-01 00:00:00

abstract：OBJECTIVES:This study focuses on the development of amlodipine bilayer buccal tablets of hydroxypropyl methylcellulose (HPMC) matrix system containing polyacrylate polymer (Carbopol(®))/β-cyclodextrin as the drug layer and ethylcellulose as the non-swellable backing layer, and their biointerfacial phenomena. METHODS:T...

journal_title：Expert opinion on drug delivery

authors： Panda B,Subhadarsini R,Mallick S

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Augmentation of simvastatin (SMV) cytotoxicity in breast carcinoma cell lines MCF-7, by: improvement of cellular uptake and loading on alpha lipoic acid (ALA). METHODS:In this study, SMV was loaded on ALA nanoparticles and characterized for surface morphology, SMV entrapment efficiency percent (%EE), zeta p...

journal_title：Expert opinion on drug delivery

authors： Fahmy UA,Aljaeid BM

更新日期：2016-12-01 00:00:00

abstract：INTRODUCTION:Many drug candidates with high therapeutic efficacy have low water solubility, which limits the administration and transport across physiological barriers, for example, the tumor tissue barrier. Therefore, strategies are needed to permeabilize the physiological barriers safely so that hydrophobic drugs may...

journal_title：Expert opinion on drug delivery

authors： Wang G,Wang J,Wu W,Tony To SS,Zhao H,Wang J

更新日期：2015-01-01 00:00:00

abstract：INTRODUCTION:Viral and non-viral vectors have been used as methods of delivery in gene therapy for many CNS diseases. Currently, viral vectors such as adeno-associated viruses (AAV), retroviruses, lentiviruses, adenoviruses and herpes simplex viruses (HHV) are being used as successful vectors in gene therapy at clinica...

journal_title：Expert opinion on drug delivery

authors： Jayant RD,Sosa D,Kaushik A,Atluri V,Vashist A,Tomitaka A,Nair M

更新日期：2016-10-01 00:00:00

abstract：IMPORTANCE OF THE FIELD:The review presents the design strategy and synthesis of multifunctional dendrimers and hyperbranched polymers with the objective to develop effective drug delivery systems. AREAS COVERED IN THIS REVIEW:Well-characterized, commercially available dendritic polymers were subjected to functionaliz...

journal_title：Expert opinion on drug delivery

authors： Paleos CM,Tsiourvas D,Sideratou Z,Tziveleka LA

更新日期：2010-12-01 00:00:00

abstract：:Beta-adrenoceptor blocking drugs (beta-blockers) are one of the most frequently used class of cardiovascular drugs that are mainly used in conventional dosage forms., which have their own limitations including hepatic first-pass metabolism, high incidence of adverse effects due to variable absorption profiles, higher ...

journal_title：Expert opinion on drug delivery

authors： Aqil M,Sultana Y,Ali A

更新日期：2006-05-01 00:00:00

abstract：INTRODUCTION:Polymers can be designed to modify their features as a function of the level and nature of the surrounding microorganisms. Such responsive polymers can endow drug delivery systems and drug-medical device combination products with improved performance against intracellular infections and biofilms. AREAS CO...

journal_title：Expert opinion on drug delivery

authors： Alvarez-Lorenzo C,Garcia-Gonzalez CA,Bucio E,Concheiro A

更新日期：2016-08-01 00:00:00

abstract：:With the advent of new, and often expensive, therapeutics designed for aerosol delivery to the lung, there is a need to improve the targeting and efficiency of their delivery. By controlling breathing patterns associated with inhaled aerosols, it has been shown that deposition in the lung can be both maximised and tar...

journal_title：Expert opinion on drug delivery

authors： Bennett WD

更新日期：2005-07-01 00:00:00

abstract：INTRODUCTION:Oral delivery of therapeutic peptide hormones offers the promise of greater patient compliance when compared to parenteral administration routes. However, it is a huge challenge in the pharmaceutical field. Due to increasing demand for oral delivery of peptide hormones such as insulin, gonadotropin-releasi...

journal_title：Expert opinion on drug delivery

authors： Varamini P,Toth I

更新日期：2016-01-01 00:00:00

abstract：INTRODUCTION:Since decades, cancer is a major public health problem worldwide. The increasing knowledge of molecular and tumor biology has significantly changed the cancer treatment paradigms during the past few years. AREA COVERED:Conventionally, the first-line treatment of solid tumors is their surgical removal foll...

journal_title：Expert opinion on drug delivery

authors： Rahman M,Alharbi KS,Alruwaili NK,Anfinan N,Almalki WH,Padhy I,Sambamoorthy U,Swain S,Beg S

更新日期：2020-06-01 00:00:00

abstract：INTRODUCTION:Cancer is a leading cause of death worldwide and efficient new strategies are urgently needed to combat its high mortality and morbidity statistics. Fortunately, over the years, nanotechnology has evolved as a frontrunner in the areas of imaging, diagnostics and therapy, giving the possibility of monitorin...

journal_title：Expert opinion on drug delivery

authors： Luque-Michel E,Imbuluzqueta E,Sebastián V,Blanco-Prieto MJ

更新日期：2017-01-01 00:00:00

abstract：INTRODUCTION:Gastroretentive floating drug delivery systems have emerged as efficient approaches for enhancing the bioavailability and controlled delivery of various therapeutic agents. Significant advancements exploiting chitosan have been made worldwide, in order to investigate these systems according to patient requ...

journal_title：Expert opinion on drug delivery

authors： Pahwa R,Saini N,Kumar V,Kohli K

更新日期：2012-05-01 00:00:00

abstract：OBJECTIVES:The aim of the present study is to evaluate the influence of factors such as biopharmaceutical properties and study protocol on the emptying of pellets from the human stomach in a fed state. METHODS:A systematic literature search for data on human gastric emptying of pellets from a fed stomach state investi...

journal_title：Expert opinion on drug delivery

authors： Bürmen B,Locatelli I,Mrhar A,Bogataj M

更新日期：2015-08-01 00:00:00

abstract：:dl-Methylphenidate (MPH) remains the most widely used pharmacological agent in the treatment of attention-deficit/hyperactivity disorder (ADHD). The predominantly dopaminergic mechanism of the psychostimulant actions has become more clearly defined. Neuroimaging and genetic studies are revealing the underlying neuropa...

journal_title：Expert opinion on drug delivery

authors： Patrick KS,González MA,Straughn AB,Markowitz JS

更新日期：2005-01-01 00:00:00