Drug delivery using multifunctional dendrimers and hyperbranched polymers.

abstract：INTRODUCTION:Use of pre-filled syringes as both a packaging and delivery system for pharmaceutical drug products is accelerating. Pre-filled syringes must meet the quality and suitability for use requirements for both systems, including compatibility with the drug product. Relevant incompatibilities between pre-filled ...

journal_title：Expert opinion on drug delivery

authors： Jenke DR

更新日期：2014-10-01 00:00:00

abstract：INTRODUCTION:Diseases of the inner ear include those of the auditory and vestibular systems, and frequently result in disabling hearing loss or vertigo. Despite a rapidly expanding pipeline of potential cochlear therapeutics, the inner ear remains a challenging organ for targeted drug delivery, and new technologies are...

journal_title：Expert opinion on drug delivery

authors： Ayoob AM,Borenstein JT

更新日期：2015-03-01 00:00:00

abstract：INTRODUCTION:Over the past several decades, liposomes have been used in a variety of applications, from delivery vehicles to cell membrane models. In terms of pharmaceutical use, they can offer control over the release of active agents encapsulated into their lipid bilayer or aqueous core, while providing protection fr...

journal_title：Expert opinion on drug delivery

authors： Bowey K,Tanguay JF,Tabrizian M

更新日期：2012-02-01 00:00:00

abstract：INTRODUCTION:Diabetic Retinopathy (DR) is one of the most common causes of blindness among the working population worldwide. Clearly, there is an unmet clinical need to find better treatment options for DR. Areas covered: The literature search was conducted on PubMed with no limitation on language or year of publicatio...

journal_title：Expert opinion on drug delivery

authors： Nirmal J,Radhakrishnan K,Moreno M,Natarajan JV,Laude A,Lim TH,Venkatraman S,Agrawal R

更新日期：2016-11-01 00:00:00

abstract：OBJECTIVES:The aim of the present study is to evaluate the influence of factors such as biopharmaceutical properties and study protocol on the emptying of pellets from the human stomach in a fed state. METHODS:A systematic literature search for data on human gastric emptying of pellets from a fed stomach state investi...

journal_title：Expert opinion on drug delivery

authors： Bürmen B,Locatelli I,Mrhar A,Bogataj M

更新日期：2015-08-01 00:00:00

abstract：:Objective: Conventional chloramphenicol (CHL) eye drops are widely used anti-infection formulations for acute bacterial conjunctivitis. However, the therapeutic effects are limited by insufficient concentration in the conjunctival sac. Hence, the objective of this study is to formulate and develop novel CHL eye drops ...

journal_title：Expert opinion on drug delivery

authors： Xu Y,Zhang C,Zhu X,Wang X,Wang H,Hu G,Fu Q,He Z

更新日期：2019-06-01 00:00:00

abstract：INTRODUCTION:A major problem with conventional antitumor therapeutics is nonselective delivery of cytotoxic drugs to normal vital organs and tissues but little delivery to tumor tissues. AREAS COVERED:Here, the authors describe the tumor selective delivery of antitumor drugs by taking advantage of nano-sized drugs and...

journal_title：Expert opinion on drug delivery

authors： Nakamura H,Fang J,Maeda H

更新日期：2015-01-01 00:00:00

abstract：INTRODUCTION:Simvastatin (SV) is a drug from the statin class, currently used orally as an anti-cholesterolemic drug. It inhibits the 3-hydroxy-3-methyl-glutaryl-Coenzyme A (HMG-CoA) reductase to reduce cholesterol synthesis. Recently, it has been found that SV also has several other protective pharmacological actions ...

journal_title：Expert opinion on drug delivery

authors： Tulbah AS,Ong HX,Colombo P,Young PM,Traini D

更新日期：2016-10-01 00:00:00

abstract：IMPORTANCE OF THE FIELD:Cancer is the most formidable human disease. Owing to the heterogeneity of cancer, a single-treatment modality is insufficient for the complete elimination of cancer cells. Therapeutic strategies from various aspects are needed for cancer therapy. These therapeutic agents should be carefully sel...

journal_title：Expert opinion on drug delivery

authors： Kaneda Y

更新日期：2010-09-01 00:00:00

abstract：INTRODUCTION:Recent advances in pharmacological therapies to treat ocular diseases such as glaucoma, age-related macular degeneration, diabetic macular edema and retinal vascular occlusions have greatly improved the prognosis for these diseases. Due to these advances in pharmacological therapy, there is a great deal of...

