Endothelial nanomedicine for the treatment of pulmonary disease.

Abstract:

INTRODUCTION:Even though pulmonary diseases are among the leading causes of morbidity and mortality in the world, exceedingly few life-prolonging therapies have been developed for these maladies. Relief may finally come from nanomedicine and targeted drug delivery. AREAS COVERED:Here, we focus on four conditions for which the pulmonary endothelium plays a pivotal role: acute respiratory distress syndrome, primary graft dysfunction occurring immediately after lung transplantation, pulmonary arterial hypertension and pulmonary embolism. For each of these diseases, we first evaluate the targeted drug delivery approaches that have been tested in animals. Then we suggest a 'need specification' for each disease: a list of criteria (e.g., macroscale delivery method, stability, etc.) that nanomedicine agents must meet in order to warrant human clinical trials and investment from industry. EXPERT OPINION:For the diseases profiled here, numerous nanomedicine agents have shown promise in animal models. However, to maximize the chances of creating products that reach patients, nanomedicine engineers and clinicians must work together and use each disease's need specification to guide the design of practical and effective nanomedicine agents.

journal_name

Expert Opin Drug Deliv

authors

Brenner JS,Greineder C,Shuvaev V,Muzykantov V

doi

10.1517/17425247.2015.961418

subject

Has Abstract

pub_date

2015-02-01 00:00:00

pages

239-61

issue

2

eissn

1742-5247

issn

1744-7593

journal_volume

12

pub_type

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