Abstract:
INTRODUCTION:A nanosuspension or nanocrystal suspension is a versatile formulation combining conventional and innovative features. It comprises 100% pure drug nanoparticles with sizes in the nano-scale range, generally stabilized by surfactants or polymers. Nanosuspensions are usually obtained in liquid media with bottom-up and top-down methods or by their combination. They have been designed to enhance the solubility, the dissolution rate and the bioavailability of drugs via various administration routes. Due to their small sizes, nanosuspensions can be also considered a drug delivery nanotechnology for the preparation of nanomedicine products. AREAS COVERED:This review focuses on the state of the art of the nanocrystal-based formulation. It describes theory characteristics, design parameters, preparation methods, stability issues, as well as specific in vivo applications. Innovative strategies proposed to obtain nanomedicine formulation using nanocrystals are also reported. EXPERT OPINION:Many drug nanodelivery systems have been developed to increase the bioavailability of drugs and to decrease adverse side effects, but few can be industrially manufactured. Nanocrystals can close this gap by combining traditional and innovative drug formulations. Indeed, they can be used in many pharmaceutical dosage forms as such, or developed as new nano-scaled products. Engineered surface nanocrystals have recently been proposed as a dual strategy for stability enhancement and targeting delivery of nanocrystals.
journal_name
Expert Opin Drug Delivjournal_title
Expert opinion on drug deliveryauthors
Leone F,Cavalli Rdoi
10.1517/17425247.2015.1043886subject
Has Abstractpub_date
2015-01-01 00:00:00pages
1607-25issue
10eissn
1742-5247issn
1744-7593journal_volume
12pub_type
杂志文章,评审abstract:INTRODUCTION:RNA interference (RNAi) is a powerful mechanism for gene silencing with the potential to greatly impact the development of new therapies for many human diseases. Short interfering RNAs (siRNAs) may be the ideal molecules for therapeutic RNAi. However, therapeutic siRNAs face significant challenges that mus...
journal_title:Expert opinion on drug delivery
pub_type: 杂志文章,评审
doi:10.1517/17425247.2014.866089
更新日期:2014-02-01 00:00:00
abstract::The treatment of genetic diseases using therapeutic gene transfer is considered to be a significant development. This development has brought with it certain limitations, and the process of overcoming these barriers has seen a drastic change in gene delivery. Many metal ions such as Mg2+, Mn2+, Ba2+ and, most importan...
journal_title:Expert opinion on drug delivery
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doi:10.1517/17425247.3.2.235
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abstract::The treatment of oral and periodontal diseases and associated anomalies accounts for a significant proportion of the healthcare burden, with the manifestations of these conditions being functionally and psychologically debilitating. Growth factors are critical to the development, maturation, maintenance and repair of ...
journal_title:Expert opinion on drug delivery
pub_type: 杂志文章,评审
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abstract:IMPORTANCE OF THE FIELD:The prediction of the in vivo drug release characteristics of modified release (MR) oral dosage forms by in vitro dissolution tests is a prerequisite for successful product development. AREAS COVERED IN THIS REVIEW:To improve the predictive power of dissolution testing, the authors recently dev...
journal_title:Expert opinion on drug delivery
pub_type: 杂志文章,评审
doi:10.1517/17425247.2010.527943
更新日期:2010-11-01 00:00:00
abstract:INTRODUCTION:Management of Osteoarthritis (OA) still is a challenge for clinicians. Taking into account a multidisciplinary approach including pharmacological and non-pharmacological treatments, intra-articular (IA) injection could be considered as an effective local therapy. Areas covered This review provides a new pe...
journal_title:Expert opinion on drug delivery
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abstract:BACKGROUND:Pulmonary cell culture models for the development of new aerosol medicines are attracting increasing interest. Ease of handling, ethical acceptance and high explanatory power are the main advantages of cell culture systems in pulmonary drug research. OBJECTIVE:Pulmonary cell culture models are described and...
journal_title:Expert opinion on drug delivery
pub_type: 杂志文章,评审
doi:10.1517/17425247.5.6.641
更新日期:2008-06-01 00:00:00
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journal_title:Expert opinion on drug delivery
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journal_title:Expert opinion on drug delivery
pub_type: 杂志文章,评审
doi:10.1517/17425240903548232
更新日期:2010-03-01 00:00:00
abstract::Objective: Conventional chloramphenicol (CHL) eye drops are widely used anti-infection formulations for acute bacterial conjunctivitis. However, the therapeutic effects are limited by insufficient concentration in the conjunctival sac. Hence, the objective of this study is to formulate and develop novel CHL eye drops ...