journal_title：Expert opinion on drug delivery

authors： Kang-Mieler JJ,Osswald CR,Mieler WF

更新日期：2014-10-01 00:00:00

abstract：INTRODUCTION:Gastroretentive floating drug delivery systems have emerged as efficient approaches for enhancing the bioavailability and controlled delivery of various therapeutic agents. Significant advancements exploiting chitosan have been made worldwide, in order to investigate these systems according to patient requ...

journal_title：Expert opinion on drug delivery

authors： Pahwa R,Saini N,Kumar V,Kohli K

更新日期：2012-05-01 00:00:00

abstract：INTRODUCTION:Viral and non-viral vectors have been used as methods of delivery in gene therapy for many CNS diseases. Currently, viral vectors such as adeno-associated viruses (AAV), retroviruses, lentiviruses, adenoviruses and herpes simplex viruses (HHV) are being used as successful vectors in gene therapy at clinica...

journal_title：Expert opinion on drug delivery

authors： Jayant RD,Sosa D,Kaushik A,Atluri V,Vashist A,Tomitaka A,Nair M

更新日期：2016-10-01 00:00:00

abstract：INTRODUCTION:RNA interference (RNAi) is a powerful mechanism for gene silencing with the potential to greatly impact the development of new therapies for many human diseases. Short interfering RNAs (siRNAs) may be the ideal molecules for therapeutic RNAi. However, therapeutic siRNAs face significant challenges that mus...

journal_title：Expert opinion on drug delivery

authors： McMahon KM,Thaxton CS

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND:The advent of therapeutic proteins highlights the need for delivery systems that protect and extend the duration of its action. Ranibizumab-VEGF is one such drug used for treating wet AMD. This paper describes a facile method to sustain bioactive ranibizumab release from PLGA-based particles. METHODS:Two em...

journal_title：Expert opinion on drug delivery

authors： Chua HY,Lui YS,Bhuthalingam R,Agrawal R,Wong T,Preiser PR,Venkatraman S

更新日期：2018-12-01 00:00:00

abstract：INTRODUCTION:Rapid clearance of drugs from the body results in short therapeutic half-life and is an integral property of many protein and peptide-based drugs. To maintain the desired therapeutic effect patients are required to administer higher doses more frequently, which is inconvenient and risks undesirable side ef...

journal_title：Expert opinion on drug delivery

authors： Sleep D

更新日期：2015-05-01 00:00:00

abstract：IMPORTANCE OF THE FIELD:Efficient systemic delivery of low-molecular-mass therapeutics to neuronal tissue remains a central issue not only to drug development but also to the chronic treatment of a range of neurodegenerative disorders. AREAS COVERED IN THIS REVIEW:This review discusses the potential of using RNA inter...

journal_title：Expert opinion on drug delivery

authors： Campbell M,Ozaki E,Humphries P

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND:The delivery of drugs through the buccal mucosa has received a great deal of attention over the last two decades, and yet there are not many buccal delivery products available on the market. OBJECTIVE:This review outlines the advantages and disadvantages of buccal drug delivery, provides a historical perspe...

journal_title：Expert opinion on drug delivery

authors： Pather SI,Rathbone MJ,Senel S

更新日期：2008-05-01 00:00:00

abstract：INTRODUCTION:Glioblastoma is a type of brain cancer arises from glial cells. Glioblastoma multiforme (GBM), a subtype of glioblastoma, is the most common and most aggressive primary brain tumor. Currently, GBM therapy includes surgery and post-operative high-doses of radiation and chemotherapy. This therapeutic strateg...

journal_title：Expert opinion on drug delivery

authors： Gutkin A,Cohen ZR,Peer D

更新日期：2016-11-01 00:00:00

abstract：INTRODUCTION:Nanocarrier-based delivery systems offer multiple benefits to overcome limitations of the traditional drug dosage forms, such as protection of the drug, enhanced bioavailability, targeted delivery to disease site, etc. Nanocarriers have exhibited tremendous successes in targeted delivery of therapeutics to...

journal_title：Expert opinion on drug delivery

authors： Majumder J,Minko T

更新日期：2020-10-08 00:00:00

abstract：BACKGROUND:Although various injected peptide and protein therapeutics have been developed successfully over the past 25 years, several pharmacokinetic and immunological challenges are still encountered that can limit the efficacy of both novel and established biotech molecules. OBJECTIVE AND METHOD:PEGylation is a pop...

journal_title：Expert opinion on drug delivery

authors： Ryan SM,Mantovani G,Wang X,Haddleton DM,Brayden DJ

更新日期：2008-04-01 00:00:00

abstract：INTRODUCTION:Calcium channel blockers are a very important class of antihypertensive drugs. Most calcium channel blockers (CCBs) exhibiting low oral bioavailability are required to be taken more than once a day due to their short half-lives which result in poor patient compliance. There is an ineluctable requirement fo...

journal_title：Expert opinion on drug delivery

authors： Ahad A,Al-Jenoobi FI,Al-Mohizea AM,Aqil M,Kohli K

更新日期：2013-08-01 00:00:00

abstract：INTRODUCTION:Skin disorders will continue to cause complications in patients. At present, there is an expansion of research into dermatologic treatment due to a critical need for new treatment options to treat skin diseases. AREAS COVERED:The skin itself provides a natural barrier against particle penetration for topi...

journal_title：Expert opinion on drug delivery

authors： Gupta M,Agrawal U,Vyas SP

更新日期：2012-07-01 00:00:00

abstract：INTRODUCTION:The development of therapeutics for central nervous system (CNS) disorders is still considered a challenging area in drug development due to insufficient translocation through the blood-brain barrier (BBB). Under normal conditions, BBB restrict the penetration of more than 98% of blood-borne molecules incl...

journal_title：Expert opinion on drug delivery

authors： Al-Ahmady ZS

更新日期：2018-04-01 00:00:00

abstract：:Directly delivering liquid using direct current power was a dream for 40 years. Now, the electrokinetic pump can accomplish it. This review reports recent developments in microfabricated electrokinetic pump technologies and their applications, and also discusses the electrophoresis pump and elctroosmotic pump, as well...

journal_title：Expert opinion on drug delivery

authors： Chen L,Choo J,Yan B

更新日期：2007-03-01 00:00:00

abstract：BACKGROUND:Pulmonary cell culture models for the development of new aerosol medicines are attracting increasing interest. Ease of handling, ethical acceptance and high explanatory power are the main advantages of cell culture systems in pulmonary drug research. OBJECTIVE:Pulmonary cell culture models are described and...

journal_title：Expert opinion on drug delivery

authors： Bur M,Lehr CM

更新日期：2008-06-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Alendronate sodium (ALS) is the most common drug used for the treatment of osteoporosis. The challenges facing ALS use include: very poor oral bioavailability (0.6%), esophageal ulcers, and complicated instructions for its use. The objective of this research is to utilize nanotechnology to for...

journal_title：Expert opinion on drug delivery

authors： Hosny KM,Ahmed OA,Al-Abdali RT

更新日期：2013-06-01 00:00:00

abstract：IMPORTANCE OF THE FIELD:Recently, there has been substantial progress in the development of integrin targeted pharmaceuticals and drug delivery systems. Integrin is an important member in the cell adhesion molecule family, which is involved in regulation of complex biological conditions, from keeping normal physiologic...

journal_title：Expert opinion on drug delivery

authors： Wang Z,Chui WK,Ho PC

更新日期：2010-02-01 00:00:00

abstract：INTRODUCTION:A nanosuspension or nanocrystal suspension is a versatile formulation combining conventional and innovative features. It comprises 100% pure drug nanoparticles with sizes in the nano-scale range, generally stabilized by surfactants or polymers. Nanosuspensions are usually obtained in liquid media with bott...

journal_title：Expert opinion on drug delivery

authors： Leone F,Cavalli R

更新日期：2015-01-01 00:00:00

abstract：INTRODUCTION:Dextran is a family of natural polysaccharides that is widely under investigation for use as polymeric carriers in novel drug delivery systems. The optimal drug delivery (and consequently maximum therapeutic effect) will be accomplished when carrier systems are used mainly for drugs with antitumoral activi...

journal_title：Expert opinion on drug delivery

authors： Varshosaz J

更新日期：2012-05-01 00:00:00

abstract：:Therapeutic antibodies are well established as an important class of drugs in modern medicine. The exquisite specificity and affinity for a specific target offered by antibodies has also encouraged their development as delivery vehicles for agents such as radionuclides to target tissues, for radioimmunoimaging and rad...

journal_title：Expert opinion on drug delivery

authors： Kenanova V,Wu AM

更新日期：2006-01-01 00:00:00