journal_title:Expert opinion on drug delivery
pub_type: 杂志文章
doi:10.1080/17425247.2019.1609447
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journal_title:Expert opinion on drug delivery
pub_type: 杂志文章,评审
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更新日期:2018-05-01 00:00:00
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journal_title:Expert opinion on drug delivery
pub_type: 杂志文章,评审
doi:10.1080/17425247.2016.1188800
更新日期:2016-11-01 00:00:00
abstract::Introduction: Pulmonary drug delivery is a complex field of research combining physics which drive aerosol transport and deposition and biology which underpins efficacy and toxicity of inhaled drugs. A myriad of preclinical methods, ranging from in-silico to in-vitro, ex-vivo and in-vivo, can be implemented.Areas cove...
journal_title:Expert opinion on drug delivery
pub_type: 杂志文章,评审
doi:10.1080/17425247.2020.1730807
更新日期:2020-04-01 00:00:00
abstract:INTRODUCTION:Topically applied small interfering RNA (siRNA) can be an effective treatment for skin disorders. Using noninvasive strategies can be a safe and effective siRNA-permeation-enhancement approach for facilitating skin delivery. It has been demonstrated that noninvasive approaches for enhancing siRNA transport...
journal_title:Expert opinion on drug delivery
pub_type: 杂志文章,评审
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更新日期:2016-01-01 00:00:00
abstract:INTRODUCTION:Cancer is a leading cause of death worldwide and efficient new strategies are urgently needed to combat its high mortality and morbidity statistics. Fortunately, over the years, nanotechnology has evolved as a frontrunner in the areas of imaging, diagnostics and therapy, giving the possibility of monitorin...
journal_title:Expert opinion on drug delivery
pub_type: 杂志文章,评审
doi:10.1080/17425247.2016.1205585
更新日期:2017-01-01 00:00:00
abstract:INTRODUCTION:Gemcitabine, an anticancer drug, is a nucleoside analog deoxycytidine antimetabolite, which acts against a wide range of solid tumors. The limitation of gemcitabine is its rapid inactivation by the deoxycytidine deaminase enzyme following its in vivo administration. AREAS COVERED:One of the most promising...
journal_title:Expert opinion on drug delivery
pub_type: 杂志文章,评审
doi:10.1517/17425247.2011.632630
更新日期:2011-12-01 00:00:00
abstract:INTRODUCTION:Fueled by a growing global expectation of the health and medical fields, billions of dollars/euros/pounds are invested every year in the research of new biological and chemical entities. However, little interest is seen in the development of novel drug delivery systems. One such system, pre-filled syringe ...
journal_title:Expert opinion on drug delivery
pub_type: 杂志文章,评审
doi:10.1517/17425247.2014.923400
更新日期:2014-09-01 00:00:00
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journal_title:Expert opinion on drug delivery
pub_type: 社论
doi:10.1517/17425247.2014.894505
更新日期:2014-05-01 00:00:00
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journal_title:Expert opinion on drug delivery
pub_type: 杂志文章,评审
doi:10.1517/17425247.2.6.1075
更新日期:2005-11-01 00:00:00
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journal_title:Expert opinion on drug delivery
pub_type: 杂志文章
doi:10.1080/17425247.2018.1517740
更新日期:2018-10-01 00:00:00
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journal_title:Expert opinion on drug delivery
pub_type: 杂志文章,评审
doi:10.1517/17425247.5.4.371
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journal_title:Expert opinion on drug delivery
pub_type: 杂志文章
doi:10.1080/17425247.2017.1264386
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journal_title:Expert opinion on drug delivery
pub_type: 杂志文章,评审
doi:10.1517/17425247.2012.681775
更新日期:2012-06-01 00:00:00
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journal_title:Expert opinion on drug delivery
pub_type: 杂志文章
doi:10.1517/17425247.2013.799136
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journal_title:Expert opinion on drug delivery
pub_type: 杂志文章,评审
doi:10.1517/17425247.2010.490554
更新日期:2010-07-01 00:00:00
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journal_title:Expert opinion on drug delivery
pub_type: 杂志文章,评审
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journal_title:Expert opinion on drug delivery
pub_type: 杂志文章,评审
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journal_title:Expert opinion on drug delivery
pub_type: 杂志文章,评审
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journal_title:Expert opinion on drug delivery
pub_type: 杂志文章,评审
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journal_title:Expert opinion on drug delivery
pub_type: 杂志文章,评审
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更新日期:2013-06-01 00:00:00
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journal_title:Expert opinion on drug delivery
pub_type: 杂志文章,评审
doi:10.1517/17425247.2015.961418
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